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Enhancement of antitumor vaccine in ablated hepatocellular carcinoma by high-intensity focused ultrasound

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World Journal of Gastroenterology 2010年第28期16卷 3584-3591页

作者： Ying Zhang jian Deng Jun feng feng Wu Institute of Ultrasonic Engineering in Medicine Chongqing Medical University Chongqing 400016 China

AIM:To investigate whether tumor debris created by high-intensity focused ultrasound(HIFU)could trigger antitumor immunity in a mouse hepatocellular carcinoma model. METHODS:Twenty C57BL/6J mice bearing H22 hepatocellular carcinoma were used to generate antitumor *** mice underwent HIFU ablation,and the remaining 10 mice received a sham-HIFU procedure with no ultrasound *** normal mice were randomly divided into HIFU vaccine,tumor vaccine and control *** mice were immunized with HIFU-generated vaccine,tumor-generated vaccine,and saline,*** addition,20 mice bearing H22 tumors were successfully treated with HIFU ablation. The protective immunity of the vaccinated mice was investigated before and after a subsequent H22 tumor *** the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide assay,the cytotoxicity of splenic lymphocytes co-cultured with H22 cells wasdetermined in vitro before the tumor challenge,and tumor volume and survival were measured in vivo after the challenge in each *** mechanism was also explored by loading the vaccines with bone marrowderived dendritic cells(DCs). RESULTS:Compared to the control,HIFU therapy, tumor-generated and HIFU-generated vaccines significantly increased cytolytic activity against H22 cells in the splenocytes of the vaccinated mice(Phan in the tumor vaccine group(P han the vaccinated mice in the remaining three groups(P< 0.001).After bone marrow-derived DCs were incubated with HIFU-generated and tumor-generated vaccines, the number of matur

关键词： Hepatocellular carcinoma High-intensity focused ultrasound Immune response Immunogenicity Immunotherapy Thermal ablation Tumor vaccine

Highly Sensitive Spectrofluorimetric Determination of Trace Amounts of Indium(Ⅲ) with Salicylaldehyde Salicyloylhydrazone

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Chemical Research in Chinese Universities 2002年第2期18卷 183-188页

作者： han Fang WANG Hong jian TANG Bo Department of Chemistry Shandong Normal UniversityJinan 250014P.R.China

The fluorescent reaction of salicylaldehyde salicyloylhydrazone(SASH) with indium(Ⅲ) was studied in detail. Based on this chelation reaction, a sensitive spectrofluorimetric method was developed for the determination of indium in a water ethanol(volume ratio 3∶7) medium at pH 4 0. Under the condition, the In SASH complex displays an excitation and emission maxima at 396 and 461 nm, respectively. The linear range of the method is from 4 7 to 1000 ng/mL and the detection limit is 0 94 ng/mL. The molar ratio of indium to the reagent is 1∶1. The interferences of other ions were studied. The method was successfully applied to the determination of indium in the chemical reagents of lead, tin, zinc, zinc chloride and geological samples by standard addition method.

关键词： Indium determination Salicylaldehyde salicyloylhydrazone Spectrofluorimetry

Some Theorems for Hypersurface of Randers Spaces

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Acta Mathematica Sinica,English Series 2020年第10期36卷 1125-1139页

作者： Jin Tang LI jian feng ZhanG School of Mathematical Sciences Xiamen UniversityXiamen 361005P.R.China Department of Mathematics Lishui UniversityLishui 323000P.R.China

In this paper,we consider the hypersurfaces of Randers space with constant flag curvature.(1)Let(M^n+1,F)be a Randers–Minkowski ***(M^n,F)is a hypersurface of(M^n+1,F)with constant flag curvature K=1,then we can prove that M is Riemannian.(2)Let(M^n+1,F)be a Randers space with constant flag ***(M,F)is a compact hypersurface of(M^n+1,F)with constant mean curvature|H|.Then a pinching theorem is established,which generalizes the result of[***.,120,1223–1229(1994)]from the Riemannian case to the Randers space.

