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A Meta-Analysis of the Prognostic and Clinicopathological Significance of circZFR in Human Gastrointestinal Cancers

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FLOW PAST TWO ROTATING CIRCULAR CYLINDERS IN A SIDE-BY-SIDE ARRANGEMENT

International Journal of Clinical Medicine（临床医学国际期刊） 2024年第3期 134页

作者： Christian Cedric Bongolo Erick Thokerunga Yu Zhang jian-cheng tu

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Journal of Hydrodynamics 2009年第2期21卷 143-151页

作者： GUO Xiao-hui LIN jian-zhong tu cheng-xu WANG Hao-li China Jiliang University Hangzhou 310018 China

Measurements were performed using Particle Image Velocimetry （PIV） to analyze the modification of flow by the combined effects of the rotation and the Reynolds number on the flow past two rotating circular cylinders in a side-by-side-arrangement at a range of 425 〈 Re ≤ 1130,0 ≤α ≤4 （ α is the rotational speed） at one gap spacing of T / d = 1.11 （T and d are the distance between the centers of two cylinders and the cylinder diameter, respectively）. A new Immersed-Lattice Boltzmann Method （ILBM） scheme was used to study the effect of the gap spacing on the flow. The results show that the vortex shedding is suppressed as rotational speed increases. The flow reaches a steady state when the vortex shedding for both cylinders is completely suppressed at critical rotational speed. As the rotational speed further increases, the separation phenomenon in the boundary layers disappears at the attachment rotational speed. The critical rotational speed and attachment rotational speed become small as Reynolds number increases. The absolute rotational speed of cylinders should be large at same critical rotational speed and attachment rotational speed in the case of large Reynolds number. The gap spacing has an important role in changing the pattern of vortex shedding. It is very different in the mechanism of vortex shedding suppression for the flows around two rotating cylinders and single rotating cylinder.

关键词： flow around two rotating cylinders side-by-side arrangement measurement simulation vortex shedding suppression

Multi-scale collaborative design method for macroscopic thermal optimization and mesoscopic woven structure of hypersonic vehicle's TOCMC leading edge

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Chinese Journal of Aeronautics 2024年第4期37卷 524-541页

作者： Chenwei ZHAO Zecan tu Junkui MAO jian HUI Pingting CHEN College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 21016China Integrated Energy Institute Nanjing University of Aeronautics and AstronauticsNanjing 210016China

A new thermal protection design method for hypersonic vehicle's leading edge is proposed, which can effectively reduce temperature of the leading edge without additional cooling measures. This method reduces the leading-edge's temperature by the multi-scale collaborative design of the macroscopic thermal optimization and the mesoscopic woven structures of Three-dimensional Orthogonal Woven Ceramic Matrix Composites(TOCMC). The macroscopic thermal optimization is achieved by designing different mesoscopic woven structures in different regions to create combined heat transfer channels to dredge the heat. The combined heat transfer channel is macroscopically represented by the anisotropic thermal conductivity of TOCMC. The thermal optimization multiple linear regression model is established to optimize the heat transport channel, which predicts Theoretical Optimal Thermal Conductivity Configuration(TOTCC) in different regions to achieve the lowest leading-edge temperature. The function-oriented mesostructure design method is invented to design the corresponding mesostructure of TOCMC according to the TOTCC, which consists of universal thermal conductivity prediction formulas for TOCMC. These universal formulas are firstly derived based on the thermal resistance network method, which is verified by experiments with an error of 6.25%. The results show that the collaborative design method can effectively reduce the leading edge temperature by about 12.8% without adding cooling measures.

关键词： Multi-scale collaborative design Thermal optimization Ceramic matrix composite Hypersonic vehicle Thermal protection Intelligent optimization

Mechanisms of fracture propagation from multi-cluster using a phase field based HMD coupling model in fractured reservoir

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Petroleum Science 2024年第3期21卷 1829-1851页

作者： Yun-Jin Wang Bo Wang Hang Su tu Chang Ren-cheng Dong Li-Zhe Li Wei-Yu Tang Ting-Xue jiang Fu-jian Zhou State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBejing2249China China University of Petroleum-Beijing at Karamay Karamay834000XinjiangChina China National Oil and Gas Exploration and Development Corporation Ltd. Beijing100034China University of Texas at Austin United States SINOPEC Research Institute of Petroleum Engineering Beijing100101China

