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Massive GGAAs in genomic repetitive sequences serve as a nuclear reservoir of NF-κB

Journal of Genetics and Genomics 2018年第4期45卷 193-203页

作者： jian wu Qiao Wang Wei Dai Wei Wang ming Yue Jinke Wang State Key Laboratory of Bioelectronics Southeast University Department of Infectious Diseases The First Affiliated Hospital of Nanjing Medical University

Nuclear factor kB（NF-kB） is a DNA-binding transcription factor. Characterizing its genomic binding sites is crucial for understanding its gene regulatory function and mechanism in cells. This study characterized the binding sites of NF-kB ReIA/p65 in the tumor neurosis factor-a（TNFa） stimulated HeLa cells by a precise chromatin immunoprecipitation-sequencing（ChIP-seq）. The results revealed that NF-kB binds nontraditional motifs（nt-motifs） containing conserved GGAA quadruplet. Moreover, nt-motifs mainly distribute in the peaks nearby centromeres that contain a larger number of repetitive elements such as satellite, simple repeats and short interspersed nuclear elements（SINEs）. This intracellular binding pattern was then confirmed by the in vitro detection, indicating that NF-kB dimers can bind the nontraditional kB（nt-KB） sites with low affinity. However, this binding hardly activates *** study thus deduced that NF-kB binding nt-motifs may realize functions other than gene regulation as NF-kB binding traditional motifs（t-motifs）. To testify the deduction, many ChIP-seq data of other cell lines were then analyzed. The results indicate that NF-kB binding nt-motifs is also widely present in other cells. The ChIP-seq data analysis also revealed that nt-motifs more widely distribute in the peaks with low-fold enrichment. Importantly, it was also found that NF-kB binding nt-motifs is mainly present in the resting cells, whereas NF-kB binding t-motifs is mainly present in the stimulated cells. Aston？ishingly, no known function was enriched by the gene annotation of nt-motif peaks. Based on these results, this study proposed that the nt-KB sites that extensively distribute in larger numbers of repeat elements function as a nuclear reservoir of NF-kB. The nuclear NF-kB proteins stored at nt-KB sites in the resting cells may be recruited to the t-KB sites for regulating its target genes upon stimulation.

关键词： NF-κB Binding region GGAA Storage

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Research on shape optimization of CSG dams

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Water Science and Engineering 2011年第4期4卷 445-454页

作者： Xin CAI Ying-li wu jian-gang YI Yu ming College of Mechanics and Materials Hohai University Naijing 210098 P R. China College of Water Conservancy and Hydropower Engineering Hohai University Naijing 210098 P. R. China Geotechnical Engineering Department Nanjing Hydraulic Research Institute Nanjing 210024 P. R. China

The multi-objective optimization method was used for shape optimization of cement sand and gravel （CSG） dams in this study. The economic efficiency, the sensitivities of maximum horizontal displacement and maximum settlement of the dam to water level changes, the overall stability, and the overall strength security were taken into account during the optimization process. Three weight coefficient selection schemes were adopted to conduct shape optimization of a dam, and the case studies lead to the conclusion that both the upstream-and downstream dam slope ratios for the optimal cross-section equal 1：0.7, which is consistent with the empirically observed range of 1：0.6 to 1;0.8 for the upstream and downstream dam slope ratios of CSG dams. Therefore, the present study is of certain reference value for designing CSG dams.

关键词： CSG dam shape optimization sensitivity analysis

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Influence of modeling approaches and structural parameters on impact resistance of the human porous cranium

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Acta Mechanica Sinica 2021年第6期37卷 910-928,I0001页

作者： Qianqian wu jian Xiong Center for Composite Materials and Structures Harbin Institute of TechnologyHarbin150001China

