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基于Laguerre的多组分稀土萃取分布式模型预测控制

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控制与决策 2025年第03期40卷 1005-1014页

作者：朱建勇张琳陆荣秀杨辉华东交通大学电气与自动化工程学院江西省先进控制与优化重点实验室

针对多级子工艺稀土萃取生产采用人工根据经验逐级调药的方式,容易导致人工循环调药、生产指标波动大的问题,提出一种基于Laguerre函数的分布式模型预测控制方法调节药剂量.首先,基于多稀土组分萃取机理建立具有串联结构的分布式状态空... 详细信息

针对多级子工艺稀土萃取生产采用人工根据经验逐级调药的方式,容易导致人工循环调药、生产指标波动大的问题,提出一种基于Laguerre函数的分布式模型预测控制方法调节药剂量.首先,基于多稀土组分萃取机理建立具有串联结构的分布式状态空间方程,拓展成嵌有积分器的增广状态空间模型;其次,利用多组分稀土萃取中各级子工艺仅与其上游子工艺存在耦合的特点,构造一种具有输入约束的非迭代递阶求解分布式药剂量目标优化函数;由于采用较大的预测时域能够实现更高的控制精度,但会急剧增大其计算量,为此,利用Laguerre函数表示控制增量,将原目标函数转化为含有Laguerre系数的目标函数,并利用二次规划进行求解.这种方法使得计算量与预测时域无关,而仅与Laguerre函数的系数数量有关,不会随着预测时域的范围改变.仿真实验表明了所提出方法的有效性.

关键词：溶剂萃取预测函数串联过程状态空间约束处理分布式预测控制

客货混运下高铁运行图与货物配装方案协同优化

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控制与决策 2025年第1期40卷 308-316页

作者：米雷卢亚菡杨立兴戚建国北京交通大学系统科学学院北京100044

客货混运新模式为我国高速铁路运营管理带来了新的机遇和挑战.鉴于此,以最小化列车停站时间、货物滞留数量和运营成本为目标,以列车到发时刻、动车组编组和货物配装计划为决策变量,为客货混运下高铁运行图与货物配装方案协同优化问题构... 详细信息

客货混运新模式为我国高速铁路运营管理带来了新的机遇和挑战.鉴于此,以最小化列车停站时间、货物滞留数量和运营成本为目标,以列车到发时刻、动车组编组和货物配装计划为决策变量,为客货混运下高铁运行图与货物配装方案协同优化问题构建一类整数线性规划模型.为验证模型的有效性,以京沪高速铁路为背景进行数值实验,并调用CPLEX软件求解.结果表明:在尽可能减小对客运服务影响的前提下,所提出方法能够通过灵活决策列车时刻表及增加列车编组,提高列车运力;与采用固定列车时刻表的货物配装优化方案相比,协同优化方法能够在小幅增加列车停靠时间的情况下大幅提升货物运输量,可为相关运营部门制定客货混运计划提供一定的理论支撑.

关键词：铁路运输客货混运列车编组高铁快运列车运行图

Diversity and Complexity of Soil Organic Carbon in Typical Wetlands of Louisiana, USA

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Chinese Geographical Science 2025年第2期 415-422页

作者： YU lu jianG Qijun ZHAO Wenwen ZHANG Zhongsheng WANG Jim jian School of Economics and Management Yancheng Institute of Technology College of Economics and Management Shanghai Ocean University Northeast Institute of Geography and Agroecology Chinese Academy of Sciences University of Chinese Academy of Sciences School of Plant Environmental and Soil Sciences Louisiana State University Agricultural Center

