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3′-Daidzein sulfonate sodium protects against memory impairment and hippocampal damage caused by chronic cerebral hypoperfusion

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Neural Regeneration Research 2018年第9期13卷 1561-1567页

作者： Xiao Li Rui-Zhen Liu Qi zeng Zhi-hua huang jian-Dong Zhang Zong-Liang Liu Jing zeng Hai Xiao Gannan Medical University Ganzhou Jiangxi Province China Department of Ultrasound First Affiliated Hospital of Gannan Medical University Ganzhou liangxi Province China Department of Pathology First Affiliated Hospital of Gannan Medical University Ganzhou Jiangxi Province China

3′-Daidzein sulfonate sodium（DSS） is a new synthetic water-soluble compound derived from daidzein,a soya isoflavone that plays regulatory roles in *** this study,we hypothesized that the regulatory role of DSS in neurobiology exhibits therapeutic effects on hippocampal damage and memory *** validate this hypothesis,we established rat models of chronic cerebral hypoperfusion（CCH） by the permanent occlusion of the common carotid arteries using the two-vessel occlusion *** weeks after modeling,rat models were intragastrically administered 0.1,0.2,and 0.4 mg/kg DSS,once a day,for 5 successive *** Morris water maze test was performed to investigate CCH-induced learning and memory *** assay was used to analyze apoptosis in the hippocampal CA1,CA3 regions and dentate ***-eosin staining was performed to observe the morphology of neurons in the hippocampal CA1,CA3 regions and dentate *** blot analysis was performed to investigate the phosphorylation of PKA,ERK1/2 and CREB in the hippocampal PKA/ERK1/2/CREB signaling *** showed that DSS treatment greatly improved the learning and memory deficits of rats with CCH,reduced apoptosis of neurons in the hippocampal CA1,CA3 regions and dentate gyrus,and increased the phosphorylation of PKA,ERK1/2,and CREB in the *** findings suggest that DSS protects against CCH-induced memory impairment and hippocampal damage possibly through activating the PKA/ERK1/2/CREB signaling pathway.

关键词： nerve regeneration learning and memory deficits chronic cerebral hypoperfusion 3'-daidzein sulfonate sodium PKAIERK1/2/CREB signaling pathway neuroprotection hippocampus neural regeneration

Characterization and Wettability of ZnO Film Prepared by Chemical Etching Method

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Chemical Research in Chinese Universities 2013年第2期29卷 333-337页

作者： GUO hua-xi JIA Hui-ying zeng jian-bo CONG Qian REN Lu-quan Key Laboratory of Bionic Engineering Ministry of Education Jilin University Changchun 130025 P. R. China

ZnO thin films were prepared by a chemical etching method and their wettability was investigated. The structure and surface composition structure were characterized by means of scanning electron microscopy, X-ray photoelectronic spectrometry（XPS）, X-ray diffraction（XRD） and Raman spectrometry. These analyses reveal that the etched films were large-scale micro-nanohierarchical structures composed of a Zn core and a ZnO coating. Superhy- drophobic surfaces with water contact angles of over 150~ were obtained by n-octadecanethiol（ODT） modification. The XPS and Raman results indicate that ODT molecules were bound to the ZnO surface with the S head group by forming Zn--S bond.

关键词： ZnO Chemical etching Micro-nanostructure Raman spectrometry Wettability

The Luminescence Properties of M' type of YTaO_4∶Eu

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Chemical Research in Chinese Universities 1999年第3期15卷 226-231页

作者： LI Bo GU Zhen-nan DONG Yi LIN jian-hua SU Mian-zeng Chemistry Department State key Laboratory of Rare Earth Materials Chemistry and ApplicationsPeking UniversityBejing 100871P.R.China

A series of Eu 3+ doped of Mtype of yttrium orthotantalate Y 1-x Eu x TaO 4( x =0-0.30) was sythesized. The influence of activator concentration on luminescence properties was studied in detail. The strong evidence from excitation spectra, emission spectra and diffusive reflection spectra of this system shows that there is energy transfer from TaO 3- 4 to Eu 3+ via the charge transfer and spectral overlap.

关键词： Tantalate Rare earth Luminescence

Local scour by multiple slit-type energy dissipaters

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Journal of Hydrodynamics 2020年第6期32卷 1221-1224页

作者： Li Yao jian-hua Wu College of Water Conservancy and Ecological Engineering Nanchang Institute of TechnologyNanchang330099China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210098China

Energy dissipation and scour control are all the key issues for the design of hydraulic *** the basis of the high energy dissipation for the multiple slit-type energy dissipaters(M-STED)developed by the authors,in this work,the characteristics of the scour hole for the M-STED were experimentally investigated through three sets of those physical models with five cases and a scour hole form index was *** results show that,the M-STED results in not only the high energy dissipation but also the mild upstream slope of the scour hole thanks to the scour hole form index of larger than 0.5,which is in favor of the safety of the release works.

