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Research in Astronomy and Astrophysics 2024年第2期24卷 185-189页

作者： Ying-Ru Lin cai-Juan Pan Wei-jian Lu School of Information Engineering Baise UniversityBaise 533000China School of Materials Science and Engineering Baise UniversityBaise 533000China

This paper explores the correlation between the fractional variation of the ionizing continuum and CⅣbroad absorption lines(BALs)with different ionization *** results reveal anti-correlations between fractional variation of the continuum and fractional equivalency width(EW)variation of the CⅣB ALs without AlⅢB AL/mini-BALs at corresponding velocities,providing evidence for the widespread influence of the ionizing continuum variability on the variation of ***,for CⅣBALs accompanied by AlⅢBAL/mini-BALs(LoBAL groups),no significant correction is *** absence of such a correlation does not rule out the possibility that variations in these low-ionization lines are caused by ionizing continuum variability,but rather suggests the influence of B AL saturation to some *** saturation effect is reflected in the distribution of the fractional EW variation,where the CⅣBAL group accompanied by AlⅢBAL has a smaller standard deviation for the best-fitting Gaussian component than the two BAL groups without AlⅢB ***,the distribution of fractional variation of their continuum does not show any significant *** the saturation influence,another potential explanation for the lack of correlations in the LoBAL groups may be the effects of other variability mechanisms besides the ionization change,such as clouds transiting across the line of sight.

关键词： (galaxies:)quasars absorption lines-(galaxies:)quasars general-galaxies active

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用于步态分析的足底压力监测系统研究进展

科学通报 2024年第4期69卷 565-577页

作者：徐婷孙哲方剑苏州大学纺织与服装工程学院苏州215123

随着我国人口老龄化的加剧,人们对于健康监测的需求逐步提高,步态分析作为分析个体生理信号和提供人体物理信息的重要评估工具,在疾病诊断、预防跌倒、康复、人机交互等领域的应用日益广泛.本文首先介绍了步态分析的重要性和足底压力监... 详细信息

随着我国人口老龄化的加剧,人们对于健康监测的需求逐步提高,步态分析作为分析个体生理信号和提供人体物理信息的重要评估工具,在疾病诊断、预防跌倒、康复、人机交互等领域的应用日益广泛.本文首先介绍了步态分析的重要性和足底压力监测的研究现状,以及各种足底压力监测系统的特点.其次,总结了足部生理特征,即足底压力中心点和步态相位的常用划分方法;分析了用于足底压力监测的各种柔性压力传感器——其材料及特点、集成和连接方式,概述了常用的步法识别算法.最后,对足底压力监测系统的设计方向以及进一步研究提出了建议.

关键词：步态分析足底压力压力监测智能鞋垫柔性传感器

Efficacy of robot-assisted thoracoscopic surgery in the treatment of pulmonary sequestration in children

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World Journal of Pediatric Surgery 2024年第2期7卷 119-124页

作者： Liang Liang Zheng Tan ting Huang Yue Gao jian Zhang jiangen Yu Jie Xia Qiang Shu Departmentof Thoracic Surgery Children's HospitalZhejiang University School of MedicineNational Clinical ResearchCenterforChild HealthHangzhouZhejiangChina Department of Cardiac surgery Children'sHospital.Zheiiang surgery Children's HospitalZhejiang University School of MedicineNationalClinical Research Center for Child HealthHangzhouZhejiangChina

Objective This study was performed to evaluate the efficacy of robot-assisted thoracoscopic surgery(RATS)in the treatment of pulmonary sequestration(PS)in *** All video-assisted thoracoscopic surgery(VATS)and RAST performed on patients with PS at a single center from May 2019 to July 2023 were *** x2 and Wilcoxon tests were used to compare the perioperative outcomes between VATS and RATS *** Ninety-three patients underwent RATS while 77 patients underwent *** both two groups,one patient converted to thoracotomy and no surgical mortality *** median operation time was longer for the RATS group compared with the VATS group(75 min vs.60 min,p<0.001).A lower ratio of chest tube indwelling(61.3%vs.90.9%,p<0.001),fewer drainage days(1.0 day vs.2.0 days,p<0.001),and a shorter postoperative length of stay(5.0 days vs.6.0 days,p<0.001)were found in the RATS group than that in the VATS *** significant difference was found in the incidence of short-term postoperative complications(hydrothorax and pneumothorax)between two *** RATS was safe and effective in children with PS over 6 months old and more than 7 ***,RATS led to better short-time postoperative outcome than ***-institutional studies are warranted to compare differences in long-term outcomes between RATS and VATS.

