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The gender difference of utilization of cardiac implantable electronic device in China： data from Arrhythmia Interventional Therapy Data Registry

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Journal of Geriatric Cardiology 2018年第4期15卷 310-314页

作者： Ruo-Han CHEN Ke-Ping CHEN Wei HUA Jing XU Lin CHEN Yang-gang SU Xi SU jian-gang zou Ji YAN Jing-Feng WANG Bao-Peng TANG Mei-Xiang XIANG Shu ZHANG Center of Arrhythmia Fuwai Hospital Chinese Academy of Medical Sciences Peking union Medical College Beijing China Department of Cardiology Tian Jing Chest Hospital Tianjing China Department of Cardiology FuJian Provincial Hospital Fuzhou China Department of Cardiology ZhongShan Hospital FuDang University Shanghai China Department of Cardiology WuHan Asia Cardiology Hospital Wuhan China Department of Cardiology the Ftrst Affiliated Hospital of Nangjing Medical University NanJing China Department of Cardiology AnHui Provincial Hospital Hefei China Department of Cardiology Sun- Yat-Sen Memorial Hospital Guangzhou China Department of Cardiology the First Affiliated Hospital of Xinjiang Medical University Urumichi China Department of Cardiology the Second Affiliated Hospital of Zhejiang University of School of Medical Hangzhou China

Background Cardiac implantable electronic devices （CIEDs） greatly improve survival and life quality of patients. However, there are gender differences regarding both the utilization and benefit of these devices. In this prospective CIED registry, we aim to appraise the gender differences in CIED utilization in China. Methods Twenty centers from 14 provinces in China were included in our registry study. All patients who underwent a CIED implantation in these twenty centers between Jan 2015 and Dec 2016 were included. Results A total of 8570 patients were enrolled in the baseline cohort, including 7203 pacemaker, 664 implantable cardiac defibrillators （ICD） implants and 703 cardiac resynchronization therapy device （CRT/D）. Totally, 4117 （48.0%） CIED patients were female, and more than 59% pacemaker patients were female, but women account only one third of ICD or CRT/D implantation in this registry. There were significant differences between genders at pacemaker and ICD indications. Female was more likely received a pacemaker due to sick sinus syndrome （SSS）（63.9% vs. 51.0%, P 〈 0.001）. Female patients receiving an ICD were more likely due to cardiac ion channel disease （29.2% vs. 4.2%, P 〈 0.001）. The percentage of utilization of dual-chamber pacemaker in female patients was significantly higher than male （85.3% vs. 81.1%, P 〈 0.001）. But male patients were more likely received a cardiac resynchronization therapy devices with defibrillator than female （56.5% vs. 41.9%, P = 0.001）. In pacemaker patient, male was more likely to have structure heart disease （31.3% vs. 28.0%, P = 0.002）. In ICD patient, male patients were more likely to have ischemic heart disease （48.2% vs. 29.2%, P 〈 0.001）. The mean age of women at the time of CRT/D implantation was older than men （P = 0.014）. Nonischemic cardiomyopathy （70.9%） was the most common etiology in the patients who underwent the treat？ment of CRT/D, no matter male or female. Conclusions In real-world setting, female do have

关键词： Cardiac implantable electronic devices Gender Registry

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A Simulation Study to Assess Impacts of Habitat-Dependent Parameters of Surplus Production Model on Stock Assessment of Chilean Jack Mackerel in the Southeast Pacific Ocean

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Journal of Ocean University of China 2025年第1期24卷 169-181页

作者： LI gang CAO Yangming CAO Jie CHEN Xinjun zou Xiaorong College of Marine Science Shanghai Ocean UniversityShanghai 201306China National Engineering Research Center for Oceanic Fisheries Shanghai 201306China The Key Laboratory of Sustainable Exploitation of Oceanic Fisheries Resources Ministry of EducationShanghai 201306China Department of Applied Ecology Center for Marine Sciences and TechnologyNorth Carolina State UniversityMorehead CityNC 28557USA

