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Valproic acid reduces autophagy and promotes functional recovery after spinal cord injury in rats

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Neuroscience Bulletin 2013年第4期29卷 484-492页

作者： Hai-Hu Hao Li Wang Zhi-jian guo Lang Bai Rui-Ping Zhang Wei-Bing Shuang Yi-Jia Jia Jie Wang Xiao-Yu Li Qiang Liu Department of Orthopaedics Dayi Hospital of Shanxi Medical University Department of Physiology Shanxi Medical University Department of Orthopaedics Taiyuan City Centre Hospital Department of Radiology First Hospital of Shanxi Medical University Department of Urology First Hospital of Shanxi Medical University

Secondary damage is a critical determinant of the functional outcome in patients with spinal cord injury （SCI）, and involves multiple mechanisms of which the most important is the loss of nerve cells mediated by multiple factors. Autophagy can result in cell death, and plays a key role in the development of SCI. It has been recognized that valproic acid （VPA） is neuroprotective in certain experimental animal models, however, the levels of autophagic changes in the process of neuroprotection by VPA treatment following SCI are still unknown. In the present study, we determined the extent of autophagy after VPA treatment in a rat model of SCI. We found that both the mRNA and protein levels of Beclin-1 and LC3 were significantly increased at 1, 2, and 6 h after SCI and peaked at 2 h; however, Western blot showed that autophagy was markedly decreased by VPA treatment at 2 h post-injury. Besides, post-SCI treatment with VPA improved the Basso-Beattie-Bresnahan scale, increased the number of ventral horn motoneurons, and reduced myelin sheath damage compared with vehicle-treated animals at 42 days after SCI. Together, our results demonstrated the characteristics of autophagy expression following SCI, and foundthat VPA reduced autophagy and enhanced motor function.

关键词： spinal cord injury autophagy valproicacid: LC3:Beclin-1

Mg-9Gd-3Y镁合金PEO工艺制备复相陶瓷层电化学腐蚀行为

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材料热处理学报 2014年第10期35卷 189-194页

作者：王萍王刚李建平杨忠郭永春西安工业大学陕西省光电功能材料与器件重点实验室陕西西安710021

采用等离子体电解氧化(PEO)工艺在Mg-9Gd-3Y镁合金表面制备了复相陶瓷层。通过微观结构分析及电化学测试技术研究了PEO陶瓷层的微观组织及腐蚀行为。结果表明,偏铝酸盐体系中PEO法制备的陶瓷涂层主要由MgO和MgAl2O4相组成,还有少量MgF2... 详细信息

采用等离子体电解氧化(PEO)工艺在Mg-9Gd-3Y镁合金表面制备了复相陶瓷层。通过微观结构分析及电化学测试技术研究了PEO陶瓷层的微观组织及腐蚀行为。结果表明,偏铝酸盐体系中PEO法制备的陶瓷涂层主要由MgO和MgAl2O4相组成,还有少量MgF2相,其中MgAl2O4尖晶石相约占陶瓷层的19.87%,且由非贯通的等离子体放电微孔与喷射沉积复相氧化物组成。浸泡初期,PEO陶瓷层表现出较好的耐蚀性;浸泡后期,陶瓷层腐蚀电流密度Icorr逐渐增大,陶瓷层电阻Rct快速减小,144 h后陶瓷层的保护能力迅速下降,且陶瓷层表面出现点蚀及裂纹萌生;浸泡过程中,交流阻抗谱由浸泡0~72 h的两个容抗弧转变为浸泡144~300 h的单容抗弧和感抗弧组成,表明腐蚀介质已渗透整个陶瓷层,并萌生点蚀。腐蚀产物主要由Mg(OH)2相组成。陶瓷层的腐蚀主要由等离子体放电微孔开始,逐渐向四周蔓延并形成放射状裂纹而加速腐蚀。

关键词： Mg-Gd-Y合金等离子体电解氧化(PEO) 陶瓷层电化学腐蚀极化曲线交流阻抗

sPLA2-IB Level Correlates with Hyperlipidemia and the Prognosis of Idiopathic Membranous Nephropathy

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Current Medical Science 2020年第4期40卷 683-690页

作者： Li-yan YANG Yuan-sheng WU Bin-bin DAI Song-hua LIN Hong CHEN guo-ping LI Xuan TAO jian-xin WAN Yang-bin PAN Department of Nephrology the First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005China Shanghai Pudong Hospital Fudan University Pudong Medical CenterShanghai 201399China Department of Cardiology the First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005China Department of Pathology the First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005China

