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Synergistic effect of all-trans-ret inoic acid and arsenic trioxide on growth inhibition and apoptosis in human hepatoma, breast cancer, and lung cancer cells in vitro

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World Journal of Gastroenterology 2005年第36期11卷 5633-5637页

作者： Le-Min Lin Bao-Xin Li jian-bing xiao Dan-Hua Lin Bao-Feng Yang Department of General Surgery The First ClinicalCollege Harbin Medical University Harbin 150001 Heilongjiang Province China Department of Pharmacology Harbin Medical University Harbin150086 Heilongjiang Province China

AIM： To investigate the effect of all-trans-retinoic acid （ATRA） on arsenic trioxide （As2O3）-induced apoptosis of human hepatoma, breast cancer, and lung cancer cells in an attempt to find a better combination therapy for solid tumors. METHODS： Human hepatoma cell lines HepG2, Hep3B, human breast cancer cell line MCF-7, and human lung adenocarcinoma cell line AGZY-83-a were treated with As203 together with ATRA. Cell survival fraction was determined by MTT assay, cell viability and apoptosis were measured by annexin V-fluorescein isothiocyanate （FITC） and PI staining, and intracellular glutathione （GSH） and glutathione-S-transferase （GST） activities were determined using commercial kits. RESULTS： Cytotoxicity of ATRA was low. ATRA （0.1, 1, and 10 μmol/L） could synergistically potentiate As2O3 to exert a dose-dependent inhibition of growth and to induce apoptosis in each of the cell lines. HepG2 and Hep3B with low intracellular GSH or GST activities were remarkably sensitive to As2O3 or As2O3＋ATRA, while AGZY-83-a with higher GSH or GST activities was less sensitive to As2O3 or As2O3＋ATRA. Treatment with 2 μmol/L As2O3 for 72 h significantly decreased intracellular GSH and GST levels in each of the cell lines, and 1 μmol/L ATRA alone reduced minimal intracellular GSH and GST levels. ATRA potentiated the effect of As2O3 on intracellular GSH levels, but intracellular GST levels were not significantly affected by the combination of As2O3 and ATRA for 72 h as compared to As2O3 ***： ATRA can strongly potentiate As2O3- induced growth-inhibition and apoptosis in each of the cell lines, and two drugs can produce a significant synergic effect. The sensitivity to As2O3 or As2O3＋ATRA is inversely proportional to intracellular GSH or GST levels in each of the cell lines. The GSH redox system may be the possible mechanism by which ATRA synergistically potentiates As203 to exert a dose-dependent inhibition of growth and to induce apoptosis. 2005 The WJG Press and Els

关键词： Arsenic trioxide AII-trans-retinoic acid Hepatocellular carcinoma Cancer of breast and lung Glutathione Glutathione-S-tra nsferase

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Association between anesthesia technique and complications after hip surgery in the elderly population

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World Journal of Clinical Cases 2022年第9期10卷 2721-2732页

作者： Ling-Song Guo Li-Nan Wang jian-bing xiao Min Zhong Gao-Feng Zhao Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Department of Anaesthesiology Guangdong Provincial Hospital of Chinese Medicine(the Second Affiliated Hospital of Guangzhou University of Chinese Medicine)Guangzhou 510000Guangdong ProvinceChina

BACKGROUND Spinal anesthesia is superior to general anesthesia for postoperative recovery in older patients(≥65 age).However,evidence for this is *** To evaluate the effect of anesthesia on postoperative complications in older patients undergoing hip *** This is a retrospective,propensity score-matched,cohort ***≥65-years-old who underwent hip surgery at the Traditional Chinese Medicine of Guangdong Provincial Hospital in China from October 2016 to June 2020 were *** operative methods were femoral fracture’s internal fixation and hip *** orthopedic doctors in different hospitals of our group have varied requirements for patients’out-of-bed time after ***,spinal anesthesia or general anesthesia was selected according to the requirements of the orthopedic *** primary outcome of this study was complications during the hospitalization of the postoperative *** length of hospital stay,postoperative blood transfusion,routine blood analysis,renal function,coagulation function,and inflammatory correlations were secondary *** score matching(PSM)was performed utilizing logistic *** Among the 864 patients identified from the electronic medical record data database,we screened out those with incomplete medical record *** PSM of the baseline values of the two groups of patients,data of 309 patients(206 patients in spinal anesthesia group and 103 patients in general anesthesia)were utilized in this study.67/309 patients had complications,including postoperative limb dysfunction,pulmonary infection,delirium,lower extremity venous thrombosis,and *** incidence of complications was not related to anesthesia methods(P>0.05),but the levels of D-Dimer(P=0.017),fibrinogen(P=0.005),and high-sensitivity C-reactive protein(hs CRP)(P=0.002)in the spinal anesthesia group were significantly higher than those in the general anesthesia *** Anesthesia technolog

