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Cardiac Hypertrophy is Positively Regulated by MicroRNA-24 in Rats

Chinese Medical Journal 2018年第11期131卷 1333-1341页

作者： Juan Gao Min Zhu Rui-Feng Liu jian-shu zhang Ming Xu Department of Cardiology and Institute of Vascular Medicine Peking University Third Hospital Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry of Health Key Laboratory of Molecular Cardiovascular Science Ministry of Education Beijing Key Laboratory of Cardiovascular Receptors Research Beijing 100191 China

Background： MicroRNA-24 （miR-24） plays an important role in heart failure by reducing the efficiency of myocardial excitation-contraction coupling. Prolonged cardiac hypertrophy may lead to heart failure, but little is known about the role of miR-24 in cardiac hypertrophy. This study aimed to preliminarily investigate the function of miR-24 and its mechanisms in cardiac hypertrophy. Methods： Twelve Sprague-Dawley rats with a body weight of 50 ± 5 g were recruited and randonlly divided into two groups： a transverse aortic constriction （TAC） group and a sham surgery group. Hypertrophy index was measured and calculated by echocardiography and hematoxylin and eosin staining. TargetScans algorithm-based prediction was used to search for the targets of miR-24, which was subsequently confirmed by a real-time polymerase chain reaction and luciferase assay, lmmunofluorescence labeling was used to measure the cell surface area, and 3H-leucine incorporation was used to detect the synthesis of total protein in neonatal rat cardiac myocytes （NRCMs） with the overexpression of miR-24. In addition, flow cytometry was performed to observe the alteration in the cell cycle. Statistical analysis was carried out with GraphPad Prism v5.0 and SPSS 19.0. A two-sided P 〈 0.05 was considered as the threshold for significance. Results： The expression of miR-24 was abnormally increased in TAC rat cardiac tissue （ t =-2.938, P 〈 0.05）. TargetScans algorithm-based prediction demonstrated that CDKN 1B （p27, Kip 1 ）, a cell cycle regulator, was a putative target of miR-24, and was confirmed by luci ferase assay. The expression of p27 was decreased in TAC rat cardiac tissue （t = 2.896, P 〈 0.05）. The overexpression of miR-24 in NRCMs led to the decreased expression of p27 （t = 4.400, P 〈 0.01 ）, and decreased G0/G 1 arrest in cell cycle and cardiomyocylc hypertrophy. Conclusion： MiR-24 promotes cardiac hypertrophy partly by affecting the cell cycle through down-regulation of p27 expression.

关键词： Cardiac Hypertrophy Cell Cycle MicroRNA MicroRNA-24 p27

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An efficient and modular modeling for launch dynamics of tubed rockets on a moving launcher

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Defence Technology（防务技术） 2021年第6期17卷 2011-2026页

作者： Qin-bo Zhou Xiao-ting Rui Guo-ping Wang jian-shu zhang Institute of Launch Dynamics Nanjing University of Science and TechnologyNanjingJiangsu Province210094PR China

This paper develops a modular modeling and efficient formulation of launch dynamics with marching fire(LDMF)using a mixed formulation of the transfer matrix method for multibody systems(MSTMM)and Newton-Euler formulation.Taking a ground-borne multiple launch rocket systems(MLRS),the focus is on the launching subsystem comprising the rocket,flexible tube,and tube tail.The launching subsystem is treated as a coupled rigid-flexible multibody system,where the rocket and tube tail are treated as rigid bodies while the flexible tube as a beam with large motion.Firstly,the tube and tube tail can be elegantly handled by the MSTMM,a computationally efficient order-N formulation.Then,the equation of motion of the in-bore rocket with relative kinematics w.***.t.the tube using the Newton-Euler method is derived.Finally,the rocket,tube,and tube tail dynamics are coupled,yielding the equation of motion of the launching subsystem that can be regarded as a building block and further integrated with other subsystems.The deduced dynamics equation of the launching subsystem is not limited to ground-borne MLRS but also fits for tanks,self-propelled artilleries,and other air-borne and naval-borne weapons undergoing large motion.Numerical simulation results of LDMF are given and partially verified by the experiment.

