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Multidisciplinary comprehensive treatment of massive hepatocellular carcinoma with hemorrhage:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2225-2232页

作者： Xian-Shuai Kou Fan-Fan Li Yun Meng jian-Ming Zhao Sheng-Fen Liu lan Zhang The First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Department of Thoracic Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Department of Orthopedics Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC),a major contributor to cancer-related deaths,is particularly prevalent in Asia,largely due to hepatitis B virus *** prognosis is generally *** case report contributes to the medical literature by detailing a unique approach in treating a large HCC through multidisciplinary collaboration,particularly in patients with massive HCC complicated by ruptured bleeding,a scenario not extensively documented *** SUMMARY The patient presented with large HCC complicated by intratumoral *** involved a multidisciplinary approach,providing individualized *** strategy included drug-eluting bead transarterial chemoembolization,sorafenib-targeted therapy,laparoscopic partial hepatectomy,and standardized sintilimab monoclonal antibody *** months after treatment,the patient achieved complete radiological remission,with significant symptom *** studies showed no lesions or recurrence,and clinical assessments confirmed complete *** report is notable as possibly the first docu-mented case of successfully treating such complex HCC conditions through integrated multidisciplinary efforts,offering new insights and a reference for future similar *** This study demonstrated effective multidisciplinary treatment for massive HCC with intratumoral bleeding,providing insights for future similar cases.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Sorafenib Translational therapy Multidisciplinary team Case report

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Microfacies and diagenetic alteration in a semi-deep to deep lacustrine shale: The Yanchang Formation in the Ordos Basin, China

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Petroleum Science 2024年第3期21卷 1524-1538页

作者： Bin Bai Jing-Yue Hao Ling Fu Yu-Xi Liu jian-Peng Wang lan Wang Kevin G.Taylor Lin Ma PetroChina Research Institute of Petroleum Exploration and Development Department of Earth and Environmental Sciences University of Manchester College of Earth Sciences Jilin University Department of Chemical Engineering University of Manchester

The mineralogical development and diagenetic sequence of lacustrine shales in the Chang 7 Member of the Yanchang Formation in the Ordos Basin are detailed studied. A model of their depositional system and a diagenetic diagram are proposed in this study. Through detailed petrographic, mineralogical, and elemental analyses, four distinct shale types are identified: argillaceous shale, siliceous shale, calcareous shale, and carbonate, clay, and silt-bearing shale. The main diagenetic process in argillaceous shale is the transformation of illite to smectite, negatively impacting shale porosity. Siliceous shale undergoes carbonate cementation and quartz dissolution, contributing to increased porosity, particularly in *** shale experiences diagenesis characterised by carbonate formation and dissolution, with a prevalence of siderite. In carbonate, clay, and silt-bearing shale, the dissolution of K-feldspar contributes to illitization of kaolinite. Argillaceous shale, characterised by more clay minerals and lower mesopore volume, is identified as a potential hydrocarbon seal. Siliceous shale, with the highest pore volume and abundant inter-mineral pores, emerges as a promising shale oil reservoir. These findings contribute to a comprehensive understanding of shale properties, aiding in the prediction of shale oil exploration potential in the studied area.

关键词： Ordos Basin Yanchang Formation Chang 7 Member Diagenesis Microfacies

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Ultrafast modulable 2DEG Huygens metasurface

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Photonics Research 2024年第5期12卷 1004-1015页

作者： HONGXIN ZENG XUAN CONG SHIQI WANG SEN GONG LIN HUANG lan WANG HUAJIE LIANG FENG lan HAOYI CAO ZHENG WANG WEIPENG WANG SHIXIONG LIANG ZHIHONG FENG ZIQIANG YANG YAXIN ZHANG TIE JUN cui Terahertz Communication Laboratory School of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 611730China Zhangjiang Laboratory Shanghai 201210China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313098China National Key Laboratory of Solid-State Microwave Devices and Circuits Hebei Semiconductor Research InstituteShijiazhuang 050051China Institute of Electromagnetic Space and State Key Laboratory of Millimeter Waves Southeast UniversityNanjing 210096China

