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Combinational benefit of antihistamines and remdesivir for reducing SARS-CoV-2 replication and alleviating inflammation-induced lung injury in mice

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Zoological Research 2022年第3期43卷 457-468页

作者： Meng-Li Wu Feng-Liang Liu Jing Sun Xin Li jian-ru qin Qi-Hong Yan Xia Jin Xin-Wen Chen Yong-Tang Zheng Jin-Cun Zhao jian-Hua Wang College of Life Science Henan Normal UniversityXinxiangHenan 453007China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhouGuangdong 510530China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthFirst Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510182China University of Chinese Academy of Sciences Beijing 100049China

COVID-19 is an immune-mediated inflammatory disease caused by SARS-CoV-2 infection,the combination of anti-inflammatory and antiviral therapy is predicted to provide clinical *** recently demonstrated that mast cells(MCs)are an essential mediator of SARS-CoV-2-initiated *** also showed that spike protein-induced MC degranulation initiates alveolar epithelial inflammation for barrier disruption and suggested an off-label use of antihistamines as MC stabilizers to block degranulation and consequently suppress inflammation and prevent lung *** this study,we emphasized the essential role of MCs in SARS-CoV-2-induced lung lesions in vivo,and demonstrated the benefits of co-administration of antihistamines and antiviral drug remdesivir in SARS-CoV-2-infected ***,SARSCoV-2 spike protein-induced MC degranulation resulted in alveolar-capillary injury,while pretreatment of pulmonary microvascular endothelial cells with antihistamines prevented adhesion junction disruption;predictably,the combination of antiviral drug remdesivir with the antihistamine loratadine,a histamine receptor 1(HR1)antagonist,dampened viral replication and inflammation,thereby greatly reducing lung *** findings emphasize the crucial role of MCs in SARS-CoV-2-induced inflammation and lung injury and provide a feasible combination antiviral and anti-inflammatory therapy for COVID-19 treatment.

关键词： SARS-CoV-2 Mast cell Remdesivir Antihistamine Combinational therapy

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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang Fan Yang jian-qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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新质生产力的运行机理、生成逻辑与模式建构——基于生产力与生产关系辩证统一的视角

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新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 89-97页

作者：李勇坚张海汝中国社会科学院财经战略研究院北京100005 浙江财经大学浙江杭州310018 江苏省社会科学院经济研究所江苏南京210004

新质生产力是创新发挥主导作用,摆脱传统经济增长方式、生产力发展路径,具有高科技、高效能、高质量特征,符合新发展理念的先进生产力质态。纵观三次科技革命变革生产力的历程,新质生产力的产生和发展是生产力与生产关系相互作用的结果... 详细信息

新质生产力是创新发挥主导作用,摆脱传统经济增长方式、生产力发展路径,具有高科技、高效能、高质量特征,符合新发展理念的先进生产力质态。纵观三次科技革命变革生产力的历程,新质生产力的产生和发展是生产力与生产关系相互作用的结果,具有生产力与生产关系的双重内涵和发展要求。新质生产力以新型劳动者、新型劳动资料、新型劳动对象及其组合模式和新型生产关系为架构要素与发展基础,其生成逻辑与运行机理是由技术革命性突破引发,在催生新型生产力要素、新型要素组合模式的基础上促使与新质生产力相适应的新型生产关系变革形成,新型生产关系的反作用促进新质生产力进一步生成的过程。发展新质生产力要以实施创新驱动战略、加快产业深度转型、构建要素生态系统和全面深化改革为基本模式和关键路径。亟须加快实现高水平科技自立自强,加快技术革命性创新;促进产业深度转型,构建现代化产业体系;促进生产要素创新配置,构建新质生产要素系统;全面深化改革,加快建立健全与新质生产力相适应的新型生产关系,促进新质生产力加快形成发展。

关键词：新质生产力新型生产关系技术革命性突破全面深化改革

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HMFI分子筛Bronsted酸性位点与碱性分子的作用机制

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原子与分子物理学报 2025年第4期42卷 1-7页

作者：郑健秦康秦玉才宋丽娟中石化石油化工科学研究院有限公司北京100083 辽宁石油化工大学辽宁省石油化工催化科学与技术重点实验室抚顺113001

采用密度泛函理论(DFT)方法,以单铝、双铝和三铝酸性位点HMFI分子筛为模型分子筛,计算去质子化能考察HMFI分子筛的本征酸性,以NH_(3)分子作为模型分子,计算NH_(3)分子在HMFI分子筛中的吸附能与去质子化能进行关联性分析,并进一步考察NH_... 详细信息

采用密度泛函理论(DFT)方法,以单铝、双铝和三铝酸性位点HMFI分子筛为模型分子筛,计算去质子化能考察HMFI分子筛的本征酸性,以NH_(3)分子作为模型分子,计算NH_(3)分子在HMFI分子筛中的吸附能与去质子化能进行关联性分析,并进一步考察NH_(3)分子与HMFI分子筛的作用机制.研究表明分子筛Bronsted酸(简称B酸)强度与B酸数量没有强相关性,在考虑B酸位数量的同时须考虑B酸位的分布.酸性位点数量和分布的差异均可以调控NH_(3)分子的吸附构象,并且可以通过调节HMFI分子筛孔道对分子施加相互作用的模式,解析分子的结构和电子性质,精准调控分子的进一步转化.此项工作可以为未来高效多孔材料有效物种活性位的构建提供新思路.

