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Exploring the therapeutic potential of Qi Teng Mai Ning recipe in ischemic stroke and vascular cognitive impairment

Traditional Medicine Research 2024年第10期9卷 21-35页

作者： Jia-Yan Yao Yue-Lan Yang wei-jian chen Hai-Ying Fan Department of Neurosurgery Changxing People’s HospitalChangxing 313100China Department of Ultrasound Medicine Changxing People’s HospitalChangxing 313100China Department of Orthopedics The Fifth Clinical College of Guangzhou University of Chinese MedicineGuangzhou 510095China

Background:This study aims to explore the therapeutic effects of the Qi Teng Mai Ning recipe on ischemic stroke and vascular cognitive impairment through its potential to modulate cellular autophagy,with a focus on identifying its active ingredients and their target ***:The study began with the identification of active ingredients in the Qi Teng Mai Ning *** proceeded to screen the gene expression omnibus database for ischemic stroke and vascular cognitive impairment-associated differentially expressed mRNAs and to identify cellular autophagy-related proteins via the Human Autophagy *** proteins were annotated with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes functions and subjected to molecular docking with the recipe’s core active *** vitro cell experiments were conducted on hypoxic HT22 cells,involving CCK8 assay,lentiviral transfection to silence autophagy related 9B(ATG9B),immunofluorescence staining,and qPCR validation to investigate the effects of the recipe on ***:The analysis identified 104 active ingredients targeting 408 proteins and forming a complex ingredient-target *** 55 ischemic stroke-related and 909 vascular cognitive impairment-related differentially expressed mRNAs revealed 14 co-expressed *** docking showed quercetin,kaempferol,myrcene,and conferone as key ingredients targeting autophagy-related *** experiments indicated that the recipe significantly enhanced cell viability under hypoxic conditions,reduced apoptosis,and modulated the expression of autophagy-related factors,thereby decreasing apoptosis rates in HT22 ***:The Qi Teng Mai Ning recipe offers protective effects against ischemic stroke and vascular cognitive impairment by modulating autophagy-related *** efficacy highlights the potential of traditional Chinese medicine in treating these conditions,though further research is needed to fully understand its

关键词： Qi Teng Mai Ning recipe autophagy ischemic stroke vascular cognitive impairment traditional Chinese medicine

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Prediction and evaluation of optimum quenching temperature and microstructure in a 1300 MPa ultra-high-strength Q&P steel

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Journal of Iron and Steel Research(International) 2022年第2期29卷 307-315页

作者： Peng-fei Gao Ju-hua Liang wei-jian chen Feng Li Zheng-zhi Zhao Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation Beijing100083China Key Laboratory of Materials Physics Institute of Solid State PhysicsChinese Academy of SciencesHefei230031AnhuiChina

The quenching and partitioning steel is the representative of the third generation of advanced high-strength *** effect of quenching temperature on the microstructure and mechanical property of ferrite-containing quenching and partitioning steel was studied by intercritical annealing quenching and partitioning *** preparing a test steel with a tensile strength of 1300 MPa and total elongation of 19%,it is found that the actual optimum quenching temperature was lower than that calculated according to the constrained carbon *** results indicate that the martensite start temperature of the austenite was overestimated when considering the diffusion of carbon *** grain size which is affected by low temperature and the existence of ferrite during intercritical annealing influenced the optimum quenching temperature.A scheme considering the diffusion of various alloying elements and austenite grain size was proposed and *** this scheme,the optimum quenching temperature of intercritically annealed quenching and partitioning steel with complex microstructures was well predicted.

关键词： Quenching and partitioning Constrained carbon equilibrium Retained austenite Martensite start temperature Plasticity Quenching temperature

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Trace elements in magmatic and hydrothermal quartz:Implications on the genesis of the Xingluokeng Tungsten Deposit,South China

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Acta Geochimica 2024年第3期43卷 441-458页

作者： Qing-Qing Zhang You-wei chen jian-Feng Gao State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China

