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Decreased expression of Neurensin-2 correlates with poor prognosis in hepatocellular carcinoma

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World Journal of Gastroenterology 2009年第38期15卷 4844-4848页

作者： Hai-Qing Ma Xiao-Ting Liang Jing-Jing Zhao Hui Wang jian-cong sun Yi-Bing Chen Ke Pan jian-Chuan Xia Key Laboratory of Oncology in Southern China and Departmentof Experimental Research Sun Yat-sen University Cancer CenterGuangzhou 510060 Guangdong Province China

AIM： To investigate the expression of Neurensin-2 （NRSN2） in hepatocellular carcinoma （HCC） and its prognostic values in predicting survival. METHODS： The expression and prognostic significance of NRSN2 in HCC was examined by performing immunohistochemical analysis using a total of 110 HCC clinical tissue samples, and Western blotting analysis to further confirm the result. RESULTS： Decreased NRSN2 expression was shown in 70.9% cases. Loss of NRSN2 expression in HCC was significantly related to tumor size （P = 0.006）. Larger tumor size was related to negative expression of NRSN2. Patients showing negative NRSN2 expression had a significantly shorter overall survival than those with positive expression （P = 0.008）. Multivariate Cox regression analysis indicated that NRSN2 expression level was an independent factor of survival （P = 0.013）. Western blotting analysis further confirmed decreased expression of NRSN2 in tumor tissues compared with non-tumorous tissues. CONCLUSION： Our study indicated that NRSIV2 could be a tumor suppressor gene for HCC and a candidate biomarker for long-term survival in HCC.

关键词： Neurensin-2 Hepatocellular carcinoma Expression Immunohistochemical analysis Prognosis

Cyclic Gradient Methods for Unconstrained Optimization

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Journal of the Operations Research Society of China 2024年第3期12卷 809-828页

作者： Ya Zhang cong sun School of Science Beijing University of Posts and TelecommunicationsBeijing100876China

Gradient method is popular for solving large-scale *** this work,the cyclic gradient methods for quadratic function minimization are extended to general smooth unconstrained optimization *** with nonmonotonic line search,we prove its global ***,the proposed algorithms have sublinear convergence rate for general convex functions,and R-linear convergence rate for strongly convex *** experiments show that the proposed methods are effective compared to the state of the arts.

关键词： Gradient method Unconstrained optimization Nonmonotonic line search Global convergence

High expression level of EDIL3 in HCC predicts poor prognosis of HCC patients

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World Journal of Gastroenterology 2010年第36期16卷 4611-4615页

作者： jian-cong sun,Xiao-Ting Liang,Ke Pan,Hui Wang,Jing-Jing Zhao,jian-Jun Li,Hai-Qing Ma,Yi-Bing Chen,jian-Chuan Xia,State Key Laboratory of Oncology in South China,Cancer Center,sun Yat-Sen University,Guangzhou 510060,Guangdong Province,China State Key Laboratory of Oncology in Southern China Cancer Center Sun Yat-Sen University Guangzhou 510060 Guangdong Province China.

AIM:To determine the role of epidermal growth factor-like repeats and discoidin I-like domains 3(EDIL3)in pathogenesis of hepatocellular carcinoma(HCC)by investigating the EDIL3 expression in HCC and its prognostic value for ***:EDIL3 expression was detected in 101 HCC surgical tissue samples with immunohistochemistry method,and its relation with clinicopathologic features and prognosis of HCC patients was ***:EDIL3 was highly expressed in 48.5%of the HCC *** the EDIL3 expression level did not correlate with any clinicopathological parameters,KaplanMeier survival analysis showed that high expression level of EDIL3 resulted in a significantly poor prognosis of HCC patients(log-rank test,P=0.010).Multivariate Cox's analysis showed that the EDIL3 expression level was a significant and independent prognostic parameter for the overall survival rate of HCC patients(hazard ratio=1.978,95%confidence interval =1.139-3.435,P=0.015).CONCLUSION:High expression level of EDIL3 pre-dicts poor prognosis of HCC ***3 may be a potential target of antiangiogenic therapy for HCC.

