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3DPhenoFish:Application for two-and three-dimensional fish morphological phenotype extraction from point cloud analysis

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Zoological Research 2021年第4期42卷 492-501页

作者： Yu-Hang Liao Chao-Wei Zhou Wei-Zhen Liu Jing-Yi Jin Dong-Ye Li fei Liu Ding-Ding Fan Yu Zou Zen-Bo Mu jian Shen Chun-Na Liu Shi-Jun Xiao Xiao-Hui Yuan Hai-Ping Liu Department of Computer Science Wuhan University of TechnologyWuhanHubei 430070China Institute of Fisheries Science Tibet Academy of Agricultural and Animal Husbandry SciencesLhasaTibet 850000China Key Laboratory of Freshwater Fish Reproduction and Development(Ministry of Education) College of FisheriesSouthwest UniversityChongqing 402460China Jiaxing Key Laboratory for New Germplasm Breeding of Economic Mycology JiaxingZhejiang 314000China Huadian Tibet Energy Co. LtdLhasaTibet 851415China China Institute of Water Resources and Hydropower Research Beijing 100038China

Fish morphological phenotypes are important resources in artificial breeding,functional gene mapping,and population-based studies in aquaculture and *** morphological measurement of phenotypes is rather expensive in terms of time and *** importantly,manual measurement is highly dependent on operational experience,which can lead to subjective phenotyping ***,we developed 3DPhenoFish software to extract fish morphological phenotypes from three-dimensional(3D)point cloud *** for background elimination,coordinate normalization,image segmentation,key point recognition,and phenotype extraction were developed and integrated into an intuitive user ***,18 key points and traditional 2D morphological traits,along with 3D phenotypes,including area and volume,can be automatically obtained in a visualized *** fine-tuning of key points and customized definitions of phenotypes are also allowed in the *** 3DPhenoFish,we performed high-throughput phenotyping for four endemic Schizothoracinae species,including Schizopygopsis younghusbandi,Oxygymnocypris stewartii,Ptychobarbus dipogon,and Schizothorax *** indicated that the morphological phenotypes from 3DPhenoFish exhibited high linear correlation(>0.94)with manual measurements and offered informative traits to discriminate samples of different species and even for different populations of the same *** summary,we developed an efficient,accurate,and customizable tool,3DPhenoFish,to extract morphological phenotypes from point cloud data,which should help overcome traditional challenges in manual measurements.3DPhenoFish can be used for research on morphological phenotypes in fish,including functional gene mapping,artificial selection,and conservation studies.3DPhenoFish is an open-source software and can be downloaded for free at https://***/lyh24k/3DPhenoFish/tree/master.

关键词： Fish Phenomics Morphology Point cloud 3D scanning

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压剪作用下多节理类岩试样力学性质及破坏判据

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岩土力学 2019年第3期40卷 1013-1022页

作者：高青鹏曹平王飞王柱中南大学资源与安全工程学院湖南长沙410083

为研究骨料粒径及节理倾角对岩体的力学性质影响,采用两种不同粒径骨料的砂浆制作不同倾角平行节理试样进行压剪试验,并利用声发射系统监测试样加载过程。试验结果表明:骨料粒径增大,试样的峰值剪切强度增大;随节理倾角增大,粗颗粒试样... 详细信息

为研究骨料粒径及节理倾角对岩体的力学性质影响,采用两种不同粒径骨料的砂浆制作不同倾角平行节理试样进行压剪试验,并利用声发射系统监测试样加载过程。试验结果表明:骨料粒径增大,试样的峰值剪切强度增大;随节理倾角增大,粗颗粒试样的峰值剪应力呈先增加后减小的趋势,细颗粒试样的峰值剪应力呈增―减―增―减的规律;声发射计数随试样加载呈现规律变化,其在试样峰值剪应力后达到最大值。利用Mohr-Coulomb破坏准则建立岩石压剪断裂判据。经分析,裂纹尖端应力强度因子比值KⅡc/KⅠc值只与岩石材料的内摩擦角?有关,且KⅡc/KⅠc值随内摩擦角?增加而增大。

关键词：压剪试验节理倾角声发射骨料粒径断裂判据

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Discovery of New Iridoids as Farnesoid X Receptor Agonists from Morinda officinalis: Agonistic Potentials and Molecular Stimulation

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Chinese Journal of Chemistry 2021年第5期39卷 1288-1296页

作者： Zhi-Lin Luan fei Qiao Wen-Yu Zhao Wen-Hua Ming Zhen-Long Yu Jie Liu Sheng-Yun Dai Shuang-Hui jiang Chao-Jie Lian Cheng-Peng Sun Bao-Jing Zhang jian Zheng Shuang-Cheng Ma Xiao-Chi Ma Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention College of PharmacyCollege of Integrative MedicineDalian Medical UniversityDalianLiaoning 116044China National Institutes for Food and Drug Control Beijing 102629China