The Xingluokeng deposit is the largest gran-ite-related tungsten deposit within the Wuyi metallogenic belt in South *** Xingluokeng intrusion primarily consists of porphyritic biotite granite,biotite granite,andfine-grained *** deposit is represented by veinlet-disseminated mineralization with K-feldspathization and biotitization,alongside quartz-vein mineralization with gre-isenization and *** study investigates in-situ analyses of quartz compositions from both the intrusion and hydrothermal veinlets and *** element correlations indicate that trivalent Al^(3+)and Fe^(3+)replace Si^(4+)within the quartz lattice,with monovalent cations(such as Li^(+),Na^(+),and K^(+))primarily serving as charge *** Ge/Al ratios(<0.013)of quartz from granites suggest a mag-matic *** low Al/Ti and Ge/Ti ratios,accompanied by high Ti contents in quartz,suggest that the porphyritic biotite granite and biotite granite are characterized by rela-tively low levels of differentiation and high crystallization *** contrast,thefine-grained granite exhibits a higher degree of fractionation,lower crystallization tem-peratures,and a closer association with tungsten *** contents in quartz from quartz veins indicate Qz-Ⅰformed at temperatures above 400°C,while Qz-Ⅱto Qz-Ⅴformed at temperatures below 350°*** in different generations of quartz,as indicated by Al content and(Al+Fe)/(Li+Na+K)ratio,suggest that Qz-Ⅰprecipi-tated from a less acidicfluid with a stable pH,whereas Qz-Ⅱto Qz-Ⅴoriginated from a more acidicfluid with notable pH ***,alkaline alteration and acidic alteration supplied the essential Ca and Fe for the precipita-tion of scheelite and wolframite,respectively,highlighting a critical mechanism in tungsten mineralization at the Xin-gluokeng deposit.

关键词： Quartz Xingluokeng Tungsten deposit Trace elements South China

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Effect of Cr and isothermal holding temperature on microstructure and properties of complex phase steel with high formability(CH steel)

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Journal of Iron and Steel Research(International) 2023年第2期30卷 328-337页

作者： Xiao-hong Chu Peng-fei Gao wei-jian chen Feng Li Tao Kang Yan Zhao Xian-dong Yin Zheng-zhi Zhao Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing100083China Beijing Laboratory for Modern Transportation Advanced Metal Materials and Processing Technology University of Science and Technology BeijingBeijing100083China Technical Center Shougang Jingtang United Iron and Steel Co.Ltd.Tangshan063200HebeiChina

The effects of Cr contents(0.3 and 1.0 wt.%)and isothermal holding temperatures(400,440,and 480℃)on the microstructure evolution and properties of complex phase steel with high formability(CH steel)were investigated using dilatometry,scanning electron microscopy,transmission electron microscopy(TEM),and X-ray *** results show that the microstructures of CH steel with 0.3 wt.%Cr are ferrite,granular bainite,martensite,and retained austenite,while no ferrite is observed in the microstructure of CH steel with 1.0 wt.%Cr in the same *** promotes the precipitation of(Nb,Ti)C in the high-temperature austenite region through theoretical calculations and TEM *** retards the bainite transformation and refines the grain size of CH ***,as isothermal holding temperature increases from 400 to 480℃,the bainite and retained austenite fractions of two CH steels decrease,while the martensite fraction increases in the steels after final ***,the strength has an increasing tendency and the total elongation has a decreasing tendency with increasing isothermal temperature.

关键词： Complex phase steel High formability steel CH steel Cr Isothermal holding temperature Microstructure Mechanical property

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Digital signal acquisition system for complex nuclear reaction experiments

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Nuclear Science and Techniques 2024年第1期35卷 124-133页

作者： wei-Liang Pu Yan-Lin Ye jian-Ling Lou Jia-Hao chen School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China Institute of Applied Physics and Computational Mathematics Beijing 100094China

A digital data-acquisition system based on XIA LLC products was used in a complex nuclear reaction experiment using radioactive ion beams.A flexible trigger system based on a field-programmable gate array(FPGA)parametrization was developed to adapt to different experimental sizes.A user-friendly interface was implemented,which allows converting script language expressions into FPGA internal control *** proposed digital system can be combined with a conventional analog data acquisition system to provide more *** performance of the combined system was veri-fied using experimental data.

