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Ionospheric vertical total electron content prediction model in low-latitude regions based on long short-term memory neural network

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Chinese Physics B 2022年第8期31卷 347-358页

作者： Tong-Bao Zhang hui-jian liang Shi-Guang Wang Chen-Guang Ouyang Department of Precision Instrument Tsinghua UniversityBeijing 100084China State Key Laboratory of Precision Measurement Technology and Instrument Tsinghua UniversityBeijing 100084China Department of Electronic Engineer Tsinghua UniversityBeijing 100084China

Ionosphere delay is one of the main sources of noise affecting global navigation satellite systems, operation of radio detection and ranging systems and very-long-baseline-interferometry. One of the most important and common methods to reduce this phase delay is to establish accurate nowcasting and forecasting ionospheric total electron content models. For forecasting models, compared to mid-to-high latitudes, at low latitudes, an active ionosphere leads to extreme differences between long-term prediction models and the actual state of the ionosphere. To solve the problem of low accuracy for long-term prediction models at low latitudes, this article provides a low-latitude, long-term ionospheric prediction model based on a multi-input-multi-output, long-short-term memory neural network. To verify the feasibility of the model, we first made predictions of the vertical total electron content data 24 and 48 hours in advance for each day of July 2020 and then compared both the predictions corresponding to a given day, for all days. Furthermore, in the model modification part, we selected historical data from June 2020 for the validation set, determined a large offset from the results that were predicted to be active, and used the ratio of the mean absolute error of the detected results to that of the predicted results as a correction coefficient to modify our multi-input-multi-output long short-term memory model. The average root mean square error of the 24-hour-advance predictions of our modified model was 4.4 TECU, which was lower and better than5.1 TECU of the multi-input-multi-output, long short-term memory model and 5.9 TECU of the IRI-2016 model.

关键词： long-short-term memory neural network equatorial ionosphere vertical total electron content vertical total electron content(vTEC)

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Real-time frequency transfer system over ground-to-satellite link based on carrier-phase compensation at 10-16 level

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Chinese Physics B 2021年第8期30卷 260-268页

作者： hui-jian liang Shi-Guang Wang Yu Bai Si-Chen Sun Li-Jun Wang Department of Electronic Engineering Tsinghua UniversityBeijing 100084China State Key Laboratory of Precision Measurement Technology and Instruments Tsinghua UniversityBeijing 100084China Department of Precision Instruments Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China

We demonstrate a novel and stable frequency transfer scheme over ground-to-satellite link based on real-time carrier-phase detection and *** performed a zero-baseline measurement with the designed system,an uninterrupted frequency standard signal is recovered in the reception station without additional post-correction of delay error caused in the route,which is because the phase error of the entire route is tracked and compensated continuously in *** achieve this goal,we employed two carriers in the system and the differential signal is transferred in order to eliminate the instability results from the local oscillator at the satellite transponder as well as the common-mode noise induced in the transfer route and microwave *** stability of 3×10^(-16) with an integration time of 1 day was achieved and the time fluctuation during one day was measured to be about±20 *** sources and possible solutions are *** zero-baseline method shows a promising result for real-time satellite-based time and frequency transfer and deserves further research to find whether it works between long-baseline stations.

关键词： frequency transfer ground-to-satellite link carrier-phase compensation

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Effects of protein synthesis inhibitors on the behavioral sensitization induced by a single morphine exposure in mice

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中国药理通讯 2008年第3期25卷 40-41页

作者： Juan Luo jian-hui liang Department of Neuropharmacology National Institute on Drug Dependence Peking University 38 Xueyuan Road Beijing 100191 PR China

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L-type calcium channel blockers enhance 5-HTP-induced antinociception in mice

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Acta Pharmacologica Sinica 2004年第5期25卷 102-108页

作者： jian-hui liang1, Jun-xu LI, Xu-hua WANG, Bi CHEN, Ying LU, Pan ZHANG, Rong HAN, Xiang-feng YEDepartment of Neuropharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China Department of Neuropharmacology National Institute on Drug Dependence Peking University Beijing 100083 China

AIM: To investigate the involvement of L-type Ca2+ channels in antinociceptive action induced by the 5-HT precursor,5-hydroxytryptophan (5-HTP). METHODS: Female Kunming mice were treated with either 5-HTP (20-80 mg/kg,ip) alone, or the combination of 5-HTP and fluoxetine (2-8 mg/kg, ip), pargyline (15-60 mg/kg, ip), nimodipine (2.5-10 mg/kg, ip), nifedipine (2.5-10 mg/kg, ip), verapamil (2.5-10 mg/kg, ip), CaCl2 (5-20 mmol/L, icv), or EGTA(0.5-3 mmol/L, icv) prior to the hot-plate test (55 C, hind-paw licking latency). In addition, locomotor activity inmice treated with 5-HTP alone was measured using an ambulometer with five activity boxes. RESULTS: Ipinjection of 5-HTP alone had no influence on the spontaneous locomotor activity, whereas dose-dependently in-creased the latency to licking hind-paw in the hot-plate test in mice. The inhibitory effects of 5-HTP on nociceptiveresponse were significantly enhanced by fluoxetine in the mouse hot-plate test. At a sub-effective dose, pargylinecould cause a leftward shift in the dose-response curve of 5-HTP-induced antinociception. Co-administration with5-HTP and nimodipine, nifedipine, or verapamil obviously potentiated the antinociceptive effects elicited by ***, 5-HTP-induced antinociception was antagonized by CaCl2 and enhanced by EGTA injected icv in themouse hot-plate test. CONCLUSION: These findings suggest that systemic administration of 5-HTP may yield theantinociceptive effects, which are related to Ca2+ influx from extracellular fluid through L-type Ca2+ channels.

