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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting li Wei Zhang jian Wu Hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

主冷却剂流量连续变化调节反应堆功率可行性研究

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船海工程 2013年第1期42卷 160-162页

作者：罗诚王少明郝建立海军工程大学武汉430033

通过建立主冷却剂流量连续变化调节反应堆功率仿真模型,引入二回路负荷变化,对核反应堆热工水力瞬态过程进行分析研究,并与控制棒调节功率方案进行对比。结果表明:在低功率运行工况下,通过连续改变主冷却剂流量能够实现反应堆功率的调节... 详细信息

通过建立主冷却剂流量连续变化调节反应堆功率仿真模型,引入二回路负荷变化,对核反应堆热工水力瞬态过程进行分析研究,并与控制棒调节功率方案进行对比。结果表明:在低功率运行工况下,通过连续改变主冷却剂流量能够实现反应堆功率的调节,并满足反应堆热工安全性和机动性的要求。

关键词：核动力装置主冷却剂流量连续变化运行安全

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三通道偏振成像系统的标定研究

科学技术与工程 2016年第36期16卷 161-165页

作者：梁建琦闫皓李涛杨江涛王晨光唐军中北大学电子测试技术国家重点实验室太原030051

针对现有偏振成像系统无法对天空进行实时性检测的问题,提出一种实时三通道偏振成像系统。对系统存在的误差来源进行详细分析并针对相应误差提出标定方法。利用积分球对CCD线性度进行标定,通过对采集灰度信息的处理,得出光源亮度与图像... 详细信息

针对现有偏振成像系统无法对天空进行实时性检测的问题,提出一种实时三通道偏振成像系统。对系统存在的误差来源进行详细分析并针对相应误差提出标定方法。利用积分球对CCD线性度进行标定,通过对采集灰度信息的处理,得出光源亮度与图像灰度呈线性关系;同时针对三路独立通道之间灰度响应不一致问题,利用积分球产生完全非偏振光对灰度响应非一致性误差进行了多次重复标定与校正。标定实验结果表明,通过对CCD线性度标定和灰度响应不一致性的标定,灰度响应不一致性得到了明显改善,提高了偏振信息的解析精度,系统偏振角测量误差小于0.6%。

关键词：偏振积分球 CCD标定非一致性校正误差

观测低高度太阳方位计算罗经差的软件程序设计

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武汉船舶职业技术学院学报 2009年第4期8卷 40-43页

作者：李红祥吴建华李昊武汉理工大学航运学院湖北武汉430063

通过观测低高度太阳方位计算罗经差是船舶在开阔大洋上航行时求罗经差常用的方法,为了能更加方便、快捷并且准确地求出罗经差,本文在基于Visual Basic(VB)环境的下设计开发了计算罗经差的Visual Basic(VB)软件程序。该软件程序可将观测... 详细信息

通过观测低高度太阳方位计算罗经差是船舶在开阔大洋上航行时求罗经差常用的方法,为了能更加方便、快捷并且准确地求出罗经差,本文在基于Visual Basic(VB)环境的下设计开发了计算罗经差的Visual Basic(VB)软件程序。该软件程序可将观测及查表计算所得的数据直接输入,避免将所得数据类型进行转化再代入公式计算的繁锁,该软件程序能够减小求罗经差的计算量,提高求罗经差的速度、精度及准确率。通过与一般计算器求罗经差的实例进行对照,证明了该软件程序的实用性及应用该软件程序的优越性。

关键词：天体赤纬天体地方时角罗方位 VisualBasic(VB)

Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can li Zi-Jia hao Xu-Ya Chai Pei-Sai li Yang liu li-Xia liu Ying Xu Pan-Pan Yang ling-E li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (lity rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

Theoretical and experimental investigation on novel 2D maglev servo proportional valve

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Chinese Journal of Aeronautics 2021年第4期34卷 416-431页

作者： Bin MENG hao XU jian RUAN Sheng li Key Laboratory of Special Purpose Equipment and Advanced Manufacturing Technology Ministry of Education Zhejiang University of TechnologyHangzhou 310018China

This paper presents a novel two-dimensional maglev servo proportional cartridge valve(2 D maglev valve),where a contactless maglev coupling is introduced between electro-mechanical converter and valve body to realize functions of force transmission,spool position feedback and linear-rotary motion *** configuration can effectively reduce cost of both valve manufacturing and electro-mechanical converter,while still maintain features of 2 D valve such as null pilot leakage,high power-to-weight ratio and excellent anti-pollution ***,the characteristic equation of the valve is derived using linear theory,and the stability criterion is established for parameter *** influences of crucial structural parameters such as initial height of overlapping area,width of high-pressure and low-pressure holes,acting radius of magnetic force,pitch angle of maglev coupling,length of sensitive chamber and system pressure on the dynamic response are investigated based on AMESim numerical *** prototype valve is then designed and manufactured and a special test rig is *** no-load flow characteristic,load flow characteristic,leakage characteristic,amplitude and phase frequency characteristics and step response under different system pressures are *** experimental results are in a good agreement with the simulated *** an over-damped system,the prototype valve has excellent working stability,which can reach a no-load flow rate of 105.9 L/min with hysteresis of 3.51%,amplitude bandwidth of 28.7 Hz and phase bandwidth of 42.8 Hz under 21 *** research indicates that the 2 D maglev valve can be a potential solution of flow rate control valve for flight control surface system of civil aircraft with high pressure and large flow rate application.

