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Safety of butylphthalide and edaravone in patients with ischemic stroke:a multicenter real-world study

Journal of Geriatric Cardiology 2023年第4期20卷 293-308页

作者： Shu-Xian lyu Dong-Fang QIAN Yu-Fei FENG Cheng-Wu SHEN Lu-Bo GUO jian-tao lyu Peng-Fei JIN Ting LI Si-Yuan TAN Zi-Xuan ZHANG Lin HUANG Xue ZHONG Le-Qun SU Xin HU Xin HUANG Xue-Yan CUI Department of Clinical Pharmacy the First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalShandong Medicine and Health Key Laboratory of Clinical PharmacyShandongChina Beijing North Medical Health Economic Research Center BeijingChina Department of Pharmacy Peking University People’s HospitalBeijingChina Department of Pharmacy Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityShandongChina Department of Pharmacy Central Hospital Affiliated to Shandong First Medical UniversityShandongChina Department of Pharmacy Yantai Affiliated Hospital of Binzhou Medical University(the Second School of Clinical Medicine of Binzhou Medical University)ShandongChina Department of Pharmacy National Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application(Beijing Hospital)BeijingChina

BACKGROUND Butylphthalide(NBP)and edaravone(EDV)injection are common acute ischemic stroke medications in China,but there is a lack of large real-world safety studies on *** study aimed to determine the incidence of adverse events,detect relevant safety signals,and assess the risk factors associated with these medications in real-world *** In this study,data of acute ischemic stroke patients were extracted from the electronic medical record database of six tertiary hospitals between January 2019 and August *** confounders were eliminated using propensity score *** drugs’safety was estimated by comparing the results of 24 laboratory tests standards on liver function,kidney function,lipid level,and coagulation *** drugs’relative risk was estimated by logistic regression.A third group with patients who did not receive NBP or EDV was constructed as a *** sequence symmetry analysis was used to evaluate the associations between adverse events and NBP and EDV,*** 81,292 patients were included in this *** propensity score matching,the NBP,EDV,and third groups with 727patients in each *** the 15 test items,the incidence of adverse events was lower in the NBP group than in the EDV group,and the differences were statistically *** multivariate logistic regression equation revealed that NBP injection was not a promoting factor for abnormal laboratory test results,whereas EDV had statistically significant effects on aspartate transaminase,low-density lipoprotein cholesterol and total *** sequence symmetry analysis showed that NBP had a weak correlation with abnormal platelet *** had a positive signal associated with abnormal results in gamma-glutamyl transferase,alanine aminotransferase,aspartate aminotransferase,prothrombin time,and platelet *** In a large real-world population,NBP has a lower incidence of adverse events and a

关键词： patients drugs injection

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基于消费者介入理论的在线购买行为影响要素及预测研究

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管理工程学报 2025年第2期39卷 144-161页

作者：陶婉琼王子卓王健浙江工商大学统计数据工程技术与应用协同创新中心浙江大学管理学院浙江吉利控股集团有限公司浙江工商大学管理工程与电子商务学院浙江工商大学现代商贸研究中心

本文主要研究消费者在线购买行为的影响。本文首先从参与强度、消费者类型、购物流程类型和广告点击次数四个维度定义了表征消费者在线购买决策心理特征的消费者介入水平,然后基于消费者介入理论分别从群体水平和个体水平的视角分析消... 详细信息

本文主要研究消费者在线购买行为的影响。本文首先从参与强度、消费者类型、购物流程类型和广告点击次数四个维度定义了表征消费者在线购买决策心理特征的消费者介入水平,然后基于消费者介入理论分别从群体水平和个体水平的视角分析消费者介入水平维度对其购物数量和购物时间间隔等行为的影响。以此为基础,本文采用多种机器学习方法构建了消费者在线购买行为预测模型。通过对不同预测模型的比较发现,神经网络回归模型对购物数量预测的误差性最小和拟合度最高,而梯度提升回归模型对购物时间间隔预测的性能最好。同时,通过特征变量的重组设置对比实验,本文验证了在购买行为预测模型中引入介入水平维度的有效性和合理性。研究结果揭示了消费者介入水平对在线购买行为的影响规律,不仅丰富了相关理论,而且对网购平台和商家精确预测消费者购买行为、优化服务策略等方面具有重要的指导意义。