关键词： Randers space hypersurfaces constant mean curvature constant flag curvature

Formation of hypereutectic silicon particles in hypoeutectic Al-Si alloys under the influence of high-intensity ultrasonic vibration

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China Foundry 2013年第2期10卷 118-123页

作者： Xiaogang jian Qingyou han Fuel Cell Energy DanburyCT 06810USA MET Department Purdue UniversityWest LafayetteIN 47906USA

The modification of eutectic silicon is of general interest since fine eutectic silicon along with fine primary aluminum grains improves mechanical properties and ductilities. In this study, high intensity ultrasonic vibration was used to modify the complex microstructure of aluminum hypoeutectic alloys. The ultrasonic vibrator was placed at the bottom of a copper mold with molten aluminum. Hypoeutectic AI-Si alloy specimens with a unique in-depth profile of microstructure distribution were obtained. Polyhedral silicon particles, which should form in a hypereutectic alloy, were obtained in a hypoeutectic AI-Si alloy near the ultrasonic radiator where the silicon concentration was higher than the eutectic composition. The formation of hypereutectic silicon near the radiator surface indicates that high-intensity ultrasonic vibration can be used to influence the phase transformation process of metals and alloys. The size and morphology of both the silicon phase and the aluminum phase varies with increasing distance from the ultrasonic probe/radiator. Silicon morphology develops into three zones. Polyhedral primary silicon particles present in zone I, within 15 mm from the ultrasonic probe/radiator. Transition from hypereutectic silicon to eutectic silicon occurs in zone II about 15 to 20 pm from the ultrasonic probe/radiator. The bulk of the ingot is in zone III and is hypoeutectic AI-Si alloy containing fine lamellar and fibrous eutectic silicon. The grain size is about 15 to 25 IJm in zone I, 25 to 35 IJm in zone II, and 25 to 55 pm in zone II1. The morphology of the primary a-AI phase is also changed from dendritic （in untreated samples） to globular. Phase evolution during the solidification process of the alloy subjected to ultrasonic vibration is described.

关键词： eutectic solidification aluminum alloys microstructure and ultrasonic vibration

Distributed anonymous data perturbation method for privacy-preserving data mining

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第7期10卷 952-963页

作者： feng LI Jin MA jian-hua LI School of Electronic Information and Electrieal Engineering Shanghai Jiao Tong University Shanghai 200030 China

Privacy is a critical requirement in distributed data mining. Cryptography-based secure multiparty computation is a main approach for privacy preserving. However, it shows poor performance in large scale distributed systems. Meanwhile, data perturbation techniques are comparatively efficient but are mainly used in centralized privacy-preserving data mining (PPDM). In this paper, we propose a light-weight anonymous data perturbation method for efficient privacy preserving in distributed data mining. We first define the privacy constraints for data perturbation based PPDM in a semi-honest distributed environment. Two protocols are proposed to address these constraints and protect data statistics and the randomization process against collusion attacks: the adaptive privacy-preserving summary protocol and the anonymous exchange protocol. Finally, a distributed data perturbation framework based on these protocols is proposed to realize distributed PPDM. Experiment results show that our approach achieves a high security level and is very efficient in a large scale distributed environment.

关键词： Privacy-preserving data mining (PPDM) Distributed data mining Data perturbation

Transport of cadmium from soil to grain in cereal crops: A review

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Pedosphere 2021年第1期31卷 3-10页

作者： jian feng MA Ren Fang SHEN Ji feng SHAO Institute o f Plant Science and Resources Okayama UniversityChuo 2-20-1Kurashiki 710-0046Japan State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityLin'An 311300China

Due to rapid urbanization and industrialization, many soils for crop production are contaminated by cadmium(Cd), a heavy metal highly toxic to many organisms. Cereal crops such as rice, wheat, maize, and barley are the primary dietary source of Cd for humans, and reducing Cd transfer from soil to their grains is therefore an important issue for food safety. During the last decade, great progress has been made in elucidating the molecular mechanisms of Cd transport, particularly in rice. Inter-and intraspecific variations in Cd accumulation have been observed in cereal crops. Transporters for Cd have been identified in rice and other cereal crops using genotypic differences in Cd accumulation and mutant approaches. These transporters belong to different transporter families and are involved in the uptake, vacuolar sequestration, root-to-shoot translocation, and distribution of Cd. Attempts have been made to reduce Cd accumulation in grains by manipulating these transporters through overexpression or knockout of the transporter genes, as well as through marker-assisted selection breeding based on genotypic differences in Cd accumulation in the grains. In this review, we describe recent progress on molecular mechanisms of Cd accumulation in cereal crops and compare different molecular strategies for minimizing Cd accumulation in grains.