关键词： Launch dynamics Marching fire Transfer matrix method for multibody systems Multiple launch rocket system

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Strengthening the Disciplinary Construction of History of Medicine: A Call for Action by Chinese Academy of Medical Sciences & Peking Union Medical College

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Chinese Medical Sciences Journal 2023年第2期38卷 94-96页

作者： jian-Hong Yao Da-Qing zhang Xin-Zhong Yu shu-jian zhang Yong-An zhang Xiang-Yin Yang Zhong He Huan Liu Yong Wang Yue-Ying Jin School of Medical Humanities and Social Sciences Peking Union Medical College&Chinese Academy of Medical SciencesBejing 100730China School of Medical Humanities Peking UniversityBejing 100191China Faculty of History Nankai UniversityTianjin 300072China institute of Chinese Medical Literature and Culture Shandong University of Traditional Chinese MedicineJinan250355China College of Liberal Arts Shanghai UniversityShanghai 200444China School of History Renmin University of ChinaBeijing 100086China

Recent years have witnessed a dynamic develop of Peking Union Medical College(PUMC),which was founded in 1921,and Chinese Academy of Medical Sciences(CAMS),which was founded in 1956.In the new era of building a"Healthy China",General Secretary Xi Jinping has emphasized the importance of a profound understanding of the Chinese civilization to let the world better know and understand China,and urged efforts to combine theories and practices to expound how to better uphold the Chinese path,promote the Chinese spirit,and pool together the Chinese strength[1].As an active response,PUMC organized the first Conference of History of Medicine on May 20-21,2023[2],Based on the rich history of PUMC and with an attempt to explore history,inherit the traditional Chinese culture,and promote the spirit of modern medicine,we issued the following call at the conference。

关键词： History combine Peking

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Distribution of pathogenic bacteria and antimicrobial sensitivity of eye infections in Suzhou

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 700-706页

作者： Li zhang Hai-zhang You Guo-Hui Wang Wei Xu jian-Shan Li Qing-Liang Zhao shu Du Department of Hospital-Acquired Infection Control Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Administrative Office Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Clinical Laboratory Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Pharmacy Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Corneal and Lacrimal Passage Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Fundus Diseases and Ocular Trauma Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina

AIM:To investigate the types of bacteria in patients with eye infections in Suzhou and their drug resistance to commonly used antibacterial drugs.METHODS:The clinical data of 155 patients were retrospectively collected in this study,and the pathogenic bacteria species and drug resistance of each pathogenic bacteria were analyzed.RESULTS:Among the 155 patients(age from 12 to 87 years old,with an average age of 57,99 males and 56 females)with eye infections(160 eyes:74 in the left eye,76 in the right eye and 5 in both eyes,all of which were exogenous),71(45.81%)strains were gram-positive bacteria,23(14.84%)strains were gram-negative bacteria and 61(39.35%)strains were fungi.Gram-positive bacteria were highly resistant to penicillin and erythromycin(78.87%and 46.48%respectively),but least resistant to vancomycin at 0.Gram-negative bacteria were highly resistant to cefoxitin and compound sulfamethoxazole(100%and 95.65%respectively),but least resistant to meropenem at 0.Comparison of the resistance of gram-positive and gram-negative bacteria to some drugs revealed statistically significant differences(P<0.05)in the resistance of both to cefoxitin,cotrimoxazole,levofloxacin,cefuroxime,ceftriaxone and ceftazidime,and both had higher rates of resistance to gram-negative bacteria than to gram-positive bacteria.The distribution of bacterial infection strains showed that Staphylococcus epidermidis was the most common strain in the conjunctiva,cornea,aqueous humor or vitreous body and other eye parts.Besides,Fusarium and Pseudomonas aeruginosa were also among the most common strains of conjunctival and corneal infections.CONCLUSION:Gram-positive bacteria are the dominant bacteria in eye infections,followed by gram-negative bacteria and fungi.Considering the resistance of gramnegative bacteria to multiple drugs,monitoring of bacteria should be strengthened in eye bacterial infections for effective prevention and control to reduce complications caused by eye infections.

关键词： eye infection pathogenic bacteria drug resistance antimicrobial sensitivity test

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Aero-Hydro-Elastic-Servo Modeling and Dynamic Response Analysis of A Monopile Offshore Wind Turbine Under Different Operating Scenarios

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China Ocean Engineering 2024年第3期38卷 379-393页

作者： XIE shuang-yi GAO jian LI Yong-ran jianG shu-xin zhang Cheng-lin HE Jiao College of Mechanical Engineering Chongqing University of TechnologyChongqing 400044China Beijing Institute of Precision Mechatronics and Controls Beijing 100076China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China Fishery Machinery and Instrument Research Institute Chinese Academy of Fishery SciencesShanghai 200092China School of Mechanical and Power Engineering Chongqing University of Science&TechnologyChongqing 401331China

