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Aggregated structures and their functionalities in hydrogels

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Aggregate

Aggregate 2021年第2期2卷 16-27页

作者： Kunpeng Cui jian ping gong Institute for Chemical Reaction Design and Discovery(WPI-ICReDD) Hokkaido UniversitySapporoJapan Soft Matter GI-CoRE Hokkaido UniversitySapporoJapan Faculty of Advanced Life Science Hokkaido UniversitySapporoJapan

Biological soft tissues and hydrogels belong to the same category of soft and wet *** of them are composed of polymer network and a certain amount of water,and permeable to small *** tissues possess elaborated structures and exhibit outstanding *** the other hand,hydrogels are usually amorphous with poor *** recent years,various hydrogels with robust functionalities have been developed by introducing aggregated structures into the gel networks,widely extend their applications in diverse fields,such as soft actuators,biological sensors,and structural *** strategies are usually used to fabricate aggregated structure into hydrogels,including molecular self-assembling,microphase separation,crystallization,and inorganic *** aggregated structures entail the gel very different functionalities.A simple aggregated structure is able to bring multiple functionalities and a combination of mechanical performances of the *** this review,we describe the strategies used to construct aggerated structure in hydrogels and discuss about the close relation between the aggregated structure and *** also highlight the role of nonequilibrium aggregated structure in fabricating hydrogels with dynamic memorizing-forgetting behavior and point out the remaining challenges.

关键词： aggregated structure functionality hydrogel

Hierarchical Control Strategy for Load Regulation Based on Stackelberg Game Theory Considering Randomness

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 929-941页

作者： Tingyu jiang ping Ju C.Y.Chung Yuzhong gong College of Energy and Electrical Engineering Hohai UniversityNanjing 211100China Department of Electrical Engineering City University of Hong KongHong Kong CF624China Department of Electrical and Computer Engineering University of SaskatchewanSaskatoonSK S7N 5A9Canada CSEE IEEE

Demand response has been recognized as a valuable functionality of power systems for mitigating power *** paper proposes a hierarchical control strategy among the distribution system operator(DSO),load aggregators(LAs),and thermostatically controlled loads(TCLs);the strategy includes a scheduling layer and an executive layer to provide load *** the scheduling layer,the DSO(leader)offers compensation price(CP)strategies,and the LAs(followers)respond to CP strategies with available regulation power(ARP)*** of the DSO and LAs are modeled according to their behaviors during the load regulation *** game is adopted to capture interactions among the players and leader and to obtain the optimal strategy for each participant to achieve ***,considering inevitable random factors in practice,e.g.,renewable generation and behavior of users,two different stochastic models based on sample average approximation(SAA)and parameter modification are formulated with improved scheduling *** the executive layer,distributed TCLs are triggered based on strategies determined in the scheduling layer.A self-triggering method that does not violate user privacy is presented,where TCLs receive external signals from the LA and independently determine whether to alter their operation *** simulations are performed on the modified IEEE-24 bus system to verify effectiveness of the proposed strategy.

关键词： Demand response hierarchical control load regulation self-triggering method Stackelberg game

Targeting tau in Alzheimer's disease:from mechanisms to clinical therapy

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Neural Regeneration Research 2024年第7期19卷 1489-1498页

作者： Jinwang Ye Huali Wan Sihua Chen gong-ping Liu Shenzhen Key Laboratory of Marine Biotechnology and Ecology College of Life Sciences and OceanographyShenzhen UniversityShenzhenGuangdong ProvinceChina Department of Laboratory Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Co-innovation Center of Neurodegeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Pathophysiology School of Basic Medicine and the Collaborative Innovation Center for Brain ScienceKey Laboratory of Ministry of Education of China and Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Alzheimer’s disease is the most prevalent neurodegenerative disease affecting older *** features of Alzheimer’s disease include extra cellular aggregation of amyloid-βplaques and the accumulation of neurofibrillary tangles,fo rmed by tau protein,in the *** there are amyloid-β-ta rgeting therapies for the treatment of Alzheimer’s disease,these therapies are costly and exhibit potential negative side *** evidence suggests significant involvement of tau protein in Alzheimer’s disease-related *** an important microtubule-associated protein,tau plays an important role in maintaining the stability of neuronal microtubules and promoting axonal *** fact,clinical studies have shown that abnormal phosphorylation of tau protein occurs before accumulation of amyloid-βin the *** therapeutic strategies targeting tau protein have begun to emerge,and are considered possible methods to prevent and treat Alzheimer’s ***,abnormalities in post-translational modifications of the tau protein,including aberrant phosphorylation,ubiquitination,small ubiquitin-like modifier(SUMO)ylation,acetylation,and truncation,contribute to its microtubule dissociation,misfolding,and subcellular *** causes mitochondrial damage,synaptic impairments,gliosis,and neuroinflammation,eventually leading to neurodegeneration and cognitive *** review summarizes the recent findings on the underlying mechanisms of tau protein in the onset and progression of Alzheimer’s disease and discusses tau-targeted treatment of Alzheimer’s disease.