关键词： surgery sequestration robot

Burden of gastrointestinal cancers among working-age population over past thirty years in China

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3955-3979页

作者： Yu Dong Zhuan-Zhuan Fan Wen-ting Li jian Kang Yan Zhang Yue Guan Hui-Qing Xu Jie Yuan Fei Xu Department of Gastroenterology Nanjing First HospitalNanjing Medical UniversityNanjing 210006Jiangsu ProvinceChina Department of Primary Healthcare Management Nanjing Municipal Center for Disease Control and PreventionNanjing 210003Jiangsu ProvinceChina Department of Emergency The First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Epidemiology Nanjing Medical University School of Public HealthNanjing 211116Jiangsu ProvinceChina

BACKGROUND Although gastrointestinal(GI)cancers have been becoming a great public health concern in China,there is currently a lack of comprehensive literature on the overall burden and changing trends of GI cancers in the working-age *** To assess the burden of GI cancers and to examine the overall,age-and genderspecific trends among the working-age population in China from 1990 to *** Data were extracted from the Global Burden of Disease Study *** burden of GI cancers was indicated by incidence,mortality,disability-adjusted life-years(DALYs),age-standardized incidence rate(ASIR),age-standardized mortality rate,and age-standardized DALYs *** in the burden of GI cancers from 1990 to 2019 were examined using annual percent change and average annual percent change with Joinpoint regression *** For overall GI cancers,a declining trend was observed in the ASIR,age-standardized mortality rate,and agestandardized DALYs rate,with reductions of 0.74%,2.23%,and 2.22%,respectively,from 1999 to 2019 in the Chinese working-age ***,an increasing trend was observed in the ASIR for overall GI cancers from *** number of either incident cases,mortality cases,and DALYs was higher for colon/rectum cancer and liver cancer in younger participants but lower for esophageal,gallbladder,biliary tract,pancreatic,and stomach cancer among older ***,sex disparity in the GI cancers burden was also examined over 30 *** The total burden of GI cancers remained heavy among the working-age population in China,although declining trends were observed from 1999 to *** in the GI cancers burden existed between sexes,age groups,and cancer ***-based precision prevention strategies are needed to tackle GI cancers among working-age individuals,considering the age,sex,and cancer type disparities in China.

关键词： Gastrointestinal cancer Working-age population Disease burden Disability-adjusted life-years Chinese

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一体化小堆失水事故响应及后果研究

核动力工程 2024年第1期45卷 149-155页

作者：蔡伟乐志东魏婷深圳中广核工程设计有限公司上海分公司上海200241

为全面分析一体化小型模块式反应堆(简称小堆)失水事故,基于RELAP5程序建立了包括堆芯、主回路和安全壳在内的整体分析模型,对堆芯和安全壳瞬态响应及环境放射性后果进行计算分析,结果表明事故后果满足小堆安全审评原则规定的验收准则... 详细信息

为全面分析一体化小型模块式反应堆(简称小堆)失水事故,基于RELAP5程序建立了包括堆芯、主回路和安全壳在内的整体分析模型,对堆芯和安全壳瞬态响应及环境放射性后果进行计算分析,结果表明事故后果满足小堆安全审评原则规定的验收准则。此外,提出了改进的紧贴式安全壳方案及可选的参数配置,计算结果表明采用改进方案可使一回路和安全壳压力很快达到平衡,更早终止破口流量,从而减少一回路失水量和放射性释放量,提升堆芯安全性并降低事故剂量后果,壳外水池容量可保障安全壳长期冷却。研究成果可为一体化小堆工程应用和安全壳设计提供参考依据。

关键词：一体化小型模块式反应堆(简称小堆) 失水事故瞬态响应放射性后果紧贴式安全壳

Psychometric validation of the Chinese version of the dry eye-related quality-of-life score questionnaire

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1614-1620页

作者： Yu-Wen Liu Shu-Jia Guo Jia-Ni Li Yu-ting Zhang Wei-Jie Ouyang Yu-Qian Wang cai-Hong Huang Yi Liao Jiaoyue Hu Zuguo Liu Xiamen University Affiliated Xiamen Eye Center Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceFujian Engineering and Research Center of Eye Regenerative MedicineEye Institute of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361005Fujian ProvinceChina Department of Ophthalmology Xiang’an Hospital of Xiamen UniversityXiamen 361005Fujian ProvinceChina Department of Ophthalmology the First Affiliated Hospital of University of South ChinaHengyang 421001Hunan ProvinceChina