关键词：决策科学电子商务消费者介入在线购买行为预测模型

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Effects of Degrees of Motion Freedom on Free-Fall of A Sphere in Fluid

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China Ocean Engineering 2018年第5期32卷 605-613页

作者： LIU Lei YANG jian-min lyu Hai-ning TIAN Xin-liang PENG tao State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration(CISSE) Shanghai 200240China

Free-fall of a sphere in fluid is investigated at a Galileo number of 204 by direct numerical simulations(DNS). We mainly focus on the effects of different degrees-of-freedom(DOFs) of the sphere motion during free-fall. The characteristics of free-fall are compared with those of flow past a fixed sphere. Additional numerical tests are conducted with constraints placed on the translational or rotational DOFs of the sphere motion to analyze different DOFs of sphere motion. The transverse motion contributes significantly to the characteristics of free-fall; it results in the retardation of the vortex shedding, leading to the decrease of the Strouhal number. In addition, the transversal sphere motion exhibits the tendency to promote the sphere rotation. On the contrary, the effects of the sphere rotation and vertical oscillations during free-fall are negligible.

关键词： free-fall direct numerical simulation degree of motion freedom

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Study on Transient Gap Resonance with Consideration of the Motion of Floating Body

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China Ocean Engineering 2022年第6期36卷 994-1006页

作者： GAO Jun-liang lyu Jing WANG Jing-hua ZHANG jian LIU Qian ZANG Jun ZOU tao School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China Key Laboratory of Port Waterway and Sedimentation Engineering of MOTNanjing Hydraulic Research InstituteNanjing 210029China Department of Civil and Environmental Engineering the Hong Kong Polytechnic UniversityHong KongChina Centre for Infrastructure Geotechnical and Water Engineering(IGWE)Department of Architecture and Civil EngineeringUniversity of BathBA27AYU.K Shandong Provincial Key Laboratory of Ocean Engineering Qingdao 266100China

In this paper, the transient fluid resonance phenomenon inside a narrow gap between two adjacent boxes excited by the incident focused waves with various spectral peak periods and focused wave amplitudes is simulated by utilizing the open-sourced computational fluid dynamics software, Open FOAM. The weather-side box is allowed to heave freely under the action of waves, and the lee-side box keeps fixed. This paper mainly focuses on how both the spectral peak period and the focused wave amplitude affect the free-surface amplification inside the gap, the motion of the weather-side box, and the wave loads(including the vertical and the horizontal wave forces) acting on both *** comparison, another two-box system with both boxes fixed is also considered as a control group. It is found that the motion of the weather-side box significantly changes the characteristics of the transient gap resonance, and it would cause that the fluid resonant period becomes 1.4-1.6 times that of the two-box system with both boxes *** the concerned physical quantities(i.e., the free-surface amplification in the gap, the motion of the weather-side box, the wave loads) are found to closely depend on both the spectral peak period and the focused wave amplitude.

关键词： transient gap resonance focused waves free-surface amplification wave loads heave motion OpenFOAM

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Microstructure Characterization and Mechanical Properties of FGH 95 Turbine Blade Retainers

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Journal of Iron and Steel Research International 2010年第9期17卷 73-78页

作者： tao Yu JIA jian LIU jian-tao Central Iron and Steel Research Institute Beijing 100081 China