Pelagic fish are the most abundant species in upwelling regions,contributing 25%of total global fisheries ***-driven changes in the marine environment play a crucial role in their population *** Chilean jack mackerel(Trachurus murphyi)as an example,this study conducted simulations to quantify the impacts of environmental variations on the stock assessment.A habitat-based surplus production model was developed by integrating suitable habitat area into the model parameters carrying capacity(K)and intrinsic growth rate(r),with a suitable habitat area serving as the proxy for the environmental conditions for Chilean jack mackerel in the Southeast Pacific *** dynamics of Chilean jack mackerel stock and fisheries data were simulated,and four assessment models with different configurations were built to fit simulated data,with or without considering environmental *** results indicated that Joint K-r model,which integrated both parameters with the suitable habitat area index,outperformed the others by coming closest to the‘true'population *** habitat variations in the estimation model tended to overestimate biomass and underestimate harvest rate and reference *** observation and process error,the results were estimated with bias,while FMSY is relatively *** research illustrates the importance to consider random errors and environmental influences on populations,and provides foundation guidelines for future stock assessment.

关键词： Trachurus murphyi simulations suitable habitat area stock assessment errors Southeast Pacific Ocean

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Hypoxia reoxygenation induces premature senescence in neonatal SD rat cardiomyocytes

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Acta Pharmacologica Sinica 2007年第1期28卷 44-51页

作者： Feng-xiang ZHANG~2 Ming-long CHEN~2 Qi-jun SHAN jian-gang zou Chun CHEN Bing YANG Dong-jie XU Yu JIN Ke-jiang CAO~3 Department of Cardiology,First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China Department of Cardiology First Affiliated Hospital of Nanjing Medical University Nanjing China

Aim:To investigate whether hypoxia reoxygenation induces premature senes-cence in neonatal Sprague-Dawley(SD)rat ***:Cardio-myocytes were isolated from neonatal SD rat heart and identified by *** control cultures were incubated at 37℃ in a humidified atmo-sphere of 5% CO2and 95% *** hypoxic cultures were incubated in a modularincubator chamber filled with 1% O2,5% CO2,and balance N2for 6 *** reoxygen-ated cultures were subjected to 1% O2and 5% CO2 for 6 h,then 21% oxygen for 4,8,12,24,and 48 h,*** proliferation was determined using bromo-deoxyuridine *** ultrastructure of cardiomyocytes was observed byusing an electron microscope.β-Galactosidase activity was determined by usinga senescence β-galactosidase Staining Kit.p16INK4aand telomerase reverse tran-scriptase(TERT)mRNA levels were measured by real time quantitative *** expression was determined by *** activi-ties were assayed by using the Telo TAGGG Telomerase PCR ELISA(plus)***:The initial cultures consisted of pure cardiomyocytes identified by *** proportion of BrdU positive cells was reduced significantly in thehypoxia reoxygenation-treated group(P<0.01).Under the condition of hypoxiareoxygenation,mitochondrial dehydration appeared;p16INK4aand TERT mRNAlevels,β-galactosidase activity,TERT protein expression and telomerase activi-ties were all significantly increased(P<0.01 or P<0.05).Conclusion:These dataindicate that premature senescence could be induced in neonatal SD rat cardiomyo-cytes exposed to hypoxia *** TERT significantly increased,it could not block senescence.

关键词： cardiomyocytes hypoxia reoxygenation p16INK4a telomerase reverse transcriptase β-galactosidase

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Transition-metal-free isofunctional reaction of α,β-unsaturated ketones/nitriles

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Science China Chemistry 2025年第2期68卷 499-504页

作者： Runyou Ye Jialin Ming Qinyue Tao Tian-Yu Gao jian-Heng Ye Da-gang Yu Xiangge Zhou Key Laboratory of Green Chemistry&Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064China Inner Mongolia Key Laboratory of Fine Organic Synthesis Inner Mongolia UniversityHohhot 010021China

Isofunctional reactions involving the cleavage of carbon-carbon double bonds(C=C)hold an important position in organic synthesis,as they allow for the restructuring of alkene carbon chains and enable the exchange of functional groups without introducing exogenous ***,these reactions are primarily divided into C=C/C=C metathesis and C=C/C=O metathesis,with most relying on the use of transition metal *** report herein a C=C/CH_(2) metathesis reaction that obviates the need for transition metals and directing groups,and is characterized by economic and straightforward *** reaction not only facilitates the replacement of nitriles with ketones,but also enables the replacement of ketones with nitriles,demonstrating great universality.

