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Effect of lactulose on establishment of a rat non-alcoholic steatohepatitis model

World Journal of Gastroenterology 2005年第32期11卷 5053-5056页

作者： jian-gao fan zheng-jie xu guo-liang wang Department of Gastroenterology Shanghai First People's Hospital Jiaotong University Shanghai 200080 China

AIM： To explore the relationship between changes of intestinal environment and pathogenesis of non-alcoholic steatohepatitis （NASH）. METHODS： Forty-two Sprague-Dawley rats were randomly dMded into model group （n = 24）, treatment group （n = 12）, and control group （n = 6）. The rats of model and treatment groups were given high-fat diet, and those of the control group were given normal diet. Furthermore, the rats of treatment group were given lactulose after 8 wk of high-fat diet. Twelve rats of the model group were killed at 8 wk of high-fat diet. At the 16 wk the rats of treatment group, control group, and the rest of the model group were killed. The serum levels of aminotransferase were measured and the histology of livers was observed by H＆E staining. RESULTS： The livers of rats presented the pathological features of steatohepatitis with higher serum levels of alanine aminotransferase （ALT） and aspartate aminotransferase （AST） in the model group after 16 wk. Compared to the model group, the serum levels of ALT and AST in treatment group decreased significantly and were close to the normal group, and the hepatic inflammation scores also decreased markedly than those in the model group after 16 wk （5.83±2.02 vs 3.63±0.64, P〈0.05）, but were still higher than those in the model group after 8 wk （3.63±0.64 vs 1.98±0.90, P〈0.05）. However, the degree of hepatic steatosis had no changes in treatment group compared to the model group after 16 wk. CONCLUSION： Lactulose could ameliorate the hepatic inflammation of rats with steatohepatitis induced by fat- rich diet, but could not completely prevent the development of steatohepatitis. It is suggested that intestinal environmental changes such as intestinal bacteria overgrowth, are one of the important factors in the pathogenesis of NASH.

关键词： NASH Lactulose Intestinal environment

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The energy response of LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals for GECAM

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Nuclear Science and Techniques 2024年第2期35卷 110-122页

作者： Pei-Yi Feng Xi-Lei Sun zheng-Hua An Yong Deng Cheng-Er wang Huang jiang Jun-jie Li Da-Li Zhang Xin-Qiao Li Shao-Lin Xiong Chao zheng Ke Gong Sheng Yang Xiao-Jing Liu Min gao Xiang-Yang Wen Ya-Qing liu Yan-Bing xu Xiao-Yun Zhao Jia-Cong Liu fan Zhang Hong Lu Particle and Astrophysics Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Experimental Physics Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of South ChinaHengyang 421001China National Engineering Research Center for Rare Earth Grirem Advanced Materials Co.Ltd.and General Research Institute for Nonferrous MetalsBeijing 100088China

The GECAM series of satellites utilizes LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals as sensitive materials for gamma-ray detectors(GRDs).To investigate the nonlinearity in the detection of low-energy gamma rays and address the errors in the calibration of the E-C relationship,comprehensive tests and comparative studies of the three aforementioned crystals were conducted using Compton electrons,radioactive sources,and mono-energetic *** nonlinearity test results of the Compton electrons and X-rays demonstrated substantial differences,with all three crystals presenting a higher nonlinearity for X/-rays than for Compton *** the LaBr_(3)(Ce)and LaBr_(3)(Ce,Sr)crystals having higher absolute light yields,they exhibited a noticeable nonlinear decrease in the light yield,especially at energies below 400 *** NaI(Tl)crystal demonstrated an"excess"light output in the 6-200 keV range,reaching a maximum"excess"of 9.2%at 30 keV in the X-ray testing and up to 15.5%at 14 keV during Compton electron testing,indicating a significant advantage in the detection of low-energy gamma ***,we explored the underlying causes of the observed nonlinearity in these *** study not only elucidates the detector responses of GECAM,but also initiates a comprehensive investigation of the nonlinearity of domestically produced lanthanum bromide and sodium iodide crystals.

