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Quality of care for patients with inflammatory bowel disease in East China

World Journal of Gastroenterology 2008年第4期14卷 612-616页

作者： Qin Zhu Qian Cao jian-min si Department of Gastroenterology Sir RunRun Shaw Hospital School of Medicine Zhejiang UniversityHangzhou 310016 Zhejiang Province China Department of Gastroenterology Sir Run Run ShawHospital School of Medicine Zhejiang University Hangzhou310016 Zhejiang Province China Department of Pharmacology University of Califonia at Los Angeles United States

AIM： To investigate the quality of care for a hospital based-cohort of patients with inflammatory bowel disease （IBD） from East China according to the current practice guidelines, METHODS： A retrospective review was conducted, involving 177 patients with IBD admitted to sir Run Run Shaw Hospital, College of Medicine, Zhejiang University between June 2000 and June 2006. Data regarding demographic and clinical characteristics as well as medical therapy including use of oral aminosalisylates, topical therapy, corticosteroid agents, immunomodulatory agents （such as azathioprine） at admission and outpatient clinic visit were analyzed. RESULTS： A total of 177 eligible patients were evaluated in this study, including 71 patients with Crohn＇s disease （CD） and 106 with ulcerative colitis （UC）. All were the Han nationality Chinese with active disease at baseline. All the 106 patients with ulcerative colitis received optimal doses of aminosalisylate while 27 of 68 （39.7%） patients with ileal or colonic CD received the suboptimal doses of aminosalisylate. The incidence of suboptimal dose of aminosalisylate was significantly higher in CD patients with small intestine involvement only （52.8% vs 25.0%, P = 0.019）. Thirty-one （54.4%） patients with active distal or left-sided ulcerative colitis received topical therapy, and 27.8% of patients suffering from severe inflammatory bowel disease did not receive oral or intravenous steroid therapy. Among the 51 patients for whom thiopurine was indicated, only 10 （19.6%） received immunomodulatory agents, and more thanhalf of the 8 patients received a suboptimal dose of azathiopurine with no attempt to increase its dosage. CONCLUsiON： The quality of care for IBD patients can be further improved. A suboptimal dose of aminosalicylate is used in treatment of patients with CD, especially in those with small intestine involved only. Topical mesalazine is inadequately used in patients with distal or left-sided colitis. Oral or intravenous steroid

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Quality of care Guidelines

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Effect of H pylori infection and its eradication on hyperammo-nemia and hepatic encephalopathy in cirrhotic patients

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World Journal of Gastroenterology 2008年第12期14卷 1914-1918页

作者： Shu-Jie Chen Liang-Jing Wang Qin Zhu jian-Ting Cai Tao Chen jian-min si Department ofGastroenterology Sir Run Run Shaw Hospital Zlaejiang UniversitySchool of Medicine Hangzhou 310016 Zhejiang Province China Department ofGastroenterology Second Affiliated Hospital Zhejiang UniversitySchool of Medicine Hangzhou 310009 Zhejiang Province China

AIM： To investigate the relationship between H pylori infection, blood ammonia concentration and hepatic encephalopathy （HE）, and the effect of Hpylori eradication in cirrhotic patients. METHODS： From July 2003 to January 2005, 457 cirrhotic patients in five regions of Zhejiang Province were enrolled. Patients were evaluated for demographics, number connection test, Hpylori infection, liver impairment, blood ammonia concentration and HE. Patients with Hpylori infection were given I wk therapy with omeprazole plus clarithromycin and tinidazole. ^14C urea breath test was performed and mental symptoms and blood ammonia level were reassessed after RESULTS： Overall H pylori infection rate was 60.6%, and HE occurred in 47.5% of cirrhotic patients. Subclinical HE （SHE） was detected in 55 of 117 cirrhotic patients. Blood ammonia concentration in H pylori negative （n = 180） and positive （n = 277） cirrhotic patients was 53.8 ± 51.4 and 78.4 ± 63.6 μmol/L, respectively （P 〈 0.01）, which was significantly reduced to 53.5 ± 37.7 μmol/L after bacterium eradication （n = 126）（P 〈 0.01）. Blood ammonia was 97.5 ± 81.0 μmol/L in H pylori-positive cirrhotic patients, and this did not significantly change in those with persistent infection after Hpylori eradication （n = 11）. HE was more frequently observed in patients with H pylori infection than in those without （58.5% vs 30.6%, P 〈 0.01）. HE rate significantly dropped to 34.1% after H pylori eradiation （P 〈 0.01）. H pylori prevalence significantly differed among cirrhotic patients with HE （74.4%）, SHE （69.1%）, and those without HE （53.2%）（P 〈 0.05）. Blood ammonia level was significantly different among cirrhotic patients with HE （94.5 ± 75.6 μmol/L）, SHE （59.9 ± 49.2 μmol/L）, and without HE （47.3 ± 33.5 μmol/L）（P 〈 0.05）. Logistic regression analysis showed that blood ammonia concentration, Child-Pugh stage, upper gastrointestinal bleeding, electrolyte disturbance, and urea nitrogen were risk factors for HE. CONCLUsiON： H pylori in