关键词： isofunctional reaction transition-metal-free C=C cleavage base-promoted Michael addition

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Cardiac electrical and mechanical synchrony of super-responders to cardiac resynchronization therapy

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Chinese Medical Journal 2020年第2期133卷 141-147页

作者： Ke-Bei Li Zhi-Yong Qian Xue-Song Qian Yong Zhou Di-Di Zhu Yuan-Hao Qiu Yao Wang Xiao-Feng Hou jian-gang zou Yu-Feng Sheng Department of Cardiology The Affiliated Zhangjiagang Hospital of Soochow UniversityZhangjiagangJiangsu 215600China Department of Cardiology First Affiliated HospitalNanjing Medical UniversityNanjingJiangsu 210029China Department of Cardiology Zhongda Hospital Southeast UniversityNanjingJiangsu 210029China

Background:Super-responders(SRs)to cardiac resynchronization therapy(CRT)regain near-normal or normal cardiac *** extent of cardiac synchrony of SRs and whether continuous biventricular(BIV)pacing is needed remain *** aim of this study was to evaluate the cardiac electrical and mechanical synchrony of ***:We retrospectively analyzed CRT recipients between 2008 and 2016 in 2 centers to identify SRs,whose left ventricular(LV)ejection fraction was increased to≥50%at *** synchrony was evaluated in intrinsic and BIV-paced *** synchrony was estimated by QRS duration and LV mechanical synchrony by single-photon emission computed tomography myocardial perfusion ***:Seventeen SRs were included with LV ejection fraction increased from 33.0±4.6%to 59.3±6.3%.The intrinsic QRS duration after super-response was 148.8±30.0 ms,significantly shorter than baseline(174.8±11.9 ms,P=0.004,t=3.379)but longer than BIV-paced level(135.5±16.7 ms,P=0.042,t=2.211).Intrinsic LV mechanical synchrony significantly improved after super-response(phase standard deviation[PSD],51.1±16.5°vs.19.8±8.1°,P<0.001,t=5.726;phase histogram bandwidth(PHB),171.7±64.2°vs.60.5±22.9°,P<0.001,t=5.376)but was inferior to BIV-paced synchrony(PSD,19.8±8.1°vs.15.2±6.4°,P=0.005,t=3.414;PHB,60.5±22.9°vs.46.0±16.3°,P=0.009,t=3.136).Conclusions:SRs had significant improvements in cardiac electrical and LV mechanical *** intrinsic synchrony of SRs was still inferior to BIV-paced rhythm,continued BIV pacing is needed to maintain longstanding and synchronized contraction.

关键词： Cardiac resynchronization Super-responders Electrical synchrony Mechanical synchrony

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Microvolt T-wave alternans complemented with electrophysiologic study for prediction of ventricular tachyarrhythmias in patients with arrhythmogenic right ventricular cardiomyopathy: a long-term follow-up study

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Chinese Medical Journal 2019年第12期132卷 1406-1413页

作者： She-Liang Xue Xiao-Feng Hou Kang-Yun Sun Yao Wang Zhi-Yong Qian Quan-Peng Wang Si-Peng Shen Hong-Li Yin Rong Zhang Hai-Ping Yin jian-gang zou Department of Cardiology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Cardiology The Affiliated Wujin Hospital of Jiangsu UniversityChangzhouJiangsu 213002China Department of Cardiology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhouJiangsu 215008China Department of Biostatistics School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Key Laboratory of Targeted Intervention in Cardiovascular Disease Collaborative Inn ovation Center for Cardiovascular Disease Translational MedicineNanjing Medical University NanjingJiangsu 211166China