关键词： Epidermal growth factor-like repeats and discoidin I-like domains 3 Hepatocellular carcinoma Prognosis Angiogenesis

MicroED as a powerful technique for the structure determination of complex porous materials

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Chinese Journal of Structural Chemistry 2024年第3期43卷 41-54页

作者： Chao Ma cong Lin jian Li State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityKowloonHong Kong China

Porous materials have garnered significant attention in recent *** the intrinsic relationship between their structures and properties requires precise knowledge of their atomic ***-crystal X-ray diffraction(SCXRD)has traditionally been the primary method for elucidating such structures,but it demands large,high-quality crystals,often exceeding 5μm in *** growth of these crystals can be a time-consuming process,especially for one-and two-dimensional *** explore structures at the nanoscale,MicroED(microcrystal electron diffraction(ED))offers unprecedented insights into the realm of *** revolutionary technique enables researchers to uncover intricate details within nanoscale structures,promising to reshape our fundamental understanding of *** this review,we delve into the applications of MicroED in the study of various porous materials,including zeolites,metal-organic frameworks(MOFs),and covalent organic frameworks(COFs).We emphasize the pivotal role of MicroED in nanomaterial characterization,enabling precise crystallographic analysis and phase identification.

关键词： Atomic structure MicroED Porous materials Three-dimensional electron diffraction

Navigating Epstein–Barr virus autoimmunity:role of NK cells and T cells in multiple sclerosis

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Signal Transduction and Targeted Therapy 2024年第3期9卷 833-835页

作者： Chu Xie cong sun Mu-Sheng Zeng State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouP.R.China

In a recent study published in Cell,Vietzen and colleagues discovered the novel role of natural killer(NK)cells and EBVspecific CD8+T cell response in controlling EBV-inducing autoimmune response and collectively def... 详细信息

关键词： Epstein sclerosis killer

Effect of alumina occurrence form on metallurgical properties of hematite and magnetite pellets

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Journal of Iron and Steel Research International 2024年第4期31卷 797-809页

作者： jian Pan Chen-mei Tang cong-cong Yang De-qing Zhu Zheng-qi Guo Wei-qun Huang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina Exploration and Development of Geology and Mineral Resources Co. Ltd.Nanchang 330030JiangxiChina

The effect of alumina occurrence form on the metallurgical properties of both hematite and magnetite pellets was investigated at the same Al_(2)O level of 2 wt.%,including reduction index(RI),low-temperature reduction disintegration index(RDI),reduction swelling index(RSI),and high-temperature softening-dripping *** mineralogy of fired pellets was also studied to reveal the influence of alumina occurrence form on the phase composition and *** the results,the alumina occurrence form presents tremendous impacts on the metallurgical perfor-mance of both magnetite and hematite *** of all alumina occurrence forms contributes to inferior reducibility of pellets,especially in the case of gibbsite for magnetite pellets with a RI of 58.4%and kaolinite for hematite pellets with a RI of 56.8%.However,addition of all alumina occurrence forms improves the RDI of magnetite pellets,while there is no significant difference among various alumina occurrence *** contrast,alumina occurrence forms have little influence on the RDI of hematite *** presence of free alumina,gibbsite,and kaolinite tends to improve the RSI of hematite and magnetite pellets,whereas hercynite gives the opposite trend with a RSI of 25.6%.For softening-dripping performance of magnetite pellets,all alumina occurrence forms contribute to narrower softening-melting ***,alumina,gibbsite,and kaolinite give narrower softening-dripping interval,at 229,217,and 88℃,respectively,whereas addition of hercynite results in the largest melting range at 276℃ due to its high melting *** hematite pellets,free alumina,gibbsite,and hercynite tend to enlarge melting range,whereas kaolinite contributes to lower dripping temperature of 1148℃ and narrow softening-dripping interval of 88℃ due to the formation of a greater amount of slag phase at high temperatures.

关键词： Oxidized pellet Magnetite Hematite Alumina occurrence form Metallurgical performance Blast furnace

A combined evaluation of the characteristics and antibiotic resistance induction potential of antibiotic wastewater during the treatment process

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Journal of Environmental Sciences 2024年第4期138卷 626-636页

作者： sun Miao Yanyan Zhang cong Men Yiou Mao jiane Zuo State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China School of Energy and Environmental Engineering Beijing Key Laboratory of Resource-Oriented Treatment of Industrial PollutantsUniversity of Science and Technology BeijingBeijing 100083China High School Affiliated to Renmin University of China Beijing 100080China Tsinghua Shenzhen International Graduate School Shenzhen 518055China