关键词： acetylation Alzheimer’s disease cognitive deficits gliosis mitochondria damage neuroinflammation phosphorylation synaptic impairments tau tau immunotherapy

Single-atom Rh catalysts for efficiently degrading Rhodamine B with high concentration

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Rare Metals 2024年第5期43卷 2331-2338页

作者： Shou-Yao Hu jian-ping Guan Run-Ze Ma Yu Tao Dong-Hao Liu Jia-Xin gong Yu Xiong Department of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China

Highly concentrated dye wastewater has a serious effect on the quality of natural waters;thus,developing novel catalysts to degrade dyes rapidly and efficiently is of great *** the first time,this study reports an Rh single atom loaded on a nitrogen-doped carbon(SA-Rh/CN)*** catalyst exhibits an excellent processing capacity for high concentrations of Rhodamine B(Rh B),high catalytic activity(95.7% degradation of Rh B in60 min)and excellent stability(93.5% degradation efficiency after 10 stable runs).

关键词： catalyst. catalysts loaded

Therapeutic Effect and Safety of Ustekinumab for Plaque Psoriasis: A Meta-analysis

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Chinese Medical Sciences Journal 2014年第3期29卷 131-138页

作者： Yi Liu jian-ping gong Wen-fang Li Department of Dermatology Luzhou Medical College Department of Hepatibiliary Surgery the Second Affiliated Hospital of Chongqing Medical University

Objective To evaluate the efficacy and safety of ustekinumab in the therapy of plaque psoriasis. Methods Literatures published up to November 2013 were collected from Cochrane library, MEDLINE, and PubMed which were related with ustekinumab for plaque psoriasis. The efficacy was estimated using relative risk of Psoriasis Area and Severity Index(PASI) 75 response rate at the week 12 endpoint in clinical trials, and adverse effects were also analyzed. Meta-analysis was carried out by using Review Manager 5.1. Results Six randomized control trials consistent with the inclusion criteria were selected and reviewed. Ustekinumab 45 mg group and 90 mg group could get better therapeutic effect compared with the placebo group(all P0.05), except that infection rate in ustekinumab 45 mg group was higher than the placebo group(P=0.02). Conclusions Ustekinumab is an effective and safe therapeutic method for plaque psoriasis. However, further longer time analysis of safety is needed.

关键词： Meta分析治疗效果银屑病安全性块型上呼吸道感染 MEDLINE 随机对照试验

Glucose metabolic reprogramming-related parameters for the prediction of 28-day neurological prognosis and all-cause mortality in patients after cardiac arrest:a prospective single-center observational study

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World Journal of Emergency Medicine 2024年第3期15卷 197-205页

作者： Subi Abudurexiti Shihai Xu Zhangping Sun Yi jiang ping gong Department of Emergency Medicine Ruijin Hospital Affi liated to Shanghai Jiaotong University School of MedicineShanghai 200025China Department of Emergency Medicine Shenzhen People's Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affi liated HospitalSouthern University of Science and Technology)Shenzhen 518020China Department of Emergency Medicine the First Affi liated Hospital of Dalian Medical UniversityDalian 116011China Department of Emergency Medicine General Hospital of Tianjin Medical UniversityTianjin 300052China

BACKGROUND:We aimed to observe the dynamic changes in glucose metabolic reprogrammingrelated parameters and their ability to predict neurological prognosis and all-cause mortality in cardiac arrest patients after the restoration of spontaneous circulation(ROSC).METHODS:Adult cardiac arrest patients after ROSC who were admitted to the emergency or cardiac intensive care unit of the First Aflliated Hospital of Dalian Medical University from August 1,2017,to May 30,2021,were *** to 28-day survival,the patients were divided into a non-survival group(n=82) and a survival group(n=38).Healthy adult volunteers(n=40) of similar ages and sexes were selected as *** serum levels of glucose metabolic reprogrammingrelated parameters(lactate dehydrogenase [LDH],lactate and pyruvate),neuron-specific enolase(NSE) and interleukin 6(IL-6) were measured on days 1,3,and 7 after *** Acute Physiology and Chronic Health Evaluation II(APACHE II) score and Sequential Organ Failure Assessment(SOFA) score were *** Cerebral Performance Category(CPC) score was recorded on day 28 after ***:Following ROSC,the serum LDH(607.0 U/L vs.286.5 U/L),lactate(5.0 mmol/L vs.2.0 mmol/L),pyruvate(178.0 μmol/L vs.70.9 μmol/L),and lactate/pyruvate ratio(34.1 vs.22.1) significantly increased and were higher in the non-survivors than in the survivors on admission(all P<0.05).Moreover,the serum LDH,pyruvate,IL-6,APACHE II score,and SOFA score on days 1,3 and 7 after ROSC were significantly associated with 28-day poor neurological prognosis and 28-day all-cause mortality(all P<0.05).The serum LDH concentration on day 1 after ROSC had an area under the receiver operating characteristic curve(AUC) of 0.904 [95% confidence interval [95% CI]:0.851–0.957]) with 96.8% specificity for predicting 28-day neurological prognosis and an AUC of 0.950(95% CI:0.911–0.989) with 94.7% specificity for predicting 28-day all-cause mortality,which was the highest among the glucose metabo

