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Chinese Medicine Prolongs Overall Survival of Chinese Patients with Advanced Gastric Cancer: Treatment Pattern and Survival Analysis of a 20-Year Real-World Study

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Chinese Journal of Integrative Medicine 2024年第6期30卷 489-498页

作者： CAO Ni-da ZHU Xiao-hong MA Fang-qi XU Yan DONG Jia-huan QIN Meng-meng LIU Tian-shu ZHU chun-chao GUO Wei-{1. DING Hong-hua GUO Yuan-biao LIU Li-kun SONG Jin-jie WU Ji-ping CHENG Yue-lei ZENG Lin ZHAO Ai-guang Oncology Department I Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai200032China Oncology Department Zhongshan HospitalFudan UniversityShanghai200032China Gastrointestinal Surgery Department Renji HospitalShanghai Jiaotong University School of MedicineShanghai200127China Oncology Department Fudan University Shanghai Cancer CenterShanghai200032China Oncology Department Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200080China Traditional Chinese Medicine Department Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai200025China Oncology Department Shanxi Traditional Chinese Medicine HospitalTaiyuan030012China Oncology Department Xiyuan HospitalChina Academy of Chinese Medical ScienceBeijing102445China Oncology Department Yunnan Province Hospital of Traditional Chinese MedicineKunming650021China Oncology Department Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Shanghai NewCore Biotechnology Co. Ltd.Shanghai200240China

Objective To describe the treatment patterns and survival status of advanced gastric cancer(AGC)in China in the past two decades,and objectively evaluate the impact of standardized Chinese medicine(CM)treatment on the survival of AGC *** This multicenter registry designed and propensity score analysis study described the diagnosis characteristics,treatment-pattern development and survival status of AGC from 1. hospitals in China between January 1.2000 and July 31.*** survival(OS)was evaluated between non-CM cohort(standard medical treatment)and CM cohort(integrated standard CM treatment≥3 months).Propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)were performed to adjust any difference in average outcomes for *** A total of 2,001.patients histologically confirmed locally advanced and/or metastasis stomach and gastroesophageal junction adenocarcinoma were *** them,1.607 received systemic chemotherapy,21.(1..74%)accepted molecular targeted therapy,44(2.2%)received checkpoint inhibitor therapy,and 769(38.43%)received ***-drug regimen was the main choice for first-line treatment,with fluoropyrimidine plus platinum as the most common regimen(530 cases,60.09%).While 45.71.(1. cases)of patients with HER2 amplification received trastuzumab in *** application of apatinib increased(33.33%)in *** application of checkpoint inhibitors has increased since *** analysis showed that Lauren mixed type(P=0.01.),cycles of first-line treatment>6(P=0.000),CM(P=0.000),palliative gastrectomy(P=0.000),trastuzumab(P=0.01.),and apatinib(P=0.008)were independent prognostic factors for the OS of *** PSM and IPTW,the median OS of CM cohort and non-CM cohort was 1..1. and 1..45 months,respectively(P1..Conclusions In real-world practice for AGC in China,therapy choices consisted with ***-drug regimen was the main first-line *** CM treatment was an independent

关键词： advancedgastriccancer real-world study treatment pattern survival analysis Chinese medicine

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Whole-genome Sequencing Reveals Autooctoploidy in Chinese Sturgeon and Its Evolutionary Trajectories

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 51-65页

作者： Binzhong Wang Bin Wu Xueqing Liu Yacheng Hu Yao Ming Mingzhou Bai Juanjuan Liu Kan Xiao Qingkai Zeng Jing Yang Hongqi Wang Baifu Guo chun Tan Zixuan Hu Xun Zhao Yanhong Li Zhen Yue Junpu Mei Wei {1.g Yuanjin Yang Zhiyuan Li Yong Gao Lei Chen {1.bo {1. Hejun Du Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes Yichang 443100China Chinese Sturgeon Research Institute China Three Gorges CorporationYichang 443100China Yangtze River Biodiversity Research Center China Three Gorges CorporationWuhan 430014China BGI-Shenzhen Shenzhen 518083China BGI Genomics BGI-ShenzhenShenzhen 518083China Department of Biotechnology and Biomedicine Technical University of DenmarkLyngby 2800Denmark River Basin Complex Administration Center China Three Gorges CorporationYichang 443100China BGI-Sanya BGI-ShenzhenSanya 572025China Yangtze Eco-Environment Engineering Research Center China Three Gorges CorporationBeijing 100038China

