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World Journal of Clinical Cases 2022年第18期10卷 6175-6183页

作者： Wen-Peng Huang Li-Ming Li jian-bo gao Department of Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Clear cell sarcoma-like tumor of the gastrointestinal tract(CCSLGT)is a rare malignant gastrointestinal mesenchymal soft tissue *** genetic feature is EWSR1 gene ***,it is often accompanied by a varying number of CD68-positive osteoclast-like giant *** mostly occurs in the small intestinal wall of young people and *** terms of clinical manifestations,there is no significant difference between it and other gastrointestinal tumors,and the diagnosis depends on immunohistochemistry and gene *** SUMMARY A 16-year-old man developed dizziness and fatigue 2 mo ago,and 10 d ago showed progressive exacerbation of paroxysmal epigastric pain and stopped flatulence and *** tomography showed a soft tissue mass in the distal *** complete resection of the lesion,it was diagnosed by combined immunohistochemical and genetic examination as *** surgery,the patient gradually developed lymph node,liver,lung,bone,left thigh,pleura and adrenal *** survival time was 4 years and 8 *** Whole abdominal computed tomography enhancement is recommended for patients with gastrointestinal *** is no effective treatment for CCSLGT with multiple metastases via the lymphatic system and bloodstream after surgical resection.

关键词： Clear cell sarcoma-like tumor of the gastrointestinal tract Metastasis X-ray computed tomography Case report

Primary clear cell sarcoma of soft tissue in the posterior cervical spine invading the medulla oblongata:A case report

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World Journal of Clinical Cases 2022年第21期10卷 7571-7576页

作者： Chen-Chen Liu Wen-Peng Huang jian-bo gao Department of Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Clear cell sarcoma(CCS)is a rare and highly malignant soft tissue tumor,usually occurring in the deep soft tissues of the distal tendons and aponeurosis of the extremities,especially the feet and *** originating in the head and neck is extremely *** clinical manifestations of CCS in the head and neck are not typical,and the imaging manifestations have certain characteristics,but the diagnosis still depends on pathological examination and genetic *** SUMMARY A 33-year-old male patient had paroxysmal headache for more than 4 years,accompanied by nausea and vomiting,which could be relieved after *** tomography angiography showed a left paraspinal soft tissue ***-enhanced imaging showed obvious uneven enhancement with adjacent bone lytic *** resonance imaging examination showed isosignal on T_(1)-weighted images,slightly high signal on T_(2)-weighted images(T_(2)WI),high signal on Tirm fat suppression sequence,significantly high signal on diffusion weighted imaging,and obvious and uneven *** lesion invaded the anterior medulla oblongata through the left atlantoaxial foramen and compressed the cervical spinal cord on T_(2)*** CCS of soft tissue was diagnosed by pathology and genetic *** CCS should be considered in the differential diagnosis of soft tissue tumors of the head and neck,and their diagnosis depends on pathological examination and genetic testing.

关键词： Clear cell sarcoma Soft tissue Medulla oblongata Tomography X-ray computed Magnetic resonance imaging Case report

Pleomorphic adenoma of the left lacrimal gland recurred and transformed into myoepithelial carcinoma after multiple operations:A case report

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World Journal of Clinical Cases 2022年第11期10卷 3630-3638页

作者： Wen-Peng Huang Li-Ming Li jian-bo gao Department of Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Myoepithelial carcinoma(MC)is a clinically rare malignancy,there is controversy regarding its etiology and its biological behavior is not fully *** surgical resection is the main treatment *** describe a case of pleomorphic adenoma(PA)with multiple postoperative recurrences after malignant transformation,and the history of the disease in this patient was more than 20 *** resection during the first surgery of PA and long-term postoperative follow-up is *** SUMMARY A 34-year-old male with PA and a history of 5 postoperative recurrences over 21 years,each surgically removed,presented 15 d ago with headache,nasal congestion,protrusion of the right eyeball and loss of vision in the right eye,with progressively worsening *** patient underwent surgery,and MC was confirmed by pathology examination.A small PA component was locally visible under light *** patient had a recurrence of the tumor 2 mo after surgery and underwent surgical *** During the first operation for PA,care should be taken not to rupture the envelope to prevent tumor cell implantation,and when complete resection is not possible due to the anatomical site,postoperative radiotherapy is necessary to control the lesion and prevent infiltration and malignant transformation of the tumor to *** tomography and magnetic resonance imaging is important for establishing diagnosis and developing a treatment plan.

