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Self-assembly of Gold Nanoparticle Chains between Nanoelectrodes

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Chinese Chemical Letters 2006年第6期17卷 845-847页

作者： Ning GU jian hui liao Lan HUANG Zhi Rui GUO Wei YU Li Na XU Jing WANG Key Laboratory of Molecular and Biomolecular Electronics Department of Biological Science and Medical Engineering Southeast University Nanjing 210096

A novel strategy has been developed for construction of nanoparticle chains between nanoelectrodes with bifunctional molecules by taking advantage of linear aggregation of colloidal particles in organis solvents. As confirmed by scanning electron microscopy （SEM）,an individual nanoparticle chain bridged the electrode pair. The present approach makes this technique to be cheap and may be applicable in microelectronic industry.

关键词： Self-assembly nanoparticle chain nanoelectrode.

Surgical treatment of nonfunctioning islet cell tumor: report of 41 cases

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Hepatobiliary & Pancreatic Diseases International 2004年第3期3卷 469-472页

作者： Ke-jian Guo, Hai-hui liao, Yu-Lin Tian, Ren-Xuan Guo, San-Guang He and Kui Shen Department of Surgery, First Affiliated Hospital, Chi-na Medical University, Shenyang 110001 , China Department of Surgery First Affiliated Hospital China Medical University Shenyang 110001 China.

BACKGROUND: Nonfunctioning islet cell tumor (NIT)as a rare pancreatic endocrine neoplasm is characterized byunspecific clinical symptoms and is hard to diagnose. InChina, NIT accounts for 15%-41% in pancreatic endocrineneoplasms just next to insulinoma. In this study, weevaluated the surgical modalities of ***: From January 1978 through February 2002, 41patients with NIT were treated at the Department of Sur-gery of the First Affiliated Hospital, China Medical Univer-sity, Shenyang, China. Tumors in the head of the pancreaswere noted in 28 patients, and in the body or in the tail in13 patients. The mean diameter of the tumors was 10. 7cm. Fifteen patients underwent enucleation and 21 receivedpancreatectomy. Tumors were unresectable in 5 patientsbecause of extensive infiltration. The mean diameter was9.6 cm in patients treated by enucleation, 13.1 cm in thoseby pancreaticoduodenectomy, 9.9 cm in those by distalpancreatectomy, and 11.6 cm in those with ***: The curative resection rate was 88% (n =36),and the complication rate after enucleation and pancreatec-tomy was 33% ( n = 5 ) and 14% (n=3), respectively. Nolocal recurrence was found after both enucleation and pan-createctomy. Liver metastases occurred in 3 patients treatedby ***: Both enucleation and pancreatectomy areeffective for NIT of the pancreas. No local recurrence hasbeen found in patients treated by the two surgical proce-dures. The complication rates of the two modalities arecomparable.

关键词： pancreatic neoplasms islet cell surgery

Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： Jie Bai jian hui Jia Yu Wang Chun Cheng Yang Qing jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

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十味建中汤临床应用体会

TMR经典中医研究 2021年第2期4卷 12-16页

作者：廖建辉苏州市吴江区第四人民医院江苏苏州215231

十味建中汤出自“吴门验方”,由归芪建中汤加熟地,山药而成。笔者在临床中主要将此方用于治疗缺铁性贫血及以右关芤脉为主的失眠患者,常取得满意疗效。本文主要从方药解析、验案举隅两个方面进行探讨,以期揭示处方治病之原理。

关键词：十味建中汤缺铁性贫血失眠吴门验方

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang Wen-hui Wei Shu-hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang jian Wu hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Optimization Method for Cross-regional Maximum Power Purchase Capacity in Regional Power Grids Ensuring Supply Scenarios

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Dianwang Jishu/Power System Technology 2025年第1期49卷 232-241页

作者： Xu, Hao Jia, Longwen Liu, Zhicheng Xu, jian Huang, Yanbo liao, Siyang Central China Branch of State Grid Corporation of China Hubei Province Wuhan 430077 China School of Electrical Engineering and Automation Wuhan University Hubei Province Wuhan 430072 China