关键词： LaBr_(3)(Ce)detector LaBr_(3)(Ce,Sr)detector NaI(Tl)detector GECAM Energy response Light yield nonlinearity

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Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang Li Li‑Jiao wang Xiang‑Biao Qiu Jing‑Wen Li Wei xu Tao Li Ze‑Bin Lin Chang‑Jun Ning Yong‑Hao Chen Rui‑Rui fan Kang Sun Jing‑Yu Tang Rong Zhang Han‑Tao Jing Bo Mei Qi An Hao‑fan Bai jiang‑Bo Bai jie Bao Ping Cao Qi‑Ping Chen Zhen Chen Zeng‑Qi Cui An‑Chuan fan Chang‑Qing Feng fan‑Zhen Feng Ke‑Qing gao Min‑Hao Gu Chang‑Cai Han Zi‑jie Han guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei‑Hua Jia Hao‑Yu jiang Wei jiang Zhi‑jie jiang zheng‑Yao Jin Ling Kang Bo Li Chao Li Gong Li Jia‑Wen Li Xiao Li Yang Li jie Liu Rong Liu Shu‑Bin Liu Guang‑Yuan Luan Bin‑Bin Qi jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑Cheng wang Zhao‑Hui wang Zhong‑Wei Wen Xiao‑Guang Wu xuan Wu Li‑Kun Xie Yi‑Wei Yang Han Yi Yong‑Ji Yu guo‑Hui Zhang Lin‑Hao Zhang Mo‑Han Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑liang Zhang Yue Zhang Zhi‑Yong Zhang Mao‑Yuan Zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

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Diagnosis,treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children:experts'consensus statement updatedforthe Omicron variant

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World Journal of Pediatrics 2024年第3期20卷 272-286页

作者： Rong-Meng jiang zheng-De Xie Yi jiang Xiao-Xia Lu Run-Ming Jin Yue-jie zheng Yun-Xiao Shang Bao-Ping xu Zhi-Sheng Liu Gen Lu Ji-Kui Deng Guang-Hua Liu Xiao-Chuan wang jian-She wang Lu-Zhao Feng Wei Liu Yi zheng Sai-Nan Shu Min Lu Wan-Jun Luo Miao Liu Yu-Xia Cui Le-Ping Ye A-Dong Shen Gang Liu Li-Wei gao Li-Juan Xiong Yan Bai Li-Kai Lin Zhuang Wei Feng-Xia xue Tian-You wang Dong-Chi Zhao jian-Bo Shao Daniel Kwok-keung Ng Gary Wing-kin Wong zheng-Yan Zhao Xing-wang Li Yong-Hong Yang Kun-Ling Shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Pediatrics Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Respiratory Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Respiratory Shenzhen Children's HospitalShenzhen 518038China Department of Pediatric Respiratory Shengjing Hospital Affiliated to China Medical UniversityShenyang 110004China Department of Respiratory Beijing Children's HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China Department of Neurology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Respiratory Guangzhou Women and Children's Medical CenterGuangzhou 510623China Department of Infectious Diseases Shenzhen Children's HospitalShenzhen 518038China Department of Pediatrics Fujian Branch of Shanghai Children's Medical CenterFujian Children's HospitalFuzhou350005China Department of Clinical Immunology and Allergy Children's Hospital of Fudan UniversityNational Center for Children's HealthShanghai 201102China Department of Infectious Diseases Children's Hospital of Fudan UniversityNational Center for Children's Health.Shanghai

It has been more than 3 years since the novel coronavirus(SARS-CoV-2)pandemic raged *** coronavirus disease 2019(COVID-19)has greatly influenced human *** to data from the World Health Organization(WHO),there were ove... 详细信息

关键词： prevention infection statement

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Application of alginate in inflammatory bowel disease

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Biomedical Engineering Communications 2024年第2期3卷 10-16页