This paper constructs a coupled aero-hydro-elastic-servo simulation framework for a monopile offshore wind turbine(OWT).In this framework,a detailed multi-body dynamics model of the monopile OWT including the gearbox,blades,tower and other components(nacelle,hub,bedplate,etc.)has been explicitly established.The effects of pile−soil interaction,controller and operational conditions on the turbine dynamic responses are studied systematically in time domain and frequency domain.The results show that(1)a comprehensive drivetrain model has the capability to provide a more precise representation of the complex dynamic characteristics exhibited by drivetrain components,which can be used as the basis for further study on the dynamic characteristics of the drivetrain.(2)The pile−soil interaction can influence the wind turbine dynamic responses,particularly under the parked condition.(3)The effect of the pile−soil interaction on tower responses is more significant than that on blade responses.(4)The use of the controller can substantially affect the rotor characteristics,which in turn influences the turbine dynamic responses.(5)The tower and blade displacements under the operational condition are much larger than those under the parked condition.The model and methodology presented in this study demonstrate potential for examining complex dynamic behaviors of the monopile OWTs.To ensure accuracy and precision,it is imperative to construct a detailed model of the wind turbine system,while also taking into account simulation efficiency.

关键词： offshore wind turbine(OWT) pile−soil interaction dynamic response parked condition operating condition

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Chiral transmission by an open evolution trajectory in a non-Hermitian system

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Light(Science & Applications) 2024年第4期13卷 628-636页

作者： Xiaoqian shu Qi Zhong Kai Hong Oubo You jian Wang Guangwei Hu Andrea Alù shuang zhang Demetrios N.Christodoulides Lin Chen Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China. Zhejiang Lab Hangzhou 311121China. CREOL College of Optics and PhotonicsUniversity of Central FloridaOrlandoFlorida 32816USA. Department of Physics The University of Hong KongHong KongChina. School of Electrical and Electronic Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore. Photonics Initiative Advanced Science Research CenterCity University of New YorkNew YorkNY 10031USA. Shenzhen Huazhong University of Science and Technology Research Institute Shenzhen 518063China

Exceptional points(EPs),at which two or more eigenvalues and eigenstates of a resonant system coalesce,are associated with non-Hermitian Hamiltonians with gain and/or loss elements.Dynamic encircling of EPs has received significant interest in recent years,as it has been shown to lead to highly nontrivial phenomena,such as chiral transmission in which the final state of the system depends on the encircling handedness.Previously,chiral transmission for a pair of eigenmodes has been realized by establishing a closed dynamical trajectory in parity-time-(PT-)or anti-PT-symmetric systems.Although chiral transmission of symmetry-broken modes,more accessible in practical photonic integrated circuits,has been realized by establishing a closed trajectory encircling EPs in anti-PTsymmetric systems,the demonstrated transmission efficiency is very low due to path-dependent losses.Here,we demonstrate chiral dynamics in a coupled waveguide system that does not require a closed trajectory.Specifically,we explore an open trajectory linking two infinite points having the same asymptotic eigenmodes(not modes in PT-and anti-PT-symmetric systems),demonstrating that this platform enables high-efficiency chiral transmission,with each eigenmode localized in a single waveguide.This concept is experimentally implemented in a coupled silicon waveguide system at telecommunication wavelengths.Our work provides a new evolution strategy for chiral dynamics with superior performance,laying the foundation for the development of practical chiral-transmission devices.

关键词： chiral system symmetric

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Nanophononic metamaterials induced proximity effect in heat flux regulation

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Frontiers of physics 2024年第2期19卷 149-156页

作者： jian zhang Haochun zhang Gang zhang School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Institute of High Performance Computing Agency for ScienceTechnology and Research(A*STAR)Singapore 138632Singapore

Recent studies have shown that the construction of nanophononic metamaterials can reduce thermal conductivity without affecting electrical properties,making them promising in many fields of application,such as energy conversion and thermal management.However,although extensive studies have been carried out on thermal conductivity reduction in nanophononic metamaterials,the local heat flux characteristic is still unclear.In this work,we construct a heat flux regulator which includes a silicon nanofilm with silicon pillars.The regulator has remarkable heat flux regulation ability,and various impacts on the regulation ability are explored.Surprisingly,even in the region without nanopillars,the local heat current is still lower than that in pristine silicon nanofilms,reduced by the neighboring nanopillars through the thermal proximity effect.We combine the analysis of the phonon participation ratio with the intensity of localized phonon modes to provide a clear explanation.Our findings not only provide insights into the mechanisms of heat flux regulation by nanophononic metamaterials,but also will open up new research directions to control local heat flux for a broad range of applications,including heat management,thermoelectric energy conversion,thermal cloak,and thermal concentrator.