Coastal wetlands store large amounts of soil organic carbon（SOC）, and have assumed key roles in mitigating increasing CO2in the atmosphere. The ongoing debate about SOC stabilization mechanisms stems partly from our incomplete understanding of its complex chemical architecture at the molecular scale. Deciphering the molecular composition of soil organic matter is crucial for revealing mechanisms that govern SOC persistence. This study utilized the field sampling data from 2016 and aimed to characterize molecular composition of SOC in typical salt marsh（SM） and freshwater marsh（FM） in Louisiana coastal regions, USA by extending the application of graph networks with pyrolysis-gas chromatography-mass spectrometry, and then to quantify potential links between SOC persistence and molecular diversity and network complexity. The results revealed that SOC predominantly consisted of alkyl compounds（Alkyl）, phenol（Ph）, lignin（Lg）, and aliphatic compounds, constituting 23.21% and 27.85%, 17.84% and 21.55%, 16.94% and 15.49%,17.20% and 15.93% of total ion chromatogram（TIC） in SM and FM wetlands, respectively. Molecular diversity in SM was higher than that in FM, while the network graph exhibited greater complexity in FM, featuring 167 and 123 nodes, and 1935 and 1982 edges in the network graphs of SOC from SM and FM, respectively. Correlation analysis confirmed positive relations between molecular diversity indices, network complexity, and abundance of stable carbon isotopes(δ13C). The variance partitioning analysis（VPA） supplied that soil nutrients exerted the most significant control on SOC persistence. Molecular diversity and network complexity, when combined with soil nutrients, could explain 34% of the variances in SOC persistence.

关键词：

Blocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2

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Science China(Life Sciences) 2025年第1期68卷 189-203页

作者： Wenjie Li Wenyi mei Hewei jiang Jie Wang Xiaoli Li Lina Quan Yanyan Diao Yanni Ma Sisi Fan Zhuwei Xie Mengdie Gong Huan Zhu Dewen Bi Feng Zhang Lei Ma jian Zhang Yufeng Gao Aris Paschalidis Honghuang Lin Fangfang Liu Kangdong Liu Mingliang Ye Zhenjiang Zhao Yajun Duan Zhuo Chen Yufang Xu Weilie Xiao Shengce Tao Lili Zhu Honglin Li Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science&TechnologyShanghai 200237China Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationYunnan Characteristic Plant Extraction LaboratoryYunnan Provincial Center for Research&Development of Natural ProductsState Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanSchool of Pharmacy and School of Chemical Science and TechnologyYunnan UniversityKunming650500China CAS Key Laboratory of Separation Sciences for Analytical Chemistry National Chromatographic R&A CenterDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Department of Cardiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Department of Infectious Diseases The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Medicine University of Massachusetts Chan Medical SchoolWorcester MA 01655USA Department of Pathophysiology School of Basic Medical SciencesAcademy of Medical ScienceCollege of MedicineZhengzhou UniversityZhengzhou 450001China Innovation Center for AI and Drug Discovery East China Normal UniversityShanghai 200062China Lingang Laboratory Shanghai 200031China

Targeting the PD-1/PD-L1 axis with small-molecular inhibitors is a promising approach for ***,we identify a natural pentacyclic triterpenoid,Pygenic Acid A(PA),as a PD-1 signaling *** exerts anti-tumor activity in hPD-1 knock-in C57BL/6 mice and enhances effector functions of T cells to promote immune responses by disrupting the PD-1 signaling ***,we identify SHP-2 as the direct molecular target of PA for inhibiting the PD-1 signaling ***,mechanistic studies suggest that PA binds to a new druggable site in the phosphorylated PD-1 ITSM recognition site of SHP-2,inhibiting the recruitment of SHP-2 by *** together,our findings demonstrate that PA has a potential application in cancer immunotherapy and occupying the phosphorylated ITSM recognition site of SHP-2 may serve as an alternative strategy to develop PD-1 signaling *** addition,our success in target recognition provides a paradigm of target identification and confirmation for natural products.