Natural fractures(NFs)are common in shale and tight reservoirs,where staged multi-cluster fracturing of horizontal wells is a prevalent technique for reservoir *** NFs and stress interference are recognized as significant factors affecting hydraulic fracture(HF)propagation,the combined influence of these factors remains poorly *** address this knowledge gap,a novel coupled hydromechanical-damage(HMD)model based on the phase field method is developed to investigate the propagation of multi-cluster HFs in fractured *** comprehensive energy functional and control functions are established,while incorporating dynamic fluid distribution between multiple perforation clusters and refined changes in rock mechanical parameters during hydraulic *** HMD coupled multi-cluster HF propagation model investigates various scenarios,including single HF and single NF,reservoir heterogeneity,single HF and NF clusters,and multi-cluster HFs with NF *** results show that the HMD coupling model can accurately capture the impact of approach angle(θ),stress difference and cementation strength on the interaction of HF and *** criterion of the open and cross zones is not *** NF angle(a)is not a decisive parameter to discriminate the *** to the relationship between approach angle(θ)and NF angle(a),the contact relationship of HF can be divided into three categories(θ=a,θa).The connected NF can increase the complexity of HF by inducing it to form branch fracture,resulting in a fractal dimension of HF as high as2.1280 at angles of±45°.Inter-fracture interference from the heel to the toe of HF shows the phenomenon of no,strong and weak ***,under the influence of NFs,distant HFs from the injection can become dominant ***,as a gradually increases,inter-fracture stress interference becomes the primary factor influencing HF propagation,gradually superseding the dominance of NF

关键词： HMD coupling Phase field Natural fracture Flow distribution Hydraulic fracturing Inter-fracture interference

Vesicular drug delivery systems for oral absorption enhancement

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Chinese Chemical Letters 2024年第7期35卷 73-88页

作者： Linghui Zou Meng cheng Kaili Hu jianfang Feng Liangxing tu jiangxi University of Chinese Medicine Nanchang 330006China Guangxi University of Chinese Medicine Nanning 530200China Shanghai University of Traditional Chinese Medicine Shanghai 201203China

Oral administration is the most acceptable route of drug delivery at this stage due to its convenience,safety,and ***,drugs given orally are exposed to a complex gastrointestinal environment,causing a tremendous challenge for their successful absorption into the *** the past decades,researchers have developed various novel pharmaceutical technologies to improve oral absorption,among which the vesicular drug delivery system(like liposomes,niosomes and transfersomes)has received extensive ***,there have been several investigations confirming the improved effect of vesicular drug delivery systems on oral drug ***,the clinical translation of oral vesicular drug delivery systems has been less impressive than implied by the positive results,and few vesicular formulations for oral use have been marketed *** this background,this article provides an overview of the current applications and challenges associated with the vesicular delivery systems available for oral drug delivery,specifically liposomes,niosomes,transfersomes,chitosomes and *** composition,formation mechanism,drug delivery advantages and application cases of these carriers in oral drug delivery are *** possible mechanisms by which vesicular carriers enhance oral drug absorption are analyzed in terms of the in vivo process of oral ***,the challenges that oral vesicular carriers now face,such as safety,undefined in vivo fate,and scale-up production,are summarized,while possible strategies to deal with them are *** reviewing the aforementioned,it can facilitate a more comprehensive knowledge of vesicular systems that can be used for oral drug delivery,providing a theoretical basis and reference for the design of oral formulations.

关键词： Vesicular Oral Mechanism Drug delivery Liposome Niosomes Transfersomes Chitosomes Bilosomes

Single-structure 3-axis Lorentz force magnetometer based on an AlN-on-Si MEMS resonator

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Microsystems & Nanoengineering 2024年第3期10卷 75-86页

作者： cheng tu Xu-heng Ou-Yang Ying-jie Wu Xiao-sheng Zhang School of Integrated Circuit Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

This work presents a single-structure 3-axis Lorentz force magnetometer(LFM)based on an AlN-on-Si MEMS *** operation of the proposed LFM relies on the flexible manipulation of applied excitation currents in different directions and frequencies,enabling the effective actuation of two mechanical vibration modes in a single device for magnetic field measurements in three ***,the excited out-of-plane drum-like mode at 277 kHz is used for measuring the x-and y-axis magnetic fields,while the in-plane square-extensional mode at 5.4 MHz is used for measuring the z-axis magnetic *** different configurations of applied excitation currents ensure good crossinterference immunity among the three *** to conventional capacitive LFMs,the proposed piezoelectric LFM utilizes strong electromechanical coupling from the AlN layer,which allows it to operate at ambient pressure with a high *** understand and analyze the measured results,a novel equivalent circuit model for the proposed LFM is also reported in this work,which serves to separate the effect of Lorentz force from the unwanted capacitive *** demonstrated 3-axis LFM exhibits measured magnetic responsivities of 1.74 ppm/mT,1.83 ppm/mT and 6.75 ppm/mT in the x-,y-and z-axes,respectively,which are comparable to their capacitive counterparts.