The order Acipenseriformes,which includes sturgeons and paddlefishes,represents“living fossils”with complex genomes that are good models for understanding whole-genome duplication(WGD)and ploidy evolution in ***,we sequenced and assembled the first high-quality chromosome-level genome for the complex octoploid Acipenser sinensis(Chinese sturgeon),a critically endangered species that also represents a poorly understood ploidy group in *** results show that *** is a complex autooctoploid species containing four kinds of octovalents(8n),a hexavalent(6n),two tetravalents(4n),and a divalent(2n).An analysis taking into account delayed rediploidization reveals that the octoploid genome composition of Chinese sturgeon results from two rounds of homologous WGDs,and further provides insights into the timing of its ploidy *** study provides the first octoploid genome resource of Acipenseriformes for understanding ploidy compositions and evolutionary trajectories of polyploid fishes.

关键词： Chinese sturgeon Whole-genome sequencing Autooctoploid Polyploidization and diploidization Whole-genome duplication

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基于边缘计算的并行密钥隔离聚合签名方案

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电子学报 2024年第3期52卷 1002-1015页

作者：周利峰殷新春宁建廷扬州大学信息工程学院江苏扬州225127 扬州大学广陵学院江苏扬州225128 福建师范大学计算机与网络空间安全学院福建福州350007 中国科学院信息工程研究所信息安全国家重点实验室北京100093

无线医疗传感器网络的出现为患者的治疗带来了极大的便利.但是,无线医疗传感器网络中往往都使用不可信的公共信道进行数据通信并且只有唯一的云服务器处理大量的医疗数据,这就导致了通信安全、隐私保护、密钥泄露、云服务器计算负担过... 详细信息

无线医疗传感器网络的出现为患者的治疗带来了极大的便利.但是,无线医疗传感器网络中往往都使用不可信的公共信道进行数据通信并且只有唯一的云服务器处理大量的医疗数据,这就导致了通信安全、隐私保护、密钥泄露、云服务器计算负担过大、延迟高等问题.此外,现有的大多数无证书聚合签名方案无法抵抗完全选择密钥攻击.针对上述问题,本文提出一种适用于无线医疗传感器网络基于边缘计算的无证书并行密钥隔离聚合签名方案.方案引入边缘计算的架构使得签名的验证和聚合过程在更靠近终端用户的边缘层进行,在降低中心云服务器计算负担的同时还能有效的保护患者的隐私.本文方案继承了无证书和密钥隔离技术的优点,同时避免了复杂的证书管理、密钥托管以及密钥暴露等问题.在随机预言模型下证明了本文方案可以抵抗完全选择密钥攻击、Type I攻击以及Type II攻击.性能分析表明,与相关无证书签名方案相比,本文方案的计算开销至少可降低74.03%,通信开销至少可降低25%.

关键词：无线医疗传感器网络无证书聚合签名并行密钥隔离边缘计算随机预言模型完全选择密钥攻击

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政府补贴对新能源企业创新意愿和创新行为的影响

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气候变化研究进展 2024年第3期20卷 373-383页

作者：郭剑锋杨晓晗谭显春中国科学院科技战略咨询研究院北京100190 中国科学院大学公共政策与管理学院北京100049

新能源企业是绿色创新主要力量,补贴是激励企业创新的常见手段,但补贴对新能源企业创新的激励作用未被系统性分析。文中创新性地把新能源企业的创新分为意愿和行为两个层面,以沪深两市新能源上市公司为研究对象,借助阈值回归和调节效应... 详细信息

新能源企业是绿色创新主要力量,补贴是激励企业创新的常见手段,但补贴对新能源企业创新的激励作用未被系统性分析。文中创新性地把新能源企业的创新分为意愿和行为两个层面,以沪深两市新能源上市公司为研究对象,借助阈值回归和调节效应模型,分析了补贴对新能源企业在创新意愿和创新行为两个方面的影响,以及补贴在创新意愿到创新行为转化中的调节作用。结果表明,补贴对创新意愿有显著促进作用,对创新行为的影响呈“S型”,对创新意愿的转化有正向调节作用,对小规模、低负债、高盈利企业的创新有更强激励作用。研究结论有助于新能源企业补贴政策的制定和评估。

