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Artificial intelligence empowers the second-observer strategy for colonoscopy:a randomized clinical trial

Gastroenterology Report 2023年第1期11卷 216-223页

作者： Pu Wang Xiao-Gang liu Min Kang Xue Peng Mei-ling Shu Guan-Yu Zhou Pei-Xi liu Fei Xiong Ming-Ming Deng Hong-Fen Xia jian-jun li Xiao-Qi Long Yan Song liang-Ping li Department of Gastroenterology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanP.R.China Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuanP.R.China Department of Gastroenterology Xinqiao HospitalThird Military Medical UniversityChongqingP.R.China Department of Gastroenterology Suining Central HospitalSuiningSichuanP.R.China

Background:In colonoscopy screening for colorectal cancer,human vision limitationsmay lead to highermiss rate of lesions;artificial intelligence(AI)assistance has been demonstrated to improve polyp ***,there still lacks direct evidence to demonstrate whether AI is superior to trainees or experienced nurses as a second observer to increase adenoma detection during *** this study,we aimed to compare the effectiveness of assistance fromAI and human observer during ***:A prospective multicenter randomized study was conducted from 2 September 2019 to 29 May 2020 at four endoscopy centers in *** patients were randomized to either computer-aided detection(CADe)-assisted group or observer-assisted *** primary outcome was adenoma per colonoscopy(APC).Secondary outcomes included polyp per colonoscopy(PPC),adenoma detection rate(ADR),and polyp detection rate(PDR).We compared continuous variables and categorical variables by using R studio(version 3.4.4).Results:A total of 1,261(636 in the CADe-assisted group and 625 in the observer-assisted group)eligible patients were ***(0.42 vs 0.35,P=0.034),PPC(1.13 vs 0.81,Plinical outcome of colonoscopy and reduce disturbance to routine practice(*** No.:ChiCTR1900025235).

关键词： artificial intelligence colon cancer screening adenoma early detection computer-aided detection

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Stenting for left main coronary artery occlusion in adolescent: A case report

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World Journal of Cardiology 2010年第7期2卷 211-214页

作者： jian-jun li Bo Xu Ji-lin Chen jian-jun li Bo Xu Ji-Lin Chen Department of Cardiology Fuwai Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100037 China.

Acute total or subtotal occlusion of left main coronary artery (LMCA) is a catastrophic and mostly fatal event. Patients may present with cardiogenic shock and die whenever this event occurs. Survival is strongly dependent on the presence of collateral blood flow to the left coronary artery or a dominant right coronary artery, and emergency intervention for preserving the left ventricular function. Here, we present a case of a 14-year-old boy with subtotal occlusion of the LMCA accompanying acute myocardial infarction probably caused by congenital syphilis according to his positive serum syphilis antibody. His survival was closely associated with a dominant right coronary artery and timely thrombolytic therapy. Finally, he was treated with angioplasty and paclitaxel-eluting stent implantation. He was followed up after stenting and was doing quite well at the time when we wrote this paper.

关键词： Left main coronary artery Paclitaxel-eluting stent Adolescent Acute myocardial infarction

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COMPARISON OF SHORT- AND LONG-TERM OUTCOMES BETWEEN CYPHER AND TAXUS DRUG-ELUTING STENTS FOR IN-STENT RESTENOSIS

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Chinese Medical Sciences Journal 2007年第1期22卷 5-8页

作者： Ji-lin Chen Yue-jin Yang Shu-bin Qiao Min Yao Xue-wen Qin Bo Xu Hai-bo liu Yong-jian Wu Jin-qing Yuan Jue Chen Shi-jie You jun Dai jian-jun li Run-lin Gao Center for Diagnosis ＆ Treatment of Coronary Heart Disease Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100037

