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Efficacy of peripheral blood stem cell transplantation versus conventional chemotherapy on anaplastic large-cell lymphoma:a retrospective study of 64 patients from a single center

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Chinese Journal of Cancer 2012年第11期31卷 532-540页

作者： Xiao-Hui He Bo Li Shuang-Mei Zou Mei Dong Sheng-Yu Zhou jian-liang yang Li-Yan Xue Sheng yang Peng Liu Yan Qin Chang-Gong Zhang Xiao-Hong Han Yuan-Kai Shi Department of Medical Oncology Deparkment of Pathology Cancer Institute and HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China.

Anaplastic large-cell lymphoma(ALCL) is characterized by frequently presenting adverse factors at *** groups believed aggressive treatment strategies such as autologous stem cell transplantation brought survival benefit for ALCL ***,few compared these approaches with conventional chemotherapy to validate their ***,we report a study comparing the efficacy of peripheral blood stem cell transplantation(PBSCT) and conventional chemotherapy on ALCL.A total of 64 patients with primary systemic ALCL were studied *** median follow-up period was 51 months(range,1-167 months).For 48 patients undergoing conventional chemotherapy only,the 4-year event-free survival(EFS) and overall survival(OS) rates were 70.7% and 88.3%,***,16 patients underwent PBSCT,including 11 at first remission(CR1/PR1),3 at second remission,and 2 with disease progression during first-line *** 4-year EFS and OS rates for patients underwent PBSCT at first remission were 81.8% and 90.9%,*** with conventional chemotherapy,PBSCT did not show superiority either in EFS(P = 0.240) or in OS(P = 0.580) when applied at first *** analysis showed that patients with B symptoms(P = 0.001),stage III/IV disease(P = 0.008),bulky disease(P = 0.075),negative anaplastic lymphoma kinase(ALK) expression(P = 0.059),and age ≤ 60 years(P = 0.054) had lower ***,PBSCT significantly improved EFS in patients with B symptoms(100% vs.50.8%,P = 0.027) or bulky disease(100% vs.52.8%,P = 0.045) when applied as an up-front *** on these results,we conclude that,for patients with specific adverse factors such as B symptoms and bulky disease,PBSCT was superior to conventional chemotherapy in terms of EFS.

关键词：造血干细胞移植疗效比较淋巴瘤外周血化疗变性 EFS 单因素分析

A retrospective analysis of real-world outcomes of elderly Chinese patients with diffuse large B-cell lymphoma

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Chinese Medical Journal 2019年第15期132卷 1807-1814页

作者： Peng Liu Ying Han Shi-Yu jiang Xiao-Hui He Yan Qin Lin Gui Sheng-Yu Zhou Li-Qiang Zhou jian-liang yang Sheng yang Ting-Yu Wen Yuan-Kai Shi Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs Beijing 100021 China

Background:Elderly patents with diffuse large B-cell lymphoma (DLBCL) have a worse prognosis than younger patients,and the optimal treatment strategy for this group remains *** conducted a retrospective analysis to investigate the clinical features and outcomes of elderly patients (>60 years) and to assess the impact of clinical and molecular factors on outcome in this age ***:From April 2006 to December 2012,a total of 349 elderly patients with DLBCL from the National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences,and Peking Union Medical College were included in this *** were further divided into two age groups (61-69 years and ≥70 years).We compared clinical characteristics and outcomes between ***:Of 349 total patients,204 (58.5%) were aged 61 to 69 years,and 145 (41.5%) patients were aged 70 years or *** for the Eastern Cooperative Oncology Group performance status,clinical characteristics were comparable between the two *** a median follow-up of 82 (range,1-129) months,the 5-year overall survival (OS) and progression-free survival (PFS) rates were 51.9% and 45.8%,*** 5-year OS rates for patients aged 61 to 69 years and those over 70 years were 58.3% and 42.8%(P =0.007),respectively,and the 5-year PFS rates were 51.0% and 38.6%(P =0.034).Treatment regimens including rituximab provided a higher 5-year OS rate (63.1% vs.37.1%,P < 0.001) and PFS rate (56.6% vs.31.8%,P < 0.001) than chemotherapy *** patients aged 61 to 69 years,chemotherapy plus rituximab resulted in a higher 5-year OS rate (66.7% vs.46.4%,P =0.002) and PFS rate (60.0% vs.38.1%,P =0.002) than chemotherapy *** patients aged ≥70 years,there was a marked survival advantage in patients who received chemotherapy plus rituximab (5-year OS rate:57.7% vs.25.4%,P < 0.001;5-year PFS rate:51.3% vs.23.9%,P < 0.001) compared with that seen in those who received chemotherapy *** analysis es