AIM:To psychometrically validate the Chinese version of the dry eye-related quality-of-life score questionnaire(DEQSCHN)among Chinese patients with dry ***:This study involved 231 participants,including 191 with dry eye disease(DED)comprising the dry eye disease group,and 40 healthy participants forming the control *** were required to complete the DEQS-CHN,and Chinese dry eye questionnaire and undergo clinical tests including the fluorescein breakup time(FBUT),corneal fluorescein staining(CFS),and Schirmer I *** assess the internal consistency and retest reliability,Cronbach’sαand the intraclass correlation coefficient(ICC)were *** validity was assessed by item-level content validity index(ICV)and an average scale-level content validity index(S-CVI/Ave).Construct validity was assessed by confirmatory factor *** concurrent validity was assessed by calculating correlations between DEQS-CHN and Chinese dry eye *** validity was evaluated through nonparametric tests,with receiver operating characteristic(ROC)curve serving as conclusive indicators of the questionnaire’s distinguishing ***:The Cronbach’sαcoefficients for frequency and degree of ocular symptoms,impact on daily life,and summary score were 0.736,0.704,0.811,0.818,0.861,and 0.860,respectively,and the ICC were 0.611,0.677,0.715,0.769,0.711,and 0.779,*** I-CVI scores ranged from 0.833 to 1.000,with an S-CVI/Ave of *** factor analysis results exhibited a wellfitting model consistent with the original questionnaire[χ^(2)/df=2.653,incremental fit index(IFI)=0.924,comparative fit index(CFI)=0.924,Tucker-Lewis index(TLI)=0.909,and root mean square error of approximation(RMSEA)=0.065].There was a moderate positive correlation between the DEQS-CHN and the Chinese dry eye questionnaire(r^(2)=0.588).The dry eye group demonstrated significantly higher scores compared to the control group,and the area under

关键词： dry eye quality-of-life questionnaire

Clinicopathological significance and immunotherapeutic outcome of claudin 18.2 expression in advanced gastric cancer:A retrospective study

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Chinese Journal of Cancer Research 2024年第1期36卷 78-89页

作者： Changsong Qi Xiaoyi Chong ting Zhou Mingyang Ma Jifang Gong Miao Zhang jian Li Jun Xiao Xiaohui Peng Zhen Liu Zonghai Li Lin Shen Xiaotian Zhang State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China CARsgen Therapeutics Co. LtdShanghai 200231China CARsgen Life Sciences Co. LtdShanghai 200131China

Objective: Immunotherapeutic outcomes and clinical characteristics of claudin 18 isoform 2 positive(CLDN18.2-positive) gastric cancer(GC) vary in different clinical studies, making it difficult to optimize antiCLDN18.2 therapy. We conducted a retrospective analysis to explore the association of CLDN18.2 expression with clinicopathological characteristics and immunotherapeutic outcomes in ***: A total of 536 advanced GC patients from 2019 to 2021 in the CT041-CG4006 and CT041-ST-01clinical trials were included in the analysis. CLDN18.2 expression on ≥40% of tumor cells(2+, 40%) and CLDN18.2 expression on ≥70% of tumor cells(2+, 70%) were considered the two levels of positively expressed GC. The clinicopathological characteristics and immunotherapy outcomes of GC patients were analyzed according to CLDN18.2 expression ***: CLDN18.2 was expressed in 57.6%(cut-off: 2+, 40%) and 48.9%(cut-off: 2+, 70%) of *** death-ligand 1(PD-L1) and CLDN18.2 were co-expressed in 19.8% [combined positive score(CPS)≥1, CLDN18.2(cut-off: 2+, 40%)] and 17.2% [CPS≥5, CLDN18.2(cut-off: 2+, 70%)] of ***18.2 expression positively correlated with younger age, female sex, non-gastroesophageal junction(nonGEJ), and diffuse phenotype(P<0.001). HER2 and PD-L1 expression were significantly lower in CLDN18.2-positive GC(both P<0.05). Uterine adnexa metastasis(P<0.001) was more frequent and liver metastasis(P<0.001)was less common in CLDN18.2-positive GC. Overall survival and immunotherapy-related progression-free survival(ir PFS) were inferior in the CLDN18.2-positive ***: CLDN18.2-positive GC is associated with poor prognosis and worse immunotherapeutic outcomes. The combination of anti-CLDN18.2 therapy, anti-PD-L1/PD-1 therapy, and chemotherapy for GC requires further investigation.