关键词： Myoepithelial carcinoma Pleomorphic adenoma Magnetic resonance

X-ray diagnosis of synchronous multiple primary carcinoma in the upper gastrointestinal tract

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World Journal of Gastroenterology 2011年第14期17卷 1817-1824页

作者： Zhi-Hao Yang jian-bo gao Song-Wei Yue Hua Guo Xue-Hua Yang Department of Radiology The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 Henan Province China

AIM:To analyze the radiological features of multiple primary carcinoma (MPC) in the upper gastrointestinal (GI) tract,study its biological characteristics and evaluate X-ray examination in its diagnosis. METHODS:Hypotonic double-contrast GI radiography was performed in 59 multiple primary carcinoma cases,pathologically proved by surgery or endoscopy biopsy. Radiological findings were analyzed. RESULTS:Of the 59 cases,esophageal MPC (EMPC) was seen in 24,esophageal and gastric MPC (EGMPC) in 27 and gastric MPC (GMPC) in 8. Of the 49 lesions found in 24 EMPC,hyperplastic type was seen in 23,medullary type in 9. The lesions were located at the upper (n = 17),middle (n = 19) or lower (n = 13) segment of the esophagus. In 27 EGMPC,the esophageal lesions were located at the middle (n = 16) or lower (n = 11) segment of the esophagus,while the gastric le-sions were located at the gastric cardia (n = 16),fundus (n = 1),body (n = 3) and antrum (n = 7). The esophageal lesions were mainly of the hyperplastic type (n = 12) or medullary type (n = 7),while the gastric lesions were mainly of the hyperplastic type (n = 18). A total of 119 lesions in the 59 patients with synchronous multiple carcinoma were proved by surgery or endoscopy biopsy,and preoperative upper radiographic examination detected 100 of them (84.03% sensitivity). Eighteen (52.94%) of the T1 lesions were found during preoperative diagnosis by radiographic examination. Moreover,only 3 (3.53%) of the T2-4 lesions were misdiagnosed. CONCLUSION:Hypotonic double-contrast upper gastrointestinal examination,providing accurate information about lesion morphology,location and size,can serve as a sensitive technique for the preoperative diagnosis of MPC.

关键词： Multiple primary carcinoma Upper gastrointestinal tract Radiography

Malignant giant cell tumors of the tendon sheath of the right hip:A case report

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World Journal of Clinical Cases 2022年第29期10卷 10763-10771页

作者： Wen-Peng Huang Ge gao Qi Yang Zhao Chen Yong-Kang Qiu jian-bo gao Lei Kang Department of Nuclear Medicine Peking University First HospitalBeijing 100034China Department of Medical Imaging Peking University First HospitalBeijing 100034China Department of Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Malignant giant cell tumor of the tendon sheath(MGCTTS)is an extremely rare malignant tumor originating from synovial and tendon sheath tissue with highly aggressive biological behavior and a high rate of local recurrence and distant metastasis which should be considered a highly malignant sarcoma and managed *** to systemically treat MGCTTS remains a *** this case,a patient with MGCTTS suffered a recurrence after 2 surgical resections received adjuvant chemotherapy and radiation therapy,but the treatment outcome remained *** clinical trials and better understanding of the biology and molecular aspects of this subtype of sarcoma are needed while novel medicines should be developed to efficiently target particular *** SUMMARY A 52-year-old man presented with persistent dull pain in the right groin accompanied by limited right hip motion starting 6 mo *** months before his attending to hospital,the patient’s pain worsened,presenting as severe pain when standing or walking,limping,and inability to straighten or move the right lower *** excision was performed and MGCTTS was confirmed by pathology *** recurrences occurred after surgical resection,moreover,the treatment outcome remained poor after adjuvant chemotherapy and radiation *** patient died only 10 mo after the initial *** MGCTTS is characterized by a joint mass with pain and limited *** typically grows along the tendons and infiltrated into the surrounding muscle and bone tissue,with a stubborn tendency to relapse,as well as pulmonary *** surgical resection provides a choice of treatment whereas post-operation care should be taken to preserve the function of the *** and radiotherapy can be used as alternative treatments when radical resection cannot be performed.