Summary:Recent studies suggested that serum secretory phospholipase A2 group IB(sPLA2-IB)was increased in idiopathic membranous nephropathy(IMN).However,the interference of high lipemia on the sPL.A2-IB levels was not taken into account in these *** present study aimed to investigate the correlation between sPLA2-IB and lipemia,and the clinical merit of sPLA2-IB in the prediction of prognosis of IMN patients.A total of 64 IMN patients,39 immunoglobulin A nephropathy(IgAN)patients and 64 healthy controls were included in the *** levels of serum sPLA2-IB,lipemia and proteinuria were *** IMN patients were followed up for 6 *** stages were made for all IgAN and IMN *** results showed that the levels of serum sPLA2-IB,cholesterol and low-density lipoprotein cholesterol(LDL-C)were significantly higher,and the levels of albumin and high-density lipoprotein cholesterol(HDL-C)were significantly lower in IMN patients than in healthy controls and IgAN *** sPLA2-IB levels were also found to be higher in IgAN patients than in heathy controls,but the association of serum sPLA2-IB levels with proteinuria,cholesterol and albumin was only shown in IMN *** against M-type receptor for secretory phospholipase A2(PLA2R1)was positive in 813%IMN *** sPLA2-IB deposition,podocyte fused processes,and density deposition on thickened basement membrane were seen in IMN patients,but not in IgAN *** patients with lower sPLA2-IB and proteinuria levels were found to have better outcome after the 6-month *** IMN patients,sPLA2-IB levels were significantly increased in both serum and renal *** conclusion,serum sPLA2-IB was closely correlated with proteinuria,albumin and cholesterol,and IMN patients with lower sPLA2-IB levels were more likely to achieve a better outcome.

关键词： sPLA2-IB lipemia idiopathic membranous nephropathy prognosis

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面向复杂电磁环境的多天线信道估计技术

电子与信息学报 2016年第9期38卷 2221-2226页

作者：胡苏郭惠婷武刚电子科技大学通信抗干扰国家级重点实验室成都610054 信息感知技术协同创新中心西安710071

对于基于认知无线电架构的多天线信道估计技术,由于传统零相关序列是在全部频谱可用前提下设计的,在复杂电磁环境的频谱限制下,传统零相关序列部分频域元素发生变化,且不再满足原始序列的周期相关特性,因此不能直接应用于复杂电磁环境... 详细信息

对于基于认知无线电架构的多天线信道估计技术,由于传统零相关序列是在全部频谱可用前提下设计的,在复杂电磁环境的频谱限制下,传统零相关序列部分频域元素发生变化,且不再满足原始序列的周期相关特性,因此不能直接应用于复杂电磁环境的多天线信道估计。该文介绍了多天线通信系统的信道估计算法并指出对理想序列的要求,然后针对复杂电磁环境,即在存在频谱空穴的条件下,联合优化频谱受限和良好周期相关程度两大评价指标,设计出适用的序列集合,作为训练序列应用到认知无线电系统的信道估计算法中,仿真结果验证了新序列集合的有效性。

关键词：多天线信道估计复杂电磁环境频谱受限序列设计

Increased expression of serum gelsolin in patients with osteosarcoma

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Chinese Medical Journal 2012年第2期125卷 262-269页

作者： Jin Song Shen Jing-nan Peng jian-qiang Wang Jin Huang gang Li Ming-tao Sun Yat Sen Univ Affiliated Hosp 1 Dept Musculoskeletal Oncol Guangzhou 510080 Guangdong Peoples R China Guangdong Med Coll Affiliated Fu Tian Hosp Dept Orthoped Surg Shenzhen 518033 Guangdong Peoples R China Sun Yat Sen Univ Zhongshan Med Coll Prote Lab Guangzhou 510080 Guangdong Peoples R China

Background Identification of potential serum biomarkers of osteosarcoma to aid in its early diagnosis and in the discovery of possible therapeutic targets is an area of increasing *** Two-dimensional difference-in-gel electrophoresis was used to assess multiple serum samples in patients with *** addition,differential expression of protein biomarkers was characterized in osteosarcoma serum by using matrix-assisted desorption/ionization time-of-flight mass spectrometry coupled with database *** samples from four individuals with osteosarcoma and four age- and sex-matched healthy control subjects were *** Fifty-eight significant protein spot features in the osteosarcoma sera were *** spot features were excised,digested with trypsin,and analyzed with mass *** was down-regulated only in ***,Western blotting and enzyme linked immunosorbent assay （ELISA） confirmed decreased levels of gelsolin in the osteosarcoma serum *** These results indicated that gelsolin might have great potential as a biomarker of osteosarcoma and as a potential target for gene therapy.

