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弥散加权成像在新生儿重度缺氧缺血性脑病早期评价中的意义

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中华儿科杂志 2007年第11期45卷 843-847页

作者：富建华薛辛东毛健陈丽英王晓明中国医科大学附属盛京医院儿科沈阳110004 中国医科大学附属盛京医院放射科沈阳110004

目的探索新生儿重度缺氧缺血性脑病(HIE)早期弥散加权成像(DWI)动态演变规律及其意义。方法对2006年1月至2007年2月收住我院14例重度 HIE 患儿,分别于生后72 h,7、14、21 d 及8个月行 DWI 及常规 MRI 扫描。结果 72 h内,常规 MRI 的 T_... 详细信息

目的探索新生儿重度缺氧缺血性脑病(HIE)早期弥散加权成像(DWI)动态演变规律及其意义。方法对2006年1月至2007年2月收住我院14例重度 HIE 患儿,分别于生后72 h,7、14、21 d 及8个月行 DWI 及常规 MRI 扫描。结果 72 h内,常规 MRI 的 T_1加权(T_1WI)和 T_2加权(T_2WI)均未见异常,DWI 表现为双侧腹外侧丘脑对称性的高信号;7 d 常规 MRI 表现双侧腹外侧丘脑对称性 T_1WI 高信号,T_2WI 稍低信号,DWI 表现为双侧基底节高信号,而初期腹外侧丘脑高信号消失;14 d 常规 MRI 双侧丘脑、基底节对称性 T_1WI 高信号,T_2WI 低信号;21 d 常规 MRI 双侧丘脑及基底节 T_1WI 高信号,T_2WI 高信号,DWI 则未见明显异常;8个月常规 MRI 脑沟变深、脑室扩大及脑外间隙增宽,基底节 T_2WI 不规则的高信号。结论重度 HIE(主要因急性的完全性窒息所致)生后初期 DWI 显示相同的病变部位(腹外侧丘脑和基底节)和相似的病变程度,但其异常信号很快消失,而常规 MRI 可继之弥补 DWI 的不足。

关键词：磁共振成像弥散缺氧缺血脑病婴儿新生

Aggressive surgical resection does not improve survival in operable esophageal squamous cell carcinoma with N2-3 status

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World Journal of Gastroenterology 2015年第28期21卷 8644-8652页

作者： Yu-Zhen Zheng Wei Zhao Yi Hu Xiao-Xiao Ding-Lin Jing Wen Hong Yang Qian-Wen Liu Kong-Jia Luo Qing-Yuan huang Jun-Ying Chen jian-hua fu Department of Thoracic Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Esophageal Cancer Institute Department of Medical Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Oncology Sun Yat-sen Memorial Hospital Department of Experimental Research Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine

AIM:To investigate the influence of nodal status on response and clarify the optimal treatment for operable esophageal squamous cell carcinoma(OSCC).METHODS:We retrospectively analyzed 1490 OSCC patients who underwent transthoracic esophagectomy and lymphadenectomy between December 1996 and December 2009 at the Sun Yat-sen University Cancer *** surgical approach and the number of resected lymph nodes(LNs) were considered in the assessment of *** were classified according to their nodal statuses(NO vs N1 vs N2-3).Overall survival was defined as the time from the date of death or final *** analysis was performed using the Kaplan-Meier method and differences between curves were assessed by the logrank *** and multivariate Cox regression analyses were used to identify factors associated with *** significance was assumed at a P<***:With a median time from surgery to the last censoring date for the entire cohort of 72.2 mo,a total of 631 patients were still alive at the last follow-up and the median survival time was 35.5 *** surgical approach(left transthoracic vs Ivor-Lewis/tri-incisional)was verified as independent prognostic significance in patients with NO or N1 status,but not in those with N2-3 *** results were also observed with the number of resected LNs(≤14 vs ≥15).Compared with surgery alone,combined therapy achieved better outcomes in patients with N1 or N2-3 status,but not in those with NO *** those with N2-3status,neither the surgical approach nor the number of resected LNs reached significance by univariate analysis,with unadjusted HRs of 0.826(95%CI:0.644-1.058) and 0.849(95%CI:0.668-1.078),respectively,and aggressiveness of surgery did not influence the outcome;the longest survival was observed in those patients who received the combined ***:Combined therapy has a positive role in OSCC with LN metastasis,and aggressive surgical resection does not i

关键词： Esophageal neoplasm Lymph nodes Prognosis Surgery

光通过散射介质聚焦的空间位相逐个单元调节方法

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生物化学与生物物理进展 2018年第3期45卷 336-350页

作者：方龙杰张熙程张诚左浩毅朱建华高福华庞霖四川大学物理科学与技术学院成都610064

本研究在分析现有散射介质聚焦方法的基础上,提出一种利用单元裂解进行波前位相调制,将经过强散射介质的散射光聚焦的快速收敛方法.文中详细地描述了这一新方法的原理,并同现有逐个单元调节方法进行运行对比.单元裂解方法的物理本质,即... 详细信息

本研究在分析现有散射介质聚焦方法的基础上,提出一种利用单元裂解进行波前位相调制,将经过强散射介质的散射光聚焦的快速收敛方法.文中详细地描述了这一新方法的原理,并同现有逐个单元调节方法进行运行对比.单元裂解方法的物理本质,即为实现空间光调制器的调制各单元光波之间同位相干涉.本方法具有更高的信噪比,并且聚焦收敛的速度快.这一新方法为进一步开展生物成像的光学理论研究提供了新思路.

