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Correlation between Polyphenol Contents and Antioxidant Activities in Different Echinacea Purpurea Varieties

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Current Medical Science 2023年第4期43卷 831-837页

作者： Xiao-jing LIN Zheng-shi-yu LAI Qun LUO Mei KONG min-jian liang Hong WU Mei BAI Guangdong Technology Research Center for Traditional Chinese Veterinary Medicine and Natural Medicine South China Agricultural UniversityGuangzhou 510642China Qilu Animal Health Products Company Jinan 250033China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life SciencesSouth China Agricultural UniversityGuangzhou 510642China

Objective:Polyphenols are complex compounds containing multiple phenolic hydroxyl *** are widely distributed in plants and have antioxidant *** the antioxidant activities of the cultivated varieties of Echinacea are similar to or better than those of the wild ones and the relationship between the accumulation of polyphenols and their antioxidant activities are still not ***:Folin-Ciocalteu method,high performance liquid chromatography(HPLC),2,2-diphenyl-1-picrylhydrazyl(DPPH)radical scavenging assay,ferric ion reducing antioxidant power(FRAP)assay,2,2'-azino-bis(3-ethylbenzothiazoline-6)-sulfonic acid(ABTS)radical scavenging assay,and Fe^(2+)chelating ability assay were used,respectively,to detect the total polyphenols and 5 kinds of caffeic acid derivatives(chicoric acid,caffeic acid,caftaric acid,chlorogenic acid,and 1,5-dicaffeoylquinic acid)in the roots,stems,leaves,and flowers,and the antioxidant activities of 3 varieties of Echinacea:*** L.,cultivar ***'Aloha',and ***'White Swan'.Results:*** *** the highest contents of total polyphenols,5 caffeic acid derivatives and antioxidant activities,followed by ***'White Swan'and ***'Aloha',***'White Swan'had the strongest ability to remove the DPPH,ABTS·^(+)and free radicals,and to chelate Fe^(2+);*** *** the strongest ability to reduce *** correlation analyses revealed that the contents of total polyphenols and caffeic acid derivatives of *** *** ***'White Swan'were correlated with their antioxidant ***:*** *** the most appropriate material for the development of medicinal ***'White Swan'could be used as a substitute for *** *** terms of its antioxidant activity.

关键词： antioxidant activity caffeic acid derivatives Echinacea purpurea medicinal plants total polyphenol

基于前额脑电多尺度小波对数能量熵的驾驶疲劳检测分析

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中国公路学报 2020年第6期33卷 182-189页

作者：闵建亮蔡铭中山大学智能工程学院智能交通系统重点实验室广东广州510006

为研究脑机接口(BCI)在交通运输中的应用,减少因疲劳驾驶导致的交通安全事故,提出基于前额脑电(EEG)信号多尺度小波对数能量熵的驾驶疲劳检测方法。首先,设计驾驶仿真模拟试验,利用脑电帽采集26名被试清醒驾驶和疲劳驾驶的前额EEG信号,... 详细信息

为研究脑机接口(BCI)在交通运输中的应用,减少因疲劳驾驶导致的交通安全事故,提出基于前额脑电(EEG)信号多尺度小波对数能量熵的驾驶疲劳检测方法。首先,设计驾驶仿真模拟试验,利用脑电帽采集26名被试清醒驾驶和疲劳驾驶的前额EEG信号,试验过程中,使用主观检测方法每隔20min对被试进行问询;其次,应用MATLAB对采集到的EEG数据进行预处理,基于2种驾驶状态形成被试初始样本数据集;进而,在该数据集基础上,利用多尺度熵的概念,提取EEG信号小波对数能量熵(WLE)特征,同时提取经典模糊熵(FE)特征进行比较分析;然后,运用极限学习机(ELM)对提取的特征数据集进行快速有效的精准分类,并使用留一交叉验证法进行验证评估;最后,对比经典FE分类表现,并结合多种性能指标对驾驶疲劳检测结果进行综合比较。研究结果表明:在本文试验条件下,基于多尺度WLE(MWLE)的前额EEG疲劳识别率显著高于基于多尺度FE(MFE)的识别率,其理论平均正确率达91.8%;基于多尺度熵的EEG信号特征提取方法能有效提高驾驶疲劳识别效果和算法效率;多种性能指标表明前额EEG的WLE可以作为衡量驾驶疲劳的有效生理指标;结果验证了采用基于ELM对MWLE的前额EEG信号进行驾驶疲劳检测方法的有效性和实用性,有助于促进可穿戴BCI在疲劳驾驶预警中的应用。