Failure mechanism and impact resistance of a human porous cranium are studied in detail by means of theoretical and numerical *** is hypothesized that pore distribution of a cranium directly affects cranial energy absorption,and a stretched beam model and a real beam model are taken as the example for the ***,for the purpose of comparison with numerical results,a theoretical model is also proposed for the prediction of residual velocity and contact force of the impactor for an impacted *** with the real beam model,the stretched beam model containing through-thickness pores is easily deformed under the impact,thereby buffering well the external impact *** energy absorption efficiency of both the stretched beam model and real beam model is concerned with the threshold velocity for penetration which is directly related to the size of the structural damage ***,there is good agreement between numerical and theoretical *** addition,the effect of structural geometric parameters(shape and size of the impactor)on the impact resistance of the skull bone is theoretically *** study provides reference for the evaluation of the energy absorption and failure mechanism of the skull under impact loads.

关键词： Skull porous structure Impact resistance Modeling approach Theoretical prediction Influence of structural parameters

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Effect of gastric fluid on adsorption and desorption of endocrine disrupting chemicals on microplastics

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Frontiers of Environmental Science & Engineering 2022年第8期16卷 193-205页

作者： Jie wu jian Lu Jun wu CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone Research(YIC)Chinese Academy of Sciences(CAS)Shandong Key Laboratory of Coastal Environmental ProcessesYICCASYantai 264003China University of Chinese Academy of Sciences Beijing 100049China Yantai Research Institute Harbin Engineering UniversityYantai 264006China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

Microplastics and endocrine disrupting chemicals are emerging pollutants in the marine environment because of their potential *** effect of gastric fluid on the adsorption and desorption of 17β-estradiol(E2)and 17α-ethynylestradiol(EE2)to microplastics was *** adsorption and desorption isotherms of E2/EE2 on microplastics could be well fitted by the Freundlich model while the Gibbs free energy of these processes were negative,proving that the reaction occurred spontaneously on the heterogeneous surface of the *** ratios of EE2(55%–59%)on PVC were larger than that of E2(49%–55%)to indicate that EE2 was less stable in gastric fluid,which could be explained by the fact that the hydrophobicity of EE2 was greater than E2.E2/EE2 were more easily desorbed from PVC in the gastric fluid and the desorption amount(5.25–12.91/7.19–17.86μg/g)increased by 2.51 times in comparison with that in saline solution(2.22–7.81/2.87–10.80μg/g).The decrease of pH and the increase of ionic strength in gastric fluid could further strengthen desorption of E2/EE2 from *** promotion of gastric juice on desorption of PVC was achieved by reducing the hydrophobicity of the PVC *** desorption rate of E2/EE2 at 18°C and 38°C was respectively 44%–47%/46%–50%and 49%–55%/56%–59%,indicating that PVC loaded with E2/EE2 had a relatively greater risk of releasing pollutants in the gastric fluid of constant temperature marine organisms while higher temperatures exposed higher hazards for variable temperature *** interaction between microplastics and pollutants might be mainly hydrophobic interaction.

关键词： Microplastics Gastric fluid Endocrine-disrupting chemicals Adsorption Desorption

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Adsorption and desorption of steroid hormones on saline soil

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Frontiers of Environmental Science & Engineering 2022年第11期16卷 177-190页

作者： Jie wu jian Lu Jun wu CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China University of Chinese Academy of Sciences Beijing 100049China Yantai Research Institute Harbin Engineering UniversityYantai 264006China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

Soil organic matter content was the main driving factor affecting adsorption and desorption process of 17β-estradiol(E2)and 17α-ethynylestradiol(EE2)on saline *** adsorption and desorption of E2 and EE2 on three saline soils showed the similar behavior that soil with the highest organic content possessed the highest adsorption capacity and the lowest desorption capacity for E2 and *** adsorption capacity of untreated soil samples(with organic matter)was larger than that of soil samples without organic *** soil with the largest adsorption capacity,adsorption capacity of E2/EE2 on the untreated soil and soil colloid(with organic matter)respectively reached 0.15/0.30μg/g and 0.16/0.33μg/g while the soil and soil colloid without organic matter hardly adsorbed *** adsorption capacity of E2/EE2 at the initial concentration of 100μg/L was 25/15 times higher than that at the initial concentration of 5μg/L.E2 and EE2 had the same adsorption sites on saline soil while EE2 possessed higher competition intensity for adsorption sites than ***-first-order model(R^(2)=0.995–0.986)and Langmuir model(R^(2)=0.989–0.999)could better fit the adsorption process of E2 or *** thermodynamic study further showed that the adsorption of E2/EE2 on saline soil was a spontaneous exothermic *** desorption capacity of EE2/E2 accounted for 40%/78%of the total adsorption capacity to possibly exert potential risk to the *** variation of the salinity led to the variation of soil organic carbon which subsequently changed the adsorption and desorption behaviors of endocrine disrupting chemicals in coastal saline *** study provides a new insight on the interfacial behavior of endocrine disrupting chemicals on saline soil.