FGH 95 is a powder metallurgy （P/M） processed superalloy, which was developed in the 1980s in China. One of the applications of FGH 95 was high pressure turbine blade retainers. The manufacturing processes used to produce FGH 95 blade retainers consisted of atomization by plasma rotating electrode process （PREP）, hot isostatic pressing （HIP） at super-solvus temperature and a sub-solvus solution heat treatment. The material had an equiaxed grain structure （ASTM 6.5-7.5）. The γ precipitates in as-HIP FGH 95 showed a tri-model distribution. Carbides in the alloy were MC type and precipitated at grain boundaries. The prior particle boundaries （PPB） in the material originated mainly from γ＇ phase. Statistics of the mechanical properties data from batch production of the FGH 95 blade retainers were investigated. The as-HIP FGH 95 blade retainers showed high strength at room temperature and 650 ℃, excellent creep resistance and outstanding stress rupture strength at 650 ℃.

关键词： FGH95 as-HiP P/M superalloy blade retainer microstructure mechanical property

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Efficient and selective extraction of uranium from seawater based on a novel pulsed liquid chromatography radionuclide separation method

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Nuclear Science and Techniques 2023年第2期34卷 13-27页

作者： jian‑Hua Ye tao Yu State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices East China University of TechnologyNanchang 330013China School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

The novel pulsed liquid chromatography radionuclide separation method presented here provides a new and promising strategy for the extraction of uranium from *** this study,a new chromatographic separation method was proposed,and a pulsed nuclide automated separation device was developed,alongside a new chromatographic *** length of this chromatographic column was 10 m,with an internal warp of 3 mm and a packing size of 1 mm,while the total separation units of the column reached 12,*** most favorable conditions for the separation of nuclides were then obtained through optimizing the separation conditions of the device:Sample pH in the column=2,sample injection flow rate=5.698 mL/min,chromatographic column heating temperature=60℃.Separation experiments were also carried out for uranium,europium,and sodium ions in mixed solutions;uranium and sodium ions in water samples from the Ganjiang River;and uranium,sodium,and magnesium ions from seawater *** separation factors between the different nuclei were then calculated based on the experimental data,and a formula for the separation level was *** experimental results showed that the separation factor in the mixed solution of uranium and europium(1:1)was 1.088,while achieving the initial separation of uranium and europium theoretically required a 47-stage *** the separation factor of 1.50for the uranium and sodium ions in water samples from the Ganjiang River,achieving the initial separation of uranium and sodium ions would have theoretically required at least a 21-stage ***,for the seawater sample separation experiments,the separation factor of uranium and sodium ions was 1.2885;therefore,more than 28 stages of sample separation would be required to achieve uranium extraction from *** novel pulsed liquid chromatography method proposed in this study was innovative in terms of uranium separation and enrichment,while expanding the possibilities

关键词： Pulsed liquid chromatography Nuclide separation Seawater uranium extraction Uranium enrichment

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Degradation of organics using LaFeO_(3)as a persulfate activator under low-intensity ultra-violet-light irradiation:Catalytic performance and mechanism

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Journal of Rare Earths 2022年第7期40卷 1043-1052页

作者： Yumei Li jian Fan Xiaonan Feng tao tao School of Environment Huazhong University of Science and TechnologyWuhan 430074China School of Energy and Environment Inner Mongolia University of Science and TechnologyBaotou 014010China

ABO_(3)-type perovskite oxides with abounding defect structures and diverse physical chemistry attributes have been extensively studied in heterogeneous *** LaFeO_(3)perovskites fabricated via the sol-gel method were used as peroxydisulfate(PDS)activators for methylene blue(MB)degradation under low-intensity ultra-violet(UV)-light to evaluate the degradation efficiency of organic pollutants and *** results indicate that under low-intensity UV irradiation,the developed UV/LaFeO_(3)/PDS system shows excellent degradation ability of organic pollutants in a wide pH *** spin resonance and radical quenching experiments verify that SO_(4)^(·-),·OH,h^(+)and ^(1)O_(2)are generated during the activation process,and ^(1)O_(2)plays a dominant role in MB *** of low oxidation state Fe(Ⅱ)and O_(2)^(2-)/O^(-)on the LaFeO_(3)surface shows that oxygen vacancy,as the electron transfer mediator,enhances the redox cycle efficiency of Fe(Ⅱ)/Fe(Ⅲ).Photogenerated electrons of LaFeO_(3)involved in the cyclic transformation of Fe(Ⅱ)/Fe(Ⅲ)and PDS activation further increase the number of active radicals and thus promote the synergistic effect of photocatalytic coupled with sulfate radicalbased advanced oxidation processes.