作者： Rui-xue Kang Ying Zhuang Ming-jie Liu Qi Han Wei-Li Zhang Wei-Yu fan xue gao Jia-zheng Zhou jian-Bin Zhang Collage of Pharmacy Dalian Medical UniversityDalian 116044China Laboratory Animal Center Dalian Medical UniversityDalian 116044China

Inflammatory bowel disease(IBD)represents a chronic inflammatory condition profoundly impacting the gastrointestinal *** prevalence has markedly risen in both developed and developing nations over recent *** the absence of definitive etiological elucidation,therapeutic strategies predominantly revolve around pharmacological interventions aimed at symptom ***(AG)is a polysaccharide of marine origin that has garnered significant attention due to its inherent biocompatibility,pH sensitivity,and *** exploration within drug delivery systems for IBD treatment stems from its natural sourcing,non-cytotoxic nature,and economic ***,AG demonstrates facile interpolymeric cross-linking,facilitating the formation of a cohesive network conducive to sustained drug release ***-based carrier systems for sustained drug release,and targeted drug delivery have been widely *** article reviews the pathogenesis of IBD and the current drugs,AG-based drug delivery systems and their properties in alleviating *** prospect of further development of AG in the field of biopharmaceutical and drug delivery is prospected.

关键词： alginate inflammatory bowel disease drug delivery

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Blocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2

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Science China Life Sciences 2024年

作者： Wenjie Li Wenyi Mei Hewei jiang jie wang Xiaoli Li Lina Quan Yanyan Diao Yanni Ma Sisi fan Zhuwei Xie Mengdie Gong Huan Zhu Dewen Bi Feng Zhang Lei Ma jian Zhang Yufeng gao Aris Paschalidis Honghuang Lin fangfang Liu Kangdong Liu Mingliang Ye Zhenjiang Zhao Yajun Duan Zhuo Chen Yufang xu Weilie Xiao Shengce Tao Lili Zhu Honglin Li Innovation Center for AI and Drug Discovery East China Normal University Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science&Technology Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine (Ministry of Education)Shanghai Jiao Tong University Lingang Laboratory Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationYunnan Characteristic Plant Extraction LaboratoryYunnan Provincial Center for Research&Development of Natural ProductsState Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanSchool of Pharmacy and School of Chemical Science and TechnologyYunnan University CAS Key Laboratory of Separation Sciences for Analytical Chemistry National Chromatographic R&A CenterDalian Institute of Chemical PhysicsChinese Academy of Sciences Department of Cardiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of China Department of Infectious Diseases The First Affiliated Hospital of Anhui Medical University Department of Medicine University of Massachusetts Chan Medical School Department of Pathophysiology School of Basic Medical SciencesAcademy of Medical ScienceCollege of MedicineZhengzhou University

Targeting the PD-1/PD-L1 axis with small-molecular inhibitors is a promising approach for immunotherapy. Here, we identify a natural pentacyclic triterpenoid, Pygenic Acid A(PA), as a PD-1 signaling inhibitor. PA exerts anti-tumor activity in hPD-1 knock-in C57BL/6 mice and enhances effector functions of T cells to promote immune responses by disrupting the PD-1 signaling transduction. Furthermore, we identify SHP-2 as the direct molecular target of PA for inhibiting the PD-1 signaling transduction. Subsequently, mechanistic studies suggest that PA binds to a new druggable site in the phosphorylated PD-1 ITSM recognition site of SHP-2, inhibiting the recruitment of SHP-2 by PD-1. Taken together, our findings demonstrate that PA has a potential application in cancer immunotherapy and occupying the phosphorylated ITSM recognition site of SHP-2 may serve as an alternative strategy to develop PD-1 signaling inhibitors. In addition, our success in target recognition provides a paradigm of target identification and confirmation for natural products.