Huygens metasurfaces have demonstrated remarkable potential in perfect transmission and precise wavefront modulation through the synergistic integration of electric resonance and magnetic ***,prevailing active or reconfigurable Huygens metasurfaces,based on all-optical systems,encounter formidable challenges associated with the intricate control of bulk dielectric using laser equipment and the presence of residual thermal effects,leading to limitations in continuous modulation ***,we present an ultrafast electrically driven terahertz Huygens metasurface that comprises an artificial microstructure layer featuring a two-dimensional electron gas(2DEG)provided by an AlGaN/GaN heterojunction,as well as a passive microstructure *** precise manipulation of the carrier concentration within the 2DEG layer,we effectively govern the current distribution on the metasurfaces,inducing variations in electromagnetic resonance modes to modulate terahertz *** modulation mechanism achieves high efficiency and contrast for terahertz wave *** investigations demonstrate continuous modulation capabilities of up to 6 GHz,a modulation efficiency of 90%,a transmission of 91%,and a remarkable relative operating bandwidth of 55.5%.These significant advancements substantially enhance the performance of terahertz metasurface ***,our work not only enables efficient amplitude modulation but also introduces an approach for the development of high-speed and efficient intelligent transmissive metasurfaces.

关键词： heterojunction precise surface

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Impact of uterine artery embolization on ovarian function and pregnancy outcome after uterine-fibroids treatment:A prospective study

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World Journal of Clinical Cases 2024年第15期12卷 2551-2559页

作者： Jing-Lei Liu Zhi-Hui Liang Bao cui jian-Yu Liu Li Sun Department of Interventional Treatment 980(Bethune International Peace)Hospital of PLA Joint Logistics Support ForcesShijiazhuang 050082Hebei ProvinceChina Department of Obstetrics and Gynecology 980(Bethune International Peace)Hospital of PLA Joint Logistics Support ForcesShijiazhuang 050082Hebei ProvinceChina

Uterine fibroids are benign tumors that originate from smooth muscle cells of the *** is the most common gynecological disorder,affecting up to 80%of women of reproductive *** fibroids can cause various symptoms such as abnormal uterine bleeding,pelvic pain,infertility,and pregnancy *** treatment options for uterine fibroids include medical therapy,surgical intervention,and minimally invasive *** To compare ovarian function of women with uterine fibroids who did or did not undergo uterine artery embolization(UAE).METHODS This prospective cohort study enrolled 87 women with symptomatic uterine fibroids who underwent UAE,and 87 women with the same symptoms who did not undergo UAE but received conservative management or other *** two groups were matched for age,body mass index,parity,and baseline characteristics of uterine *** primary outcome was ovarian function that was evaluated by serum levels of follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),and anti-Müllerian hormone(AMH),as well as ovarian reserve tests,such as antral follicle count(AFC)and ovarian volume(OV).The secondary outcome was fertility that was evaluated based on the menstrual cycle,ovulation,conception,pregnancy,and *** participants were followed-up for 36 months and assessed at 1,3,6,12,24,and 36 months after *** The study found that the most common minor complication of UAE was postembolization syndrome in 73.6% of women,resolving within a *** significant differences were observed between the UAE group and the control group in serum levels of reproductive hormones(FSH,LH,E2,AMH)and ovarian reserve indicators(AFC,OV)at any point up to 36 months ***,there were no significant differences in conception,pregnancy,or delivery rates,with the average time to conception and gestational age at delivery being similar between the two *** weights were also ***

关键词： Uterine fibroids Uterine artery embolization Ovarian function Fertility Pregnancy outcome Embolic agent

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Aseismic performances of constrained damping lining structures made of rubber-sand-concrete