关键词：政府补贴创新意愿创新行为阈值回归

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基于亏缺灌溉的利津县多目标种植结构优化研究

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节水灌溉 2024年第10期 22-28,40页

作者：毕春宁孙斌薛建春杨萌内蒙古科技大学经济与管理学院内蒙古包头014010 山东省水利科学研究院济南250014

针对利津县当地灌溉水资源远远不能满足农田灌溉用水的难题,采用亏缺灌溉的调控方式控制作物生育期灌溉用水量,选取作物经济效益、综合水分生产力、生态效益最大为目标,运用多目标优化模型(AE-FOS-MOP)进一步对利津县不同水平年下的农... 详细信息

针对利津县当地灌溉水资源远远不能满足农田灌溉用水的难题,采用亏缺灌溉的调控方式控制作物生育期灌溉用水量,选取作物经济效益、综合水分生产力、生态效益最大为目标,运用多目标优化模型(AE-FOS-MOP)进一步对利津县不同水平年下的农作物进行种植结构调整。研究表明:①亏缺灌溉方式下,灌溉水量仍不能满足农田灌溉用水需求,但显著缓解了灌溉水供需矛盾。②在保证粮食安全生产的前提下,不同水平年下模型优化的结果有效地调整了粮经作物的比例并实现了节约耕地。③现状年(2022年)通过调减冬小麦、水稻、玉米、棉花的播种面积,增加花生的播种面积,可实现经济效益提升1.9%,综合水分生产力提升4.5%,生态效益提升3.1.。④规划年(2025、2035年)进一步增加蔬菜、花生的种植规模,经济效益分别提升9.5%、1..3%,生态效益分别提升1..9%、1..1.,综合水分生产力分别提升2.1.、5.0%,节水率分别为8.2%、5.5%。

关键词：利津县亏缺灌溉 AE-FOS-MOP 不同水平年种植结构调整

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数字金融与企业突破式创新——基于监督和融资双渠道的分析

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管理评论 2024年第2期36卷 222-235页

作者：孙健李菡旻袁淳李哲中央财经大学会计学院北京100081 中央财经大学企业数字化转型研究中心北京100081

突破式创新是突破以往技术,影响未来技术的创新。本文探究了数字金融发展对上市公司突破式创新的影响,发现数字金融的发展显著促进了上市公司的突破式创新,且数字金融通过发挥监督治理效应和缓解融资约束两个路径作用于突破式创新;相比... 详细信息

突破式创新是突破以往技术,影响未来技术的创新。本文探究了数字金融发展对上市公司突破式创新的影响,发现数字金融的发展显著促进了上市公司的突破式创新,且数字金融通过发挥监督治理效应和缓解融资约束两个路径作用于突破式创新;相比于使用深度,数字金融的覆盖广度更能对突破式创新发挥作用。进一步研究发现,在非国有企业、处于成长期的企业和有IT背景的高管人数比例更高的企业中,数字金融对突破式创新的促进作用更强。此外,数字金融的发展具有区域溢出效应,周边城市数字金融发展也能促进本地上市公司突破式创新的发展。本研究对数字金融的经济后果以及突破式创新的影响因素的相关研究有一定的增量贡献。

关键词：数字金融突破式创新融资约束监督效应

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Silylated and acetylated β-cyclodextrins for gas chromatographic stationary phases

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Journal of Central South University of Technology 2001年第4期8卷 239-243页

作者： TANG Ke wen 1.2 ,YI jian ming 2,ZHOU {1. shan 1.ZHONG Shi an 1.(1. College of Chemistry and Chemical Engineering, Central South University, Changsha 41.083, China 2. College of Chemistry and Chemical Engineering, Yueyang Normal University 1. College of Chemistry and Chemical Engineering Central South University 410083 Changsha China 2. College of Chemistry and Chemical Engineering Yueyang Normal University 414000 Yueyang China

Two new chiral stationary phases, 2,3 di O acetyl 6 O trimethylsilyl β cyclodextrin (DATBCD) and 2,6 di O trimethylsilyl 3 O acetyl β cyclodextrin(DTABCD), were synthesized, their structures were identified by means of infrared and NMR spectra. Capillary columns were coated with the two stationary phases by dynamic method. The chromatographic properties, and enantiomers separation, such as ketone, esters, alcohols and olefines, were investigated on the silylated and acetylated β cyclodextrin stationary phases. The experimental results show that the silylated and acetylated β cyclodextrins are suitable to be used as capillary gas chromatographic stationary phases, the relative polarity of DATBCD and DTABCD stationary phases is respectively 41.3 and 3928, the column efficiencies are respectively 3084 and 41.8, and DATBCD is of stronger enantioselectivity than DTABCD, capacity factor of the first eluted enantiomer ( k 1. and separation factor(α)of α phenylethanol on DATBCD stationary phase are respectively 8.23 and 1.01..