关键词： Saline soil Steroid hormones Adsorption Desorption Soil organic matter

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Determination and Analysis of Hardenability for Hot-Forging Die Steels with Deep-Hardening

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Journal of Iron and Steel Research International 2000年第1期7卷 27-30页

作者： ZHAO Gang jianG Min QIN Gao-wu HAO Shi-ming GU Rong DAI jian-ming Northeastern University Research Institute of Fushun Steel Plant

ERH end-quenching method was used to determine the hardenability of four kinds hot-forging die steels with deep-hardening and hence the order of their hardenability was *** tempering hardness of the steels was measured and the tempering resistance was *** was approved that ERH method is effective for the determination of hardenability of deep-hardening steel and the beginning of hardness drop in the ERH specimen is caused by bainite occurring.

关键词： hardenability deep-hardening steel hot-forging die steel tempering resistance

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Ultraviolet Photoelectron Spectroscopy Study of Oxygen Adsorption on Rb-Covered InSb (111) Surfaces

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Chinese Physics Letters 1998年第8期15卷 605-607页

作者： wu jian-xin MA Mao-sheng LIU Xian-ming Structure Research Laboratory University of Science and Technology of ChinaHefei 230026

Oxygen adsorption on Rb-covered InSb(111)surface has been studied at room temperature as a function of Rb coverage using ultraviolet photoelectron *** low O_(2) exposures,the intensity ratio of O^(2-)_(2) to O^(2-)increases with Rb *** surfaces with low Rb coverages are mainly covered by Sb oxides,causing an increase of work *** high Rb coverages,the Sb atoms are oxidized below a thin layer of Rb peroxide,which is related to an initial decrease of the work *** high O_(2) exposures,the intensity of O^(-)_(2) ion increases with Rb coverage.

关键词： spectroscopy. function. Oxygen

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Optimization of iron ore blending based on replacing Australian low alumina limonite

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Journal of Iron and Steel Research International 2023年第9期30卷 1675-1686页

作者： Bin Li Heng Zhou jian Huang Zong-wang Zhang Xue-feng She jian-fang Wang Sheng-li wu ming-yin Kou State Key Laboratory of Advanced Metallurgy School of Metallurgical and Ecological EngineeringUniversity of Science and Technology BeijingBeijing 100083China Shougang Jingtang Iron and Steel Co. Ltd.Tangshan 063200HebeiChina Key Laboratory of Knowledge Automation for Industrial Processes of Ministry of Education School of Automation and Electrical EngineeringUniversity of Science and Technology BeijingBeijing 100083China Delong Iron and Steel Co. Ltd.Xingtai 054009HebeiChina

Mauritanian iron ore powder(OM)has advantages of high iron grade,low aluminum content,and low loss on ignition,which can be used as a new mineral to replace low alumina limonite that has been exhausted in ***,it will have a certain negative impact on sintering because of its high SiO_(2) *** mechanism of SiO_(2) content affecting the sintering behavior was first studied through FactSage ***,the liquid fluidity,penetration,and high-temperature performance of different iron ore powders were ***,the optimization of ore blending structure was studied by the micro-sintering method and the sinter pot *** results show that the increase in SiO_(2) content can reduce the assimilation *** low penetration of OM can lead to an increase in the amount of liquid,and the high SiO_(2) content of OM increases the viscosity of the liquid *** is more,the increase in SiO_(2) also increases the formation of silicate and fayalite phase and inhibits the formation of silico-ferrite of calcium and aluminum(SFCA).To optimize ore blending structure,OM and the low SiO_(2) powder OD from Australia were used together,which improves the content of SFCA by 2.04%and decreases the contents of calcium silicate and fayalite by 0.63%and 4.99%,*** results of the sinter pot test indicated that the properties of sinter have been improved.