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1522-1537页

作者： Xiancheng Mei Qian Sheng jian Chen Zhen cui jianhe Li Chuanqi Li Daniel Dias State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Key Laboratory of Water Grid Project and Regulation of Ministry of Water Resources Changjiang Institute of SurveyPlanningDesign and ResearchWuhan430010China Laboratory 3SR CNRS UMR 5521Grenoble Alpes UniversityGrenoble38000France School of Automotive and Transportation Engineering Hefei University of TechnologyHefei23009China

Flexible damping technology considering aseismic materials and aseismic structures seems be a good solution for engineering *** this study,a constrained damping structure for underground tunnel lining,using a rubber-sand-concrete(RSC)as the aseismic material,is *** aseismic performances of constrained damping structure were investigated by a series of hammer impact *** damping layer thickness and shape effects on the aseismic performance such as effective duration and acceleration amplitude of time-domain analysis,composite loss factor and damping ratio of the transfer function analysis,and total vibration level of octave spectrum analysis were *** hammer impact tests revealed that the relationship between the aseismic performance and damping layer thickness was not linear,and that the hollow damping layer had a better aseismic performance than the flat damping layer *** aseismic performances of constrained damping structure under different seismicity magnitudes and geological conditions were *** effects of the peak ground acceleration(PGA)and tunnel overburden depth on the aseismic performances such as the maximum principal stress and equivalent plastic strain(PEEQ)were *** numerical results show the constrained damping structure proposed in this paper has a good aseismic performance,with PGA in the range(0.2-1.2)g and tunnel overburden depth in the range of 0-300 m.

关键词： Constrained damping structure Aseismic performance Hammer impact tests Damping layer Peak ground acceleration Overburden depth

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A 1-bp deletion in the MC04g1399 is highly associated with failure to produce fruit wart in bitter gourd

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Horticultural Plant Journal 2024年第1期10卷 171-180页

作者： Jia Liu Junjie cui Jichi Dong jian Zhong Chunfeng Zhong Fanchong Yuan Wendong Guan Fang Hu Jiaowen Cheng Kailin Hu College of Horticulture South China Agricultural UniversityGuangzhouGuangdong 510642China Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(South China) Ministry of Agriculture and Rural AffairsGuangzhouGuangdong 510642China Guangdong Vegetables Engineering Research Center GuangzhouGuangdong 510642China Department of Horticulture Foshan UniversityFoshanGuangdong 528225China Henry Fok School of Biology and Agricultural Shaoguan UniversityShaoguanGuangdong 512023China

Fruit wart is an important appearance trait influencing consumer preferences of bitter gourd(Momordica charantia L.).The molecular genetic mechanisms underlying fruit wart formation in bitter gourd are largely *** this study,genetic analysis based on four generations showed that fruit wart formation in bitter gourd was controlled by a single dominant locus named as *** Fwa locus was initially mapped into a 4.82 Mb region on pseudochromosome 4 by BSA-seq analysis and subsequently narrowed down to a 286.30 kb region by linkage analysis.A large F2population consisting of 2360 individuals was used to screen recombinants,and the Fwa locus was finally fine mapped into a 22.70 kb region harboring four protein-coding genes through recombination ***04g1399,encoding an epidermal patterning factor 2-like protein,was proposed as the best candidate gene for Fwa via sequence variation and expression *** addition,a 1-bp insertion and deletion(InDel)variation within MC04g1399 was converted to a cleaved amplified polymorphic sequence(CAPS)marker that could precisely distinguish between the warty and non-warty types with an accuracy rate of 100%among a wide panel of 126 bitter gourd germplasm *** results not only provide a scientific basis for deciphering the molecular mechanisms underlying fruit wart formation but also provide a powerful tool for efficient genetic improvement of fruit wart via marker-assisted selection.