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Calibration of the cryogenic measurement system of a resonant haloscope cavity

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Chinese Physics C 2024年第7期48卷 31-37页

作者：贺冬樊洁高昕高宇 Nick Houston 姬忠庆金贻荣李闯李金勉李田军刘世航牛家树彭智慧孙亮孙铮王佳卫镨先吴利娜相忠诚杨峤立张驰张文星张欣郑东宁郑瑞丰周建勇 Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Key Laboratory for Matter Microstructure and Function of Hunan ProvinceDepartment of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha 410081China Institute of Physics Chinese Academy of SciencesBeijing 100190China College of Physics Sichuan UniversityChengdu 610065China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Institute of Theoretical Physics Faculty of ScienceBeijing University of TechnologyBeijing 100124China Beijing Academy of Quantum Information Sciences Beijing 100193China College of Mechanical and Electrical Engineering Wuyi UniversityNanping 354300China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Institute of Theoretical Physics Shanxi UniversityTaiyuan 030006China College of Physics and Optoelectronic Engineering Department of PhysicsJinan UniversityGuangzhou 510632China School of Sciences Xi'an Technological UniversityXi'an 710021China Tsung-Dao Lee Institute and School of Physics and Astronomy Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China National Astronomical Observatories Chinese Academy of Sciences20ADatun RoadChaoyang DistrictBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

Possible light bosonic dark matter interactions with the Standard Model photon have been searched using microwave resonant *** this paper,we describe the cryogenic readout system calibration of a 7.138 GHz copper cavity with a loaded quality factor Q_(1)=10^(4)whose operation at a temperature of 22 mK is based on a dilution *** readout system consists of High Electron Mobility Transistors working as cryogenic amplifiers at 4 K,plus room-temperature amplifiers and a spectrum analyzer for signal power *** tested the system with a superconducting two-level system based on a single-photon source in the microwave frequency *** obtained an overall 95.6 dB system gain and–71.4 dB attenuation in the cavity's input *** effective noise temperature of the measurement system is 7.5 K.

关键词： dark matter superconducting two-level system Mollow triplet

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人参皂苷Re通过Nrf2/HO-1/PGC-1α通路调控线粒体生物发生减轻H9c2心肌细胞缺氧/复氧损伤的研究

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中国中药杂志 2024年第4期49卷 1064-1072页

作者：辛高杰陈原原刘子馨胥淑娟张会雨郭帆彭涵李磊韩笑刘建勋付建华中国中医科学院西苑医院基础医学研究所北京100091 国家中医心血管病临床医学研究中心北京100091

该文探讨了人参皂苷Re通过核因子E2相关因子2(nuclear factor-erythroid 2-related factor 2,Nrf2)/血红素氧合酶-1(heme oxidase-1,HO-1)/过氧化物增殖体激活受体γ共激活因子-1α(PGC-1α)调控线粒体生物发生减轻H9c2细胞缺氧/复氧(hypoxia/reoxygenation,H/R)损伤的机制。将H9c2细胞缺氧培养4 h再复氧培养2 h构建心肌细胞H/R损伤模型。Re预给药干预后,首先检测细胞活性、超氧化物歧化酶(superoxide dismutase,SOD)活性、丙二醛(malondialdehyde,MDA)含量、细胞内活性氧(Cyto-ROS)和线粒体内活性氧(Mito-ROS)水平,评估Re通过抗氧化应激对H9c2细胞H/R损伤的保护作用。其次通过荧光探针检测线粒体膜电位(mitochondrial membrane potential,ΔΨ_(m))、线粒体膜通透性开放孔(membrane permeability open pore,mPTP)变化情况,通过免疫荧光检测TOM20表达水平,研究Re对线粒体的保护作用。进一步用免疫印迹检测caspase-3、cleaved caspase-3、Cyto C、Nrf2、HO-1、PGC-1α蛋白表达水平,探讨Re抗氧化应激保护线粒体减轻H/R损伤的具体机制。结果显示,与模型组相比,Re有效减轻H9c2细胞H/R损伤氧化应激反应,Re可显著升高细胞中SOD活性,降低MDA含量,降低Cyto-ROS和Mito-ROS水平;Re对线粒体有较好保护作用,升高ΔΨ_(m),降低mPTP开放,升高TOM20表达;进一步研究表明Re促进Nrf2、HO-1、PGC-1α蛋白表达,降低凋亡相关调节因子caspase-3向cleaved caspase-3活化、Cyto C蛋白表达。综上所述,人参皂苷Re减轻H9c2细胞H/R损伤的具体机制与通过Nrf2/HO-1/PGC-1α通路促进线粒体生物发生,进而升高线粒体数量、改善线粒体功能,增强细胞抗氧化应激能力,减轻细胞凋亡有关。