关键词： capillary gas chromatography silylated and acetylated β-cyclodextrins enantiomeric separation

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Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

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Science China(Life Sciences) 2024年第1期67卷 67-82页

作者： chun-Kui Zhang Pan Wang Yuan-Yuan Ji {1.-Shuai Zhao Jun-Xiang Gu Xian-Xia Yan Hong-Wei Fan Ming-Ming Zhang Yu Qiao Xiao-Die Liu Bao-Juan Li Ming-Hui Wang Hai-Long Dong Hao-Hong Li Peng-Cheng Huang Yun-Qing Li Wu-Gang Hou Jin-Lian Li Tao Chen Department of Anatomy and K.K.Leung Brain Research Centre Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Basic Medical Sciences Beijing 100850China Key Laboratory of Ministry of Public Health for Forensic Science Xi’an Jiaotong UniversityXi’an 710061China Department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China School of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated Mental Health Centre and Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The MOE Frontier Research Center of Brain&Brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as ***,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely *** we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1.of mice with depression *** determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA ***,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic *** of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic *** study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

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新型γ-咔啉衍生物的合成及其抑菌活性研究

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有机化学 2024年第1期44卷 204-215页

作者：霍海波李桂霞王世军韩春师宝君李健长治学院生命科学系山西长治046011 长治医学院基础医学部山西长治046011 长治学院化学系山西长治046011 西北农林科技大学植物保护学院陕西杨陵712100

以哌啶酮和4-甲氧基苯肼为起始原料,通过Fischer吲哚合成得到中间体9,经过氧化、酰化以及烷基化构建出新型衍生物45个.所有的目标产物都进行了抗金黄色葡萄球菌、大肠埃希菌、铜绿假单胞杆菌、茄科雷尔氏菌的抑菌活性研究.结果显示:5-(... 详细信息

以哌啶酮和4-甲氧基苯肼为起始原料,通过Fischer吲哚合成得到中间体9,经过氧化、酰化以及烷基化构建出新型衍生物45个.所有的目标产物都进行了抗金黄色葡萄球菌、大肠埃希菌、铜绿假单胞杆菌、茄科雷尔氏菌的抑菌活性研究.结果显示:5-(4'-甲氧基苯甲酰基)-8-甲氧基-γ-咔啉(1.g)、5-(2'-呋喃甲酰基)-8-甲氧基-γ-咔啉(1.n)、5-(2'-溴苄基)-8-甲氧基-γ-咔啉(1.f)、5-(3'-溴苄基)-8-甲氧基-γ-咔啉(1.g)、5-(4'-三氟甲氧基苄基)-8-甲氧基-γ-咔啉(1.h)、溴化2-(4'-氯苄基)-8-甲氧基-γ-咔啉(1.e)具有良好的抑菌活性,特别是化合物1.f和1.h展现出了与阳性对照氨苄西林钠相当的活性,其最小抑菌浓度为8μg/mL.探索了化合物1.h对铜绿假单胞菌的作用机制,确定了其抑菌机制是通过破坏细菌的细胞壁发挥抑菌作用.进一步对该系列衍生物的构效关系进行了讨论,并总结出若干影响该类化合物生物活性的关键因素,为开发新的抗生素提供参考.

关键词： 8-甲氧基-N2&N5取代γ-咔啉抑菌活性构效关系抑菌机制

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A meshless method by using radial basis function for numerical solutions of wave shoaling equation

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Journal of Hydrodynamics 2019年第1期31卷 83-92页

作者： Lin-jian Wu Yuan-zhan Wang Yi Li1.{1.-ning Ji National Engineering Research Center for Inland Waterway Regulation School of River and Ocean EngineeringChongqing Jiaotong UniversityChongqing 400074China State Key Laboratory of Hydraulic Engineering Simulation and Safety Collaborative Innovation Center for Advanced Ship and Deep-Sea ExplorationTianjin UniversityTianjin 300072China

In this present study,a numerical method is proposed for solving the wave shoaling differential equations with turbulent and laminar boundary layers by using the meshless method based on the radial basis *** numerical solutions are compared with those of the finite difference method to see the accuracy,the validity and the applicability of the methodology developed in this *** meshless method by using the radial basis function can effectively improve the computational *** findings in this paper provide a significant support for the study of wave shoaling problems.

关键词： Meshless method radial basis function wave shoaling differential equation

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