关键词： Digital signal acquisition system Trigger Programmable logic Timestamp

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Construct a 3D microsphere of HMX/B/Al/PTFE to obtain the high energy and combustion reactivity

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Defence Technology（防务技术） 2024年第2期32卷 45-54页

作者： jian Wang Jie chen Yaofeng Mao Yongjun Deng wei Cao Fude Nie Jun Wang Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621999PR China Shock and Vibration of Engineering Materials and Structures Key Lab of Sichuan Province Mianyang 621010PR China

Metal(aluminum and boron)based energetic materials have been wildly applied in various fields including aerospace,explosives and micro-devices due to their high energy ***,the low combustion efficiency and reactivity of metal fuels,especially boron(B),severely limit their practical ***,multi-component 3D microspheres of HMX/B/Al/PTFE(HBA)have been designed and successfully prepared by emulsion and solvent evaporation method to achieve superior energy and combustion *** reactivity and energy output of HBA are systematically measured by ignitionburning test,constant-volume explosion vessel system and bomb *** to the increased interfacial contact and reaction area,HBA shows higher flame propagation rate,faster pressurization rate and larger combustion heat of 29.95 cm/s,1077 kPa/s,and 6164.43 J/g,which is 1.5 times,3.5 times,and 1.03 times of the physical mixed counterpart(HBA-P).Meanwhile,HBA also shows enhanced energy output and reactivity than 3D microspheres of HMX/B/PTFE(HB)resulting from the high reactivity of *** reaction mechanism of 3D microspheres is comprehensively investigated through combustion emission spectral and thermal analysis(TG-DSC-MS).The superior reactivity and energy of HBA originate from the surface etching of fluorine to the inert shell(Al_(2)O_(3) and B_(2)O_(3))and the initiation effect of Al to *** work offers a promising approach to design and prepare high-performance energetic materials for the practical applications.

关键词： HMX/B/Al/PTFE 3D microspheres Surface etching Reaction mechanism

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Adhesion strength of tetrahydrofuran hydrates is dictated by substrate stiffness

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Petroleum Science 2024年第1期21卷 667-673页

作者： Yan-Wen Lin Tong Li Yi Zhang wei-wei Yan Xiao-Ming chen Zhi-Sen Zhang jian-Yang Wu Department of Physics Research Institute for Biomimetics and Soft MatterJiujiang Research Institute and Fujian Provincial Key Laboratory for Soft Functional Materials ResearchXiamen UniversityXiamen361005FujianChina Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201ZhejiangChina Key Laboratory of Icing and Anti/De-icing China Aerodynamics Research and Development CenterMianyang621000SichuanChina Micro-and Nano-technology Research Center State Key Laboratory for Manufacturing Systems EngineeringXi’an Jiaotong UniversityXi’an710049ShaanxiChina Electronic Materials Research Lab Key Laboratory of the Ministry of EducationXi’an Jiaotong UniversityXi’an710049ShaanxiChina NTNU Nanomechanical Lab Norwegian University of Science and Technology(NTNU)Trondheim7491Norway

Understanding the hydrate adhesion is important to tackling hydrate accretion in ***,the relationship between the Tetrahydrofuran(THF)hydrate adhesion strength(AS)and surface stiffness on elastic coatings is systemically examined by experimental shear force measurements and theoretical *** mechanical factor-elastic modulus of the coatings greatly dictates the hydrate AS,which is explained by the adhesion mechanics theory,beyond the usual factors such as wettability and structural ***,the hydrate AS increases with reducing the thickness of the elastic coatings,resulted from the decrease of the apparent surface elastic *** effect of critical thickness for the elastic materials with variable elastic modulus on the hydrate AS is also *** study provides deep perspectives on the regulation of the hydrate AS by the elastic modulus of elastic materials,which is of significance to design anti-hydrate surfaces for mitigation of hydrate accretion in petro-pipelines.

关键词： Hydrate Adhesion strength Elastic modulus Coatings

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Defect-modulated and heteroatom-functionalized Ti_(3−x)C_(2)T_(y)MXene 3D nanocavities induce growth of MoSe_(2)nanoflakes toward electrocatalytic hydrogen evolution in all pH electrolytes

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Nano Research 2024年第7期17卷 6294-6304页

作者： Ming Du Xianzhi Yang jian Zhang wei chen Huajie Huang Xinbao Zhu Xing’ao Li State Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Centre for Advanced Materials(SICAM)Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023China College of Electronic and Optical Engineering and College of Flexible Electronics Nanjing University of Posts and Telecommunications(NJUPT) Nanjing 210023China New Energy Technology Engineering Lab of jiangsu Province College of ScienceNanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023China College of Pharmaceutical and Chemical Engineering Taizhou UniversityJiaojiang 318000China College of Mechanics and Materials Hohai UniversityNanjing 210098China College of Chemical Engineering Nanjing Forestry UniversityNanjing 210037China