关键词：密度泛函理论 HMFI分子筛 Bronsted酸性质吸附性能

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Combinational benefit of antihistamines and remdesivir for reducing SARS-CoV-2 replication and alleviating inflammation-induced lung injury in mice

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Zoological Research 2022年第3期

作者： Meng-Li Wu Feng-Liang Liu Jing Sun Xin Li jian-ru qin Qi-Hong Yan Xia Jin Xin-Wen Chen Yong-Tang Zheng Jin-Cun Zhao jian-Hua Wang

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Analytic calculation of magnetic force between two current-carrying coils

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Applied Mathematics and Mechanics(English Edition) 2015年第4期36卷 475-486页

作者： Xiaofan GOU jian qin College of Mechanics and Materials Hohai University

Current-carrying coils are basic elements in electromagnetic equipments, for example, in high field magnets from high temperature superconducting wires or tapes. In the assembly of these systems and their current-carrying operation, unavoidable mis- alignment and shift from the original position can be induced by disturbances such as the imbalance of magnetic force due to safety problems. For two current-carrying coils with non-coplanar axes, the analytic expression of the magnetic force between the two coils is presented according to the rule of Ampere circulation and the Biot-Savart law. Based on the expression, the dependence of the magnetic force on the size and the relative position of each other is further investigated, and the variation of the magnetic force is obtained with the above parameters.

关键词： current-carrying coil non-coplanar axis magnetic force analytic calcula-tion

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Preparation and photo-catalytic activity of TiO_2-coated medical stone-based porous ceramics

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International Journal of Minerals,Metallurgy and Materials 2013年第6期20卷 593-597页

作者： ru-qin Gao Xin-mei Hou School of Environmental and Municipal Engineering North China University of Water Resources and Electric Power School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

Medical stone-based porous ceramics as a carrier were prepared by ultra-fine grinding and low-temperature sintering method. Nano-TiO~ thin films were loaded on the carrier by chemical liquid deposition method using titanium tetrachloride as a precursor. The micro-morphology and microstructure of the synthesized samples were characterized using X-ray diffraction, scanning electron microscopy with energy dispersive spectrometry, and mercury injection method. The photo-catalytic activity of the TiO2 thin films was investigated by degrading formaldehyde. The main crystalline phase in the TiO2 thin films calcined at 550~C is anatase with the average particle size about 10 nm. The specific surface area of the carrier-coated nano-TiO2 increases from 3.68 to 5.32 m2/g. The formaldehyde removal rate of the TiO2/medical stone-based porous ceramics irradiated under an ultraviolet lamp for 120 min reaches 85.6%.

关键词： porous materials ceramics medical stone titanium dioxide thin films formaldehyde photocatalysis

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Procreating Tiles of Double Commutative-Step Digraphs

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Acta Mathematicae Applicatae Sinica 2008年第2期24卷 185-194页

作者： jian-qin Zhou Telecommunication School Hangzhou Dianzi University Hangzhou 310018 China Department of Computer Science Anhui University of Technology Ma'anshan 243002 China

Double commutative-step digraph generalizes the double-loop digraph. A double commutative-step digraph can be represented by an L-shaped tile, which periodically tessellates the plane. Given an initial tile L（l, h, x, y）, Aguil5 et al. define a discrete iteration L（p） = L（l ＋ 2p, h ＋ 2p, x ＋ p, y ＋ p）, p = 0, 1, 2,..., over L-shapes （equivalently over double commutative-step digraphs）, and obtain an orbit generated by L（l, h, x,y）, which is said to be a procreating k-tight tile if L（p）（p = 0, 1, 2, ~ ~ ~ ） are all k-tight tiles. They classify the set of L-shaped tiles by its behavior under the above-mentioned discrete dynamics and obtain some procreating tiles of double commutative-step digraphs. In this work, with an approach proposed by Li and Xu et al., we define some new discrete iteration over L-shapes and classify the set of tiles by the procreating condition. We also propose some approaches to find infinite families of realizable k-tight tiles starting from any realizable k-tight L-shaped tile L（l, h, x, y）, 0 ≤ y - x ≤ 2k ＋ 2. As an example, we present an infinite family of 3-tight optimal double-loop networks to illustrate our approaches.

关键词： Double-loop digraph double commutative-step digraph L-shaped tile procreate infinite family

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Amplified Electrochemical Immunoassay Using HRP Labeled Protein as an Inhibitor to Silver Deposition in the Presence of H_2O_2

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Chinese Chemical Letters 2006年第4期17卷 489-492页

作者： Zhao Peng CHEN jian Hui jianG Xiao Bing ZHANG Guo Li SHEN ru qin YU State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082

A novel electrochemical immunosensor with amplification effect based on the enzyme inhibition of silver deposition was proposed. In this method, the capture antibody was first immobilized onto a gold electrode via a self-assembled layer. After a sandwich immunoreaction, HRP labeled antibody was bound to the gold electrode. The HRP on the electrode inhibited silver deposition when the electrode was incubated in hydroquinone-H2O2 solution and silver ion solution. The linear sweep voltammetry was chosen to detect the deposited silver and the result showed that the peak current was linearly proportional to the content of IgG in the range of 50 to 2500 ng/mL with a detection limit of 35 ng/mL.

关键词： Immunosensor linear sweep voltammetry silver deposition.

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Noether-Type Symmetries and Associated Conservation Laws of Some Systems of Nonlinear PDEs

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Communications in Theoretical Physics 2009年第3期51卷 495-498页

作者： MEI jian-qin Department of Applied Mathematics Dalian University of Technology Dalian 116024 China

The algorithm for constructing conservation laws of Euler Lagvange type equations via Noether-type symmetry operators associated with partial Lagrangian has been presented. As applications, many new conservation laws ... 详细信息

关键词： Lie-Backlund Noether-type symmetries conservation law coupled integrable dispersionless equations coupled wave equations

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