Objective To compare the short- and long-term clinical outcomes between sirolimus-eluting stent （ Cypher stent） and paclitaxel-eluting stent （TAXUS stent） in patients with in-stent restenosis （ISR） lesions of the coronary arteries. Methods From December 2002 to March 2005, 253 patients with ISR lesions of the coronary arteries were selected and divided into two groups. Cypher group （152 cases） was treated with Cypher or Cypher Select stents, and TAXUS group （101 cases） with TAXUS stents. A total of 262 ISR lesions in these patients were treated with 308 drog-eluring stents （DESs）, including 176 Cypher or Cypher Select stents and 132 TAXUS stents. All patients were followed up for 10 months. Procedure success rates of DES implantation in both groups were observed. Major adverse cardiac events （MACE） rates in hospital and at 10 months follow-up, as well as in-DES restenosis observed using coronary angiography at follow-up were compared between two groups. Results Success rate of DES implantation was 100% in both groups. No significant difference in MACE rate during hospitalization was found between the two groups. However, at 10 months follow-up, MACE rate was higher in TAXUS group than in Cypher group （ 16.00% vs. 6.67%, P =0. 031 ）. As for coronary angiography at 10 months follow-up, we observed an increasing tendency of in-DES restenosis rate in TAXUS group compared with Cypher group （29.41% vs. 14.04%, P=0.075）. Conclusions Cypher and TAXUS DESs both have good short- and long-term outcomes in treating ISR. Cypher DES proved better long-term clinical outcome than TAXUS DES.

关键词： in-stent restenosis drug-eluting stent outcome

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Effect of angiotensin II receptor 1 antisense oligodoexynucleotides on physiological and pathophysiological growth of cardiomyocytes

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Acta Pharmacologica Sinica 2004年第5期25卷 19-27页

作者： Ying WANG2, Jin-ming WANG2, Shu-xun Yan3, Ming-jiang li2,4, jian-jun li22Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, China 3Hubei College of Traditional Chinese Medicine, Wuhan 430061,China Department of Cardiology Renmin Hospital Wuhan University Wuhan 430060 Hubei College of Traditional Chinese Medicine Wuhan 430061

AIM: To evaluate the role of angiotensin II receptor 1 antisense oligodexynucleotides (AT1R-AS-ODNs) on physi-ological and pathophysiological growth of cardiomyocytes from normotensive rats. METHODS: Cardiomyocyteswere transfected with AT1R-AS-ODNs (200 nmol/L) followed by treatment with or without angiotensin II (1 mol/L).In situ hybridization and Western blot were used for AT1R mRNA and protein detection, respectively. c-jun N-terminal protein kinase (JNK) activity was characterized by immune complex kinase assay. c-jun protein expres-sion was examined by immunocytochemistry. DNA content was detected by flow cytometric assay. Atrial natri-uretic factor (ANF) expression was identified by radioimmunoassay. RESULTS: Treatment with AT1R-AS-ODNsfor 24 h resulted in 51.2 % decrease in AT1R mRNA and 60.7 % in protein (Pjun protein expression, and DNA content were not altered by AT1R-AS treatment in absenceof overactive hormonal system. After treatment with angiotensin II for 30 min, both p46JNK and p54JNK wererobustly activated. By 2 h, c-jun protein expression was increased. By 24 h, angiotensin II caused a markedincrease both in G0/G1 and G2/M DNA content, and increased ANF expression by 1.8-fold. All these were inhibitedby AT1R-AS-ODNs pretreatment. In contrast, sense sequence was ineffective. CONCLUSION: Decrease ofAT1R expression by AS-ODNs did not interfere with normal growth, but protected cardiomyocytes from angio-tensin II-dependent pathophysiological growth.