Background: The long-term predicted value of microvolt T-wave alternans (MTWA) for ventricular tachyarrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) remains unclear. Our study explored the characteristics of MTWA and its prognostic value when combined with an electrophysiologic study (EPS) in patients with ARVC. Methods: All patients underwent non-invasive MTWA examination with modified moving average (MMA) analysis and an EPS. A positive event was defined as the first occurrence of sudden cardiac death, documented sustained ventricular tachycardia (VT), ventricular fibrillation, or the administration of appropriate implantable cardioverter defibrillator therapy including shock or antitachycardia pacing. Results: Thirty-five patients with ARVC (age 38.6 ± 11.0 years;28 males) with preserved left ventricular (LV) function were recruited. The maximal TWA value (MaxValt) was 17.0 (11.0–27.0)μV. Sustained VT was induced in 22 patients by the EPS. During a median follow-up of 99.9 ± 7.7 months, 15 patients had positive clinical events. When inducible VT was combined with the MaxValt, the area under the curve improved from 0.739 to 0.797. The receiver operating characteristic curve showed that a MaxValt of 23.5 μV was the optimal cutoff value to identify positive events. The multivariate Cox regression model for survival showed that MTWA (MaxValt, hazard ratio [HR], 1.06;95% confidence interval [CI], 1.01–1.11;P = 0.01) and inducible VT (HR, 5.98;95% CI, 1.33–26.8;P = 0.01) independently predicted positive events in patients with ARVC. Conclusions: MTWA assessment with MMA analysis complemented by an EPS might provide improved prognostic ability in patients with ARVC with preserved LV function during long-term follow-up.

关键词： Modified moving average analysis Microvolt T-wave alternans Electrophysiologic study Ventricular tachyarrhythmia Arrhythmogenic right ventricular cardiomyopathy

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Construction of Ni single-atom coordinated with doped N and S elements for mild hydrogenation of methyl acrylate to methyl propionate

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Nano Research 2025年第1期18卷 217-224页

作者： Taolue Sun Chen jian gang Wang Hui Zhao Guoliang Zhang Zengxi Li Chunshan Li State Key Laboratory of Mesoscience and Engineering CAS Key Laboratory of Green Process and EngineeringBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Huizhou Institute of Green Energy and Advanced Materials Huizhou 516081China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516081China

Although the nickel-based catalyst is able toexhibit comparative catalytic activity to noble metal formethyl acrylate hydrogenation,it requires strict reactioncondition,which can be improved by regulation ofcoordination *** this study,we constructed akind of Ni single-atom coordinated with N and S(Ni-NSC)through the pyrolysis of organic Ni-based precursors at600℃.The existence and fine structure of Ni single-atom were confirmed by the spherical electron microscopicobservation in combination with the X-ray absorption spectroscopy(XAS)*** addition,the catalytichydrogenation assessment suggested that the as-prepared Ni-NSC catalyst exhibited higher activity and stability than theNi/NSC supported catalyst prepared by incipient wetness impregnation *** remarkable catalytic activity was dueto the high dispersion and density of Ni single-atom and weak adsorption energy of intermediates on these Ni sites.

关键词： methyl acrylate mild hydrogenation Ni single-atom coordination environment adsorption energy

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Topological rainbow trapping of sound waves in synthesized three-dimensional space for square lattice

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Chinese Physics B 2025年第2期34卷 309-314页

作者： Jie-Yu Lu Shi-Feng Li Xin Li Xin-Ye zou jian-Chun Cheng Key Laboratory of Modern Acoustics Ministry of Education(MOE)Institute of AcousticsDepartment of PhysicsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

The three-dimensional(3D)synthetic space offers a platform for exploring the valley Hall insulator,which is usually constructed in graphene ***,based on the valley transports in the square lattice,we construct a synthetic space by treating the rotation angle as the third dimension and observe the emergent Weyl points in this synthetic *** the construction of synthetic Weyl points results in the formation of edge states between the phononic crystal(PC)and the hard boundary,and the factors of rotation angle and the distance from the PC to the hard boundary affect the frequency of these edge states,we can construct topological rainbow concentrator based on the above *** conduct a comprehensive numerical and experimental study to explore the characteristics of topological rainbow *** work may play a driving role in the development of topological rainbow devices.