关键词： Cirrhosis Helicobacter Pylori Hepaticencephalopathy Hyperammonemia

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Identifying Carbon stars from the LAMOST pilot survey with the efficient manifold ranking algorithm

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Research in Astronomy and Astrophysics 2015年第10期15卷 1671-1694页

作者： jian-min si Yin-Bi Li A-Li Luo Liang-Ping Tu Zhi-Xin Shi jian-Nan Zhang Peng Wei Gang Zhao Yi-Hong Wu Fu-Chao Wu Yong-Heng Zhao Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of Sciences National Key Laboratory of Pattern Recognition Institute of AutomationChinese Academy of Sciences University of Chinese Academy of Sciences School of Science Liaoning University of Science and Technology

Carbon stars are excellent kinematic tracers of galaxies and can serve as a viable standard candle, so it is worthwhile to automatically search for them in a large amount of spectra. In this paper, we apply the efficient manifold ranking algorithm to search for carbon stars from the Large Sky Area Multi-Object Fiber Spectroscopic Telescope （LAMOST） pilot survey, whose performance and robustness are verified comprehensively with four test experiments. Using this algorithm, we find a total of 183 carbon stars, and 158 of them are new findings. According to different spectral features, our carbon stars are classified as 58 C-H stars, 11 C-H star candidates, 56 C-R stars, ten C-R star candidates, 30 C-N stars, three C-N star candidates, and four C-J stars. There are also ten objects which have no spectral type because of low spec- tral quality, and a composite spectrum consisting of a white dwarf and a carbon star. Applying the support vector machine algorithm, we obtain the linear optimum clas- sification plane in the J - H versus/-/- Ks color diagram which can be used to distinguish C-H from C-N stars with their J - H and H - Ks colors. In addition, we identify 18 dwarf carbon stars with their relatively high proper motions, and find three carbon stars with FUV detections likely have optical invisible companions by cross matching with data from the Galaxy Evolution Explorer. In the end, we detect four variable carbon stars with the Northern Sky Variability Survey, the Catalina Sky Survey and the LINEAR variability databases. According to their periods and ampli- tudes derived by fitting light curves with a sinusoidal function, three of them are likely semiregular variable stars and one is likely a Mira variable star.

关键词： methods: data analysis -- methods: statistical -- stars: carbon -- binaries-- stars: variables

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Outcomes of furazolidone-and amoxicillin-based quadruple therapy for Helicobacter pylori infection and predictors of failed eradication

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World Journal of Gastroenterology 2018年第40期24卷 4596-4605页

作者： Ya-Wen Zhang Wei-Ling Hu Yuan Cai Wen-Fang Zheng Qin Du John J Kim John Y Kao Ning Dai jian-min si Department of Gastroenterology Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Institute of Gastroenterology Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of Gastroenterology The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Division of Gastroenterology Loma Linda UniversityLoma LindaCA 92354United States Division of Gastroenterology Department of Internal MedicineMichigan MedicineUniversity of MichiganAnn ArborMI 48109United States