The investigation of Morinda officinalis led to the isolation of twelve compounds(1-12),including three new iridoid glycosides morindallns A-C(1-3)and nine known compounds(4-12).Their structural identifications were conducted using HRMS,1D and 2D NMR,and electronic circular dichroism(ECD)spectra as well as quantum chemical *** 6 displayed the most significantly agonistic activity against farnesoid X receptor(FXR)with an EC_(50) value of 7.18 μM,and its agonistic effect was verified through the investigation of FXR downstream target genes including small heterodimer partner 1(SHP1),bile salt export pump(BSEP),and organic solute transporter subunit alpha and beta(OSTα and OSTβ).The potential interaction of compound 6 with FXR was analyzed by molecular docking and molecular dynamics stimulation,revealing that amino acid residues Leu287;Thr288,and Ser332 played a crucial role in the activation of compound 6 towards *** findings suggested that compound 6 could be regarded as a potential candidate for the development of FXR agonists.

关键词： Morinda officinalis Iridoid Farnesoid X receptor Agonistic effect

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Veno-arterial extracorporeal membrane oxygenation as a bridge in patients with advanced heart failure:Initial experience in China

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Chinese Medical Journal 2024年第10期137卷 1228-1230页

作者： Jing Wang jian Wang Sizhe gao Gang Liu Qian Wang Shujie Yan Boyi Zhou Yuan Yuan Guodong gao Bingyang Ji Department of Cardiopulmonary Bypass Fuwai hospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100037China

To the Editor:Veno-arterial extracorporeal membrane oxygenation(VA-ECMO)has been used as a bridge in patients with advanced heart failure(AdHF)while waiting for heart transplantation(HTx).Many studies reported by developed countries have confirmed the advantages of VA-ECMO in terms of bridge to left ventricular assist device(LVAD)or HTx,with stabilizing the condition and improving the possibility of further treatment of patients.[1-3]Recent data from the Extracorporeal Life Support Organization(ELSO)[4]indicated that ECMO used as a bridge has increased by 20.5%over a ***,to date,there are few studies on the bridge experience of VA-ECMO in the mainland of China.

关键词： patients arterial ventricular

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Metabolites from the endophytic fungus HP-1 of Chinese eaglewood

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Chinese Journal of Natural Medicines 2014年第2期12卷 151-153页

作者： ZUO Wen-jian JIN Peng-fei DONG Wen-Hua DAI Hao-Fu MEI Wen-Li Key Laboratory of Biology and Genetic Resources of Tropical Crops Ministry of Agriculture Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences

AIM: To study the chemical constituents from the fermentation of the endophytic fungus HP-1 of Chinese eaglewood. METHODS: The chemical constituents were isolated by column chromatography on silica gel and Sephadex LH-20, and their structures were elucidated on the basis of spectroscopic analysis. RESULTS: Four compounds were isolated and identified as 3α, 3β, 10β-trimethyl-decahydroazuleno[6, 7]furan-8, 9, 14-triol(1), 4-hydroxyphenylacetic acid(2), 4-hydroxyphenethyl alcohol(3), and 5-hydroxymethyl-2-furancarboxaldehyde(4). CONCLUSION: Compound 1 was a new compound. Compound 2 showed antibacterial activity against Staphylococcus aureus.

关键词： Chinese eaglewood Metabolites Endophytic fungus Antibacterial activity Chaetomium sp.

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基于FPGA的细粒度并行CYK算法加速器设计与实现

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计算机学报 2010年第5期33卷 797-812页

作者：夏飞窦勇宋健雷国庆国防科学技术大学计算机学院中国人民解放军61785部队

基于随机上下文无关文法(SCFG)理论模型进行RNA二级结构预测是目前采用计算方法研究RNA二级结构的一种重要途径.由于基于SCFG模型的标准结构预测算法(Coche-Younger-Kasami,CYK)巨大的时空复杂度,对CYK算法进行加速成为计算生物学领域... 详细信息

基于随机上下文无关文法(SCFG)理论模型进行RNA二级结构预测是目前采用计算方法研究RNA二级结构的一种重要途径.由于基于SCFG模型的标准结构预测算法(Coche-Younger-Kasami,CYK)巨大的时空复杂度,对CYK算法进行加速成为计算生物学领域一个极具挑战性的热点问题.CYK的并行性能受限于算法多维度、非一致性的数据依赖关系和较低的计算/通信比,现有的基于通用微处理器结构的大规模并行处理方案不能获得令人满意的加速效果,并且大规模并行计算机系统硬件设备的购置、使用、日常维护的成本高昂,其适用性受到诸多限制.文中在深入分析CYK算法计算特征的基础上,基于FPGA平台提出并实现了一种细粒度的并行CYK算法.设计采用了对三维动态规划矩阵"按区域分割"和"逐层按列并行处理"的计算策略实现了多个处理单元间的负载均衡;采用数据预取、滑动窗口和数据传递流水线实现处理单元间的数据重用,有效解决了计算和通信间的平衡问题;设计了一种类似脉动阵列(systolic-like array)结构的主从多PE并行计算阵列,并在目前最大规模的FPGA芯片(Xilinx XC5VLX330)上成功集成了16个处理单元(processing elements),实验结果表明作者提出的CYK算法加速器结构具备良好的可扩展性.当RNA序列长度为959bps,CM模型状态数为3145时,与运行在Intel双核E5200 2.5GHzCPU、2.0GB主存通用计算上的Infernal-1.0软件相比,可获得超过14倍的加速效果.配置一个FP-GA算法加速器的通用计算平台的综合处理性能与包含20个Intel-Xeon CPU的PC集群相当,而硬件成本仅为后者的20%,系统功耗不到后者的10%.