关键词： Elderly Diffuse large B-cell lymphoma Rituximab Prognosis

Decreased Prognostic Value of International Prognostic Score in Chinese Advanced Hodgkin Lymphoma Patients Treated in the Contemporary Era

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Chinese Medical Journal 2016年第23期129卷 2780-2785页

作者： Qin Wang Yan Qin Su-Yi Kang Xiao-Hui He Peng Liu Sheng yang Sheng-Yu Zhou Chang-Gong Zhang Lin Gui jian-liang yang Yan Sun Yuan-Kai Shi Department of Medical Oncology Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China

Background： The International Prognostic Score （IPS） was developed based on the data of Western advanced Hodgkin lymphoma （HL） patients treated before 1992. Only a few studies ever evaluated the application value of IPS in Chinese population or in patients treated in the contemporary era whose outcomes has improved significantly than before. Methods： We conducted a retrospective study involving 208 previously untreated Chinese advanced HL patients, who were admitted to Cancer Hospital Chinese Academy of Medical Sciences from January 1, 1999 to April 30, 2015 and received uniform first-line treatment. The prognostic value of both IPS and the seven IPS factors for freedom-from progression （FFP） and overall survival （OS） was assessed in this population. The statistical methods included Kaplan-Meier methodology, log-rank testing, and Cox proportional hazard regression analysis. Results： With a median follow-up time of 79 months （range, 15-210 months）, the 5-year FFP and OS were 78.8% and 86.0% respectively, which improved obviously compared with the original IPS study. The IPS remained prognostic for both FFP （P = 0.041 ） and OS （P = 0.013）, but the range narrowed obviously, with 5-year FFP ranging from 87.2% to 61.5%, 5-year OS ranging from 94.1% to 69.2%, and the separation of survival curves was not as good as before. Only two of the seven IPS factors showed a significant independent prognostic value in the multivariate analysis： Stage IV （for FFP, hazard ratio [HR] = 2.219, 95% confidence interval [CI]： 1.148-3.948, P = 0.016; for OS, HR = 2.491, 95% CI： 1.159-5.355, P = 0.019） and hemoglobin 〈105 g/L （for FFP, HR = 2.136, 95% CI： 1.123-4.060, P = 0.021; for OS, HR = 2.345, 95% CI： 1.099-5.042, P = 0.028）. A simple prognostic score calculated by adding one point each for any of the two factors was prognostic both for FFP （P 〈 0.001 ） and OS （P 〈 0.001 ） with the survival curves separating very well, but the range still narrowed. Conclusions： The IPS has decreased th

关键词： Hodgkin Lymphoma International Prognostic Score Prognosis

Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-Yi Wang Yao Hao Zi-jian Wang Xiu-liang Xu jiang-Hua yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

Bendamustine treatment of Chinese patients with relapsed indolent non-Hodgkin lymphoma: a multicenter, open-label, single-arm, phase 3 study

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Chinese Medical Journal 2021年第11期134卷 1299-1309页

