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Influence of As_2O_3 combined with ginsenosides Rg3 on inhibition of lung cancer NCI-H1299 cells and on subsistence of nude mice bearing hepatoma

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Asian Pacific Journal of Tropical Medicine 2014年第10期7卷 772-775页

作者： jian-bo che Zhong-Hua Liu Hong-Bing Ma Yong Li Hui Zhao Xiao-Hui Li Wei-Chao Liu Gong-Ning Shi Huaihe River Hospital Henan University

Objective:To study the effect of arsenic trioxide（As2O3）combined with ginsenosides Rg3 on inhibiting the NCI-H1299 lung cancer cells and subsistence in nude mice bearing ***:MTT method was used to measure the inhibition effect of（As2O3）combined Rg3 on NC1-H1299 cells,and the proliferation inhibiting effect was observed via establishing the transplanted tumor model in vitro.A total of 40 tumor-bearing nude mice were randomly divided into normal saline group,（As2O3）,Rg3 and As2O3+Rg3 *** tumor model of lung cancer in nude mice was constructed,followed by injection of certain concentrations of normal saline,As2O3,ginseng saponin Rg3 and As2O3+Rg3 every *** survival duration and the tumors size of the mice were recorded and the Kaplan-Meier curve was made;microscopic observation of apoptosis of tumor cells in vivo was done using TUNEL ***:After 72 h of *** rate of tumor cell in normal saline group,As2O3 ***3 group and As2O3+Rg3 group was（5.66±0.31）%,（65.58±4.75）%,（44.69±3.32）%and（82.67±5.43）%,*** rate of tumor cell in As2O3 ***3 groap and As2O3+Rg3 group was significantly higher than that of normal saline group（P<0.01）;inhibition rate of tumor cells of As2O3+Rg3 group was significantly higher than that of the two groups given As2O3 or Rg3 alone（P<0.01）.The tumor volume of As2O3 group,Rg3 group and As2O3+Rg3 group shrank to（65.38±3.25）%,（77.68±3.43）%and（42.65±3.55）%of the original,tumor volume of saline group was 1.21 times of the original size（P<0.01）;Median survival of saline group,Rg3 group,As2O3 group were significantly shorter than that of As2O3+Rg3 group（P<0.01）;co-ordinated intervention ability of As2O3+Rg3 on NCI-H1299 cell was significantly higher than that of As2O3 or Rg3,***:As2O3 combined with Rg3 can significantly inhibit prolifaration of NCI-H1299 cells in lung cancer,prolong survival fo tumor-bearing nude mice,and promote tumor cell

关键词： As_2O_3 Rg3 Lung cancer Combination therapy

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Effect of sevoflurane on tissue permeability of lung ischemia-reperfusion injury in rats

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Asian Pacific Journal of Tropical Medicine 2014年第4期7卷 276-279页

作者： Xiao-Hui Li Zhong-Hua Liu Hong-Bing Ma Yong Li Hui Zhao jian-bo che Wei-Chao Liu Gong-Ning Shi Huaihe River Hospital Henan University Medical School Henan University

Objective:To investigate the effect of sevoflurane on tissue permeability of lung ischemiareperfusion injury(LIRI)in ***:A total of 45 wistar rats were randomly divided into3 groupsⅠ,Ⅱ,Ⅲ.Modified Eppinger method was adopted to establish the rat lung ischemiareperfusion injury ***Ⅰserved as the control group,groupⅡas ischemia reperfusion group,groupⅢas sevoflurane ischemia-reperfusion *** gas index,lung permeability index(LPI)change,lung tissue pathology change and lung water content were observed and compared between groups of rats at different time ***:During ischemia reperfusion,all rats kept balance of the MAP during different time points,SPO_2 of groupⅡandⅢdecreased significantly thanⅠgroup(P<0.05);after reperfusion lung permeability index in GroupⅡandⅢwas higher than the control group significantly(P<0.05),120 min after reperfusion LPI change and iujury of groupⅢwas significantly lower thanⅡgroup(P<0.05);interstitial and alveolar cavity effusion in of groupⅢwere lower than that of groupⅡ.Conclusions:Sevoflurane pretreatment can reduce the lung tissue permeability,and LIRI plays a protective role in LIRI.