关键词： Gastric cancer claudin18.2 CT041 PD-L1 immunotherapy

Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation

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Zoological Research 2024年第2期45卷 242-252页

作者： Xiu-Sheng Chen Rui Han Yan-ting Liu Wei Huang Qi Wang Xin Xiong Ying Zhang jian-Guo Zhao Shi-Hua Li Xiao-jiang Li Wei-Li Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)GHM Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong 510632China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

PTEN-induced putative kinase 1(PINK1),a mitochondrial kinase that phosphorylates Parkin and other proteins,plays a crucial role in mitophagy and protection against *** in PINK1 and Parkin can lead to loss of function and early onset Parkinson's ***,there is a lack of strong in vivo evidence in rodent models to support the theory that loss of PINK1 affects mitophagy and induces ***,PINK1 knockout pigs(Sus scrofa)do not appear to exhibit *** our recent work involving non-human primates,we found that PINK1 is selectively expressed in primate brains,while absent in rodent *** extend this to other species,we used multiple antibodies to examine the expression of PINK1 in pig *** contrast to tissues from cynomolgus monkeys(Macaca fascicularis),our data did not convincingly demonstrate detectable PINK1expression in pig *** of PINK1 in cultured pig cells did not result in altered Parkin and BAD phosphorylation,as observed in cultured monkey cells.A comparison of monkey and pig striatum revealed more PINK1-phosphorylated substrates in the monkey ***,PINK1 knockout in pigs did not lead to obvious changes in the phosphorylation of Parkin and *** findings provide new evidence that PINK1expression is specific to primates,underscoring the importance of non-human primates in investigating PINK1function and pathology related to PINK1 deficiency.

关键词： PINK1 Parkin Mitochondria Phosphorylation Non-human primates Pigs

Predictors of portal vein thrombosis after splenectomy in patients with cirrhosis

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World Journal of Hepatology 2024年第2期16卷 241-250页

作者： ting Li Li-Li Wang Ya-Ping Li jian Gan Xi-Sheng Wei Xiao-Rong Mao Jun-Feng Li Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710000Shaanxi ProvinceChina Department of Radiology First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Gastroenterology Yantai Affiliated Hospital of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Portal vein thrombosis(PVT)is a commonthsn complication after splenectomy in patients with ***,the predictors of postoperative PVT are not *** To investigate the predictors of PVT after splenectomy in patient with *** A total of 45 patients with cirrhosis who underwent splenectomy were consecutively enrolled from January 2017 to December *** incidence of PVT at 1 months,3 months,and 12 months after splenectomy in patients with cirrhosis was *** hematological indicators,biochemical and coagulation parameters,and imaging features were recorded at baseline and at each observation *** univariable,multivariable,receiver operating characteristic curve and timedependent curve analyses were *** The cumulative incidence of PVT was 40.0%,46.6%,and 48.9%at 1 months,3 months,and 12 months after *** analysis showed that portal vein diameter(PVD)≥14.5 mm and monthsdel end-stage liver disease(MELD)score>10 were independent predictors of PVT at 1 months,3 months,and 12 months after splenectomy(P10(P10 were independent predictors of PVT at 1 months,3 months,and 12 months after splenectomy in patient with cirrhosis.

关键词： Cirrhosis Splenectomy Portal vein thrombosis Predictors

Perioperative remedial antiviral therapy in hepatitis B virus-related hepatocellular carcinoma resection:How to achieve a better outcome

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1833-1848页

作者： Fan Mu Liang-Shuo Hu Kun Xu Zhen Zhao Bai-cai Yang Yi-Meng Wang Kun Guo jian-Hua Shi Yi Lv Bo Wang Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Anaesthesiology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Gynaecology Wenzhou Medical University Affiliated Jiaxing Women and Children HospitalJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Although the benefits of antiviral therapy for hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC)have been proven,researchers have not con-firmed the differences in patient outcomes between patients who received preoperative antiviral therapy for a period of time(at least 24 wk)and patients who received remedial antiviral therapy just before radical resection for HBV-related *** To investigate the efficacy of perioperative remedial antiviral therapy in patients with HBV-related *** A retrospective study of patients who underwent radical resection for HBV-related HCC at the First Affiliated Hospital of Xi’an Jiaotong University from January 2016 to June 2019 was *** the history of antiviral therapy,patients were assigned to remedial antiviral therapy and preoperative antiviral therapy *** Kaplan–Meier analysis revealed significant differences in overall survival(P<0.0001)and disease-free survival(P=0.035)between the two *** analysis demonstrated that a history of preoperative antiviral treatment was independently related to improved survival(hazard ratio=0.27;95%confidence interval:0.08-0.88;P=0.030).CONCLUSION In patients with HBV-related HCC,it is ideal to receive preoperative long-term antiviral therapy,which helps patients tolerate more extensive hepatectomy;however,remedial antiviral therapy,which reduces preoperative HBV-DNA levels to less than 4 Log10 copies DNA/mL,can also result in improved outcomes.

关键词： Hepatectomy Hepatitis B virus Antiviral therapy Hepatocellular carcinoma Hepatitis B virus-DNA