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Tumor recurrence and survival prognosis in patients with advanced gastric cancer after radical resection with radiotherapy and chemotherapy

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1660-1669页

作者： Shuang-Fa Nie Chen-Yang Wang Lei Li Cheng Yang Zi-Ming Zhu jian-dong fei Department of General Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 75000Hebei ProvinceChina Department of Gastrointestinal Surgery Zhongshan Hospital of Fudan UniversityShanghai 200032China

BACKGROUND Advanced gastric cancer is a common malignancy that is often diagnosed at an advanced stage and is still at risk of recurrence after radical surgical ***,as one of the important treatment methods for gastric cancer,is of great significance for improving the survival rate of ***,the tumor recurrence and survival prognosis of gastric cancer patients after radio-therapy and chemotherapy are still *** To analyze the tumor recurrence after radical radiotherapy and chemotherapy for advanced gastric cancer and provide more in-depth guidance for *** A retrospective analysis was performed on 171 patients with gastric cancer who received postoperative adjuvant radiotherapy and chemotherapy in our hospital from 2021 to *** Kaplan-Meier method was used to calculate the recurrence rate and survival rate;the log-rank method was used to analyze the single-factor prognosis;and the Cox model was used to analyze the prognosis associated with multiple *** The median follow-up time of the whole group was 63 months,and the follow-up rate was 93.6%.Stage Ⅱ and Ⅲ patients accounted for 31.0%and 66.7%,*** incidences of Grade 3 and above acute gastrointestinal reactions and hematological adverse reactions were 8.8%and 9.9%,respectively.A total of 166 patients completed the entire chemoradiotherapy regimen,during which no adverse reaction-related deaths *** terms of the recurrence pattern,17 patients had local recurrence,29 patients had distant metastasis,and 12 patients had peritoneal implantation *** 1-year,3-year,and 5-year overall survival(OS)rates were 83.7%,66.3%,and 60.0%,*** 1-year,3-year,and 5-year disease-free survival rates were 75.5%,62.7%,and 56.5%,*** analysis revealed that T stage,peripheral nerve invasion,and the lymph node metastasis rate(LNR)were independent prognostic factors for *** Postoperative intensity-

关键词： Tumor recurrence Survival prognosis Advanced gastric cancer Radical resection Retrospective study

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Accurate resection of hilar cholangiocarcinoma using eOrganmap 3D reconstruction and full quantization technique

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World Journal of Gastrointestinal Surgery 2023年第8期15卷 1693-1702页

作者： Da-Peng Cui Shuang Fan Ying-Xue Guo Qian-Wei Zhao Yue-Xin Qiao jian-dong fei Department of Hepatobiliary Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina

BACKGROUND For treatment of hilar cholangiocarcinoma(HCCA),the rate of radical resection is low and prognosis is poor,and preoperative evaluation is not sufficiently accurate.3D visualization has the advantage of giving a stereoscopic view,which makes accurate resection of HCCA *** To establish precise resection of HCCA based on eOrganmap 3D reconstruction and full quantification *** We retrospectively analyzed the clinical data of 73 patients who underwent HCCA *** patients were assigned to two *** traditional group received traditional 2D imaging planning before surgery(n=35).The eOrganmap group underwent 3D reconstruction and full quantitative technical planning before surgery(n=38).The preoperative evaluation,anatomical classification of hilar hepatic vessels,indicators associated with surgery,postoperative complications,liver function,and stress response indexes were compared between the *** Compared with the traditional group,the amount of intraoperative blood loss in the eOrganmap group was lower,the operating time and postoperative intestinal ventilation time were shorter,and R0 resection rate and lymph node dissection number were higher(P0.05).The levels of total bilirubin,Albumin(ALB),aspartate transaminase,and alanine transaminase in the eOrganmap group were significantly different from those in the traditional group(intergroup effect:F=450.400,79.120,95.730,and 13.240,respectively;all P<0.001).Total bilirubin,aspartate transaminase,and alanine transaminase in both groups showed a decreasing trend with time(time effect:F=30.270,17.340,and 13.380,respectively;all P<0.001).There was an interaction between patient group and time(interaction effect:F=3.072,2.965,and 2.703,respectively;P=0.0282,0.032,and 0.046,respectively);ALB levels in both groups tended to increase with time(time effect:F=22.490