关键词： Bitter gourd Fruit wart Bulk segregant analysis Fine-mapping Candidate gene

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Nitro-oleic acid ameliorates erectile dysfunction in a streptozotocin-induced rat model of diabetes by inhibiting oxidative stress and apoptosis and activating the NO/cGMP pathway

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Asian Journal of Andrology 2024年第1期26卷 57-66页

作者： Chang-Bo Zhao Wei-Bo Chen Wen-Zhen Wang Fang-Xin Gong cui-Qin Fan Ye Li Tian lan Wen-Jing Wang Ming-Zhen Yuan Department of Urology Shandong Provincial HospitalShandong UniversityJinan 250012China Department of Andrology Liaocheng People's HospitalShandong UniversityLiaocheng 252000China Department of Urology The Second Hospital of Shandong UniversityJinan 250012China Department of Physiology School of Basic Medical SciencesShandong UniversityJinan 250012China

The major vascular complications associated with diabetes make the management of diabetic mellitus erectile dysfunction(DMED)a challenging *** factors contributing to DMED include oxidative stress,nitric oxide(NO)/cyclic guanosine monophosphate(cGMP)pathway activation,and apoptosis,while nitro-oleic acid(NO,-OA)has been shown to be beneficial in treating these aspects of this ***,herein,investigated the effects and possible mechanisms of NO,-OA on erectile function as assessed in a streptozotocin-induced rat model of *** results revealed that the erectile function of DMED rats was significantly impaired compared with that of the control ***,in response to 4 weeks of NO,-OA treatment,there was an improvement in erectile *** expression of oxidative stress-related indicators was significantly increased and the NO/cGMP pathway was impaired in the DMED *** expression of proapoptotic factors was increased,while that of antiapoptotic factors was decreased in the DMED ***,the cell morphology in the cavernous tissue of the DMED group also changed ***,-OA treatment significantly reversed all these changes observed in the DMED *** conclusion,NO,-OA treatment partially improved erectile function in DMED rats through mechanisms that included inhibition of oxidative stress,activation of the NO/cGMP pathway,and a reduction in apoptosis.

关键词： apoptosis diabetic mellitus erectile dysfunction nitro-oleic acid NO/cGMP pathway oxidative stress

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Long-term functional maintenance of primary hepatocytes in vitro using macroporous hydrogels engineered through liquid-liquid phase separation

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Nano Research 2024年第3期17卷 1725-1736页

作者： Yang Sun Sheng Yin jian cui Zhongxia Wang Yueying Han Ding Ma Shuo Wang Junhua Wu Yi Cao Chunping jiang Xiaosong Gu Jinan Microecological Biomedicine Shandong Laboratory Jinan 250021China Collaborative Innovation Center of Advanced Microstructures National Laboratory of Solid State MicrostructureKey Laboratory of Intelligent Optical Sensing and ManipulationMinistry of EducationDepartment of PhysicsNanjing UniversityNanjing 210093China Department of Hepatobiliary Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210093China National Institute of Healthcare Data Science at Nanjing University Nanjing UniversityNanjing 210093China

Preserving the functionality of hepatocytes in vitro poses a significant challenge in liver tissue engineering and bioartificial liver,as these cells rapidly lose their metabolic and functional characteristics after *** by the macroporous structures found in native liver tissues,here we develop synthetic hydrogel scaffolds that closely mimic the liver’s structural organization through the phase separation between polyethylene glycol(PEG)and *** hydrogels exhibit interconnected macroporous structures and appropriate mechanical properties,providing an optimal microenvironment conducive to hepatocyte adhesion and the formation of sizable *** to two-dimensional hepatocyte cultures,enhanced functionalities of hepatocytes cultured in our macroporous hydrogels were observed for 14 days,as evidenced by quantitative reverse-transcription–polymerase chain reactions(qRT-PCR),immunofluorescence,and enzyme linked immunosorbent assay(ELISA)*** sequencing data further confirmed the establishment of cell–cell interactions among hepatocytes when cultured in our ***,these hepatocytes maintained a protein expression lineage that closely resembled freshly isolated hepatocytes,particularly in the Notch and tumor necrosis factor(TNF)signaling *** results suggest that the macroporous hydrogels are attractive scaffolds for liver tissue engineering.

