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Neuroscience Bulletin 2006年第1期22卷 14-20页

作者： hong-Jun YANG San-Jue HU Pu-Lin GONG jian-hong duan Department of neurology Guangzhou Liuhuaqiao Hospital Guangzhou 50010 China Institute of Neuroscience The Fourth Military Medical University Xi＇an 710032 China Department of Engineering Mechanics Xi＇an Jiaotong University Xi＇an 710049 China

Objective The relationship between compressed dorsal root ganglion （DRG） neurons and firing pattern and sensitivity of neurons was studied in chronically the Hindmarsh-Rose （HR） neuronal model. Methods Spontane- ous activities from single fibers of chronically compressed DRG neurons in rats were recorded, and divided into periodic and non-periodic firing patterns. The sensitivity of the two kinds of firing pattern neuron to sympathetic stimulation （SS） was compared. Result It was found that 27.3% of periodic firing neurons and 93.2% of non-periodic firing neurons responded to SS respectively （ periodic vs non-periodic, P 〈 0.01 ）. The responses to SS with different stimulation time were greater non-periodic firing neurons than periodic firing neurons （P 〈 0.01 ）. The non-periodic firing neurons obviously responded to SS. After the firing pattern of these neurons transformed to periodic firing pattern, their responses to SS disappeared or decreased obviously. The HR neuronal model exhibited a significantly greater response to perturbation in non-periodic （chaotic） firing pattern than in periodic firing pattern. Conelusion The non-periodic firing neurons with deterministic chaos are more sensitive to external stimuli than the periodic firing neurons.

关键词： dorsal root ganglion Hindmarsh-Rose neuronal model spontaneous activity sympathetic stimulation sensitivity chaos

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu hong-Wei Li jian-hong Shi Tan Li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

The pharmacological characterization of martentoxin on glioma BK channels

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The pharmacological characterization of martentoxin on gliom...

Stable copper boron–imidazolate cage as Cu-riched enzyme for highly efficient electrocatalytic CO2 reduction to ethylene

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Ying CHEN,jian SHI,Yan-hong duan,Lei Zhong,Yong-Hua JI School of Life Sciences,Shanghai University,Shanghai 200444,China

Martentoxin as a 37 residues peptide purified from the venom of Chinese scorpion Buthus martensi Karch(BmK) was capable of blocking large-conductance Ca-activated K(BK) channels in adrenal medulla chromaffin cells with a great *** the present study,the pharmacological effect of martentoxin on glioma BK channels(gBK),which was a splice variant of hsloαsubunits,was investigated through the electrophysiological *** results revealed that gBK were blocked by martentoxin in the absence of cytosolic Ca The inhibitory effect of martentoxin on gBK was conversed to an enhancive effect in the presence of cytosolic *** enhancement occurred without voltage-dependence but ***,martentoxin could decrease the inhibitory effect of iberiotoxin or tetrabutylammonium chloride on gBK with free Ca in the *** imaging showed that martentoxin could not evoke the oscillation of cytoplasmic Ca concentration and excluded the possible influence of martentoxin on cytosolic Ca. Therefore,the results suggested that the pharmacological effect of martentoxin on gBK was decided by cytosolic Ca and the interaction site of gBK for martentoxin might be different from that for Ibtx or tetrabutylammonium *** present study shed light on a novel mode for the interaction between neurotoxins and K channels and may provide a potential design for the BK channel-specific tool.

关键词： BK channel glioma martentoxin calcium sensitivity iberiotoxin

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Science China Chemistry 2025年

作者： Jun-Qiang Chen Qiao-hong Li Qin-Long hong Ping Shao Hai-Xia Zhang jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Single-atom catalyst has garnered widespread attention to mimic mature enzymes due to its well-defined atomic structure and coordination environments. However, since the carbon–carbon（C–C） coupling reactions require synergistic catalysis of multiple sites, single-atom catalysts suffer from insufficient active sites and unclear reaction mechanisms. Controlling the reaction intermediates in a precisely targeted pocket through careful metal–organic cage design is therefore crucial. Here, we prepare a tetrahedral [Cu6L4]-type boron–imidazolate cage integrating highly active Cu sites and optimized cavity, which exhibits enzyme like specific catalytic performance in electrochemical CO2reduction reaction（CO2RR） to enhance the selectivity of *** analyses and computational calculations suggest that the single Cu site together with neighboring boron–imidazolate ligands provides suitably synergistic effects that enable the energetically favorable formation of an *COCHO intermediate, a key step determining selectivity. As a result, the [Cu6L4]-type cage of BIC-145 achieves a Faradaic efficiency of 28% for C2H4maintaining an average current density of -3.54 mA cm-2over a 5-hour electrolysis period. This work represents the first example for studying single-metal site catalysts with ultra-low coordination numbers through the rational design of metal–organic cages.