关键词： Mauritanian iron ore powder Liquid fluidity Penetration Mineral composition Sintering Ore blending Low alumina limonite

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Source mechanism of small-moderate earthquakes and tectonic stress field in Yunnan Province

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Acta Seismologica Sinica(English Edition) 2004年第5期17卷 509-517页

作者： wu jian-ping(吴建平) ming Yue-hong(明跃红) WANG Chun-yong(王椿镛) Institute of Geophysics China Earthquake AdministrationBeijing100081China Institute of GeophysicsChina Earthquake AdministrationBeijing100081China Institute of GeophysicsChina Earthquake AdministrationBeijing100081China

In the paper, source mechanisms of 33 small-moderate earthquakes occurred in Yunnan are determined by modeling of regional waveforms from Yunnan digital seismic network. The result shows that most earthquakes occurred within or near the Chuandian rhombic block have strike-slip mechanism. The orientations of maximum compressive stresses obtained from source mechanism are changed from NNW-SSN to NS in the areas from north to south of the block, and tensile stresses are mainly in ENE-WSW or NE-SE. In the eastern Tibetan Plateau, the orientations of maximum compressive stress radiate toward outside from the plateau, and the tensile stress orientations mostly parallel to arc structures. Near 28N the orientations of both maximum compressive stress and tensile stress changed greatly, and the boundary seems to correspond to the southwestern extended line of Longmenshan fault. Outside of the Chuandian rhombic block, the orientations of P and T axes are some different from those within the block. The comparison shows that the source mechanism of small-moderate events presented in the paper is consistence with that of moderate-strong earthquakes determined by Harvard University, which means the source mechanism of small-moderate events can be used to study the tectonic stress field in this region.

关键词： source mechanism small-moderate earthquakes stress field Yunnan

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Non-linear Viscoelastic Rheological Properties of PCC/PEG Suspensions

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Chinese Journal of Chemical Physics 2009年第1期22卷 46-50页

作者： Hai-lin Yang jian-ming Ruan jian-peng Zou Qiu-mei wu Zhong-cheng Zhou Yuan-yan Xie State Key Laboratory of Powder Metallurgy Central South University Changsha 410083 China

The shear thinning and shear thickening rheological properties of PCC/PEG suspension were investigated with the increase of oscillatory amplitude stress at different constant frequencies. The results show that the complex viscosity was initially independent of stress amplitude and obvious shear thinning occurred, then dramatic shear thickening took place after reaching the minimum viscosity. Typically, in a constant frequency of 5 rad/s, the elastic modulus, viscous modulus, and tanδ （δ is the out-of-phase angle） vs. the stress amplitude was investigated. It is found that the elastic modulus initially appeared to be independent of stress amplitude and then exhibited a rapid decrease, but the viscous modulus was independent of amplitude stress at lower amplitude stress. After reaching the minimum value the viscous modulus showed a rapid increase. On the other hand, tanδ increased from 0.6 to 92, which indicates that the transition from elastic to viscous had taken place and tanδ showed a steep increase when shear thickening occurred. Lissajous plots are shown for the dissipated energy vs. different maximum stress amplitude in the shear thinning and shear thickening regions. The relationship of dissipated energy vs. maximum stress amplitude was determined, which follows a power law. In the shear thinning region the exponent was 1.91, but it steeply increases to 3.97 in the shear thickening region.

关键词： Precipitated calcium carbonate Suspension Shear thickening Dynamic oscillatory shear Rheological response

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