关键词： liver tissue engineering phase separation hepatocytes macroporous hydrogel

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Application of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy in curative surgery for esophageal cancer:A metaanalysis

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 214-233页

作者： Mao-Xiu Yuan Qi-Gui Cai Zhen-Yang Zhang jian-Zhong Zhou Cai-Yun lan jiang-Bo Lin The Graduate School Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350000Fujian ProvinceChina

BACKGROUND The effectiveness of neoadjuvant therapy in esophageal cancer(EC)treatment is still a subject of *** To compare the clinical efficacy and toxic side effects between neoadjuvant chemoradiotherapy(nCRT)and neoadjuvant chemotherapy(nCT)for locally advanced EC(LAEC).METHODS A comprehensive search was conducted using multiple databases,including PubMed,EMBASE,MEDLINE,Science Direct,The Cochrane Library,China National Knowledge Infrastructure,Wanfang Database,Chinese Science and Technology Journal Database,and Chinese Biomedical Literature Database *** up to December 2022 comparing nCRT and nCT in patients with EC were *** The analysis revealed significant differences between nCRT and nCT in terms of disease-free *** results indicated that nCRT provided better outcomes in terms of the 3-year overall survival rate(OSR)[odds ratio(OR)=0.95],complete response rate(OR=3.15),and R0 clearance rate(CR)(OR=2.25).However,nCT demonstrated a better 5-year OSR(OR=1.02)than ***,when compared to nCRT,nCT showed reduced risks of cardiac complications(OR=1.15)and pulmonary complications(OR=1.30).CONCLUSION Overall,both nCRT and nCT were effective in terms of survival outcomes for ***,nCT exhibited better performance in terms of postoperative complications.

关键词： Esophageal cancer Neoadjuvant chemoradiotherapy Radical resection for esophageal cancer Neoadjuvant chemotherapy Meta-analysis

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Temperature inversion enables superior stability for low-temperature Zn-ion batteries

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Journal of Energy Chemistry 2024年第4期91卷 245-253页

作者： Fu-Da Yu Zhe-jian Yi Rui-Yang Li Wei-Hao Lin Jie Chen Xiao-Yue Chen Yi-Ming Xie Ji-Huai Wu Zhang lan lan-Fang Que Bao-Sheng Liu Hao Luo Zhen-Bo Wang Engineering Research Center of Environment-Friendly Functional Materials Ministry of EducationInstitute of Materials Physical ChemistryHuaqiao UniversityXiamen 361021FujianChina b2 School of Electronic Engineering Guangxi University of Science and TechnologyLiuzhou 545006GuangxiChina School of Materials Science and Engineering Xiamen University of TechnologyXiamen 361024FujianChina School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Space Power-SourcesSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071GuangdongChina

It is challenging for aqueous Zn-ion batteries(ZIBs)to achieve comparable low-temperature(low-T)performance due to the easy-frozen electrolyte and severe Zn ***,an aqueous electrolyte with a low freezing point and high ionic conductivity is *** with molecular dynamics simulation and multi-scale interface analysis(time of flight secondary ion mass spectrometry threedimensional mapping and in-situ electrochemical impedance spectroscopy method),the temperature independence of the V_(2)O_(5)cathode and Zn anode is observed to be ***,dominated by the solvent structure of the designed electrolyte at low temperatures,vanadium dissolution/shuttle is significantly inhibited,and the zinc dendrites caused by this electrochemical crosstalk are greatly relieved,thus showing an abnormal temperature inversion *** the disclosure and improvement of the above phenomena,the designed Zn||V_(2)O_(5)full cell delivers superior low-T performance,maintaining almost 99%capacity retention after 9500 cycles(working more than 2500 h)at-20°*** work proposes a kind of electrolyte suitable for low-T ZIBs and reveals the inverse temperature dependence of the Zn anode,which might offer a novel perspective for the investigation of low-T aqueous battery systems.

关键词： Aqueous Zn-ion batteries Low-temperature performance Opposite temperature dependence Zndendrite growth Vanadium dissolution

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