AIM To evaluate the outcomes of furazolidone-and amoxicillin-based quadruple therapy for treatment of Helicobacter pylori(H. pylori) infection and identify predictors of failed *** Patients with H. pylori infection treated with furazolidone, amoxicillin, bismuth, and proton pump inhibitor therapy(January 2015 to December 2015) who received the ^(13)C-urea breath test > 4 wk after treatment were evaluated. Demographic and clinical data including prior H. pylori treatment attempts, medication adherence, alcohol and cigarette consumption during therapy, and treatment-related adverse events were recorded by reviewing medical records and telephone surveys. H. pylori eradication rates for overall and subgroups were evaluated. Multivariate analysis was performed to identify independent predictors of failed H. pylori *** Of the 992 patients treated and retested for H. pylori infection, the overall eradication rate was 94.5% [95% confidence interval(CI): 94.1%-95.9%]. H. pylori eradication rate of primary therapy was 95.0%(95%CI: 93.5%-96.5%), while that of rescue therapy was 91.3%(95%CI: 86.8%-95.8%). Among the 859 patients who completed the study protocol, 144(17%) reported treatment-related adverse events including 24(3%) leading to premature discontinuation. On multivariate analysis, poor medication adherence [adjusted odds ratio(AOR) = 6.7, 95%CI: 2.8-15.8], two or more previous H. pylori treatments(AOR = 7.4, 95%CI: 2.2-24.9), alcohol consumption during therapy(AOR = 4.4, 95%CI: 1.5-12.3), and possibly smoking during therapy(AOR = 1.9, 95%CI: 0.9-4.3) were associated with failed H. pylori eradication. CONCLUsiON Furazolidone-and amoxicillin-based quadruple therapy for H. pylori infection in an area with a high prevalence of clarithromycin resistance demonstrated high eradication rates as primary and rescue therapies with a favorable safety profile. Patient education targeting abstinence from alcohol during therapy and strict medication a

关键词： Helicobacter pylori Furazolidone Quadruple regimen side effects Eradication

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Klebsiella pneumoniae invasive liver abscess syndrome with purulent meningitis and septic shock: A case from China's Mainland

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World Journal of Gastroenterology 2016年第9期22卷 2861-2866页

作者： Yun Qian Chi-Chun Wong San-Chuan Lai Zheng-Hua Lin Wei-Liang Zheng Hui Zhao Kong-Han Pan Shu-Jie Chen jian-min si Department of Gastroenterology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Institute of Gastroenterology Zhejiang University Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease Li Ka Shing Institute of Health Sciences the Chinese University of Hong Kong Department of Radiology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Emergency Department Sir Run Run Shaw Hospital School of Medicine Zhejiang University Department of Critical Care Medicine Sir Run Run Shaw Hospital School of Medicine Zhejiang University

We present a rare case of invasive liver abscess syndrome due to Klebsiella pneumoniae (K. pneumoniae) with metastatic meningitis and septic shock. A previously healthy, 55-year-old female patient developed fever, liver abscess, septic shock, purulent meningitis and metastatic hydrocephalus. Upon admission, the clinical manifestations, laboratory and imaging examinations were compatible with a diagnosis of K. pneumoniae primary liver abscess. Her distal metastasis infection involved meningitis and hydrocephalus, which could flare abruptly and be life threatening. Even with early adequate drainage and antibiotic therapy, the patient’s condition deteriorated and she ultimately died. To the best of our knowledge, this is the first case of K. pneumoniae invasive liver abscess syndrome with septic meningitis reported in China's Mainland. Our findings reflect the need for a better understanding of the epidemiology, risk factors, complications, comorbid medical conditions and treatment of this disease.

关键词： Invasive liver abscess syndrome Pyogenic liver abscess Klebsiella pneumonia Meningitis Septic shock

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Protective effects of heat shock protein70 induced by geranyl-geranylacetone in atrophic gastritis in rats

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Acta Pharmacologica sinica 2007年第7期28卷 1001-1006页

作者： Wei-li LIU~2,Shu-jie CHEN~2,Yan CHEN~(2,3),Lei-min SUN~2,Wei ZHANG~2,Ya-min ZENG~2,Tian-hua ZHOU~(2,4),jian-min si~(2,5)~2 Department of Gastroenterology and Zhejiang Key laboratory of Traditional Chinese Medicine(TCM),sir Run Run Shaw Hospital,ZhejiangUniversity School of Medicine,Hangzhou 310012,China ~3 Department of Gastroenterology,Second Affiliated Hospital and ~4 Center forDisease Modeling,Zhejiang University College of Medicine,Hangzhou 310058,China Department of Gastroenterology and Zhejiang Key laboratory of Traditional Chinese Medicine (TCM) Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China Department of Gastroenterology Second Affiliated Hospital Zhejiang University College of Medicine Hangzhou China Center for Disease Modeling Zhejiang University College of Medicine Hangzhou China