Reducing kinetic energy barriers and developing accessible active sites are critical to deliver high hydrogen evolution reaction(HER)*** this paper,we synthesized defect-modulated and heteroatom(boron)-functionalized three-dimensional(3D)bowl-shaped Ti_(3−x)C_(2)T_(y)MXene(B-TCT)nanocavities coupled with the vertical growth of MoSe_(2)*** B-TCT@MoSe_(2)nanohybrids catalyst delivers the overpotentials of 49.9,52.7,and 67.8 mV to reach a HER current density of 10 mA·cm^(−2)under acidic,alkaline,and neutral conditions,*** outstanding HER activity is predominantly attributed to the heteroatom functionalization,self-adapting Ti vacancy(VTi)defect modulation,and spatial configuration design in the 3D B-TCT nanocavity,which synergistically regulate the electronic structure,activate the basal plane/edge unsaturated sites,and reduce the reaction energy *** and theoretical calculations demonstrate that strong heterogeneous interfacial bonding interactions between B-TCT and MoSe_(2)can dramatically reduce the free energy of hydrogen adsorption and facilitate efficient interfacial charge migration,thus essentially improving the HER *** used this 3D porous nanohybrid system assembled by defectrich lamellar structures to elucidate the advantageous synergistic effects of multiple mechanisms among defect structure,heteroatom functionalization,and interfacial coupling,which provided important insights for the development of efficient hybridtype catalysts.

关键词： electrocatalytic H_(2)evolution three-dimensional(3D)MXene nanocavity MoSe_(2)nanoflake self-adapting Ti vacancy defect heteroatom-functionalized interfacial interaction

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Progress in preparation of AlN-reinforced magnesium matrix composites:A review

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China Foundry 2024年第1期21卷 1-10页

作者： Lu chen Shu-lin Lü Di-jia Zhao wei Guo jian-yu Li Shu-sen Wu State Key Lab of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

As a ceramic material,AlN has very good thermophysical and mechanical *** addition,AlN is an effective refining agent for Mg alloys because it has a lattice constant similar to that of ***,AlN is an ideal reinforcement for magnesium matrix composites(MMCs),and is attracting increasing *** review addresses the development of preparation technologies for AlN-reinforced Mg matrix *** mainstream preparation techniques include stir casting,melt infiltration,powder metallurgy,and in-situ *** addition,the advantages and disadvantages of these techniques are analyzed in depth,and it is pointed out that the next direction for the preparation of high-performance AlN-reinforced MMCs is less aluminization and multiple technologies integration.

关键词： AlN MMCs preparation thermophysical property mechanical property

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Geometric phase-encoded stimuli-responsive cholesteric liquid crystals for visualizing real-time remote monitoring:humidity sensing as a proof of concept

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Light(Science & Applications) 2024年第2期13卷 283-293页

作者： Shi-Long Li Zhao-Yi chen Peng chen wei Hu Chaohong Huang Sen-Sen Li Xuejia Hu Yan-Qing Lu Lu-jian chen Department of Electronic Engineering School of Electronic Science and EngineeringXiamen University361005 XiamenChina College of Engineering and Applied Sciences Nanjing University210093 NanjingChina Fujian Key Laboratory of Ultrafast Laser Technology and Applications Xiamen University361005 XiamenChina

Liquid crystals are a vital component of modern photonics,and recent studies have demonstrated the exceptional sensing properties of stimuli-responsive cholesteric liquid ***,existing cholesteric liquid crystal-based sensors often rely on the naked eye perceptibility of structural color or the measurement of wavelength changes by spectrometric tools,which limits their practical ***,developing a platform that produces recognizable sensing signals is *** this study,we present a visual sensing platform based on geometric phase encoding of stimuli-responsive cholesteric liquid crystal polymers that generates real-time visual patterns,rather than frequency *** demonstrate this platform’s effectiveness,we used a humidity-responsive cholesteric liquid crystal polymer film encoded with a q-plate pattern,which revealed that humidity causes a shape change in the vortex beam reflected from the encoded cholesteric liquid crystal ***,we developed a prototype platform towards remote humidity monitoring benefiting from the high directionality and long-range transmission properties of laser beams carrying orbital angular *** approach provides a novel sensing platform for cholesteric liquid crystals-based sensors that offers promising practical *** ability to generate recognizable sensing signals through visual patterns offers a new level of practicality in the sensing field with stimuli-responsive cholesteric liquid *** platform might have significant implications for a broad readership and will be of interest to researchers working in the field of photonics and sensing technology.

关键词： humidity visual liquid

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