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PLG-g-mPEG Mediated Multifunctional Nanoparticles for Photoacoustic Imaging Guided Combined Chemo/Photothermal Antitumor Therapy

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Chinese Journal of Polymer Science 2023年第4期41卷 538-546,I0007页

作者： Chong Liu Ling Li zhao-Pei Guo Lin Lin Yan-Hui Li hua-Yu Tian School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun130022China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China College of Chemistry and Chemical Engineering Xiamen UniversityXiamen361005China School of Materials Science and Engineering Xiamen University of TechnologyXiamen361024China

Under laser irradiation,photothermal therapy(PTT)effectively ablates tumors above 50℃.However,hyperthermia can cause additional damage due to the inevitable heat spread to surrounding healthy ***,nanoparticles named as GI@P NPs were designed for enhanced PTT with heat shock protein 90(HSP90)inhibition at temperatures below 50℃to achieve optimal cancer therapy and avoid surrounding ***@P NPs were done by co-loading Garcinia cambogia acid(GA)and photosensitizer IR783 in polymer PLG-g-mPEG to form a nanomedicine,where IR783 with excellent photoacoustic(PA)signal acted as an excellent photothermal therapeutic agent that converted the laser energy into heat to kill tumor cells,GA was used as antitumor drug for chemotherapy and an inhibitor of HSP90 to overcome the heat resistance of tumors for efficient cryo-photothermal therapy,and PLG-g-mPEG can encapsulate IR783 and GA to increase biocompatibility and accumulate effectively in the *** GI@P NPs were injected into the mice,we could observe that the PA signals gradually increased in the tumor region and showed the strongest PA signals at 12 *** laser irradiation,the tumor temperature of the mice could raise to about 43.5℃,and the tumor was significantly inhibited after long-term monitoring by PA *** a result,gentle PTT produced by GI@P NPs exhibited good antitumor effects at relatively low temperature and minimized nonspecific thermal damage to normal *** GI@P NPs as nanomedicine enriched our understanding of various applications of polymeric carriers,especially in the biomedical field.

关键词： Mild-temperature photothermal therapy Photoacoustic imaging Polymer carrier Combination therapy Co-loading

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考虑回归水重复利用的多水源灌区灌溉用水量分析

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中国农村水利水电 2024年第4期 158-164页

作者：蒲小芳吴迪项华伟杨建赞龚兰强马黎郑丹丹中国电建集团贵阳勘测设计研究院有限公司贵州贵阳550081

多水源灌区中的灌溉回归水重复利用是普遍存在的现象,分析了灌溉回归水重复利用的机理并结合改进SWAT模型的特点概化了灌溉回归水及其重复利用量的计算方法,并说明了实际灌溉用水量的计算方法。进一步以浙江省浦江县通济桥水库灌区为实... 详细信息

多水源灌区中的灌溉回归水重复利用是普遍存在的现象,分析了灌溉回归水重复利用的机理并结合改进SWAT模型的特点概化了灌溉回归水及其重复利用量的计算方法,并说明了实际灌溉用水量的计算方法。进一步以浙江省浦江县通济桥水库灌区为实例,利用改进SWAT模型构建其水文循环模型,利用长系列实测逐月径流及实测渠首灌溉取水量率定模型参数,并进行验证。其中率定期及验证期的纳什效率系数均大于等于0.85,4条干渠灌水量模拟值与实测值的平均相对误差低于5%,表明改进SWAT模型具有良好的模拟效果且可用于模拟灌区不同水源类型的灌水量。进一步根据模型模拟结果计算得到通济桥水库灌区灌溉回归水及其重复利用量、以及灌区实际灌溉用水量,结果表明,该灌区灌溉回归水重复利用率达到40%,考虑扣除灌溉回归水重复利用量后,灌区灌溉用水量将降低约5.4%,灌区骨干水源灌溉用水量占总用水量的63%,不能代替整个灌区的灌溉用水量。进一步说明灌区实际灌溉用水量统计时应考虑扣除灌溉回归水重复利用量,尤其针对大型灌区或大范围区域,灌区灌溉用水量减少的绝对值将十分可观,可提高灌区灌溉用水量统计精度。对于有监测设施的灌区,不能仅仅以监测水量作为灌区的灌溉用水量,应模拟统计灌区内来源不同水源类型的实际灌溉用水量。