关键词： topological rainbow concentrator edge states square lattice

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Unveiling expression patterns,mechanisms,and therapeutic opportunities of transmembrane protein 106C:From pan-cancers to hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 144-162页

作者： jian-Di Li Rong-Quan He Yi-Wu Dang Zhi-Guang Huang Dan-Dan Xiong Lu Zhang Xiu-Fang Du gang Chen Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Although transmembrane protein 106C(TMEM106C)has been elucidated to be overexpressed in cancers,its underlying mechanisms have not yet been fully *** To investigate the expression levels and molecular mechanisms of TMEM106C across 34 different cancer types,including liver hepatocellular carcinoma(LIHC).METHODS We analyzed TMEM106C expression patterns in pan-cancers using microenvironment cell populations counter to evaluate its association with the tumor *** set enrichment analysis was conducted to identify molecular pathways related to *** immunoprecipitation followed by sequencing(ChIP-seq)analysis was conducted to identify upstream transcriptional regulators of *** LIHC,we examined mRNA profiles,performed in-house quantitative polymerase chain reaction,immunohistochemistry,and constructed a co-expression gene *** assays,including cell counting kit-8,cell cycle,apoptosis,migration,and invasion,were *** effect of nitidine chloride(NC)on LIHC xenograft was evaluated through RNA sequencing and molecular ***,potential therapeutic agents targeting TMEM106C were *** TMEM106C was significantly overexpressed in 27 different cancer types and presaged poor prognosis in four of these types,including *** pan-cancers,TMEM106C was inversely correlated to the abundances of immune and stromal ***,TMEM106C was significantly linked to cell cycle and DNA replication pathways in ***-seq analysis predicted CCCTC-binding factor as a pivotal transcriptional factor targeting the TMEM106C gene in *** analysis showed that TMEM106C was upregulated in 4657 LIHC compared with 3652 normal liver tissue[combined standardized mean difference=1.31(1.09,1.52)].Inhouse LIHC samples verified the expression status of *** TMEM106C expression signified worse survival conditions in LIHC patients treated with sorafenib,a tyrosin

关键词： Transmembrane protein 106C Pan-cancers Liver hepatocellular carcinoma Molecular biology Nitidine chloride

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Assessing the possibility of using large language models in ocular surface diseases

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 1-8页

作者： Qian Ling Zi-Song Xu Yan-Mei Zeng Qi Hong Xian-Zhe Qian Jin-Yu Hu Chong-gang Pei Hong Wei Jie zou Cheng Chen Xiao-Yu Wang Xu Chen Zhen-Kai Wu Yi Shao Department of Ophthalmology the First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburgNetherlands Changde Hospital Xiangya School of MedicineCentral South University(the First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai 200080China

AIM:To assess the possibility of using different large language models(LLMs)in ocular surface diseases by selecting five different LLMS to test their accuracy in answering specialized questions related to ocular surface diseases:ChatGPT-4,ChatGPT-3.5,Claude 2,PaLM2,and ***:A group of experienced ophthalmology professors were asked to develop a 100-question singlechoice question on ocular surface diseases designed to assess the performance of LLMs and human participants in answering ophthalmology specialty exam *** exam includes questions on the following topics:keratitis disease(20 questions),keratoconus,keratomalaciac,corneal dystrophy,corneal degeneration,erosive corneal ulcers,and corneal lesions associated with systemic diseases(20 questions),conjunctivitis disease(20 questions),trachoma,pterygoid and conjunctival tumor diseases(20 questions),and dry eye disease(20 questions).Then the total score of each LLMs and compared their mean score,mean correlation,variance,and confidence were ***:GPT-4 exhibited the highest performance in terms of *** the average scores of the LLMs group with the four human groups,chief physician,attending physician,regular trainee,and graduate student,it was found that except for ChatGPT-4,the total score of the rest of the LLMs is lower than that of the graduate student group,which had the lowest score in the human *** ChatGPT-4 and PaLM2 were more likely to give exact and correct answers,giving very little chance of an incorrect ***-4 showed higher credibility when answering questions,with a success rate of 59%,but gave the wrong answer to the question 28% of the ***:GPT-4 model exhibits excellent performance in both answer relevance and ***2 shows a positive correlation(up to 0.8)in terms of answer accuracy during the *** terms of answer confidence,PaLM2 is second only to GPT4 and surpasses Claude 2,SenseNova,and *** the fact t

关键词： ChatGPT-4.0 ChatGPT-3.5 large language models ocular surface diseases

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