关键词：生物信息学 RNA 二级结构预测 SCFG模型并行CYK算法 FPGA 硬件加速器

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MAGNETIZED ION-ACOUSTIC SOLITARY WAVES

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Chinese Science Bulletin 1984年第6期29卷 748-752页

作者：高飞王大贤

Ⅰ. INTRODUCTION Oblique magnetized ion-acoustic solitary waves in two temperetures, low β plasma have been recently studied by using quasineutrality approximation, i. e. neglecting dispersion due to charge separation. It is well known that stationary solitary wave is formed under the dynamic balance of nonlinear and dispersive effects, therefore,

关键词： stationary solitary dispersive assumption quasi magnet derivation compr potent straight

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A study on the energy transfer and migration in the molecules of polymeric triplet sensitizers (2) A study on delay fluorescence and polarization spectra

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Chinese Journal of Chemistry 1986年第3期4卷 203-208页

作者： gao jian-Ping WU Shih-Kang TONG Zheng-He FENG Xin-De Institute of Photographic Chemistry, Academia Sinica, Beijing Department of Chemistry, Peking University, Beijing Institute of Photographic Chemistry Academia Sinica Beijing Department of Chemistry Peking University Beijing

The triplet energy migration of polymers and copolymers of vinyl benzophenone (VBP)and vinyl naphthalene (VN) has been studied by measuring delayed fluorescence and polarizationspectra in glassy dilute solution at 77 K. Strong delayed fluorescence of PVN proves the existenceof triplet energy migration and T-T annihilation in the polymer chain. Efficient intersystem cross-ing of "BP" and efficient energy migration and transfer between chromophores along the polymerchain result in the absence of delayed fluorescence for copolymer P (VN-VBP) studied in this *** order of benzophenone phosphorescence intensity: BP>Co (VBP-St)>PVBP indicates the T-Tannihilation decreasing the phosphorescence of PVBP. Fluorescence and phosphorescence po-larization data of polymers are smaller than that of their model compounds. It is evident that energymigration exists in the polymer chain.

关键词： A study on delay fluorescence and polarization spectra A study on the energy transfer and migration in the molecules of polymeric triplet sensitizers

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RDX基含铝炸药不同尺寸的圆筒试验及数值模拟

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含能材料 2013年第6期21卷 777-780页

作者：沈飞王辉袁建飞田清政杨凯西安近代化学研究所陕西西安710065

为了研究RDX基含铝炸药在不同装药直径下的做功能力,进行了Φ25.4 mm和Φ50.0 mm两种尺寸的圆筒试验。试验结果表明,爆轰产物相对比容均为10时,Φ50.0 mm比Φ25.4 mm圆筒的膨胀速度提高约4.73%。此外,基于Lee-Tarver点火增长模型,采用... 详细信息

为了研究RDX基含铝炸药在不同装药直径下的做功能力,进行了Φ25.4 mm和Φ50.0 mm两种尺寸的圆筒试验。试验结果表明,爆轰产物相对比容均为10时,Φ50.0 mm比Φ25.4 mm圆筒的膨胀速度提高约4.73%。此外,基于Lee-Tarver点火增长模型,采用有限元动力学程序LS-DYNA对两种尺寸的圆筒试验进行了数值模拟,并与试验结果相比较,确定了该含铝炸药爆轰产物的Jones-Wilkins-Lee状态方程和反应速率方程参数。

关键词：爆炸力学含铝炸药爆轰圆筒试验数值模拟

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临近空间飞行器发汗冷却研究进展

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推进技术 2023年第1期44卷 1-15页

作者：栾芸贺菲王建华中国科学技术大学热科学和能源工程系安徽合肥230026

发汗冷却是一种针对临近空间飞行器的冷却能力极强的主动热防护方式,本文通过对国内外大量相关文献进行调研,阐述了发汗冷却的作用机理及特点,归纳总结了近些年发汗冷却取得的研究进展,主要内容涵盖结构基体材料及冷却工质的选择、研究... 详细信息

发汗冷却是一种针对临近空间飞行器的冷却能力极强的主动热防护方式,本文通过对国内外大量相关文献进行调研,阐述了发汗冷却的作用机理及特点,归纳总结了近些年发汗冷却取得的研究进展,主要内容涵盖结构基体材料及冷却工质的选择、研究方法的发展以及相关的结构优化设计等,并展望了未来可能的研究方向。

关键词：临近空间飞行器主动冷却发汗冷却结构优化组合冷却综述

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