关键词： nanophononic metamaterials proximity effect

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ZnGa_(2)S_(4):an infrared nonlinear optical material with large second-harmonic generation response and wide band gap

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Rare Metals 2024年第1期43卷 395-401页

作者： Chen-Yang zhang Xiao-Nan Niu Yan-Feng Wei shu-Xing Zhou Da-Qing Yang Ying Wang jian Wang Bing-Bing zhang College of Chemistry and Materials Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationState Key Laboratory of New Pharmaceutical Preparations and ExcipientsHebei UniversityBaoding 071002China Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices Hubei University of Arts and ScienceXiangyang 441053China Hubei Longzhong Laboratory Xiangyang 441000China Department of Chemistry and Biochemistry Wichita State UniversityKansas 67260USA

High-performance nonlinear optical(NLO)crystals are crucial devices to convert wavelength of solid-state lasers.Chalcogenides play an indispensable role in the research of infrared NLO materials.In this work,ternary chalcogenide ZnGa_(2)S_(4) with defect diamond-like structure was screened out and synthesized by chemical vapor transport method.

关键词： optical nonlinear harmonic

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Hemorrhagic cystitis in gastric cancer after nanoparticle albuminbound paclitaxel:A case report

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1084-1090页

作者： Xin-Jie zhang jian Lou Department of Cancer Center The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND The advanced first-line regimen for advanced gastric cancer is based on a combination of fluoropyrimidine and platinum and/or paclitaxel(PTX),forming a two-or three-drug regimen.Compared to conventional PTX,nanoparticle albumin-bound PTX(Nab-PTX)has better therapeutic effects and fewer adverse effects reported in studies.Nab-PTX is a great option for patients presenting with advanced gastric cancer.Herein,we highlight an adverse event(hemorrhagic cystitis)of Nab-PTX in advanced gastric cancer.CASE SUMMARY A 55-year-old male was diagnosed with lymph node metastasis after a laparo-scopic-assisted radical gastrectomy for gastric cancer that was treated by Nab-PTX and S-1(AS).On the 15th day after treatment with AS,he was diagnosed with hemorrhagic cystitis.CONCLUSION Physicians should be aware that hemorrhagic cystitis is a potential adverse event associated with Nab-PTX treatment.

关键词： Nanoparticle albumin-bound paclitaxel Hemorrhagic cystitis Gastric cancer Adverse event Case report

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Exhaust hood performance and its improvement technologies in industrial buildings:A literatu rereview

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Building Simulation 2024年第1期17卷 23-40页

作者： Jing zhang jian Wang Jun Gao Weimin zhang Architectural Engineering Institute Jinhua PolytechnicJinhua 321017China Institute of HVAC Engineering Schoolof Mechanical EngineeringTongji UniversityShanghai 200092China Tongji Architectural Design(Group)Co .LtdShanghai 200092China

The pollutant control performance of exhaust hoods plays a crucial role in the indoor air quality and energy consumption of ventilation systems in industrial buildings.To better understand the impact of local ventilation on the industrial indoor environment,this paper presents a literature review of exhaust hood performance and its improvement technologies.To create an index for evaluating the performance of exhaust hoods,the capture velocity,capture efficiency,flow ratio of pollutant emissions and exhaust airflow and energy consumption are first introduced.A number of factors affecting exhaust hood performance are assessed such as hood type,hood opening size,exhaust rate,installation distance,pollution source emission and environmental disturbance.Compared to structural improvement methods,the use of active airflow is a more effective way to improve the exhaust hood performance.The most commonly used methods for determining the exhaust rate are the controlled speed method and the flow ratio method.The use of an exhaust hood with an appropriate exhaust rate and jet parameters(for an active air-assisted hood)can effectively improve the pollutant control performance and reduce the energy consumption that would be wasted on the redundant exhaust rate.With more information focused on exhaust hood performance,this work suggests more effective strategies for improving indoor air quality and reducing energy consumption in industrial buildings.

关键词： industrial ventilation exhaust hood capture efficiency exhaust rate performance improvement

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