Antibiotic wastewater contains a variety of pollutant stressors that can induce and promote antibiotic resistance(AR)when released into the *** these substances are mostly in concentrations lower than those known to induce AR individually,it is possible that antibiotic wastewater discharge might still promote the AR transmission risk via additive or synergistic ***,the comprehensive effect of antibiotic wastewater on AR development has rarely been evaluated,and its treatment efficiency remains ***,samples were collected from different stages of a cephalosporin production wastewater treatment plant,and the potential AR induction effect of their chemical mixtures was explored through the exposure of the antibiotic-sensitive Escherichia coli K12 *** with raw cephalosporin production wastewater significantly promoted mutation rates(3.6×10^(3)-9.3×10^(3)-fold)and minimum inhibition concentrations(6.0-6.7-fold)of *** against ampicillin and *** may be attributed to the inhibition effect and oxidative stress of cephalosporin wastewater on *** AR induction effect of cephalosporin wastewater decreased after the coagulation sedimentation treatment and was completely removed after the full treatment process.A Pearson correlation analysis revealed that the reduction in the AR induction effect had a strong positive correlation with the removal of organics and biological *** indicates that the antibiotic wastewater treatment had a collaborative processing effect of conventional pollutants,toxicity,and the AR induction *** study illustrates the potential AR transmission risk of antibiotic wastewater and highlights the need for its adequate treatment.

关键词： Antibiotic wastewater treatment plant Antibiotic resistance Antibiotic resistance induction effect Correlation analysis Biological toxicity

Direct numerical simulation of shock wave/boundary layer interaction controlled by steady microjet in a compression ramp

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Chinese Journal of Aeronautics 2024年第10期37卷 83-102页

作者： Ruoye XIAO Dong sun jian YU School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China State Key Laboratory of Aerodynamics Mianyang 621000China

Shock wave/boundary layer interaction in a 24°turning angle of the compression ramp at Mach number 2.9 controlled by steady microjet is investigated using direct numerical *** different jet spacings which are termed as sparse,moderate and dense are considered,and the induced vortex system and shock structures are compared.A moderate jet spacing configuration is found to generate counter-rotating vortex pairs that transport high-momentum fluid towards the vicinity of wall and strengthen the boundary layer to resist separation,reducing the separation *** dense jet spacing configuration creates a larger momentum deficit region,reducing the friction downstream of the *** of pressure and pressure gradient reveals that dense jet spacing configuration reduces the intensity of separation *** impact of varying jet spacings on the turbulent kinetic energy transport mechanism is also investigated by decomposing the budget terms in the transport ***,the spectral characteristics of the separation region are studied using power spectral density and dynamic mode decomposition methods,revealing that moderate jet spacing configuration suppresses low-frequency fluctuations in the separation region.

关键词： Shock wave/boundary layer interaction Compression ramp Steady microjet Different jet spacings Direct numerical simulation

Effective utilization of dolomitic lead-zinc waste rock by replacing dolomite as flux in iron ore sintering process

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Journal of Iron and Steel Research International 2024年第8期31卷 1861-1872页

作者： Xin Wang cong-cong Yang jian Pan De-qing Zhu Zheng-qi Guo Guang-hui Xia Shi-juan Qu School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina Low-Carbon and Hydrogen Metallurgy Research Center Central South UniversityChangsha 410083HunanChina

With increasingly stringent environmental protection policies,cost-effective and value-added treatment of massive lead-zinc waste rock(LZWR)generated from the preconcentration process has attracted substantial attention.A type of dolomitic LZWR with 18 wt.%MgO,27 wt.%CaO,0.29 wt.%Zn and 1.43 wt.%S was used as a replacement flux in the iron ore sintering *** sinter pot tests were carried out based on an industrial ore *** results show that replacing 0%-60%of dolomite with LZWR does not adversely affect the sintering productivity,fuel consumption rate,and the quality of the sinter products,while the Zn and S elements contained in LZWR can be effectively removed with the residual Zn and S contents of the resultant sinter products being less than 0.02 and 0.055 wt.%,***,substituting LZWR for dolomite as a flux inevitably increases the SO_(2) concentration in the sintering flue gas due to its high sulfur *** the processing capacity of the sintering flue gas desulfurization system,the replacement ratio of dolomite can reach 40%,equal to LZWR consumption of 24.3 kg per ton of *** SO_(2) in sintering flue gas can be recovered to produce(NH_(4))_(2)SO_(4) or HSO_(4),while the volatilized Zn collected into the zinc-containing dust can be subsequently recycled by the rotary hearth furnace ***,it is technologically and economically feasible to use the LZWR as a replacement flux in the iron ore sintering process,providing a new way for the safe,large-scale and low-cost treatment of LZWR.

关键词： Lead Zinc waste rock Dolomite Sintering Flue gas Sinter product