As multiple levels of electricity markets become intertwined and coupled across different time scales, regional power grids, while serving as hubs for trading channels, also face a series of operational risks, such as network congestion and ensuring security and reliability of supply. In response to the supply security scenario under market-oriented models, based on the analysis of intra-provincial transmission section blocking, an optimization method for inter-regional and inter-provincial power supply capability in the electricity spot market is proposed. Firstly, based on the correlation model of inter-provincial trading channels, inter-provincial physical interconnections, and intra-provincial transmission sections, the mechanism of intra-provincial network congestion formation is analyzed. Secondly, the Gradient Boosting Decision Tree algorithm predicts intra-provincial transmission section blocking, identifying critical sections that form the boundary for electricity purchases in the spot market. Finally, to maximize electricity purchases through inter-regional channels while considering constraints on DC power injection stability, the power supply capability of the target province is optimized. The proposed method is validated by analyzing it based on actual provincial networks. © 2025 Power System Technology Press. All rights reserved.

关键词： Power markets

A newly designed big cup nitinol stent for gastric outlet obstruction

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World Journal of Gastroenterology 2010年第33期16卷 4206-4209页

作者： Ding Shi Sheng-hui liao jian-Ping Geng Department of Gastroenterology the First People’s Hospital of Yuhang District Hangzhou 311100 Zhejiang Province China School of Information Science and Engineering Central South University Changsha 410083 Hunan Province China Institute for Biomedical Engineering Nanjing University of Technology Nanjing 210009 jiangsu Province China

AIM:To find out whether a newly designed big cup nitinol stent is suitable for treatment of patients with gastric outlet obstruction resulting from gastric ***:The new stent is composed of a proximal big cup segment(20 mm in length and 48-55 mm in diameter),a middle part(60 mm in length and 20 mm in diameter)covered by a polyethylene membrane and a distal sphericity(20 mm in length and 28 mm in diameter).Half of the proximal big cup segment is also covered by a polyethlene membrane,which is adjacent to the middle part of the *** stent is preloaded in a 6.0-mm-diameter introducer *** patients with gastric outlet obstruction resulting from gastric cancer received the new stents under endoscopic and fluoroscopic ***:Technical success was achieved in 12 of 13(92.3%)*** the 12 patients in whom endoscopic stent was placed successfully,the clinical success rate was 91.7%during a follow-up of average 6.5 *** the first month follow-up,the migration rate was 0%,recurrent obstruction 0%and gastric bleeding 8.3%.During the follow-up between 2-12 mo,no migration,recurrent obstruction and gastric bleeding ***:The proximal big cup segment seems to be effective and promising for technical efficacy,clinical outcome,and preventing migration and tumor ingrowth and increasing the emptying rate of sinus ventriculi.

关键词： Endoscopic Gastric outlet Stenosis Ob- struction Stents

大鼠心肌缺血再灌注损伤与HSP_(70)的关系及三七总皂甙对其保护作用的机理研究

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实用预防医学 2006年第3期13卷 550-552页

作者：张伟徐建玲廖慧心于泽深圳市孙逸仙心血管医院广东深圳518029 深圳北大医院广州市中医药大学

目的通过检测HSP70在心肌中的表达,探讨心肌缺血再灌注与HSP70之间的关系以及三七总皂甙对缺血再灌注心肌保护作用的机制。方法Wistar大鼠60只,随机分为4组空白组、缺血再灌注组、PNS组(三七总皂甙组)和热处理组。PNS组(n=15)腹辣腔注射... 详细信息

目的通过检测HSP70在心肌中的表达,探讨心肌缺血再灌注与HSP70之间的关系以及三七总皂甙对缺血再灌注心肌保护作用的机制。方法Wistar大鼠60只,随机分为4组空白组、缺血再灌注组、PNS组(三七总皂甙组)和热处理组。PNS组(n=15)腹辣腔注射PNS150mg/kg,每日一次,连续7d;热处理组(n=15)给予热休克预处理,然后除空白组外,均采用在体缺血再灌注模型造模。缺血40min再灌注120min后检测血清CK和心肌HSP70表达水平,并同时作心肌组织病理切片和免疫组化观察。结果缺血再灌注组、PNS组和热处理组心肌HSP70表达均明显升高,PNS组和热处理组血清CK水平显著低于缺血再灌注组,病理切片亦显示相同趋势。结论HSP70在缺血再灌注心肌中呈高诱导表达,可能可以作为衡量心肌缺血再灌注损伤程度的重要指标,PNS和热休克预处理均对缺血再灌注心肌有良好的保护作用,PNS的保护作用可能与HSP70表达有关。

关键词： HSP70 CK 缺血再灌注三七总皂甙心肌