关键词： eOrganmap 3D reconstruction Full quantification technology Laparoscopic surgery Hilar cholangiocarcinoma Precise resection

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Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei dong fei Luan Juanjuan Yang Feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

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压力控制容量保证通气模式在腹腔镜胆囊切除手术中的应用

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世界华人消化杂志 2017年第6期25卷 560-564页

作者：董建民徐珍飞镇海龙赛医院麻醉科浙江省宁波市315200 镇海招宝山街道社区卫生服务中心浙江省宁波市315200

目的观察压力控制容量保证(pressure control with volume guarantee,PC-VG)通气模式对腹腔镜胆囊切除手术患者循环和通气功能的影响.方法选择择期行腹腔镜胆囊切除手术的患者60例,美国麻醉医师协会分级Ⅰ-Ⅱ级,随机分为2组(n=30):P组(P... 详细信息

目的观察压力控制容量保证(pressure control with volume guarantee,PC-VG)通气模式对腹腔镜胆囊切除手术患者循环和通气功能的影响.方法选择择期行腹腔镜胆囊切除手术的患者60例,美国麻醉医师协会分级Ⅰ-Ⅱ级,随机分为2组(n=30):P组(PC-VG模式通气组)和V组(容量控制通气组).观察2组患者气管插管后(T_0)、气腹建立后10 min(T_1)、20 min(T_2)、胆囊切除后(T_3)和手术结束(T_4)时的平均动脉压(mean arterial pressure,MAP)、心率(heart rate,HR)、呼吸频率(respiratory rate,RR)、潮气量(tidal volume,TV)、分钟通气量(minute volume,MV)、气道峰压(peak airway pressure,Ppeak)、呼气末二氧化碳分压(end-tidal carbon dioxide pressure,P_(ET)CO_2)、肺顺应性(lung compliance,C_L)和气道阻力(airway resistance,Raw).结果2组患者各时间点MAP、HR、RR、TV、MV、Ppeak和P_(ET)CO_2比较差异均无统计学意义(均P>0.05);与同组T_0时比较,2组患者其余各时间点Ppeak和Raw明显升高,C_L明显降低,差异有统计学意义(P<0.05);与V组相比,P组患者T_1-T_4时间点Raw明显降低,C_L明显升高,差异有统计学意义(P<0.05).结论PC-VG通气模式应用于腹腔镜胆囊切除手术能够维持循环功能稳定,并提高患者C_L,减小气道阻力,降低Ppeak,有利于改善患者的通气功能.

关键词：机械通气胆囊切除术,腹腔镜循环和呼吸的生理现象

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蝉花多糖的提取和生物活性及产品研发进展

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食品与机械 2023年第5期39卷 217-223,240页

作者：贾国军王小英贠建民董建飞兰州职业技术学院生物工程系甘肃兰州730070 甘肃农业大学食品科学与工程学院甘肃兰州730070 浙江泛亚生物医药股份有限公司浙江平湖314200

蝉花是一种珍贵的药食两用真菌,具有很高的食用和药用价值,而蝉花多糖是其重要的生物活性成分。文章综述了近年来蝉花多糖提取、分离纯化的技术,对蝉花多糖的抗氧化、抗肿瘤、免疫调节、抑菌作用、降血脂、降血糖、抗病毒和镇痛等生物... 详细信息

蝉花是一种珍贵的药食两用真菌,具有很高的食用和药用价值,而蝉花多糖是其重要的生物活性成分。文章综述了近年来蝉花多糖提取、分离纯化的技术,对蝉花多糖的抗氧化、抗肿瘤、免疫调节、抑菌作用、降血脂、降血糖、抗病毒和镇痛等生物活性进行了阐述,总结了蝉花产品开发与应用的现状,指出了当前蝉花相关研究中存在的问题和未来研究方向。

关键词：蝉花多糖提取方法生物活性分离纯化功能食品

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建筑工程基础底板注浆防渗技术应用分析

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工程建设与设计 2008年第10期 50-52页

作者：董剑飞河北省邯郸市鸡泽县建设局河北邯郸057350

针对地下室采用筏板基础底板处于地下水位以下,防止底板渗水的重要问题,叙述了注浆防渗技术在基础底板防渗中的应用。

关键词：基础底板注浆渗水应用分析

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窑炉玻璃液面控制研究

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化工设计通讯 2022年第3期48卷 142-143,162页