关键词： antisense oligodeoxynucleotides angiotensin receptors angiotensin II myocardium hypertrophy mitogen-activated protein kinases

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Production of Protein Feedstuff by Mixed Fermentation of Waste Lees

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Animal Husbandry and Feed Science 2010年第4期2卷 36-39页

作者： MING Hong-mei DONG Rui-li ZHOU jian liU jun li Bin College of Bioengineering Sichuan University of Science & Engineering Zigong 643000 China

[ Objective] To produce protein feedstuff by mix fermentation of waste lees. [ Method] Waste lees was fermented by mixture of Aspergillus niger, Trichoderma vinde and Candida tropicalis to produce protein feedstuff. The fermentation conditions were optimized by single factor test and orthogonal test. [ Result] The optimum fermentation conditions of waste lees are as following： raw materials with fineness of 20 meshes composed of waste lees of 750 g/kg, com meal of 50 g/kg and wheat bran of 200 g/kg; pH value of inoculum culture, 5.0; Aspergillus niger： Trichoderma viHde： Candida tropicalis, 1 ： 1 ： 1 ; inoculum size, 12% （V/V） ; fermentation temperature, 30 ℃; and fermentation time, 6 d. After fermentation, the crude protein content, pure protein content, and crude fiber content were increased by 78.97%, 56.29% and 31.60%, respectively. In addition, the fermented waste lees was rich in beneficial live microorganisms and bioactive substances such as enzymes and vitamins. [ Conclusion] Waste lees can be well fermented to produce protein feedstuff by mix fermentation.

关键词： Protein feedstuff Waste lees Mixed fermentation Fermentation conditions

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Charged Amino Acid Frequencies of Proteins over Macroevolutionary Time Scale

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Engineering（科研） 2013年第10期5卷 420-423页

作者： Yu-Juan Zhang jian-jun li You-Jin Hao Bin Chen Art and Sciences Division Chengdu College University of Electronic Science and Technology of China Chengdu China College of life Sciences Chongqing Normal University Chongqing China

Charged amino acids (AAs) are targets for selective forces in protein evolution. To fully explore the trend of charged AA frequencies evolution in macroevolutionary process from prokaryotes to eukaryotes, we extend the analysis of five charged AAs separately and total basic and acidic AAs in protein sequences of 158 prokaryotic and 63 eukaryotic predicted proteomes and 456 clusters of orthologous groups (COGs). Also, we eliminate the biases that may caused by extreme organisms in both predicted proteomes and COGs analyses. More basic AAs, His,Lysand Glu were found in eukaryotic proteins compared with prokaryotic proteins by predicted proteomes analysis. By COGs analysis, we found that basic AAs andLysfrequencies are higher in eukaryotic orthologous proteins than their prokaryotic companions, while the trend of Arg frequency is the opposite. We discussed the agreements and disagreements of two analyses and gained a more credible trend of charged AAs evolution in macroevolutionary time scale.

关键词： Charged Amino Acid Evolution

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INFLUENCE OF VOCl2-ADDITIVE IN Rh CATALYST ON CO HYDROGENATION

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Journal of Energy Chemistry 1995年第1期 52-58页

作者： ZHOU jian-Lue li jun CHEN Yao-QiangGONG Mao-Chu CHEN YuDepartment, of Chemistry caul Analytical & Testing Center Sichuan University Chengdu, Sichuan 610061

The influence of VOCl2 additive in the supported Rh catalysts derived from both Rh2 (CO )4 Cl2 and RhCl3 on CO hydrogenation was investigated. The VOCl2 additive as a promoter can effectively enhance the CO conversion and catalytic selectivity to ethanol. This effect is caused by the interaction of Rh with vanadium promoter. It is found that the Rh centers on which the gem- adsorbed CO could be formed are main active sites. The Rh2(CO)4Cl2 complex is better than the RhCl3 salt as the precursor of the Rh catalyst for the CO hydrogenation to ethanol.