关键词：灌溉回归水重复利用多水源灌区改进SWAT模型实际灌溉用水量

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Molecular Characterization and Expression Analysis of Matrix Metalloproteinase 3 in the Asian Yellow Pond Turtle Mauremys mutica

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Asian Herpetological Research 2014年第1期5卷 38-48页

作者： Mi zhao Yan SHI jian zhao Xinping ZHU Kunci CHEN Debo PAN Chengqing WEI Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation Ministry of AgriculturePearl River Fishery Research Institute Chinese Academic of Fishery Science

Matrix metallopeptidase 3 is a zinc-containing proteinase that participates in tissue remodeling and immune responses. In this study, a cDNA encoding matrix metallopeptidase 3 was isolated and characterized from the Asian yellow pond turtle Mauremys mutica（designated as MaMMP3）. The MaMMP3 cDNA is 1805 bp and consists of a 5＇-untranslated region（UTR） of 56 bp, a 3＇-UTR of 243 bp, and an open reading frame（ORF） of 1506 bp encoding 481 amino acids. Homology analysis of MaMMP3 revealed that the MaMMP3 shared 25%–63% similarity to other known MMP3 sequences. The genomic sequence covers 6007 bp. Comparative analysis of the cDNA sequence revealed that the Asian yellow pond turtle MMP3 has eight exons and seven introns. The phylogenetic tree showed that the MaMMP3 is closely related to Gallus gallus MMP3 and Taeniopygia guttata MMP3. The mRNA expression of the MaMMP3 in normal group without any bacterial challenge could be detected in all studied tissues including kidney, heart, live and spleen, with the highest level in the spleen. The results of immune challenge showed that the expression level of MaMMP3 was up-regulated in the spleen and liver. These results provided an important information for studying the roles of Asian yellow pond turtle MMP3 in immunity further.

关键词： Asian yellow pond turtle Mauremys mutica Serratia marcescens Matrix metallopeptidase 3 Immune responses

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Phase-field simulation of tip splitting in dendritic growth of Fe-C alloy

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Journal of Iron and Steel Research International 2017年第2期24卷 171-176页

作者： Yong-sheng Kang Yu-chun Jin Yu-hong zhao hua Hou Li-wen Chen Material Science and Engineering Institute North University of China Taiyuan 030051 Shanxi China

Two types of dendrite tip splitting including dendrite orientation transition and twinned-like dendrites in Fe-C alloys were investigated by phase-field method. In equiaxed growth, the possible dendrite growth directions and the effect of supersaturation on tip splitting were discussed; the dendrite orientation transition was observed, and it was found that the orientation regions of anisotropy parameters were reduced from three to two with increasing the supersaturation, which was due to the effect of interracial anisotropy controlled by the solute in front of S/L interface changing with the increase of supersaturation. In directional solidification, it was found that the twinned like dendrites were formed with the fixed anisotropy couples and no seaweed dendrites were observed; these were concluded from the results of competition between process anisotropy and inherent anisotropy. The formation process of twinned-like dendrite was investigated by tip splitting phenomenon, which was related to the chan ges of dendrite tips growth velocity. Then, the critical speed of tips splitting and solute concentration of twinned-like dendrites were investigated, and a new type of microsegregation in Fe-C alloys was proposed to supplement the dendrite growth theories.

关键词： Tip splitting Fe C alloy Interracial anisotropy Dendritic growth

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Identiffcation of soft rot resistance loci in Brassica rapa with SNP markers

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Journal of Integrative Agriculture 2022年第8期21卷 2253-2263页

作者： LIU Meng-yang WU Fang GE Yun-jia LU Yin ZHANG Xiao-meng WANG Yan-hua WANG Yang YAN Jing-hui SHEN Shu-xing zhao jian-jun MA Wei State Key Laboratory of North China Crop Improvement and Regulation Ministry of Science and Technology/Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei/Collaborative Innovation Center of Vegetable Industry in Hebei/College of HorticultureHebei Agricultural UniversityBaoding 071000P.R.China