关键词： pygenic acid A programmed death-1 immunoreceptor tyrosine-based switch motif SH2 domain-containing protein-tyrosine phosphatase-2 target identification site recognition

Generations of Integrable Hierarchies and Exact Solutions of Related Evolution Equations with Variable Coefficients

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Acta Mathematicae Applicatae Sinica 2014年第4期30卷 1085-1106页

作者： Yu-feng ZHANG Yan WANG Bin-lu FENG jian-qin mei College of Sciences China University of Mining and Technology School of Mathematics and Information Science Henan Polytechnic University School of Mathematics and Information Sciences Weifang University School of Mathematical Sciences Dalian University of Technology

We first propose a way for generating Lie algebras from which we get a few kinds of reduced 6 6 Lie algebras, denoted by R6, R8 and R1,R6/2, respectively. As for applications of some of them, a Lax pair is introduced by using the Lie algebra R6 whose compatibility gives rise to an integrable hierarchy with 4- potential functions and two arbitrary parameters whose corresponding Hamiltonian structure is obtained by the variational identity. Then we make use of the Lie algebra R6 to deduce a nonlinear integrable coupling hierarchy of the mKdV equation whose Hamiltonian structure is also obtained. Again,via using the Lie algebra R62, we introduce a Lax pair and work out a linear integrable coupling hierarchy of the mKdV equation whose Hamiltonian structure is obtained. Finally, we get some reduced linear and nonlinear equations with variable coefficients and work out the elliptic coordinate solutions, exact traveling wave solutions, respectively.

关键词： Lie algebra Hamiltonian structure exact solution

高风险高回报项目资助有助于科研创新吗?——基于科学大数据的文献耦合网络分析

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科学学研究 2025年第2期43卷 337-347页

作者：李美玲王洋阿儒涵李铭禄西安交通大学公共政策与管理学院陕西西安710049 中国科学院科技战略咨询研究院北京100190 中国科学院大学公共政策与管理学院北京100049 国家自然科学基金委员会政策局北京100085

传统竞争性项目资助容易引发科学家规避风险、开展保守性研究的问题,引起了科学共同体的广泛关注。高风险高回报项目资助被认为是能够弥补传统竞争性项目资助缺陷的有效途径。此类项目重点资助具有较高风险的科学问题研究,产出具有突破... 详细信息

传统竞争性项目资助容易引发科学家规避风险、开展保守性研究的问题,引起了科学共同体的广泛关注。高风险高回报项目资助被认为是能够弥补传统竞争性项目资助缺陷的有效途径。此类项目重点资助具有较高风险的科学问题研究,产出具有突破性、变革性和创新性的成果。在当前我国基础研究原创性成果数量较少,颠覆性创新不足的现状下,通过实证分析的方法深入研究高风险高回报项目的资助效果对完善我国科研资助体系具有重要意义。本文以高风险高回报项目的典型代表—美国国立卫生研究院“新创新者项目”为研究对象,以美国国立卫生研究院传统竞争性项目R01项目为对照组,构建不同类型项目的资助效果分析框架。通过构建学术论文的文献耦合网络,利用复杂网络社团结构划分、知识图谱以及引文频次等指标,定量测度高风险高回报项目的创新性特征,并开展了科研人员个体属性的调节效应分析。分析结果显示:(1)高风险高回报项目更加鼓励科学家开展探索性研究,其资助产出的学术论文具有更高的创新性;(2)高风险高回报项目资助产出的学术论文具有更高的学术影响力;(3)科学家的个体属性显著调节了高风险高回报项目的资助效应:青年科学家和女性科学家会强化高风险高回报项目与其资助论文创新性的正向关系,而女性科学家会弱化高风险高回报项目与其资助论文学术影响力的正向关系。最后,本文基于上述研究结论提出了优化我国政府科研项目资助体系的政策建议。

关键词：高风险高回报项目资助学术影响力创新性学术年龄性别

Synthesis and Structural Characterization of a Ni(Ⅱ) Complex [Ni(H_2O)_4(4,4'-bipy)_2](hca)_2

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Chinese Journal of Structural Chemistry 2006年第11期25卷 1392-1396页

作者： ZHOU Qiu-Xuan XU Qing-Feng lu jian-mei XIA Xue-Wei Key Laboratory of Organic Synthesis of jiangsu Province School of Chemistry and Chemical Engineering Suzhou University Suzhou 215123 China jiangsu Polytechnic University Changzhou 213016 China