关键词： serotonin 5-hydroxytryptophan fluoxetine pargyline calcium channel blockers pain measure-ment

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Effect of W -7 on the acquisition and expression of morphine-induced place preference in rats

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中国药理通讯 2005年第4期22卷 37-38页

作者： Xiang - Feng Ye Pan Zhang Rong Han jian - hui liang Department of Neuropharmacology National Institute on Drug Dependence 38 Xueyuan Road Beijing 100083 P. R. China State Key Laboratory of Natural and Biomimetic Drugs Peking University38 Xueyuan Road Beijing 100083 P. R. China.

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Effects of phosphodiesterase-4 inhibition on alcohol consumption and withdrawal anxiety in Fawn Hooded rats:Evidence for CREB phosphorylation in accumben nucleus core and central amygdala

Effects of phosphodiesterase-4 inhibition on alcohol consump...

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中国神经科学学会第十届全国学术会议

作者： Rui-Ting Wen Min Zhang Wang-Jun Qin Qing Liu Wei-Ping Wang hui liang Han-Ting Zhang jian-hui liang National Institute on Drug Dependence Peking University Departments of Behavioral Medicine & Psychiatry and Physiology & Pharmacology West Virginia University Health Sciences Center

Objective Alcohol dependence is a complex psychiatric disorder demanding development of novel *** the cyclic AMP（cyclic adenosine monophosphate,cAMP） signaling cascade has been implicated in mediating behavioral responses to alcohol,key components in this cascade may serve as potential treatment *** 4（PDE4）,an enzyme that specifically catalyzes the hydrolysis of cAMP,represents as a key point in regulating intracellular cAMP ***,it was of interest to determine whether PDE4was involved in the regulation of alcohol use and *** By using Fawn-Hooded（FH/Wjd） rats as the animal model of alcoholism,we tested the effects of rohpram,the specific PDE4 inhibitor,on ethanol intake in two-bottle choice drinking,ethanol self-administration and anxiety symptoms related to ethanol *** molecular analysis was performed to investigate the possible mechanism of rohpram ***（1） Acute administration of rohpram（0.1,0.2 mg/kg,s.c.） selectively reduced ethanol consumption in continuous- and intermittent-access to ethanol at 5%or 10%,respectively;chronic rohpram treatment time-dependently decreased 5%ethanol consumption and preference during treatment days and after the termination of rohpram *** at the highest doses（0.1 and 0.2 mg/kg） did decrease locomotor activity,but the effect lasted only 10 and 20 min,respectively,which did not likely alter long-term ethanol drinking.（2） Rohpram（0.025 mg/kg,0.05 mg/kg,s.c.） dose-dependently inhibited operant self-administration of 5%ethanol,but had no effect on 10%sucrose *** effective dose of rohpram was lower than that of naloxone（0.1 mg/kg）.（3） Anxiety-like behavior was induced following acute ethanol withdrawal after long-time two-bottle choice ***（0.1,0.2 mg/kg,s.c.） significantly reversed this effect by increasing the entries and time spent in the open arms of elevated plus maze（EPM）.（4） cAMP levels in NAc and Amy were

关键词： alcohol dependence cyclic AMP signaling phosphodiesterase-4 rolipram FH/Wjd rat

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Sutureless Intestinal Anastomosis with a Novel Device of Magnetic Compression Anastomosis

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Chinese Medical Sciences Journal 2011年第3期26卷 182-189页

作者： Chao Fan Jia Ma Hong-ke Zhang Rui Gao jian-hui Li liang Yu Zheng Wu Yi Lv Department of Hepatobiliary Surgery the First Affiliated HospitalMedical School of Xi＇an Jiaotong UniversityXi＇an 710061China

Objective To explore the feasibility and efficiency of a novel magnetic compression anastomats(MCAs) in intestinal *** A total of 36 male mongrel canines underwent intestinal anastomosis using traditional hand-sewn(n=18) or a novel MCAs(n=18).We compared the anastomosis time,postoperative complications,bursting strength of anastomoses,gross appearance,and pathology between two groups at each time-point of *** The mean anastomosis time with MCAs was significantly less than that with hand-sewn(8.50±1.95 vs.31.1±4.32 minutes,P<0.001).The blood stools and intussusceptions occurred in both groups during follow-up *** 1 mongrel canine receiving intestinal anastomosis by MCAs experienced anastomotic *** average bursting pressure of anastomoses obtained from mongrel canines undergoing intestinal anastomosis by MCAs was significantly higher than that by traditional hand-sewn at 1 week's follow-up time(P<0.05).Gross appearance of the anastomoses constructed by MCAs was relatively smoother and *** evalution of anastomoses revealed that general inflammation was greater in hand-sewn anastomoses than magnetic *** The magnetic compression anastomat is a safe and effective device of sutureless intestinal anastomosis in canine models.