Aim:To investigate the effect of geranylgeranylacetone (GGA) on the progres-sion of atrophic gastritis in rats and its potential ***:Atrophicgastritis was induced in Sprague-Dawley rats with 0.1% ammonia solution,60%ethanol,and 20 mmol/L deoxycholic acid for 24 *** by theinduction of atrophic gastritis,200 mg/kg GGA was administered by oral gavagefor 8 weeks (weeks 17-24).The histological changes in gastric mucosa werequantitated by the index of inflammation,the gastric mucosal thickness,and theamount of glands of 1 mm horizontal length in *** heat shockprotein (HSP)70 levels and distribution were determined by immunoblotting andimmunohistochemistry in gastric ***:GGA alleviated the pathologi-cal progression of atrophic gastritis with inflammation relief (inflammation index:1.40 in the GGA group and 1.65 in the atrophic gastritis group) and glandularrestoration (mucosal thickness and quantity of glands:194.3 μm and 38.7 mm inthe GGA group;123.3 μm and 32.7 mm in the atrophic gastritis group;Psignificantly induced HSP70 synthesis (Psion,aggravated the infiltration of inflammatory cellsand glandular loss in the ***:GGA prevented the progression ofatrophic gastritis in rats via the induction of HSP70 expression.

关键词： geranylgeranylacetone heat shock protein70 atrophic gastritis quercetin

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休闲运动面料抗紫外线性能的研究

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纺织科技进展 2018年第5期 4-6页

作者：简思敏江门市彩艳实业有限公司广东江门529000

使用Lambda35(UV-Vis)紫外线和可见光测试仪器,按AAATCC 183标准,对透光率和颜色2个面料抗紫外线性能比较重要的指标进行了试验分析,发现透光率越小,面料抗UV的性能越好,这一点经常在产品开发和生产中被忽略;红色和颜色越深的面料,紫外... 详细信息

使用Lambda35(UV-Vis)紫外线和可见光测试仪器,按AAATCC 183标准,对透光率和颜色2个面料抗紫外线性能比较重要的指标进行了试验分析,发现透光率越小,面料抗UV的性能越好,这一点经常在产品开发和生产中被忽略;红色和颜色越深的面料,紫外线防护性能比中浅色的好。

关键词：紫外线 UV 纬编面料 Lambda35(UV-Vis)

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Physarum polycephalum-inspired adaptive optimization design of artificial microtubular networks

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Science China Chemistry 2025年

作者： si-min Zeng Di-Wei Zheng Ting Pan Xing-Lan Ding Yun Zhang Chi-Hui Yang si-Xue Cheng Xian-Zheng Zhang Key Laboratory of Biomedical Polymers of ministry of Education&Department of Chemistry Wuhan University

Natural biological microtubular networks have undergone adaptive evolutionary selection and may offer viable solutions to design challenges in artificial microtubular networks. The plasmodium of the slime mold Physarum polycephalum(P. polycephalum) extends continuously to form a protoplasmic microtubular network structure, directly connecting food *** simulations revealed that the formation of this adaptive P. polycephalum microtubular network could be captured by a mathematical algorithm. Inspired by the P. polycephalum microtubular networks, we propose an adaptive optimization design method for artificial microtubular networks. Specifically, we utilized hydrogels with biodegradable and tissue-adhesive properties to replicate the P. polycephalum microtubular networks via photomask. In Rhodamine B diffusion and glucosecatalyzed reaction experiments, we found that the P. polycephalum microtubular networks exhibited significantly enhanced efficiency compared to vascular and artificial networks. Furthermore, we demonstrated the potential for uric acid(UA) degradation of the hydrogels with a real P. polycephalum microtubular network loaded with urate oxidase(UOx) in a rodent model of hyperuricemia. And this network achieved more than double the effect of the artificial network. This underscores the potential of natural microtubular networks to replace artificial microtubular networks.