关键词： LaFeO_(3) Peroxydisulfate Singlet oxygen Low-intensity UV-light Rare earths

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Modeling epidemic spread in transportation networks:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第2期8卷 139-152页

作者： jian Li tao Xiang Linghui He Key Laboratory of Road and Traffic Engineering of Ministry of Education Tongji UniversityShanghai 201804China College of Transportation Engineering Tongji UniversityShanghai 201804China Institute for Urban Risk Management Tongji UniversityShanghai 201804China

The emergence of novel infectious diseases has become a serious global *** transportation networks lead to rapid mobilization in the context of globalization,which is an important factor underlying the rapid spread of infectious *** systems can cause the transmission of viruses during the epidemic period,but they also support the reopening of economies after the *** the mechanism of the impact of mobility on the spread of infectious diseases is thus important,as is establishing the risk model of the spread of infectious diseases in transportation *** this study,the basic structure and application of various epidemic spread models are reviewed,including mathematical models,statistical models,network-based models,and simulation *** advantages and limitations of model applications within transportation systems are analyzed,including dynamic characteristics of epidemic transmission and decision supports for management and ***,research trends and prospects are *** is suggested that there is a need for more in-depth research to examine the mutual feedback mechanism of epidemics and individual behavior,as well as the proposal and evaluation of intervention *** findings in this study can help evaluate disease intervention strategies,provide decision supports for transport policy during the epidemic period,and ameliorate the deficiencies of the existing system.

关键词： Traffic engineering Infectious disease control Epidemic spread models Human mobility Transportation networks

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A Framework of Convergence Analysis of Mini-batch Stochastic Projected Gradient Methods

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Journal of the Operations Research Society of China 2023年第2期11卷 347-369页

作者： jian Gu Xian-tao Xiao School of Sciences Dalian Ocean UniversityDalian 116023China School of Mathematical Sciences Dalian University of TechnologyDalian 116023China

In this paper,we establish a unified framework to study the almost sure global convergence and the expected convergencerates of a class ofmini-batch stochastic(projected)gradient(SG)methods,including two popular types of SG:stepsize diminished SG and batch size increased *** also show that the standard variance uniformly bounded assumption,which is frequently used in the literature to investigate the convergence of SG,is actually not required when the gradient of the objective function is Lipschitz ***,we show that our framework can also be used for analyzing the convergence of a mini-batch stochastic extragradient method for stochastic variational inequality.

关键词： Stochastic projected gradient method Variance uniformly bounded Convergence analysis

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Simulation of 3D Flow in Turbine Blade Rows including the Effects of Coolant Ejection

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Journal of Thermal Science 2008年第2期17卷 111-115页

作者： jian-Jun LIU Bai-tao AN Yun-tao ZENG Institute of Engineering Thermophysics Chinese Academy of SciencesP. O. Box 2706 Beijing 100080 CHINA

This paper describes the numerical simulation of three-dimensional viscous flows in fir-cooled turbine blade rows with the effects of coolant ejection. A TVD Navier-Stokes flow solver incorporated with Baldwin-Lomax turbulence model and multi-grid convergence acceleration algorithm are used for the simulation. The influences of coolant ejection on the main flow are accounted by volumetric coolant source terms. Numerical results for a four-stage turbine are presented and discussed.

关键词： Numerical Simulation Air-Cooled Turbine Blade Row Coolant Ejection

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