关键词： magnetic compression anastomosis bursting strength foreign body reaction

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Different effects of valproate on methamphetamine—and cocaine—induced behavioral sensitization in mice

Different effects of valproate on methamphetamine—and cocai...

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第十一届全国神经药理学术会议

作者： Jun--Xu Li jian--hui liang Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, Beijing, 100083

Multiple intermittent administration of psychostimulants induces a behavioral sensitization, which is characterized bythe augmentation of locomotor activity and stereotyped behavior, even ther their long - term *** ki...

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Roux-en-Y choledochojejunostomy using novel magnetic compressive anastomats in canine model of obstructive jaundice

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Hepatobiliary & Pancreatic Diseases International 2012年第1期11卷 81-88页

作者： Chao Fan,Xiao-Peng Yan,Shi-Qi Liu,Chun-Bao Wang,jian-hui Li,liang Yu,Zheng Wu and Yi Lv Department of Hepatobiliary Surgery and Department of Pathology,First Affiliated Hospital,School of Medicine,Xi’an Jiaotong University,Xi’an 710061,China Department of Surgical Oncology,Third Affiliated Hospital,School of Medicine,Xi’an Jiaotong University,Xi’an 710068,China [a] Department of Hepatobiliary Surgery School of Medicine Xi'an Jiaotong University Xi'an 710061 Xi'an China [b] Department of Pathology First Affliated Hospital School of Medicine Xi'an Jiaotong University Xi'an 710061 Xi'an China [c] Department of Surgical Oncology Third Affliated Hospital School of Medicine Xi'an Jiaotong University (Shaanxi Provincial People's Hospital) Xi'an 710068 Xi'an China

BACKGROUND:The traditional hand-sewn Roux-en-Y choledochojejunostomy is technically complicated,and the incidence of postoperative complications has remained high.A set of novel magnetic compressive anastomats was introduced to facilitate choledochojejunostomy and improve the prognosis of ***:After ligating the common bile duct for 7 days,16 dogs were randomly divided into two groups (n=8 per group).Anastomats were used in the study group,and the traditional hand-sewn method was used in the control group for standard Roux-en-Y *** compared the operation time,incidence of complications,gross appearance,and pathological disparity in stoma between the two groups in 1-month and 3-month follow-up ***:The time spent on constructing the anastomosis for the study group was significantly *** no anastomotic stenosis occurred in the two groups,the narrowing rate of biliary-enteric anastomosis was much higher in the control *** was one case of bile leakage in the control group,whereas no bile leakage occurred in the study group.A smoother surface,an improved layer apposition,and a lower local inflammatory response were identified in the anastomosis of the study ***:The structures of the novel magnetic compressive anastomats are simple,and they are time-saving,safe and efficient for performing Roux-en-Y choledocho- jejunostomy procedures in a canine model of obstructive jaundice.

关键词： anastomosis,Roux-en-Y choledochostomy jaundice,obstructive magnetic compressive anastomats

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INTERACTION OF DAM AND FOUNDATION FOR CFRD CONSTRUCTED ON DEEPALLUVIUMS

INTERACTION OF DAM AND FOUNDATION FOR CFRD CONSTRUCTED ON DE...

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中日岩土工程学术会议

作者： ZE-PING Xu Yu SHAO and jian-hui liang Professor Department of Geotechnical Engineering China Institute of Water Resources and Hydropower Research Beijing 100044 China

＜正＞ For the CFRD constructed on deep alluviums, numerical method was applied to analysis the stress and deformation properties of the dam, foundation, slab and concrete diaphragm. The interaction between dam and overburden foundation was studied in detail. The analysis results show that: The rational’design for CFRD constructed in deep alluviums is to use vertical concrete diaphragm as the foundation seepage control measures. The key for the design is to keep deformation accordance of different structures, such as dam, slab, plinth, connection slabs, etc. and to meet the requirements of strength and deformation. Although the deformation of alluviums do have impacts on the stress and deformation of dam structures, those impacts could be limited in a certain scale to ensure the safe operation of the dam. For the connecting slabs between diaphragm and plinth, the short or long length may cause adverse impacts on the diaphragm. The proper length of the connecting slabs can be determined by optimal analysis.

关键词： Deep Alluviums CFRD Diaphragm Interaction

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