关键词： Malignant Tenosynovial giant cell tumor Recurrence Magnetic resonance imaging bone scintigraphy Treatment X-ray computed tomography Case report

Malignant giant cell tumor in the left upper arm soft tissue of an adolescent:A case report

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World Journal of Clinical Cases 2021年第15期9卷 3704-3710页

作者： Wen-Peng Huang Li-Na Zhu Rui Li Li-Ming Li jian-bo gao Department of Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Giant cell tumor of soft tissue(GCT-ST)is an extremely rare low-grade soft tissue tumor that is originates in superficial tissue and rarely spreads ***-ST has unpredictable *** is mainly benign,but may sometimes become aggressive and potentially increase in size within a short period of *** SUMMARY A 17-year-old man was suspected of having a fracture,based on radiography following left shoulder *** month later,the swelling of the left shoulder continued to increase and the pain was *** tomography(CT)revealed a soft tissue mass with strip-like calcifications in the left *** mass invaded the adjacent humerus and showed an insect-like area of destruction at the edge of the cortical bone of the upper *** marrow cavity of the upper humerus was enlarged,and a soft tissue density was seen in the medullary *** CT revealed multiple small nodules beneath the pleura of both lungs.A bone scan demonstrated increased activity in the left shoulder joint and proximal *** mass showed mixed moderate hypointensity and hyperintensity on T1-weighted images,and mixed hyperintensity on T2-weighted fat-saturated *** final diagnosis of GCT-ST was confirmed by *** GCT-STs should be considered in the differential diagnosis of soft tissue tumors and monitored for large increases in size.

关键词： bone scan Giant cell tumor Soft tissue Tomography X-ray computed Magnetic resonance imaging Case report

Esophageal myoepithelial carcinoma:Four case reports

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World Journal of Clinical Cases 2022年第9期10卷 2938-2947页

作者： Hao Lu Hui-Ping Zhao Yi-Yang Liu Juan Yu Rui Wang jian-bo gao Department of Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Myoepithelial carcinoma(MC)is a rare malignant neoplasm that mainly occurs in the salivary *** can be confused with many other tumors when arising outside the salivary glands because it presents with a wide spectrum of cytomorphological and immunohistochemical *** the best of our knowledge,esophageal MC has not been previously *** purpose of this study was to describe the imaging and clinicopathological features of esophageal MC to improve the understanding of the *** SUMMARY Three men and one woman diagnosed with esophageal MC were enrolled in this *** primary clinical symptom was *** mass was mainly located in the middle *** tests revealed that two patients who underwent tumor abnormal protein were *** resection was performed for all patients with no adjuvant ***-eosin staining showed infiltrative growth of epithelial cells with hyperchromatic and pleomorphic nuclei toward the *** showed that all patients were positive for P63,and most patients were positive for SOX-10,AE1/AE3,P40,and *** Ki-67 values were all higher than 60%.Patient one died one month after discharge from an unknown *** two lost to *** patient three’s four-month review,enhanced computed tomography(CT)showed anastomosis recurrence and bilateral lung *** abandoned treatment and lost to *** four attended review appointments regularly and remained in a good general *** Here,we present the first report of esophageal MC and review the relevant *** MC is more likely to occur in the middle esophagus in older patients with male dominance.A fungating type observed on CT scanning may help narrow down the differential *** change or necrosis may occur in larger *** final diagnosis should be made according to the pathological *** treatment for MC is surgical resec

关键词： Myoepithelial carcinoma Esophagus Computed tomography Diagnosis Immunohistochemistry Prognostic Case report

Spectral computed tomography in advanced gastric cancer: Can iodine concentration non-invasively assess angiogenesis?

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World Journal of Gastroenterology 2017年第9期23卷 1666-1675页

作者： Xiao-Hua Chen Ke Ren Pan Liang Yaru Chai Kui-Sheng Chen jian-bo gao Department of Radiology The First Affiliated Hospital of Zhengzhou University Surgery of Gastroenterology Luohe Central Hospital Department of Pathology The First Affiliated Hospital of Zhengzhou University