关键词： Energy dissipation scour scour hole form index multiple slit-type energy dissipater

Time-domain training sequences design for MIMO OFDM channel estimation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第4期9卷 464-469页

作者： Zhen LU jian-hua GE Department of Electronic Engineering Shanghai Jiao Tong Universiry Shanghai 200240 China Department of Communications Engineering Xidian University Xi＇an 710071 China

This paper describes a Least Squares (LS) channel estimation scheme for MIMO OFDM systems based on time-domain training sequence. We first compute the minimum mean square error (MSE) of the LS channel estimation, and then derive the optimal criteria of the training sequence with respect to the minimum MSE. It is shown that optimal time-domain training sequence should satisfy two criteria. First, the autocorrelation of the sequence transmitted from the same antenna is an impulse function in a region longer than the channel maximum delay. Second, the cross-correlation between sequences transmitted from different antennas is zero in this region. Simulation results show that the estimator using optimal time-domain training sequences has better performance than that using optimal frequency training sequence at low signal-to-noise ratio (SNR). To reduce the training overhead, a suboptimal training sequence is also proposed. Comparing with optimal training sequence, it has low computation complexity and high transmission efficiency at the expense of little performance degradation.

关键词： MIMO OFDM Channel estimation Time-domain training sequence

Shi-pi-xiao-ji formula suppresses hepatocellular carcinoma by reducing cellular stiffness through upregulation of acetyl-coA acetyltransferase 1

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2727-2741页

作者： Hui-Ying jian Zi-Cheng Liang huan Wen Zhen Zhang Pu-hua zeng Graduate School Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Provincial Hospital of Integrated Traditional Chinese and Western Cancer Research Institute of Hunan Academy of Traditional Chinese MedicineHunan Academy of Chinese MedicineChangsha 410006Hunan ProvinceChina

BACKGROUND Previous studies have shown that the Shi-pi-xiao-ji(SPXJ)herbal decoction formula is effective in suppressing hepatocellular carcinoma(HCC),but the underlying mechanisms are not ***,this study investigated whether the antitumor effects of the SPXJ formula in treating HCC were mediated by acetyl-coA acetyltransferase 1(ACAT1)-regulated cellular *** a series of experiments,we concluded that SPXJ inhibits the progression of HCC by upregulating the expression level of ACAT1,lowering the level of cholesterol in the cell membrane,and altering the cellular stiffness,which provides a new idea for the research of traditional Chinese medicine against *** To investigate the anti-tumor effects of the SPXJ formula on the malignant progression of *** HCC cells were cultured in vitro with SPXJ-containing serum prepared by injecting SPXJ formula into wild-type *** apoptotic rate and proliferative,invasive,and migratory abilities of control and SPXJ-treated HCC cells were *** force microscopy was used to determine the cell surface morphology and the Young’s modulus values of the control and SPXJ-treated HCC *** membrane cholesterol levels in HCC cells were detected using the Amplex Red cholesterol detection ***1 protein levels were estimated using western *** Compared with the vehicle group,SPXJ serum considerably reduced proliferation of HCC cells,increased stiffness and apoptosis of HCC cells,inhibited migration and invasion of HCC cells,decreased plasma membrane cholesterol levels,and upregulated ACAT1 protein ***,treatment of HCC cells with the water-soluble cholesterol promoted proliferation,migration,and invasion of HCC cells as well as decreased cell stiffness and plasma membrane cholesterol levels,but did not alter the apoptotic rate and ACAT1 protein expression levels compared with the vehicle *** SPXJ formula inhibited proliferation,invasion,and migration

关键词： Shi-pi-xiao-ji formula Hepatocellular carcinoma Cellular stiffness Plasma membrane cholesterol level AcetylcoA acetyltransferase 1

Natural gas characteristics and gas-source comparisons of the Lower Triassic Feixianguan Formation,Eastern Sichuan Basin,China

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Petroleum Science 2023年第3期20卷 1458-1470页

作者： Zi-Yun Zheng Yin-Hui Zuo hua-Guo Wen De-Ming Li Yang Luo Jia-Zhen Zhang Mei-hua Yang jian-Cheng zeng State Key Laboratory of Oiland Gas Gelogy and Exploitation Chengdu University of TechnologyChengduSichuan610059China PetroChina Southwest Oil&Gas Field Company ChengduSichuan610051China