关键词： Glucose metabolic reprogramming Lactate dehydrogenase Cardiac arrest Prognosis

Spherical Confinement Generates Entropic Force to Accelerate Polymer Chain Detachment

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Chinese Journal of Polymer Science 2024年第3期42卷 407-416,I0010页

作者： Yu-Shan Zheng jian-ping Zhou Yan Xu Kai Li Mechanical Engineering Xinjiang UniversityUrumqi 830002China

To understand the dynamic process of polymer detachment, it is necessary to determine the mean detachment time of a single breakable link, which is modeled as a spring. Normally, this time can be viewed as the escape of a Brownian particle from the potential well of the spring. However, as the free dangling length of the polymer chain increases, the conformational entropy of the chain is affected by geometric confinement. It means that the wall exerts a repulsive force on the chain, resulting in accelerated link detachment from a macroscopic perspective. In this work, we investigate the effect of entropy on the detachment rate in the case where the substrate is spherical. We demonstrate that spherical confinement accelerates chain detachment both inside and outside the sphere. An analytical expression for the mean detachment time of breakable links is given, which includes an additional pre-factor that is related to the partition function. Additionally, we analyze the expressions for entropic forces inside the sphere, outside the sphere, and on a flat wall, comparing their magnitudes to explain the difference in mean detachment time.

关键词： Polymer detachment Breakable link Entropic force Mean first passage time

Eco-evolutionary evidence for the global diversity pattern of Cycas(Cycadaceae)

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Journal of Integrative Plant Biology 2024年第6期66卷 1170-1191页

作者： jian Liu Anders JLindstrom Yiqing gong Shanshan Dong Yusheng(Chris)Liu Shouzhou Zhang Xun gong CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Department of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Global Biodiversity Conservancy 144/124 Moo3Soi Bua ThongBangsalaeSattahipChonburi 20250Thailand Key Laboratory of Southern Subtropical Plant Diversity Fairy Lake Botanical GardenShenzhen&Chinese Academy of SciencesShenzhen 518004China Department of Earth and Environmental Sciences Indiana University-IndianapolisIndianapolisIN 46202USA

The evolution of the latitudinal diversity gradient(LDG),characterized by a peak in diversity toward the tropics,has captured significant attention in evolutionary biology and ***,the inverse LDG(i-LDG)mechanism,wherein species richness increases toward the poles,remains inadequately *** are among one of the oldest lineages of extant seed plants and have undergone extensive diversification in the ***,the extant cycad abundance exhibits an i-LDG pattern,and the underlying causes for this phenomenon remain largely ***,using 1,843 nuclear genes from a nearly complete sampling,we conducted comprehensive phylogenomic analyses to establish a robust species-level phylogeny for Cycas,the largest genus within *** then reconstructed the spatial-temporal dynamics and integrated global environmental data to evaluate the roles of species ages,diversification rates,contemporary environment,and conservatism to ancestral niches in shaping the i-LDG *** found Cycas experienced decreased diversification rates,coupled with the cooling temperature since its origin in the Eocene from continental *** regions have distinctively contributed to the formation of i-LDG for Cycas,with the northern hemisphere acting as evolutionary museums and the southern hemisphere serving as ***,water-related climate variables,specifically precipitation seasonality and potential evapotranspiration,were identified as paramount factors constraining Cycas species richness in the rainforest biome near the ***,the adherence to ancestral monsoonal climates emerges as a critical factor in sustaining the diversity *** study underscores the imperative of integrating both evolutionary and ecological approaches to comprehensively unravel the mechanisms underpinning global biodiversity patterns.

关键词： cycads latitudinal diversity gradient niche conservatism spatiotemporal diversification species richness

Contrast enhanced ultrasound in diagnosing liver lesion that spontaneously disappeared:A case report

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World Journal of Clinical Cases 2021年第21期9卷 5948-5954页

作者： Zong-Ding Wang Salameen Haitham jian-ping gong Zi-Li Pen Department of Surgery Fengjie People’s HospitalChongqing 400010China Department of Hepatobiliary Surgery The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

BACKGROUND Focal liver lesions(FLLs)are abnormal masses that are distinguishable from the surrounding liver parenchyma,solid or cystic and may be benign or *** are usually detected incidentally on abdominal *** classification of FLLs is very important as it directly determines the diagnosis and treatment of *** SUMMARY A 46-year-old male patient was admitted into the hospital with tarry stool,during the investigation of this issue an incidental FLL was *** further investigation of this“incidentaloma”computerized tomography and magnetic resonance imaging reached contradictory *** lesion was then further investigated using contrast-enhanced ultrasound(CEUS)with an initial diagnosis of idiopathic FLL was acquired and observation of the FLL over time need for final diagnosis,however in the follow up the FLL disappeared *** CEUSs value for characterization of FLLs is undeniable,especially when other methods produce inconsistent results,is undeniable but with its *** and how the FLL disappeared is not known,and can be only hypothesized it was a pseudolesion.

关键词： Liver Ultrasonography Tomography Contrast enhanced ultrasound Focal liver lesions Case report