关键词： CO hydrogenation ethanol Rh catalyst vanadium promoter

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2023 China Guidelines for lipid Management

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Journal of Geriatric Cardiology 2023年第9期20卷 621-663页

作者： jian-jun li Shui-Ping ZHAO Dong ZHAO Guo-Ping LU Dao-Quan PENG Jing liU Zhen-Yue CHEN Yuan-lin GUO Na-Qiong WU Sheng-Kai YAN Zeng-Wu WANG Run-lin GAO National Center for Cardiovascular Diseases Fuwai HospitalChinese Academy of Medical SciencesBeijingChina The Second Xiangya Hospital of Central South University ChangshaHunanChina Beijing Anzhen Hospital Capital Medical UniversityBeijingChina Ruijin Hospital Shanghai Jiaotong University School of MedicineShanghaiChina Affiliated Hospital of Zunyi Medical University School of Laboratory Medicine of Zunyi Medical UniversityZunyiGuizhouChina

Atherosclerotic cardiovascular disease(ASCVD)is the leading cause of death among urban and rural residents in China,and elevated low-density lipoprotein cholesterol(LDL-C)is a risk factor for *** the increasing burden of ASCVD,lipid management is of the utmost *** recent years,research on blood lipids has made breakthroughs around the world,hence a revision of China guidelines for lipid management is imperative,especially since the target lipid levels in the general population vary in respect to the risk of *** level of LDL-C,which can be regarded as appropriate in a population without frisk factors,can be considered abnormal in people at high risk of developing *** a result,the“Guidelines for the prevention and treatment of dyslipidemia”were adapted into the“China Guidelines for lipid Management”(henceforth referred to as the new guidelines)by an Experts’committee after careful *** new guidelines still recommend LDL-C as the primary target for lipid control,with CVD risk stratification to determine its target *** guidelines recommend that moderate intensity statin therapy in adjunct with a heart-healthy lifestyle,be used as an initial line of treatment,followed by cholesterol absorption inhibitors or/and proprotein convertase subtilisin/kexin type 9(PCSK9)inhibitors,as *** new guidelines provide guidance for lipid management across various age groups,from children to the *** aim of these guidelines is to comprehensively improve the management of lipids and promote the prevention and treatment of ASCVD by guiding clinical practice.

关键词： lipid prevention hence

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Mechanical Behavior Analysis of Nitinol Stent

Mechanical Behavior Analysis of Nitinol Stent

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第十届全国生物力学学术会议暨第十二届全国生物流变学学术会议

作者： jian-jun li Sheng-zhang Wang Cheng Hua Wei Yao Xin-jian Yang Department of Mechanics and Engineering Science Fudan University Beijing Neurosurgery Institute

Failure of stent may result in loss of radial support of the stented vessel or in perforation of the vessel by the broken stent *** method of"test to success"is the traditional way to assess the stent performance under some predefined simulated physiologic conditions,which may be very costly and time consuming,especially for the fatigue evaluation that may last several *** element analysis is an extremely useful complement and has been proven to be effective and capable of providing a better understanding for stent *** the

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Research progress on microstructure evolution and hot processing maps of high strength β titanium alloys during hot deformation

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Transactions of Nonferrous Metals Society of China 2022年第12期32卷 3835-3859页

作者： liang HUANG Chang-min li Cheng-lin li Song-xiao HUI Yang YU Ming-jie ZHAO Shi-qi GUO jian-jun li National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China State Key Laboratory of Nonferrous Metals&Processes GRIMAT Engineering Institute Co.Ltd.Beijing 100086China

High strength β titanium alloys are widely used in large load bearing components in the aerospace field. At present, large parts are generally formed by die forging. Different initial microstructures and deformation process parameters will significantly affect the flow behavior. To precisely control the microstructures, researchers have conducted many studies to analyze the microstructure evolution law and deformation mechanism during hot compression. This review focuses on the microstructure evolution of high strength β titanium alloys during hot deformation, including dynamic recrystallization and dynamic recovery in the single-phase region and the dynamic evolution of the α phase in the two-phase region. Furthermore, the optimal hot processing regions, instability regions,and the relationship between the efficiency of power dissipation and the deformation mechanism in the hot processing map are summarized. Finally, the problems and development direction of using hot processing maps to optimize process parameters are also emphasized.

关键词： high strengthβtitanium alloy hot deformation microstructure evolution hot processing map

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