Soft rot caused by Pectobacterium carotovorum(Pc)is a devastating disease of Brassica rapa,causing substantial reductions in crop yield and *** genes related to soft rot resistance is the key to solving this *** characterize soft rot resistance,we screened a soft rot-susceptible Chinese cabbage(A03),a resistant pakchoi(‘huaguan’),and a resistant mutant(sr).An F_(2) population was generated by crossing susceptible Chinese cabbage A03and resistant pakchoi‘huaguan’to identify quantitative trait loci(QTLs)that confer soft rot resistance.A high-density genetic map was constructed and the three QTLs identified contain 166 *** on available transcriptome data,we analyzed the expression of the 166 genes during an important defense regulatory period in Pc infection in both A03and the resistant mutant *** the 166 genes,six candidate genes were related to the soft rot defense response in ***10B(JAZ2,BraA07g038660.3C)was located in the major soft rot resistance QTL,DRQTL-3 on A07,and we speculate that this gene may play an important role in the defense mechanism against soft rot in *** study lays the foundation for further investigations on the mechanism of soft rot resistance in *** crops.

关键词： soft rot quantitative trait loci-sequencing Brassica rapa

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Microstructures and Mechanical Properties of Mg–xAl–1Sn–0.3Mn(x=1,3,5)Alloy Sheets

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Acta Metallurgica Sinica(English Letters) 2020年第9期33卷 1217-1225页

作者： Chao-Yue zhao Xian-hua Chen Peng Peng Teng Tu Andrej Atrens Fu-Sheng Pan College of Materials Science and Engineering Chongqing UniversityChongqing 400045China Shenyang National Laboratory for Materials Science Chongqing UniversityChongqing 400045China School of Mechanical and Mining Engineering The University of QueenslandSt LuciaQLD 4072Australia

The influence of Al alloying on the microstructures and the mechanical properties of Mg–x Al–1 Sn–0.3 Mn alloy sheets was investigated. The microstructure of Mg– x Al–1 Sn–0.3 Mn consisted of α-Mg and Mg 17 Al 12 precipitates. Alloying with Al increased the amount of Mg17Al12 and the average grain size. Uniaxial tensile tests were carried out along the extrusion direction(ED), the transverse direction(TD) and 45° toward the ED. Mg–5 Al–1 Sn–0.3 Mn alloy sheet exhibited the best combination of mechanical properties along the ED: a yield strength of 142 MPa, an ultimate tensile strength of 282 MPa and an elongation of 23%. The good performance of Mg–5 Al–1 Sn–0.3 Mn sheet was mainly attributed to the large quantity of Mg17Al12 precipitates and a weak basal texture. Annealing caused static dynamic recrystallization, refined the grain size and enhanced the mechanical properties: yield strength of 186 MPa, ultimate tensile strength of 304 MPa, elongation of 21% along ED. Both strength and ductility were enhanced by Al alloying.

关键词： Mg–xAl–1Sn–0.3Mn alloys Extrusion Microstructure Mechanical properties

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Efficacy of stepwise mini-incision microdissection testicular sperm extraction for nonobstructive azoospermia with varied etiologies

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Asian Journal of Andrology 2023年第5期25卷 621-626页

作者： Yu-Xiang Zhang Chen-Cheng Yao Yu-hua huang Peng Li Er-Lei Zhi Zi-Jue Zhu jian-Xiong Zhang Fu-Jun zhao Zheng Li Ru-Hui Tian Department of Andrology The Center for Men's HealthUrologic Medical CenterShanghai Key Laboratory of Reproductive MedicineShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