关键词：空间光调制器聚焦干涉散射介质

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Ⅲ期胸段食管鳞癌根治切除术后预后因素分析

癌症 2010年第2期29卷 190-195页

作者：胡祎郑斌戎铁华傅剑华朱志华杨弘罗孔嘉李永锋华南肿瘤学国家重点实验室广东广州510060 中山大学肿瘤防治中心胸科广东广州510060

背景与目的:食管癌治疗首选手术,多数患者就诊时已是局部晚期(以Ⅲ期为主)。本研究回顾性分析手术根治切除的食管鳞癌患者的临床资料,以探讨影响患者术后生存的主要因素。方法:收集1997年1月至2004年3月中山大学肿瘤防治中心行食管癌根... 详细信息

背景与目的:食管癌治疗首选手术,多数患者就诊时已是局部晚期(以Ⅲ期为主)。本研究回顾性分析手术根治切除的食管鳞癌患者的临床资料,以探讨影响患者术后生存的主要因素。方法:收集1997年1月至2004年3月中山大学肿瘤防治中心行食管癌根治术病例临床资料,其中资料完整361例,应用Kaplan-Meier法进行生存分析,组间比较用log-rank检验,多因素分析采用Cox模型分析。结果:总的1、2、3、4和5年生存率分别为67.7%、40.6%、27.5%、23.4%和20.1%。单因素分析表明肿瘤浸润深度、淋巴结转移度、淋巴结转移区域数、淋巴结转移个数、手术并发症和手术时间均为Ⅲ期胸段食管鳞癌预后影响因素。Cox回归分析显示肿瘤浸润深度、淋巴结转移度和手术并发症是Ⅲ期胸段食管鳞癌预后的独立影响因素。结论:在Ⅲ期胸段食管鳞癌根治术后的临床和病理特征中,淋巴结转移度、肿瘤浸润深度和手术并发症是独立预后因素。

关键词：食管肿瘤手术预后

左右胸两种入路治疗胸中段食管鳞癌的手术评价

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癌症 2009年第12期28卷 1260-1264页

作者：罗孔嘉傅剑华胡祎戎铁华林鹏王欣杨弘郑斌李永锋华南肿瘤学国家重点实验室广东广州510060 中山大学肿瘤防治中心胸科广东广州510060

背景与目的:目前胸中段食管癌手术治疗的入路多数为经左胸或右胸,两者各有优缺点。既往较少文献报道手术入路对手术疗效的影响。本研究拟评价经左胸或右胸手术入路治疗胸中段食管鳞癌疗效的差异及优缺点。方法:回顾性分析1999年1月至200... 详细信息

背景与目的:目前胸中段食管癌手术治疗的入路多数为经左胸或右胸,两者各有优缺点。既往较少文献报道手术入路对手术疗效的影响。本研究拟评价经左胸或右胸手术入路治疗胸中段食管鳞癌疗效的差异及优缺点。方法:回顾性分析1999年1月至2005年6月中山大学肿瘤防治中心连续收治的胸中段食管鳞癌482例,按手术入路分为左胸组(350例)和右胸组(132例)。比较两组切除率、术后并发症、淋巴结清扫情况、复发转移模式、无病生存期、总体生存期的差异。结果:左胸组、右胸组根治性切除率分别是92.0%、92.4%(P=0.878),并发症发生率分别是35.4%、57.6%(P<0.001),平均清扫淋巴结分别为(11.8±6.6)枚和(16.3±8.0)枚(P<0.001)。左胸组、右胸组淋巴结总复发率分别是69.6%、51.1%(P=0.028),其中,纵隔淋巴结复发率分别是38.4%、15.6%(P=0.005)。左胸组、右胸组3年无病生存期分别为(22.92±0.74)个月、(25.09±1.22)个月(P=0.039)。结论:左胸入路手术操作较简便,并发症较少;右胸入路在减少淋巴结复发、提高无病生存率、总体生存率方面具有优势,能带来生存获益。

关键词：食管肿瘤/外科手术手术并发症淋巴结清扫疗效

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空空导弹系统仿真模型验证平台

系统仿真学报 2003年第6期15卷 791-792,813页

作者：王建华符文星阎杰西北工业大学航天工程学院西安710072

文章介绍了空空导弹系统仿真模型验证平台。该平台基于CLIMB方案,将不同数据资源分为五个等级。利用等级高的数据库对产生等级低的数据库资源的模型进行验证。平台集成了工程上用于仿真模型有效性评估的统计检验方法。平台验证方法完备... 详细信息

文章介绍了空空导弹系统仿真模型验证平台。该平台基于CLIMB方案,将不同数据资源分为五个等级。利用等级高的数据库对产生等级低的数据库资源的模型进行验证。平台集成了工程上用于仿真模型有效性评估的统计检验方法。平台验证方法完备且具有良好的开放性,易于扩充。最后用实例说明平台的工作界面。