作者： Yuan-Kai Shi Xiao-Nan Hong jian-liang yang Wei Xu Hui-Qiang Huang Xiu-Bin Xiao Jun Zhu Dao-Bin Zhou Xiao-Hong Han jian-Qiu Wu Ming-Zhi Zhang Jie Jin Xiao-Yan Ke Wei Li De-Pei Wu Shen-Miao yang Xin Du Yong-Qian Jia Ai-Chun Liu Dai-Hong Liu Zhi-Xiang Shen Lian-Sheng Zhang Leonard James Edward Hellriegel Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021China Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200030China Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China Department of Medical Oncology 307 Hospital of Chinese People’s Liberation ArmyBeijing 100071China Department of Lymphoma Peking University Cancer Hospital&InstituteBeijing 100142China Department of Hematology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Oncology Jiangsu Cancer Hospital&Jiangsu Institute of CancerNanjingJiangsu 210009China Department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Hematology The First Affiliated Hospital of Zhejiang University College of MedicineHangzhouZhejiang 310003China Department of Hematology Peking University Third HospitalBeijing 100191China Department of Oncology Jilin University First Affiliated HospitalChangchunJilin 130021China Department of Hematology Jiangsu Institute of HematologyThe First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215006China Department of Hematology Peking University Institute of HematologyPeking University People’s HospitalBeijing 100044China Department of Hematology Guangdong General HospitalGuangzhouGuangdong 510062China Department of Hematology and Research Laboratory of Hematology West China Hospital of Sichuan UniversityChengduSichuan 610041China Department of Medical Oncology Harbin Medical University Cancer HospitalHarbinHeilongjiang 150001China Department of Hematolo

Background:Bendamustine was approved in China on May 26th,2019 by the National Medical Product Administration for the treatment of indolent B-cell non-Hodgkin lymphoma(NHL).The current study was the registration trial and the first reported evaluation of the efficacy,safety,and pharmacokinetics of bendamustine in Chinese adult patients with indolent B-cell NHL following relapse after chemotherapy and rituximab ***:This was a prospective,multicenter,open-label,single-arm,phase 3 study(NCT01596621;C18083/3076)with a 2-year follow-up *** patients received bendamustine hydrochloride 120 mg/m2 infused intravenously on days 1 and 2 of each 21-day treatment cycle for at least six planned cycles(and up to eight cycles).The primary endpoint was the overall response rate(ORR);and secondary endpoints were duration of response(DoR),progression-free survival(PFS),safety,and *** were classified according to their best overall response after initiation of *** of patients in each response category(complete response[CR],partial response[PR],stable disease,or progressive disease)were summarized along with a twosided binomial exact 95%confidence intervals(CIs)for the ***:A total of 102 patients were enrolled from 20 centers between August 6th,2012,and June 18th,*** the time of the primary analysis,the ORR was 73%(95%CI:63%–81%)per Independent Review Committee(IRC)including 19%CR and 54%*** the follow-up period,the median DoR was 16.2 months by IRC and 13.4 months by investigator assessment;the median PFS was 18.6 months and 15.3 months,*** most common non-hematologic adverse events(AEs)were gastrointestinal toxicity,pyrexia,and *** 3/4 neutropenia was reported in 76%of *** AEs were reported in 29 patients and five patients died during the *** analysis indicated that the characteristics of bendamustine and its metabolites M3 and M4 were generally consistent

关键词： Bendamustine Non-Hodgkin lymphoma B-cell malignancy Relapsed disease Clinical trial

Design Strategy of Infrared 4-Hydroxybenzylidene-imidazolinone-Type Chromophores based on Intramolecular Charge Transfer:a Theoretical Perspective

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Chinese Journal of Chemical Physics 2023年第5期36卷 582-592,I0002页

作者： jian Song WenLong liang Shouning yang Huayan yang School of Physics Henan Normal UniversityXinxiang 453007China NMPA Key Laboratory for Research and Evaluation of Innovative Drug Henan Key Laboratory of Organic Functional Molecule and Drug InnovationCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007China