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萎缩性胃炎大鼠胃黏膜主、壁细胞和G、D细胞及外周血胃泌素、生长抑素的变化

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世界华人消化杂志 2006年第34期14卷 3261-3267页

作者：朱方石姒健敏王良静王冬飞陈萍江苏省中医药研究院消化病研究室江苏省南京市210028 浙江大学邵逸夫临床医学研究所浙江省杭州市310016

目的:研究实验性萎缩性胃炎(CAG)大鼠胃黏膜主细胞、壁细胞和G、D细胞及外周血胃泌素(GAS)、生长抑素(SS)的变化,探讨CAG发生的可能机制.方法:综合采用1mL/L的氨水和20mmol/L去氧胆酸钠及600mL/L的乙醇及建立大鼠CAG模型,观察模型大鼠... 详细信息

目的:研究实验性萎缩性胃炎(CAG)大鼠胃黏膜主细胞、壁细胞和G、D细胞及外周血胃泌素(GAS)、生长抑素(SS)的变化,探讨CAG发生的可能机制.方法:综合采用1mL/L的氨水和20mmol/L去氧胆酸钠及600mL/L的乙醇及建立大鼠CAG模型,观察模型大鼠胃黏膜病理组织学的变化,采用病理学方法和免疫组织化学方法观察大鼠胃黏膜主、壁细胞和G、D细胞的变化情况,测定外周血GAS、SS水平.结果:模型大鼠胃窦黏膜炎症、腺体萎缩改变明显,部分出现了肠上皮化生,模型大鼠胃黏膜主细胞(7.94±2.36vs13.13±4.26,t=3.014,P=0.005)壁细胞(22.89±7.28vs39.07±7.17,t=4.479,P=0.005)数及G、D细胞数(33.75±7.34vs68.76±21.75,t=4.314,P=0.025;21.21±5.83vs31.37±7.80,t=2.953,P=0.01)较正常大鼠主、壁细胞,及G、D细胞数明显减少,血清GAS含量(118.38±13.62ng/Lvs139.25±17.32ng/L,t=2.679,P=0.025)、血浆SS含量(570.04±64.37ng/Lvs435.28±38.18ng/L,t=5.092,P=0.0005)分别较正常大鼠降低和增高.结论:大鼠CAG的发生与胃黏膜屏障的破坏,主、壁细胞和G、D细胞数的减少,导致胃蛋白酶、胃酸分泌异常及GAS、SS等胃肠激素的神经内分泌调节机制紊乱有关.

关键词：萎缩性胃炎主细胞壁细胞 G细胞 D细胞胃泌素生长抑素大鼠

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Stepwise assembly to construct stable copper(I) cluster-based circularly polarized luminescent MOFs

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Science China Chemistry 2025年

作者： Jing-Wen Xie Meng-Ting Wang Yan Jin si Li jian-Hua Qin Shuang-Quan Zang Tomas C.W.Mak College of Chemistry Henan Key Laboratory of Crystalline Molecular Functional Materials Zhengzhou University College of Chemistry and Chemical Engineering Luoyang Normal University Department of Chemistry The Chinese University of Hong Kong

Circularly polarized luminescence （CPL） materials have been extensively studied in recent years owing to their widespread applications in 3D display,optical storage,optical anti-counterfeiting,and biological imaging,***（I） clusters have emerged as a promising candidate for CPL materials,driven by their cost-effectiveness,superior luminescent properties,precise structure,and low ***,the poor environmental stability of copper（I） clusters renders their synthesis and preservation challenging,thereby significantly impeding their ***,we have designed and synthesised a chiral double-coordinated ligand in order to construct copper（I） cluster nodes that can be further *** anticipated,by utilizing stepwise assembly strategy,a Cu4cluster node co-modified by chiral alkynyl ligands and triphenylphosphine was further assembled with Cd2+ions to obtain 2D layers structure,L/*** L/D-Cu4-Cd exhibits excellent stability and optical properties,including bright yellow emission,solvent-responsive luminescence,and CPL activity with a maximum glumup to 2.0×10-3,which shows potential applications in the WLED and *** interestingly,the material also exhibits deflection ability towards different wavelengths of linearly polarized light,showing certain potential in the preparation of circular polarizer.

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