关键词：仿真模型验证假设检验平台

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综合经济目标下的电厂汽轮机组最优负荷分配

上海交通大学学报 2003年第9期37卷 1388-1390页

作者：忻建华叶春傅宏涛翟海青金兴上海交通大学机械与动力工程学院上海200030 上海电力公司上海200001

提出了基于动态规划法的汽轮发电机组负荷分配的优化模型,该模型考虑了机组主要部件的低周疲劳寿命损耗、机组的最小运行时间和最小停机时间、负荷最大爬升和降负荷速度限制等约束条件,并对各种因素对负荷分配计算结果的影响进行了比较... 详细信息

提出了基于动态规划法的汽轮发电机组负荷分配的优化模型,该模型考虑了机组主要部件的低周疲劳寿命损耗、机组的最小运行时间和最小停机时间、负荷最大爬升和降负荷速度限制等约束条件,并对各种因素对负荷分配计算结果的影响进行了比较分析.文中以一个具有4台300MW机组的电厂作为运行单元,考虑运行单元内部的各种费用,并将其折合成标准煤耗量.计算结果表明,采用这种负荷分配模型,在满足电网调度负荷的前提下,可以降低煤耗率3g/(kW·h).

关键词：汽轮机组负荷分配动态规划优化

Synthesis of New Chiral Phosphine Ligands and Their Application in Asymmetric Hydrogenation of Ketones

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合成化学 2004年第Z1期12卷 24-24页

作者： XIE jian-hua fu Yu WANG Li-Xin ZHOU Qi-Lin State Key Laboratory and Institute of Elemento-organic Chemistry Nankai University Tianjin 300071 China State Key Laboratory and Institute of Elemento-organic Chemistry Nankai University Tianjin 300071 China State Key Laboratory and Institute of Elemento-organic Chemistry Nankai University Tianjin 300071 China State Key Laboratory and Institute of Elemento-organic Chemistry Nankai University Tianjin 300071 China

The design of new chiral ligands is the key in the development of transition metal catalyzed asymmetric synthesis. Many chiral diphosphine ligands have been prepared and applied in asymmetric catalytic reactions with excellent enantioselectivities. Among the chiral diphosphine ligands that have been reported, the atropisomeric C2-symmetric phosphines with a biaryl scaffold initiated by Noyori and co-workers with BINAP were found to have the widest application in the transition metal catalyzed reactions. Planar chiral diphosphines based on ferrocene or paracyclophane backbones have also been applied to a number of reactions with a remarkable degree of success. However, the spiro diphosphine compounds, another type of axially chiral ligands, have not been synthesized yet. Recently, we designed chiral phosphoramidite ligands (SIPHOS)containing a 1, 1′-spirobiindane backbone and demonstrated that these ligands can be highly efficient for the Rh-catalyzed asymmetric hydrogenation of functionalized olefins. Especially, in the case of asymmetric hydrogenation of α-arylethenylamines, the spiro monophosphoramidite ligands provided a significantly higher level of enantiocontrol compared to that of the monophosphoramidite ligands derived from BINOL. Herein we present the synthesis of spiro diphosphines (SDP) containing 1,1′-spirobiindane as a new chiral scaffold and their application in the ruthenium-catalyzed asymmetric hydrogenation of simple ketones with high activity (S/C up to 100 000) and excellent enantioselectivity (ee up to 99.5%).

关键词： Chiral phosphine, asymnetric hydrogenation.

Stepwise assembly to construct stable copper(I) cluster-based circularly polarized luminescent MOFs

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Science China Chemistry 2025年

作者： Jing-Wen Xie Meng-Ting Wang Yan Jin Si Li jian-hua Qin Shuang-Quan Zang Tomas C.W.Mak College of Chemistry Henan Key Laboratory of Crystalline Molecular Functional Materials Zhengzhou University College of Chemistry and Chemical Engineering Luoyang Normal University Department of Chemistry The Chinese University of Hong Kong

Circularly polarized luminescence （CPL） materials have been extensively studied in recent years owing to their widespread applications in 3D display,optical storage,optical anti-counterfeiting,and biological imaging,***（I） clusters have emerged as a promising candidate for CPL materials,driven by their cost-effectiveness,superior luminescent properties,precise structure,and low ***,the poor environmental stability of copper（I） clusters renders their synthesis and preservation challenging,thereby significantly impeding their ***,we have designed and synthesised a chiral double-coordinated ligand in order to construct copper（I） cluster nodes that can be further *** anticipated,by utilizing stepwise assembly strategy,a Cu4cluster node co-modified by chiral alkynyl ligands and triphenylphosphine was further assembled with Cd2+ions to obtain 2D layers structure,L/*** L/D-Cu4-Cd exhibits excellent stability and optical properties,including bright yellow emission,solvent-responsive luminescence,and CPL activity with a maximum glumup to 2.0×10-3,which shows potential applications in the WLED and *** interestingly,the material also exhibits deflection ability towards different wavelengths of linearly polarized light,showing certain potential in the preparation of circular polarizer.

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