关键词：人参皂苷Re 线粒体生物发生 Nrf2/HO-1/PGC-1α 缺氧/复氧损伤氧化应激

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Etiology and management of liver injury in patients with COVID-19

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World Journal of Gastroenterology 2020年第32期26卷 4753-4762页

作者： Rui-xu Yang Rui-Dan zheng jian-gao fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Diagnosis and Treatment Center for Liver Diseases Zhengxing HospitalZhangzhou 363000Fujian ProvinceChina Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China

The outbreak of novel coronavirus disease 2019(COVID-19)has resulted in global *** the expansion of related research,in addition to respiratory symptoms,digestive system involvement such as nausea,vomiting,and diarrhea have also been reported with ***,abnormal liver function is also frequent in biochemical tests of COVID-19 patients,which is correlated with the severity and mortality of the disease *** etiology of liver injury in patients with COVID-19 might include viral immunologic injury,drug-induced liver injury,the systemic inflammatory response,hypoxic hepatitis,and the exacerbation of preexisting liver *** liver injuries in COVID-19 are often transient and reversible,health workers need to pay attention to preexisting liver disease,monitor liver function,strengthen supportive treatment,and reduce the chance of drug-induced liver *** article reviews the epidemiological characteristics,etiology,management,and preventive strategies for liver injury in patients with COVID-19.

关键词： COVID-19 SARS-CoV-2 Coronavirus Liver injury Function test,Liver Etiology

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A mixed blessing for liver transplantation patients—Rapamycin

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Hepatobiliary & Pancreatic Diseases International 2023年第1期22卷 14-21页

作者： Guang-Han fan Chen-Zhi Zhang Feng-Qiang gao xu-Yong Wei Sun-Bin Ling Kai wang jian-guo wang Shu-Sen zheng Mehrdad Nikfarjam Xiao xu Department of Hepatobiliary and Pancreatic Surgery Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China Zhejiang University School of Medicine Hangzhou 310058China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Hangzhou 310006China Institute of Organ Transplantation Zhejiang UniversityHangzhou 310003China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University CancerGuangzhou 510060China Westlake Laboratory of Life Sciences and Biomedicine Hangzhou 310024China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalHangzhou 310000China NHC Key Laboratory of Combined Multi-Organ Transplantation Hangzhou 310003China Department of Surgery University of MelbourneAustin HealthHeidelbergVIC 3084Australia

Background:Liver transplantation(LT)is an effective treatment option for end-stage liver *** target of rapamycin(m TOR)inhibitors,such as rapamycin,are widely used post *** sources:In this review,we focused on the anti-cancer activities and metabolic side effects of rapamycin after *** literature available on Pub Med for the period of January 1999-September 2022 was *** key words were rapamycin,sirolimus,liver transplantation,hepatocellular carcinoma,diabetes,and lipid metabolism ***:Rapamycin has shown excellent effects and is safer than other immunosuppressive *** has exhibited excellent anti-cancer activity and has the potential in preventing hepatocellular carcinoma(HCC)recurrence post *** is closely related to two long-term complications after LT,diabetes and lipid metabolism ***:Rapamycin prevents HCC recurrence post LT in some patients,but it also induces metabolic *** use of rapamycin benefits the liver recipients.

关键词： Liver transplantation Rapamycin Metabolic disease Hepatocellular carcinoma Tumor recurrence

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