关键词： biological markers gelsolin osteosarcoma proteomics

Improving dynamic response of a temperature-only FBG sensor

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Optoelectronics Letters 2006年第2期2卷 101-103页

作者： LI En-bang YAO jian-quan ZHANG Wei-gang College of Precision Instrument and Opto-Electronics Engineering Tianjin University Tianjin 300072 China Faculty of Informatics University of Wollongong Wollongong NSW 2522Australia Institute of Modern Optics Nankai University Tianjin 300071 China

We report a method for improving temporal response of FBG-based temperature *** has been demonstrated that by filling thermal conductive pastes between a sensing FBG and its package,the temporal response of the FBG-ba... 详细信息

关键词： Bragg光栅 FBG 动态响应温度传感器

Adaptive fuzzy integral sliding mode pressure control for cutter feeding system of trench cutter

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Journal of Central South University 2016年第12期23卷 3302-3311页

作者：田启岩魏建华方锦辉国凯 State Key Laboratory of Fluid Power Transmission and Control Zhejiang University

A nonlinear pressure controller was presented to track desired feeding pressure for the cutter feeding system(CFS) of trench cutter(TC) in the presence of unknown external *** feeding pressure control of CFS is subjected to unknown load characteristics of rock or soil; in addition,the geological condition is *** to the complex load characteristics of rock or soil,the feeding velocity of TC is related to geological *** is worse,its dynamic model is subjected to uncertainties and its function is *** deal with the particular characteristics of CFS,a novel adaptive fuzzy integral sliding mode control(AFISMC) was designed for feeding pressure control of CFS,which combines the robust characteristics of an integral sliding mode controller and the adaptive adjusting characteristics of an adaptive fuzzy *** AFISMC feeding pressure controller is synthesized using the backstepping *** stability of the overall closed-loop system consisting of the adaptive fuzzy inference system,integral sliding mode controller and the cutter feeding system is proved using Lyapunov *** are conducted on a TC test bench with the AFISMC under different operating *** experimental results demonstrate that the proposed AFISMC feeding pressure controller for CFS gives a superior and robust pressure tracking performance with maximum pressure tracking error within ?0.3 MPa.

关键词： electro-hydraulic system cutter feeding system feeding pressure control adaptive fuzzy integral sliding mode control

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English Abstracts

暨南学报（哲学社会科学版） 2015年第3期37卷 161-164页

作者： LIU jian-ping ZHANG guo-xiao Economic College Jinan UniversityGuangzhou 510632 China

An aquaporin and an aquaglyceroporin have roles in low temperature adaptation of mosquitoes (Anopheles sinensis)

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Insect Science 2024年第6期31卷 1743-1755页

作者： Yong-Qiao Zhao Yi-Ying Tang Ju-Ping Hu Yu-Zheng Huang Kai Wan Mei-Hua Zhang Ju-Lin Li guo-Ding Zhu jian-Xia Tang National Health Commission Key Laboratory of Parasitic Disease Control and Prevention Jiangsu Provincial Key Laboratory on Parasite and Vector Control TechnologyJiangsu Provincial Medical Key laboratoryJiangsu Institute of Parasitic DiseasesWuxiJiangsuChina School of Public Health Nanjing Medical UniversityNanjingJiangsuChina Wuxi School of Medicine Jiangnan UniversityWuxiJiangsuChina

Mosquitoes(Anopheles sinensis),widely geographically distributed in Asia including China,are the primary vector of the malaria parasite Plasmodium vivax and other parasitic diseases such as Malayan *** can survive through low winter *** channels are found in all life forms,where they facilitate environmental adaptation by allowing rapid trans-cellular movement of water(classical aquaporins)or water and solutes such as glycerol(aquaglyceroporins).Here,we identified and characterized 2 aquaporin(AQP)homologs in ***:AsAQP2(*** aquaglyceroporin)and AsAQP4(*** aquaporin).When expressed in frog(Xenopus laevis)oocytes,AsAQP2 transported water,glycerol,and urea;AsAQP4 transported only *** permeation through AsAQP2 and AsAQP4 was inhibited by mercuric ***2 expression was slightly higher in adult female mosquitoes than in males,and AsAQP4 expression was significantly higher in adult *** 2 AsAQPs were highly expressed in Malpighian tubules and ***2 and AsAQP4 expression was up-regulated by blood feeding compared with sugar *** freezing point(0℃),the AsAQP4 expression level increased and *** survival time reduced compared with those at normal temperature(26℃).At low temperature(8℃),the AsAQP2 and AsAQP4 expression levels decreased and survival time was significantly longer compared with those at 26℃.These results suggest that AsAQP2 and AsAQP4 have roles in water homeostasis during blood digestion and in low temperature adaptation of ***,our results show that the 2 AQPs are important for mosquito diuresis after blood feeding and when exposed to low temperatures.

关键词： aquaporin aquaglyceroporin Anopheles sinensis blood digestion low temperature adaption