作者：董剑飞彩虹新能源有限公司陕西咸阳716000

在CRT玻壳和太阳能超白压延光伏玻璃的制造过程中,玻璃窑炉是将石英砂、纯碱、芒硝、碳酸钠等多种配合料通过加热融化成澄清的玻璃液的装置,是玻璃生产中最为重要的环节。在熔化玻璃的过程中,液面高度控制非常重要。主要对窑炉玻璃液面... 详细信息

在CRT玻壳和太阳能超白压延光伏玻璃的制造过程中,玻璃窑炉是将石英砂、纯碱、芒硝、碳酸钠等多种配合料通过加热融化成澄清的玻璃液的装置,是玻璃生产中最为重要的环节。在熔化玻璃的过程中,液面高度控制非常重要。主要对窑炉玻璃液面控制进行分析和探讨。

关键词：玻璃窑炉液面图像式

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少儿图书馆的少儿社会责任内容及其实现路径

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北方经贸 2013年第6期 101-102页

作者：董剑飞广东海洋大学图书馆广东湛江524088

目前对图书馆社会责任的研究主要集中在公共图书馆和高校图书馆这两类图书馆上,而对少年儿童图书馆的社会责任研究比较少见。少儿图书馆承担社会责任的途径主要有:要强化图书馆干部员工的社会责任意识,提高图书馆干部员工的综合素质,拓... 详细信息

目前对图书馆社会责任的研究主要集中在公共图书馆和高校图书馆这两类图书馆上,而对少年儿童图书馆的社会责任研究比较少见。少儿图书馆承担社会责任的途径主要有:要强化图书馆干部员工的社会责任意识,提高图书馆干部员工的综合素质,拓展文化服务领域。

关键词：少年儿童图书馆社会责任

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Dual-ligand chiral MOFs exhibiting circularly polarized room temperature phosphorescence for anti-counterfeiting

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Science China Chemistry 2025年

作者： Hongrui Zheng Qingqing Wang Xinchao Wang fei Wang Shangda Li jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fujian Key Laboratory of Polymer Materials College of Chemistry and Materials Science Fujian Normal University

Advanced chiral optical materials exhibiting circularly polarized room-temperature phosphorescence（CPRTP） possess significant research value. This study facilitates the synthesis of chiral metal-organic frameworks（CMOFs） with good CPRTP performance by implementing a dual-ligand strategy. By self-assembling the luminescent ligand H2BIIM with the chiral ligands L-or D-H2IDPA in the presence of Zn（II） ions, two robust three-dimensional（3D） CMOFs were successfully constructed. These complexes demonstrated intense fluorescence and exhibited prolonged yellow room-temperature phosphorescence（RTP） with a duration of up to 6 s. Notably, they exhibited both circularly polarized fluorescence(glum= ±7.57 × 10-3) and CPRTP(glum=±2.68 × 10-3). These unique properties were effectively utilized in the creation of multi-color anti-counterfeiting patterns,underscoring their promising potential for a wide range of applications.

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Breaking the structural symmetry of active sites in zeolite imidazolate framework for enhanced CO2 photoreduction

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Science China Chemistry 2025年

作者： Yupeng Han Yayu Yan Qiaohong Li Xin Wu fei Wang jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences College of Chemistry Fuzhou University

Adjusting the structure and composition of active sites is a highly effective method for activating linear ***, precise control of interfacial chemistry within molecular-scale environments presents a significant challenge in heterogeneous catalysis. In our study, we present symmetry-broken Mo-O-Co triple-atom active sites within the hybrid zeolite imidazole framework HZIF-CoMo. These sites disrupt the electronic balance and create a weak built-in electric field, thus promoting photocatalytic CO2reduction. The CO yield over HZIF-CoMo is improved to 3.1 mmol g-1h-1, which is over four times higher than the parent cobalt-imidazole framework MAF-6-Co. Both experimental and theoretical studies indicate that electronic modulation through the symmetry-breaking Mo-O-Co moiety acts as an organizing knob to accelerate charge separation and result in more carriers participating in the catalytic reaction. This work provides important insights into optimizing site-related electronic structures for targeted photocatalytic reactions.

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