关键词： Dynamic characteristic 2D valve Maglev coupling Servo proportional valve Stability criterion

Fabrication and characterization of superconducting RSFQ circuits

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Rare Metals 2019年第10期38卷 899-904页

作者： Gang li hao li jian-She liu Wei Chen Tsinghua National Laboratory for Information Science and Technology Institute of MicroelectronicsDepartment of Microelectronics and NanoelectronicsTsinghua University

To meet the specification of the qubits in our laboratory,a 0.4 kA·cm^-2 superconducting rapid single flux quantum(RSFQ) circuit was designed and successfully fabricated with an improved Nb-based self-aligned lift-off *** circuit consists of a single-fluxquantum(SFQ) pulse generator,a Josephson transmission line(JTL) and a T-flip flop(TFF),and it acts as a frequency *** values of the inductors in this circuit were extracted using InductEX and the basic function of this circuit was confirmed using the simulation software WRspice before *** fabrication,the basic parameters of this circuit were measured at ~2.5 K in a Janis He-3 *** work laid the theoretical and experimental basis for the future research on the RSFQqubit control circuits.

关键词： Rapid single flux quantum Frequency divider WRspice InductEX

后路C_(2-3)固定结合顶棒置入与单纯后路C_(2-3)固定治疗不稳定Hangman骨折的比较

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中国组织工程研究 2025年第9期29卷 1848-1854页

作者：张浩王清张建李广州王高举西南医科大学附属医院骨科四川省泸州市646000

背景:Hangman骨折中Ⅱ、ⅡA、Ⅲ型常需手术治疗,手术方式选择存在较大争议,目前均存在术后复位不全及畸形愈合等不足;前期作者团队使用C_(2-3)拉力螺钉结合经口顶棒技术间歇性推顶C2椎体治疗不稳定Hangman骨折,取得了满意的临床疗效,但... 详细信息

背景:Hangman骨折中Ⅱ、ⅡA、Ⅲ型常需手术治疗,手术方式选择存在较大争议,目前均存在术后复位不全及畸形愈合等不足;前期作者团队使用C_(2-3)拉力螺钉结合经口顶棒技术间歇性推顶C2椎体治疗不稳定Hangman骨折,取得了满意的临床疗效,但前期研究样本少,且缺少对照组比较。目的:比较后路C_(2-3)固定结合经口顶棒技术和单纯后路C_(2-3)固定治疗不稳定Hangman骨折的临床疗效。方法:回顾性分析西南医科大学附属医院收治的行后路C_(2-3)固定手术治疗的55例不稳定Hangman骨折患者临床及影像学资料,根据手术方案分为2组,其中23例患者接受后路C_(2-3)固定结合经口顶棒技术治疗(A组),32例接受单纯后路C_(2-3)固定术(B组)。比较两组患者的手术时间、术中出血量、并发症、术前及末次随访时疼痛目测类比评分、颈椎功能障碍指数、美国脊髓损伤协会脊髓损伤分级和患者满意度(Odom’s分级);另外对比各观察时间点C_(2-3)移位和成角及其他影像学指标的变化。结果与结论:①两组患者手术时间、术中出血量和术后并发症发生情况比较差异无显著性意义(P>0.05);②两组患者末次随访颈痛目测类比评分和颈椎功能障碍指数较术前获得显著改善(P0.05);③两组术前C_(2-3)成角和位移差异无显著性意义(P>0.05);术后及末次随访时,两组患者C_(2-3)成角和位移均较术前明显减小,差异有显著性意义(P0.05);术后及末次随访时,A组C_(2-3)位移和成角较B组明显减小,差异有显著性意义(P<0.05);④末次随访时,A组患者均未发生残余畸形,B组发生残余畸形4例(13%,4/32);⑤因此,后路C_(2-3)固定结合经口顶棒技术可能有利于枢椎体复位和稳定,减少畸形愈合,获得更好的复位。

关键词： Hangman骨折顶棒技术后路拉力螺钉骨折复位内固定

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第01期 369-376页

作者： Song-Meng Wang hao Nian Yan-Fang Wang li-Shuo Zheng Yu-Tao Zheng Yi-Wei Dong liping Huang Xiaoping Wang Wei jiang liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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