关键词： Sevoflurane Rats Lung ischemia-reperfusion Protection

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie jian Yu Kun-Ning Zhang Zhou-bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Electrochemical hydrogen storage properties of melt-spun Ti0.9Zr0.1V0.2Ni1.5La0.5 alloy

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Frontiers of physics 2011年第2期6卷 209-213页

作者： jian WANG Guang-bo che Qing-wei WANG Wan-xi ZHANG Li-min WANG Key Laboratory of Preparation and Applications of Environmental Friendly Materials （Ministry of Education） Jilin Normal University Siping 136000 China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

The Ti0.9Zr0.1V0.2Ni1.5La0.5 alloy samples were synthesized by melt-spinning technique at the different wheel velocity （cooling rate）, and the structure and electrochenfical hydrogen storage properties were investigated. The result indicated that the structure of the melt-spun ribbons mainly contains C14 Laves phase and V-based solid solution phase. The discharge capacity, cyclic stability, high-rate discharge ability and electrochemical kinetic of the alloy electrodes are correlated with the cooling rate （wheel velocity）, and the maximum discharge capacity is over 200 mA.h/g at the wheel velocity of 20 m/s.

关键词： Ti0.9Zr0.1V0.2Ni1.5La0.5 alloy melt-spinning hydrogen storage electrochemical prop-erties

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On Laguerre Form and Laguerre Isoparametric Hypersurfaces

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Acta Mathematica Sinica,English Series 2015年第3期31卷 501-510页

作者： jian bo FANG Department of Mathematics Tongji University School of Mathematics and Statistics Chuxiong Normal University

Let x ： M^n-1→ R^nbe an umbilical free hypersurface with non-zero principal curvatures.M is called Laguerre isoparametric if it satisfies two conditions, namely, it has vanishing Laguerre form and has constant Lauerre principal curvatures. In this paper, under the condition of having constant Laguerre principal curvatures, we show that the hypersurface is of vanishing Laguerre form if and only if its Laguerre form is parallel with respect to the Levi-Civita connection of its Laguerre metric.

关键词： Laguerre isoparametric hypersurface Laguerre second fundamental form Laguerre metric Laguerre form parallel Laguerre form

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Improved sample added LMMSE receiver based on interference mitigation for HSDPA downlink

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The Journal of China Universities of Posts and Telecommunications 2008年第2期15卷 39-44页

作者： che Wen ZHAO Hui WANG Wen-bo Key Laboratory of Universal Wireless Communications Ministry of EducationBeijing University of Posts and Telecommunications Beijing 100876 China

In the downlink of wideband code division multiple access （WCDMA） or WCDMA- high speed downlink packet access （HSDPA） system, the frequency reuse factor is equal to 1, which leads to more possible co-channel interference from neighbor cells. In this situation, user equipment（UE） with traditional receiver will suffer from significant performance degradation at the edge of the cell. To solve this problem, a receiver structure considering interference mitigation has been proposed for long term evolution（LTE） of third-generation partnership project （3GPP）. Such receiver makes use of all the interfering cells＇ channel information to perform a linear minimum mean square error （LMMSE） equalization algorithm. In this article, an improved equalization algorithm is presented, which simply adds more samples to perform one equalization operation. Simulations show that the proposed algorithm can obtain a considerable performance improvement in frequency selective fading channel, with relative little additional complexity introduced.

关键词： LMMSE HSDPA equalizer

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A PROJECTION-TYPE METHOD FOR SOLVING VARIOUS WEBER PROBLEMS

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Journal of Computational Mathematics 2006年第4期24卷 527-538页

作者： jian-lin jiang bo chen Department of Mathematics Nanjing University Nanjing 210093 China

This paper investigates various Weber problems including unconstrained Weber problems and constrained Weber problems under l1, l2 and l∞-norms. First with a transformation technique various Weber problems are turned into a class of monotone linear variational inequalities. By exploiting the favorable structure of these variational inequalities, we present a new projection-type method for them. Compared with some other projection-type methods which can solve monotone linear variational inequality, this new projection-type method is simple in numerical implementations and more efficient for solving this class of problems; Compared with some popular methods for solving unconstrained Weber problem and constrained Weber problem, a singularity would not happen in this new method and it is more reliable by using this new method to solve various Weber problems.

关键词： Linear variational inequality Various Weber problems Projection-type method Slack technique.