Partial genetically encoded 4-hy-droxybenzylidene-imidazolinone(HBI)-type chromophores are new promising fluorescent probes,which are suitable for imaging and detection of living ***-ever,the lack of infrared chro-mophores hinders the develop-ment *** more than 30 HBI-type chromophores with reg-ular structure modifications were employed and typical spectral redshift change laws and mechanisms were investigated by quantum *** show that both one-photon spectrum(OPS,absorption/emission)and two-photon absorption(TPA)can achieve large redshift via either extending conjugated lengths of frag-3 or enlarging conjugated areas of frag-1 of HBI *** redshifts of all chromophores are highly related to intramolecular charge transfer(ICT),but neutral ones are closely related to the total ICT or electron-accept-ing-numbers of frag-3,and the high correlative factor of anions is the aromaticity of frag-2 *** frag-2 bridge with high aromaticity can open a reverse charge transfer channel in anion relative to neutral,obtaining significant *** on analysis,a new 6-hydroxyl-naphthalene-imidazolinone(HNI)series,which have larger conjugated area in frag-1,are *** OPS and TPA of anionic HNI ones acquire about 76−96 nm and 119−146 nm red-shift relative to traditional HBI series respectively as a *** longest emission of anionic HNI-4 realizes more 244 nm redshift relative to *** work clarifies worthy spectral reg-ularities and redshift mechanisms of HBI-type chromophores and provides valuable design strategy for infrared chromophores synthesis in experiment.

关键词： Intramolecular charge transfer Near-infrared fluorescent chromophore 4-Hy-droxybenzylidene-imidazolinone One-photon spectrum Two-photon absorption

溴化法制备混合卤代硝基二苯醚——新型除草、杀菌剂研究(I)

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四川大学学报（自然科学版） 2002年第4期39卷 742-745页

作者：王健王玉良杨祖幸张清华陈淑华四川大学化学学院成都610064

作者研究了取代硝基二苯醚的溴化反应 ,制备了 4种新的溴、氯混合卤代硝基二苯醚化合物 ,其结构经IR 。

关键词：溴化法制备混合卤代硝基二苯醚杀菌剂合成溴化反应除草剂结构表征

A Numerical Study on the Water Impact of the Rigid/Elastic Box-Like Structure

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China Ocean Engineering 2023年第2期37卷 333-342页

作者： yang jian SUN Zhao-chen liang Shu-xiu State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

Recent damages to the box-like structures caused by wave slamming have made it necessary to study the impact problems of this kind of structure. This paper showed findings from numerical simulations of the rigid/elastic structures, aiming to gain insights into the characteristics of the problem. The results of the rigid cases showed the significance of air compressibility during the impact process, while the slamming phenomena became quite different without the effect. In the elastic cases, the trapped air made the structure vibrate at frequencies much smaller than its eigenfrequencies. Besides, the structural deformation made it easy for the trapped air to escape outwards, which weakened the air cushioning effect, especially at high impact velocities. The above analysis gives the results when the structural symmetry axis was vertical to the water(vertical impacts). In addition, the results were given when the axis was oblique to the water(oblique impacts). Compared with the vertical cases, the impact phenomena and structural response showed asymmetry. This work used the computational fluid dynamics(CFD) method to describe fluid motion and the finite element method(FEM) for the deformable structure. A two-way coupling approach was used to deal with the fluid-structure interaction in the elastic cases.

关键词： water impact fluid-structure interaction air compressibility box-like structures two-way coupling

Study of thermal decoherence of harmonic oscillators

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原子与分子物理学报 2025年第5期42卷 108-114页

作者： LI jian ZHOU Gao-liang YAN Zheng-Xin LIU Wei WANG Zhao-Qi College of Science Xi’an University of Science and TechnologyXi’an 710054China

The thermal decoherence of harmonic oscillators is investigated *** quantum system presented here is a one-dimensional oscillator with angular frequency,which is surrounded by a thermal bath of environmental *** are various environmental oscillators with different angular frequency(below an ultraviolet cutoff).At the beginning,the quantum system is a pure state and the environmental oscillators are in thermodynamic equilibrium with *** a period,the system-environment interactions inspire significant decoherence of the quantum *** decoherence is displayed by explicit calculations of the purity and von Neumann entropy of the quantum *** is worth noting that the decoherence could be significant even in the weak coupling and low temperature case due to the large amount of environmental degrees of *** the decoherence process is inspired between the quantum system and an ordinary thermal environment here,the thermal decoherence result is quite general.

关键词： Quantum decoherence Grand canonical ensemble Oscillators