AIM To investigate the correlation of iodine concentration(IC) generated by spectral computed tomography(CT) with micro-vessel density(MVD) and vascular endothelial growth factor(VEGF) expression in patients with advanced gastric carcinoma(GC).METHODS Thirty-four advanced GC patients underwent abdominal enhanced CT in the gemstone spectral imaging mode. The IC of the primary lesion in the arterial phase(AP) and venous phase(VP) were measured, and were then normalized against that in the aorta to provide the normalized IC(nI C). MVD and VEGF were detected by immunohistochemical assays, using CD34 and VEGF-A antibodies, respectively. Correlations of nI C with MVD, VEGF, and clinical-pathological features were *** both nI Cs correlated linearly with MVD and were higher in the primary lesion site than in the normal control site, but were not correlated with VEGF expression. After stratification by clinical-pathological subtypes, nI C-AP showed a statistically significant correlation with MVD, particularly in the group with tumors at stage T4, without nodular involvement, of a mixed Lauren type, where the tumor was located at the antrum site, and occurred in female individuals. nI C-VP showed a positive correlation with MVD in the group with the tumor at stage T4 and above, had nodular involvement, was poorly differentiated, was located at the pylorus site, of a mixed and diffused Lauren subtype, and occurred in male individuals. nI C-AP and nI C-VP showed significant differences in terms of histological differentiation and Lauren *** The IC detected by spectral CT correlated with the MVD. n IC-AP and n IC-VP can reflect angiogenesis in different pathological subgroups of advanced GC.

关键词： Micro-vessel density Iodine concentration Spectral computed tomography Vascular endothelial growth factor Gastric cancer

Multimodality imaging and treatment of paranasal sinuses nuclear protein in testis carcinoma:A case report

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World Journal of Clinical Cases 2022年第33期10卷 12395-12403页

作者： Wen-Peng Huang Ge gao Yong-Kang Qiu Qi Yang Le-Le Song Zhao Chen jian-bo gao Lei Kang Department of Nuclear Medicine Peking University First HospitalBeijing 100034China Department of Medical Imaging Peking University First HospitalBeijing 100034China Department of Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Nuclear protein in testis(NUT) carcinoma is a rare aggressive malignant epithelial cell tumor, previously known as NUT midline carcinoma(NMC), characterized by an acquired rearrangement of the gene encoding NUT on chromosome 15q14. Due to the lack of characteristic pathological features, it is often underdiagnosed and misdiagnosed. A variety of methods can be used to diagnose NMC, including immunohistochemistry, karyotyping, fluorescence in situ hybridization, reverse transcription-polymerase chain reaction, and next-generation sequencing. So far, there is no standard treatment plan for NMC and the prognosis is poor, related to its rapid progression, easy recurrence, and unsatisfactory treatment *** SUMMARY A 58-year-old female came to our hospital with a complaint of eye swelling and pain for 8 d. The diagnosis of NMC was confirmed after postoperative pathology and genetic testing. The patient developed nausea and vomiting, headache, and loss of vision in both eyes to blindness after surgery. Magnetic resonance imaging(MRI) and positron emission tomography/computed tomography(PET/CT) performed after 1.5 mo postoperatively suggested tumor recurrence. The patient obtained remission after radiation therapy to some extent and after initial treatment with anti-angiogenic drugs and sonodynamic therapy(SDT), but cannot achieve long-term stability and eventually developed distant metastases, with an overall survival of only 17 *** For patients with rapidly progressing sinus tumors and poor response to initial treatment, the possibility of NMC should be considered and immunohistochemical staining with anti-NUT should be performed as soon as possible, combined with genetic testing if necessary. CT, MRI, and PET/CT imaging are essential for the staging, management, treatment response assessment and monitoring of NMC. This case is the first attempt to apply heat therapy and SDT in the treatment of NMC, unfortunately, the prognosis remained poor.

关键词： Nuclear protein in testis Recurrence Magnetic resonance imaging Treatment X-ray computed tomography Positron emission tomography Case report

The Study on the Variation of the Cavity Length's Influence on the Output Pulse Train of the Actively Mode-Locked Fiber Laser

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The Journal of China Universities of Posts and Telecommunications 2005年第3期12卷 54-57页

作者： LUO Hong-e TIAN Xiao-jian gao bo College of Electronic Science and Engineering of Jinlin University Changchun 130012 P.R. China

The influence of actively mode-locked Erbium-Doped Fiber Laser （EDFL） cavity length variation on the noises of an optical pulse train is investigated, in theory and in MATLAB simulation. Using a simple model, the noise characre, tics of the output pulse train are studied. The results show that the noises of the output pulse train increase with the increasing of the variation of the cavity length. The theory analysis and the simulation results agree well. This result is very significant for us to improve the reliability and the stability of the actively mode-locked fiber laser.

关键词： actively mode-locked fiber laser phase noise simulation EDFL