The reaction of Ni（CH3COO）2.6H2O, 4-hydroxycinnamic acid （Hhca） and 4,4＇-bipyridine （bipy） ligand in water-solution afforded a mononuclear complex [Ni（H2O）4（4,4＇-bipy）2]（hca）2 which was characterized by IR, elemental analysis, TGA and single-crystal X-ray diffraction. X-ray crystallography analysis reveals that the complex is of triclinic, space group PI with a = 7.0238（14）, b = 7.2934（11）, c = 17.186（4） A, α = 87.073（13）, β = 84.354（10）, γ = 81.961（12）°, V= 866.9（3） A^3, Z = 1, Dc = 1.474 g/cm^3, F（000） = 402,μ = 62.7 mm^-1, R = 0.0411, wR = 0.0862 and GOF = 1.048. In solid state, the cation [Ni（H2O）4（4,4＇-bpy）2]^2＋ connects six nearby hca counter anions via O-H…O hydrogen bonds to form an extended 2D lattice framework and the O-…N hydrogen bonds finally link the 2D layers into an infinite 3D network.

关键词： nickel(Ⅱ) 4,4'-bipyridyl trans-4-hydroxycinnamic acid crystal structure

Research on the overload protection reliability of moulded case circuit-breakers and its test device

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第3期8卷 453-458页

作者： LI Kui lu jian-guo WU Yi QIN Zhi-jun YAO Dong-mei Electrical Apparatus Institute Hebei University of Technology Tianjin 300130 China

This paper analyzed the reliability and put forward the reliability index of overload protection for moulded case circuit breaker. The success rate was adopted as its reliability index of overload protection. Based on the reliability index and the reli- ability level, the reliability examination plan was analyzed and a test device for the overload protection of moulded case cir- cuit-breaker was developed. In the reliability test of overload protection, two power sources were used, which reduced the time of conversion and regulation between two different test currents in the overload protection test, which made the characteristic test more accurate. The test device was designed on the base of a Windows system, which made its operation simple and friendly.

关键词： Moulded case circuit breakers Overload protection Reliability Test device

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舱壁结构抑制液体晃荡砰击的试验研究

船舶力学 2025年第1期29卷 31-40页

作者：申利敏卫志军陆志妹季顺迎张大勇大连理工大学运载工程与力学学部辽宁大连116024 大连理工大学海岸和近海工程国家重点实验室辽宁大连116024 大连理工大学工业装备结构分析优化与CAE软件全国重点实验室辽宁大连116024 上海市船舶工程重点实验室上海200011 中国船舶及海洋工程设计研究院上海200011 大连理工大学海洋科学与技术学院辽宁盘锦114221

液体晃荡砰击载荷是液化天然气(LNG)运载装备液舱结构设计的关键载荷之一。液体晃荡砰击载荷过大时,会导致液舱结构产生局部破坏,进而导致液舱内液体泄露,甚至船体倾覆。基于前期数值结果,本文设计了梯形体和正方体两种壁面结构,开展了... 详细信息

液体晃荡砰击载荷是液化天然气(LNG)运载装备液舱结构设计的关键载荷之一。液体晃荡砰击载荷过大时,会导致液舱结构产生局部破坏,进而导致液舱内液体泄露,甚至船体倾覆。基于前期数值结果,本文设计了梯形体和正方体两种壁面结构,开展了不同壁面结构下的液体晃荡砰击试验。针对自由液面演化过程以及液体晃荡砰击载荷分布特性,结合统计分析方法,定性和定量地分析了壁面结构对液体晃荡砰击的抑制效果。研究结果表明,壁面结构的存在改变了液体晃荡砰击过程中的流场分布,使砰击由液体直接砰击改变为裹气液体的间接砰击。裹气液体晃荡砰击过程中产生了大量气液混合物和气泡,从而有效地降低了砰击载荷,并且正方体结构抑制砰击载荷的效果优于梯形体结构。

关键词：液体晃荡防晃结构砰击载荷试验研究统计分析