关键词： barley gene knockout gene overexpression genotypic difference maize rice transporter wheat

Synthesis and Liquid Crystalline Behavior of Side Chain Liquid Crystalline Polymers Containing Triphenylene Discotic Mesogens with Different Length Flexible Spacers

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Chinese Journal of Polymer Science 2015年第9期33卷 1245-1259页

作者： jian-feng Ban 陈盛张海良 Key Laboratory of Polymeric Materials and Application Technology of Hunan Province Key Laboratory of Advanced Functional Polymer Materials of Colleges and Universities of Hunan Province College of Chemistry Xiangtan University

A series of side chain liquid crystalline polymers （SCLCPs） containing triphenylene （Tp） units in the side chains, denoted as PMTS （without spacer） and PMTnS （n = 2, 3, 4, 6, which is the number of the methylene units between the main chain and Tp moieties in the side chains）, with different lengths of spacers were synthesized through conventional free radical polymerization. The chemical structures of the monomers were confirmed by 1H/IaC-NMR, and the phase behaviors were examined by differential scanning calorimetry （DSC）, polarized optical microscopy （POM） and wide-angle X-ray diffraction （1D and 2D WAXD）. The molecular characterization of the polymers was performed with 1H-NMR, gel permeation chromatography （GPC） and thermogravimetric analysis （TGA）. The phase behaviors of the polymers have been investigated by a combination of techniques including DSC, POM, 1D and 2D WAXD. The results showed that the length of spacer has significant effects on the LC phase behavior of polymers. For PMTS and PMT2S, they displayed the columnar phase developed by the Tp moieties and the main chain as a whole due to the strong coupling effect of the Tp moieties and the main chain. For the PMT3S, PMT4S and PMT6S, they formed the symmetry hexagonal columnar （~n） phase owing to the decoupling effect. All of these indicated that the ＂decoupling effect＂ or ＂coupling effect＂ depended on the length of spacers, leading to the different LC phase formation mechanism.

关键词： Liquid crystalline polymer Triphenylene Flexible spacer Phase behavior Columnar phase.

Topological Multiple Recurrence of Weakly Mixing Minimal Systems for Generalized Polynomials

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Acta Mathematica Sinica,English Series 2021年第12期37卷 1847-1874页

作者： Rui feng ZhanG jian Jie ZHAO School of Mathematics Hefei University of TechnologyHefei 230009P.R.China CAS Wu Wen-Tsun Key Laboratory of Mathematics and School of Mathematics University of Science and Technology of ChinaHefei 230026P.R.China

Let(X,T)be a weakly mixing minimal system,p_(1),...,p_(d) be integer-valued generalized polynomials and(p_(1),p_(2),...,p_(d))be *** there exists a residual subset X_(0) of X such that for all x∈X0,{(T^(p1(n))x,...,T... 详细信息

关键词： Generalized polynomials weakly mixing multiple recurrence

Product quality prediction based on RBF optimized by firefly algorithm

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Journal of Systems Engineering and Electronics 2024年第1期35卷 105-117页

作者： han Huihui WANG jian CHEN Sen YAN Manting College of Electronics and Information Engineering Tongji UniversityShanghai 201804China

With the development of information technology,a large number of product quality data in the entire manufacturing process is accumulated,but it is not explored and used *** traditional product quality prediction models have many disadvantages,such as high complexity and low *** overcome the above problems,we propose an optimized data equalization method to pre-process dataset and design a simple but effective product quality prediction model:radial basis function model optimized by the firefly algorithm with Levy flight mechanism(RBFFALM).First,the new data equalization method is introduced to pre-process the dataset,which reduces the dimension of the data,removes redundant features,and improves the data *** the RBFFALFM is used to predict product *** expe riments conducted on real-world product quality datasets validate that the new model RBFFALFM combining with the new data pre-processing method outperforms other previous me thods on predicting product quality.

关键词： product quality prediction data pre-processing radial basis function swarm intelligence optimization algorithm