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Feasibility study on heap bioleaching of chalcopyrite

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Rare Metals 2013年第5期32卷 524-531页

作者： bo-Wei chen jian-Kang National Engineering Laboratory of Biohydrometallurgy General Research Institute for Nonferrous Metals

Bioleaching of chalcopyrite often encountered the formation of passivation layer, which inhibited the leaching process and resulted in a low leaching rate. This inhibitory effect can be eliminated by thermophilic biole- aching. The industrial test of BioCOP technology based on thermophiles was successfully completed, which confirmed the feasibility of chalcopyrite bioleaching. However, industrial leaching rate of chalcopyrite heap bioleaching is lower. This paper described the development status and industrial test of chalcopyrite heap bioleaching technology. The reasons for the lower efficiency of chalcopyrite heap bioleaching were analyzed. The strategies for successful chalcopyrite heap bioleaching were proposed.

关键词： Chalcopyrite Heap bioleaching Thermophiles Pyrite Feasibility

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Distr ibution, risk and bioavailability of metals in sediments of Lake Yamdrok Basin on the Tibetan Plateau, China

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Journal of Environmental Sciences 2020年第11期32卷 169-179页

作者： Feifei che Junyi chen bo Zhang Xia jiang Shuhang Wang National Engineering Laboratory for Lake Pollution Control and Ecological Restoration Chinese Research Academy of Environmental SciencesBeijing l00012China

Total contents of metals in soil and sediments on the Tibetan Plateau of China have been widely analyzed,but existing information is insufficient to effectively evaluate metal ecological risk because of a lack of metal bioavailability *** this study,distribution,potential risk,mobility and bioavailability of metals in sediments of Lake Yamdrok Basin in Tibet of China were explored by combined use of total digestion,sequential extraction and the diffusive gradient in thin-films(DGT).Average concentrations of Cr,Ni,Cu,Zn,As,Cd and Pb in surface sediments were 31.25,30.31,22.00,45.04,31.32,0.13 and 13.39 mg/kg,*** levels of metals were found near the inflowing *** form was dominant in Cr,Ni,Zn,Cd and Pb,and reducible form was dominant in As and *** in surface sediments showed a low enrichment degree overall,but Cd and As had higher ecological risk levels than the other ***,there was a larger average proportion of exchangeable form of As(20.4%)and Cd(9.0%)than the other metals(1.7%-3.3%),implying their higher mobility and release *** DGT-labile concentrations of Cr,Ni,Cu,Zn,As,Cd and Pb were 0.5,4.5,0.7,25.1,60.0,0.22 and 1.0μg/L,*** DGT-labile As was significantly correlated with extractable As forms(p<0.01),suggesting that extractable As in sediments acts as a"mobile pool"for bioavailable *** results suggest potential risks of As and Cd,especially As,deserve further attention in Lake Yamdrok Basin.

关键词： Sequential extraction the Diffusive gradients in thin films(DGT) Mobility Geochemical baseline Tibet

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Insights into the adsorption/desorption of CO_(2) and CO on single-atom Fe-nitrogen-graphene catalyst under electrochemical environment

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Journal of Energy chemistry 2021年第2期30卷 20-25,I0002页

作者： Jiejie Li jian Liu bo Yang School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China CAS Key Laboratory of Low-Carbon Conversion Science&Engineering Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China University of Chinese Academy of Sciences Bejing 100049China

Single-atom metal-nitrogen-graphene(M-N-Gra) catalysts are promising materials for electrocatalytic CO_(2) reduction reaction(CO_(2) RR). However, theoretical explorations on such systems were greatly hindered because of the complexity in modeling solid/liquid interface and electrochemical environment. In the current work, we investigated two crucial processes in CO_(2) RR, i.e. adsorption and desorption of CO_(2) and CO at Fe-N_(4) center, with an explicit aqueous model. We used the ab initio molecular dynamics simulations associated with free energy sampling methods and electrode potential analysis to estimate the energetics under electrochemical environment, and found significant difference in aqueous solution compared with the same process in vacuum. The effect of applied electrode potential on the adsorption structures,charge transfer and free energies of both CO_(2) and CO on Fe-N-Gra was thoroughly discussed. These findings bring insights in fundamental understandings of the CO_(2) RR process under realistic conditions, and facilitate future design of efficient M-N-Gra-based CO_2 RR catalysts.

关键词： Single atom catalyst Electroreduction of CO_(2) Adsorption CO Ab initio molecular dynamics

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