关键词： resonator Lorentz structure

Force-position collaborative optimization of rope-driven snake manipulator for capturing non-cooperative space targets

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CHINESE JOURNAL OF AERONAUTICS 2024年第9期37卷 369-384页

作者： Li, Xiaofeng Tian, jian Wei, cheng Cao, Xibin Harbin Inst Technol Sch Astronaut Harbin 150001 Peoples R China China Acad Space Technol Beijing Inst Spacecraft Syst Engn Beijing 100094 Peoples R China

With the rapid development of space activities, non-cooperative space targets increase swiftly, such as failed satellites and upper stages, threating normal spacecrafts seriously. As there are some problems in the capture process, such as excessive collision and fast tumbling of targets, manipulator with redundant Degrees of Freedom (DOFs) can be used to improve the compliance and therefore solve these problems. The Rope-Driven Snake Manipulator (RDSM) is a combination of hyper-redundant DOFs and better compliance, and therefore it is suitable for capturing mission. In this paper, a snake manipulator mechanism is designed, and the complete kinematic model and system dynamic model considering RDSM, target and contact is established. Then, to obtain the configuration of joint with hyper-redundant DOFs, an improved motion dexterity index is proposed as the joint motion optimization target. Besides, the force-position collaborative optimization index is designed to adjust active stiffness, and the impedance control method based on the modified index is used to capture the space target. Finally, the proposed force-position collaborative optimization method is verified by virtual prototype co-simulation. The results demonstrate that based on the proposed method, the collision force is reduced by about 25% compared to normal impedance control, showing higher safety. (c) 2024 Production and hosting by Elsevier Ltd. on behalf of Chinese Society of Aeronautics and Astronautics. This is an open access article under the CC BY-NC-ND license (http://***/ licenses/by-nc-nd/4.0/).

关键词： Capturing non-cooperative space targets Rope-driven snake manipu- lator Force-position collaborative optimization Redundant degrees of free- dom Active stiffness adjustment DUAL-ARM SPACE IMPEDANCE CONTROL ROBOT DEXTERITY INDEX

Facile synthesis of high-brightness green-emitting carbon dots with narrow bandwidth towards backlight display

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Chinese Chemical Letters 2024年第5期35卷 277-282页

作者： Rui cheng Tingting Zhang Xin Huang jian Yu State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 210009China

High-performance carbon dots(CDs)allowing the application in high-end display devices are highly desirable and usually limited by the absence of simple and easy synthesis *** this work,we exploited an easy-to-implement strategy for the one-step synthesis of green-emitting CDs(G-CDs)with superb optical *** G-CDs were synthesized using m-phenylenediamine(m-PD)as a single precursor,and the reaction reacted at 180℃for 12 h The resultant G-CDs exhibit high-purity and excitationindependent green fluorescence with the photoluminescence(PL)peak located at 516 nm,full width at half maximum(FWHM)of 46 nm,and PL quantum yield(QY)of∼80%under the 470nm excitation *** G-CDs and corresponding composite film prepared with polyvinyl butyral(G-CDs@PVB)exhibit good PL stability after undergoing long-time storage for one year and 360 h exposure under 460nm blue *** G-CDs@PVB film was used as color-conversion materials in green-emitting light-emitting diode(LED)application,exhibiting a Commission internationale de l’Eclairage(CIE)chromaticity coordinate of(0.21,0.44).The film was also used in CD-based liquid crystal display(CD-LCD)application,achieving a color gamut value of 85%.This work will offer a working basis for the synthesis of high-performance CDs as well as their application in displays.

关键词： Carbon dots One-step synthesis Narrow bandwidth High quantum yield Display

Multi-objective optimization and evaluation of supercritical CO_(2) Brayton cycle for nuclear power generation

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Nuclear Science and Techniques 2024年第2期35卷 183-209页

作者： Guo-Peng Yu Yong-Feng cheng Na Zhang Ping-jian Ming Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China School of Civil Engineering and Architecture East China Jiaotong UniversityNanchang 330013China

The supercritical CO_(2) Brayton cycle is considered a promising energy conversion system for Generation IV reactors for its simple layout,compact structure,and high cycle *** models of four Brayton cycle layouts are developed in this study for different reactors to reduce the cost and increase the thermohydraulic performance of nuclear power generation to promote the commercialization of nuclear *** analysis,multi-objective optimizations,and four decision-making methods are applied to obtain each Brayton scheme’s optimal thermohydraulic and economic *** show that for the same design thermal power scale of reactors,the higher the core’s exit temperature,the better the Brayton cycle’s thermo-economic *** the four-cycle layouts,the recompression cycle(RC)has the best overall performance,followed by the simple recuperation cycle(SR)and the intercooling cycle(IC),and the worst is the reheating cycle(RH).However,RH has the lowest total cost of investment(C_(tot))of$1619.85 million,and IC has the lowest levelized cost of energy(LCOE)of 0.012$/(kWh).The nuclear Brayton cycle system’s overall performance has been improved due to *** performance of the molten salt reactor combined with the intercooling cycle(MSR-IC)scheme has the greatest improvement,with the net output power(W_(net)),thermal efficiencyη_(t),and exergy efficiency(η_(e))improved by 8.58%,8.58%,and 11.21%,*** performance of the lead-cooled fast reactor combined with the simple recuperation cycle scheme was optimized to increase C_(tot) by 27.78%.In comparison,the internal rate of return(IRR)increased by only 7.8%,which is not friendly to investors with limited *** the nuclear Brayton cycle,the molten salt reactor combined with the recompression cycle scheme should receive priority,and the gas-cooled fast reactor combined with the reheating cycle scheme should be considered carefully.

关键词： Supercritical CO_(2)Brayton cycle Nuclear power generation Thermo-economic analysis Multi-objective optimization Decision-making methods