关键词：交通工程驾驶安全多尺度熵驾驶人疲劳脑机接口(BCI) 脑电(EEG)信号极限学习机(ELM)

An Open-label, Self-control, Prospective Study on Cognitive Function, Academic Performance, and Tolerability of Osmotic-release Oral System Methylphenidate in Children with Attention-deficit Hyperactivity Disorder

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Chinese Medical Journal 2015年第22期128卷 2988-2997页

作者： Yi Zheng jian-min liang Hong-Yun Gao Zhi-Wei Yang Fu-Jun Jia Yue-Zhu liang Fang Fang Rong Li Sheng-Nan Xie jian-min Zhuo Department of Pediatrics Beijing Anding Hospital Capital Medical University Beijing 100088 China Department of Pediatric Neurology The First Hospital Jilin University Changchun Jilin 130021 China Department of Psychology Children's Hospital of Fudan University Shanghai 201102 China Department of Pediatric Psychology Shenzhen Kangning Hospital shenzhen Guangdong 518003 China Guangdong Mental Health Center Guangdong General Hospital Guangzhou Guangdong 510120 China Department of Neurology Beijing Children's Hospital Capital Medical University Beijing 100053 China Department of Pediatric Psychology Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310003 China Janssen Research and Development Departmeni Xi'an Janssen Pharmaceutical Ltd Beijing 100025 China

Background： Attention-deficit hyperactivity disorder （ADHD） is the most common mental and behavioral disorder in school-aged children. This study evaluated the effect of osmotic-release oral system （OROS） methylphenidate （MPH） on cognitive function and academic performance of Chinese school-aged children with ADHD. Methods： This 12-week, prospective, multicenter, open-label, self-controlled study enrolled 153 Chinese school-aged children with ADHD and 41 non-ADHD children. Children with ADHD were treated with once-daily OROS-MPH （18 mg, 36 mg, or 54 mg）. The primary endpoints were Inattention/Overactivity （I/O） with Aggression Conners Behavior Rating Scale （IOWA） and Digit Span Test at week 12 compared with baseline. Secondary endpoints included opposition/defiant （O/D） subscale of IOWA, Clinical Global Impression （CGI）, Coding Test, Stroop Color-word Test, Wisconsin Card Sorting Test （WCST）, academic performance on teacher-rated school examinations, and safety at week 12 compared with baseline. Both non-ADHD and ADHD children received the same frequency of cognitive operational test to avoid the possible bias caused by training. Results： A total of 128 patients were evaluated with cognitive assessments. The OROS-MPH treatment significantly improved IOWA Conners I/O subscale scores at week 12 （3.8 ± 2.3） versus baseline （10.0 ± 2.4; P 〈 0.0001）. Digit Span Test scores improved significantly （P 〈 0.0001 ） with a high remission rate （81.1%） at week 12 versus baseline. A significant （P 〈 0.0001 ） improvement was observed in O/D subscale of IOWA, CGI, Coding Test, Stroop Color-word Test, WCST, and academic performance at week 12 versus baseline. Very few practice-related improvements were noticed in the non-ADHD group at week 12 compared with baseline. No serious adverse events and deaths were reported during the study. Conclusions： The OROS-MPH treatment effectively controlled symptoms of ADHD and significantly improved academic performance and cognitive fimction of Ch

关键词： Academic Performance Attention-deficit Hyperactivity Disorder: Cognitive Function Osmotic-release Oral System-methylphenidate

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阻尼层厚度对复合材料夹芯板自由振动的影响

机械设计与制造 2017年第7期 78-81页

作者：翟彦春马军苏建民梁森潍坊科技学院机械工程学院山东寿光262700 青岛理工大学机械工程学院山东青岛266520

由于夹芯层的高阻尼结构,复合材料夹芯板结构具有较好的减振降噪的作用,因此在高端科技中得到大量的应用。基于经典板理论推导了复合材料夹芯板的振动平衡方程,首先通过实例验证了所推导的平衡方程的正确性,其次分两种情况研究了阻尼层... 详细信息

由于夹芯层的高阻尼结构,复合材料夹芯板结构具有较好的减振降噪的作用,因此在高端科技中得到大量的应用。基于经典板理论推导了复合材料夹芯板的振动平衡方程,首先通过实例验证了所推导的平衡方程的正确性,其次分两种情况研究了阻尼层厚度对复合材料夹芯板的自由振动的影响,结果表明:弹性层不变和总厚度不变两种情况下,随着阻尼层厚度的增大,前四阶固有频率逐渐降低,损耗因子值逐渐增大,并且后一种情况下更易获得较大的损耗因子值。