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang jian Wu Hui hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Classification of excitability in DRG neurons and it’s transition in CCD model

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Classification of excitability in DRG neurons and it’s tran...

Reduced conduction failure of the main axon of polymodal nociceptive C-fibres contributes to painful diabetic neuropathy in rats

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Rao-Gang XIE,jian-hong duan,Wen-Ting WANG,Yi-Hui LIU,Jun-Ling XING~*,San-Jue HU~* Institute of Neuroscience,Fourth Military Medical University,Xi''an 710032,China

＜正＞Objective Exploring whether the DRG neurons could be devided into different excitability *** could happen after injury during the development of neuropathic *** The whole DRG were prepared after digested with collagenase and *** the current mode,the neurons were classified into 3 classes according to their nonlinear property responded to the current *** 4-Aβsensitive potassium current（14-Aβ） as well as the persistent sodium current（INaP）were checked in each group and were compared among ***（1） Basically,3 classes of excitability could be *** 1 neurons responded to depolarizing current steps with a firing frequencies that varied almost linearly with the intensity of injected current,a higher and higher firing frequency occurred during the ramp *** 2 neurons had a constant firing frequency that was independent of the intensity of injected current and during the ramp stimulation,subthreshold membrane oscillation usually could be observed before the production of the *** in class 3 neurons,current injection as high as 1 nA or more evoked only a single spike,when given a ramp stimulation,no spikes could be *** normal rats with a total number of 179,cells were obtained with 13%of Class 1 （twenty-seven percent of Class 2） and sixty percent of Class 3.（2） A kind of neuropathic pain model-CCD model,which mimicks the clinical intervertebral foramen stenosis or proceding of intervertibral disc,were used for our next investigation. During the period of 2-7 days after CCD model,a significant decrease of hind-paw withdraw threshold were observed comparing to those in normal animal（3.72±0.42 g,n=44 vs 24.42±2.19 g,n=35）.And in CCD group with a total number of 134 ,the ratio was 27%,33%,and 40%for Class 1,2,3 *** a significant increase ratio for Class 1 and decrease for Class 3 were found.（3）Current examination on CCD model showed that:14-Aβcurrent in Class 3 was higher than t

关键词： neuropathic pain dorsal root ganglion neuronal classification 4-AP sensitive potassium current the persistent sodium current

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Reduced conduction failure of the main axon of polymodal noc...

中国生理学会张锡钧基金第十二届全国青年优秀生理学学术论文交流及评奖会议

作者： Wei Sun Bei Miao Xiu-Chao Wang jian-hong duan Wen-Ting Wang Fang Kuang Rou-Gang Xie Jun-Ling Xing Hui Xu Xue-Jun Song Ceng Luo San-Jue Hu Institute of Neuroscience Fourth Military Medical University Department of Neurobiology Parker University Research Institute

Painful diabetic neuropathy is a common complication of diabetes mellitus and can affect many aspects of life and severely limit patients’ daily *** of painful diabetic neuropathy are believed to originate in the peripheral nervous ***,its peripheral mechanism of hyperalgesia has remained *** studies have accumulated that polymodal nociceptive

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移动信息接收机的研制

通信学报 2004年第12期25卷 176-178页

作者：杨虹支凌云郑建宏段红光王汝言肖军重庆邮电学院重庆400065

介绍了一种新型的通信传媒设备,详细介绍了该接收机的工作机理、结构、功能特点以及软硬件的设计思路。

关键词：移动信息接收机机无线接收广播汉字显示

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao hongmei duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-hongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

A new benzylisoquinoline alkaloid from stems of Nelumbo nucifera

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Chinese Chemical Letters 2008年第3期19卷 308-310页

作者： Xu hong duan jian Qin jiang Department of Natural Medicine Chemistry China Pharmaceutical University Nanjing 210038 China

A new benzylisoquinoline alkaloid, named nelumstemine （1）, 1-（4＇-hydroxybenzoyl）-6,7-dimethoxy-3,4-dihydroisoquinoline, was isolated from the stems of Nelumbo nucifera Geartn. Its structure was established on the... 详细信息

关键词： Nelumbo nucifera Geartn Nelumstemine Dihydroisoquinoline Benzylisoquinoline alkaloids