Stepwise mini-incision microdissection testicular sperm extraction(mTESE)is a procedure that attempts to minimize testicular ***,the mini-incision approach may vary in patients with different ***,we performed a retrospective analysis of 665 men with nonobstructive azoospermia(NOA)who underwent stepwise mini-incision mTESE(Group 1)and 365 men who underwent standard mTESE(Group 2).The results showed that the operation time(mean±standard deviation)for patients with successful sperm retrieval in Group1(64.0±26.6min)was significantly shorter than that in Group2(80.2±31.3min),with P0.05),even when the etiologies of NOA were taken into *** results of consecutive multivariate logistic regression analysis(odds ratio[0R]:0.57;95%confidence interval[Cl]:0.38-0.87;P=0.009)and receiver operating characteristic(ROC)analysis(area under the ROC curve[AUC]=O.628)showed that preoperative anti-Mullerian hormone(AMH)level in idiopathic NOA patients was a potential predictor for surgical outcomes after initial three small incisions made in the equatorial region without sperm examined under an operating microscope(Steps 2-4).In conclusion,stepwise mini-incision mTESE is a useful technique for NOA patients,with comparable SRR,less surgical invasiveness,and shorter operation time compared with the standard *** AMH levels may predict successful sperm retrieval in idiopathic patients even after a failed initial mini-incision procedure.

关键词： etiology male infertility nonobstructive azoospermia standard mTESE stepwise mini-incision mTESE

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激光增材再制造修复技术的现状与发展趋势

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科学技术与工程 2024年第4期24卷 1313-1325页

作者：王军华姚成彭建军颉潭成杨芳马喜强徐彦伟河南科技大学机电工程学院洛阳471003 河南省智能制造装备工程技术研究中心洛阳471003 智能数控装备河南省工程实验室洛阳471003 河南省科学院郑州450046

激光增材再制造技术是基于激光熔覆、激光堆焊等激光沉积技术原理实现各种金属零部件损伤部位的几何尺寸或综合性能恢复的绿色制造新技术。针对激光增材再制造技术,具体阐述了增材再制造技术的国内外现状,并详细介绍了激光增材再制造的... 详细信息

激光增材再制造技术是基于激光熔覆、激光堆焊等激光沉积技术原理实现各种金属零部件损伤部位的几何尺寸或综合性能恢复的绿色制造新技术。针对激光增材再制造技术,具体阐述了增材再制造技术的国内外现状,并详细介绍了激光增材再制造的工艺类型以及在各行业的应用,最后展望了激光增材再制造技术的发展趋势。

关键词：激光增材再制造技术技术应用

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A User-Centered Multi-space Collaborative Visual Analysis for Cyber Security

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Chinese Journal of Electronics 2018年第5期27卷 910-919页

作者： ZHONG Zengsheng zhao Ying SHI Ronghua SHENG Yingshuai LIU Junrong MENG hua LIN Dan School of Information Science and Engineering Central South University Information Office Chongqing Technology and Business University Key Laboratory of Network Assessment Technology Institute of Information EngineeringChinese Academy of Sciences

Based on a university’s practice in upgrading its network management platform, presents a visual analytic system which integrates network topological space,IP space and network geographical space into a collaborative solution to help network administrators address difficulties in locating end user and troubleshooting. Throughout the development cycle, we worked alongside with users to clarify their actual demands and habitual operations through scenario application, interviews and a variety of evaluation. This user-centered approach guides us step by step to apply cyber security visualization and visual analytic technology to actual use.

关键词： Cyber security Campus network management Visual analytics User evaluation

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Transition of axial segregation patterns in a long rotating drum

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Particuology 2014年第2期12卷 128-133页

作者： Zequn Cui Yongzhi zhao Youchuan Chen Xiao Liu Zhengli hua Chilou Zhou Jinyang Zheng State Key Laboratory of Chemical Engineering Institute of Process EquipmentDepartment of Chemical and Biochemical EngineeringZhejiang University Institute of Coal Chemistry Chinese Academy of Sciences

Axial segreganon or a bidisperse mixture of particles in a long rotating drum is studied using the discrete element method. Simulation results show that particle interaction is responsible for axial segregation, the patterns of which are influenced by the end wall effect. Axial segregation patterns transform under competing influences of the end walls and the particle interaction forces. The two influential factors vary with various rotational speeds and end wall friction levels. The result is the transition of different axial segregation patterns： two large-particle bands at both ends, two small-particle bands at both ends, or a random segregation pattern where either a large-particle band or small-particle band may appear at either end.

关键词： Long rotating drumDiscrete element methodAxial segregation patternEnd wall effectRotational speed

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