关键词：经典板理论阻尼层复合材料板自由振动

基于独立成分分析降噪与集成分类器的疲劳脑电分析

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科学技术与工程 2018年第32期18卷 200-205页

作者：王海玉王映龙闵建亮胡剑锋江西农业大学计算机与信息工程学院南昌330045 江西科技学院信息技术研究所南昌330098

疲劳驾驶是引起众多交通事故的重要因素之一,脑电作为一种直接反映大脑组织电活动的信号日趋成为评估驾驶疲劳检测与预警的研究焦点。提出了一种基于Ada Boost的组合型实验方法用于分析脑电检测疲劳驾驶。实验过程中针对不同受试者采用... 详细信息

疲劳驾驶是引起众多交通事故的重要因素之一,脑电作为一种直接反映大脑组织电活动的信号日趋成为评估驾驶疲劳检测与预警的研究焦点。提出了一种基于Ada Boost的组合型实验方法用于分析脑电检测疲劳驾驶。实验过程中针对不同受试者采用独立成分分析(independent component correlation algorithm,ICA)处理分析;继而进行样本熵、信息熵、模糊熵和AR系数的特征提取;最后运用Ada Boost将最小二乘向量机基于三种核分类器集成为一个强分类器。实验结果显示,采用Ada Boost分类器分类效果优于单个核分类器,对疲劳驾驶平均识别率达到93%,五折交叉验证准确率为91. 04%,在一定程度上推动了基于脑电信号的安全驾驶辅助监控系统的研究。

关键词：疲劳驾驶脑电样本熵模糊熵信息熵 AdaBoost分类器

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集成3种不同核分类器的疲劳脑电分类

计算机工程与设计 2019年第6期40卷 1757-1762页

作者：王海玉王映龙闵建亮胡剑锋江西农业大学计算机与信息工程学院江西南昌330045 江西科技学院信息技术研究所江西南昌330098

为对疲劳脑电进行准确识别,预防疲劳驾驶带来的危害,对32导脑电信号进行预处理,对比小波变换和经验模态分析(empirical mode decomposition,EMD)去掉异常值和高频噪声情况,在效果较好的EMD基础上进行样本熵、模糊熵的提取,形成特征集,... 详细信息

为对疲劳脑电进行准确识别,预防疲劳驾驶带来的危害,对32导脑电信号进行预处理,对比小波变换和经验模态分析(empirical mode decomposition,EMD)去掉异常值和高频噪声情况,在效果较好的EMD基础上进行样本熵、模糊熵的提取,形成特征集,选用最小二乘为基分类器,采用AdaBoost (adaptive boosting)方法通过迭代增加错分样本权重,投票形成基于最小二乘支持向量机3个不同核的弱分类器集成的强分类器,实现驾驶疲劳的识别,平均准确率达95%。通过实验验证了该方法的灵活性及鲁棒性,在一定程度上推动了驾驶疲劳的研究。

关键词：脑电信号疲劳驾驶经验模态分析样本熵模糊熵

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-Yi Wang Yao Hao Zi-jian Wang Xiu-liang Xu jiang-Hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

Modular assembly of complex C-alkyl glycoside enabled via cooperative NHC and photoredox catalysis

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Science China Chemistry 2025年

作者： Rui-Qiang Jiao ming Li Xi Chen Mei-Ze Xu Tian Ding Xiao-Ping Gong Zhuo-Mei Li Xue-Yuan Liu Yong-min liang State Key Laboratory of Applied Organic Chemistry Lanzhou University College of Chemistry and Chemical Engineering Northwest Normal University

C-Alkyl glycosides are found in natural products and are indispensable in drug development programs,owing to their diverse range of medicinal ***-component reactions involving glycosyl radical addition are well documented and proved efficient for the C-alkyl glycosides ***,multicomponent reactions for the rapid and controllable construction of structurally diversified C-alkyl glycosides in a single step remains a significant challenge due to the issues associated with balancing reactivity,compatibility,and ***,we report an NHC and photoredox co-catalyzed three-component method to access complex and valuable C-alkyl *** protocol exhibits broad substrate scope and excellent chemoand ***,nine types of sugars are compatible with this *** addition,the generality of this catalytic strategy was further highlighted by the potential for scalable production,the feasibility of further modifications of the products and its successful application in the late-stage functionalization of pharmaceutical skeletons.

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