There is great controversy regarding the origin and source of natural gas in the Lower Triassic Feix-ianguan Formation in the Eastern Sichuan *** seriously restricts the study of natural gas dy-namics in the Feixianguan Formation and thus hampers natural gas exploration in the region,so further study is urgently *** experimental tests of natural gas composition,stable isotopes,and noble gas isotopes with gas chromatography(GC)and mass spectrometry(MS)studies of source rock and reservoir asphalt saturated hydrocarbons,the natural gas geochemical characteristics,the genetic identification and a gas-source comparison of the Feixianguan Formation were ***,con-strained by the thermal history,the histories of gas generation and expulsion were restored by basin simulation ***,a gas accumulation model was established for the Feixianguan *** results showed that(1)the H_(2)S-rich and H2S-poor gas reservoirs of the Feixianguan Formation are distributed on the east and west sides of the Kaijiang-Liangping trough in the Eastern Sichuan Basin,*** carbon and hydrogen isotope compositions of the natural gas in the gas reservoirs are generally heavy and have typical characteristics of high-maturity dry gas reservoirs.(2)The natural gas of the Feixianguan Formation is organic thermogenic gas,which is mainly oil-type gas generated by the secondary cracking of crude *** gas-generating parent material is mainly type II kerogen.(3)The natural gas of the Feixianguan Formation in the Eastern Sichuan Basin was mainly generated by argil-laceous source rocks of the Upper Permian Longtan Formation.(4)Natural gas accumulation occurred as follows:the paleo-structure heights were filled with crude oil in the Early Jurassic,and paleo-oil res-ervoirs were formed in the Feixianguan Formation;during the Middle-Late Jurassic,the paleo-oil res-ervoirs were cracked when the reservoir temperatures rose above 160 C,and paleo-gas reservoi

关键词： Eastern Sichuan Basin Feixianguan Formation Natural gas origin Gas-source comparison Longtan Formation

Quality of life after three kinds of esophagectomy for cancer

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World Journal of Gastroenterology 2012年第36期18卷 5106-5113页

作者： jian zeng Jin-Shi Liu Department of Thoracic Tumor Sur- gery Zhejiang Cancer Hospital Hangzhou 310004 Zhejiang Province China

AIM： TO evaluate quality of life （QOL） following Ivor Lewis, left transthoracic, and combined thoracoscopic/ laparoscopic esophagectomy in patients with esopha- geal cancer. METHODS： Ninety patients with esophageal cancer were assigned to Ivor Lewis （/7 = 30）, combined thora- coscopic/laparoscopic （n = 30）, and left transthoracic （n = 30） esophagectomy groups. The QOL-core 30 questionnaire and the supplemental QOL-esophageal module 18 questionnaire for patients with esophageal cancer, both developed by the European Organization for Research and Treatment of Cancer, were used to evaluate patients＇ QOL from 1 wk before to 24 wk after surgery. RESULTS： A total of 324 questionnaires were collect- ed from 90 patients, 36 postoperative questionnaires were not completed because patients could not be contacted for follow-up visits. QOL declined markedly in all patients at 1 wk postoperatively： preoperative and 1-wk postoperative global QOL scores in the Ivor Lewis, combined thoracoscopic/laparoscopic, and left transthoracic groups were 80.8 ± 9.3 vs 32.0 ± 16.1 （P 〈 0.001）, 81.1±9.0 vs 53.3 ± 11.5 （P 〈 0.001）, and 83.6 ± 11.2 vs 46.4 ± 11.3 （P 〈 0.001）, respectively. Thereafter, QOL recovered gradually in all patients. Patients who underwent Ivor Lewis esophagectomy showed the most pronounced decline in QOL; global scores were lower in this group than in the combined thoracoscopic/laparoscopic （P 〈 0.001） and left trans- thoracic （P 〈 0.001） groups at 1 wk postoperatively and was not restored to the preoperative level at 24 wk postoperatively. QOL declined least in patients under- going combined thoracoscopic/laparoscopic esopha- gectomy, and most indices had recovered to preopera- tive levels at 24 wk postoperatively. In the Ivor Lewis and combined thoracoscopic/laparoscopic groups, pain and physical function scores were 78.9 ± 18.5 vs 57.8 ± 19.9 （P 〈 0.001） and 59.3 ± 16.1 vs 70.2 ± 19.2 （P = 0.02）, respectively, at 1 wk postoperatively and 26.1 ± 28.6 vs 9.5 ± 15.6 （P =

关键词： Esophageal cancer Quality of life Thora-coscope Laparoscope Esophagectomy

Vibrational Resonance in Fractional-Order Anharmonic Oscillators

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Chinese Physics Letters 2012年第10期29卷 97-100页

作者： YANG jian-hua School of Mechanical and Electrical Engineering China University of Mining and TechnologyXuzhou 221116

The phenomenon of vibrational resonance in fractional-order anharmonic oscillators is *** on the method of separating slow and fast motions,the approximate solution of the response amplitude is *** analytical and numerical results show that not only the high-frequency signal but also the fractional-order damping can induce vibrational *** present results provide a new way to control periodical signals in coupled systems.

关键词： harmonic vibrational fractional