关键词： Spinal anesthesia General anesthesia Hip surgery Older population Complications

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Abdominal Fat Accumulation with Hyperuricemia and Hypercholesterolemia Quail Model Induced by High Fat Diet

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Chinese Medical Sciences Journal 2009年第3期24卷 191-194页

作者： Zhi-jian Lin bing Zhang xiao-qing Liu Hong-lian Yang Department of Clinical Chinese Pharmacy Beijing University of Chinese Medicine Beijing 100102 China

Objective To establish abdominal fat accumulation with hyperuricemia and hypercholesterolemia quail model fed with high fat diet. And then to investigate the pathological characteristics of this quail model. Methods Thirty Longcheng quails were randomly divided into two groups： control group and model group （n=15）. The control group quails were fed with normal diet and model group quails were fed with high fat diet for 14 days. After a 12-hour overnight fast, liver and abdominal fat at euthanasia as well as serum were collected. The levels of serum uric acid, total cholesterol, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C）, triglyceride, free fatty acid （FFA）, and blood glucose were assayed. The activity changes of adenosine deaminase （ADA）, xanthine oxidase （XOD）, lipoprotein lipase （LPL）, hepatic lipase （HL）, and fatty acid synthetase （FAS） were analyzed. Results Compared with control group, the abdominal fat content （0.74±0.63 vs. 1.36±0.65 g, P〈0.05） and abdominal fat index （0.44%±0.30% vs. 0.85%±0.30%, P〈0.01） as well as live lipid index （3.61%±0.65% vs. 11.33%±2.14%, P〈0.01） in model group significantly increased; the levels of serum uric acid （210.61±94,76 vs. 304.25±141.94 /amol/L, P〈0.05）, total cholesterol （4.20±0.51 vs. 20.10±11.25 mmol/L, P〈0.01）, LDL-C （1.16±0.29 vs. 10.78±6.48 mmol/L, P〈0.01）, and FFA （0.39±0.14 vs. 0.55±0.15 mmol/L, P〈0.01） in model group significantly increased; HDL-C （5.85±0.95 vs. 4.14±2.03 mmol/L, P〈0.05） significantly decreased; the levels of triglyceride and blood glucose had no significant changes （P〉0.05）; the activities of ADA （9.71±3.05 vs. 17.19±5.10 U/ml, P〈0.01） and XOD （10.58±6,88 vs. 19.22＋9.44 U/L, P〈0.01） in model group significantly increased; and FAS, LPL, HL had no significant changes （P〉0.05）. Conclusions High fat diet can induce abdominal fat accumulation with hyperuricemia and hypercholesterolemia quail model. The changes of uric acid and lipid metabolic enzyme acti

关键词： abdominal fat accumulation hyperuricemia hypercholesterolemia quail model

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基于改进倾斜刃边法的光电成像系统MTF高准确度测试

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光子学报 2016年第12期45卷 76-83页

作者：李航颜昌翔邵建兵王小朋中国科学院长春光学精密机械与物理研究所长春130033 中国科学院大学北京100049

提出一种能高准确度测试光电成像系统调制传递函数的改进的倾斜刃边法.利用一种自动确定高低阈值的改进Canny算子提取边缘位置点,对提取到的边缘位置点进行线性拟合求得刃边倾角,在利用费米函数拟合边缘扩散函数的过程中,提出一种邻域... 详细信息

提出一种能高准确度测试光电成像系统调制传递函数的改进的倾斜刃边法.利用一种自动确定高低阈值的改进Canny算子提取边缘位置点,对提取到的边缘位置点进行线性拟合求得刃边倾角,在利用费米函数拟合边缘扩散函数的过程中,提出一种邻域平均值和设定误差容限的多重去噪改进方法.通过仿真与物理实验证明了本文方法的有效性,并分析了刃边倾角、噪声变化对本文方法与传统方法MTF测试准确度的影响.实验结果表明:本文方法的调制传递函数测试准确度达到0.004 9,重复准确度达到0.003 1,皆优于传统方法;说明其具有较高的测试准确度和良好的测试重复性,并且具有较强的抗噪性,基本不受刃边倾角变化的影响.

关键词：成像系统调制传递函数噪声改进倾斜刃边法刃边倾角边缘扩散函数

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从肝经郁热看五更泻

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中国中医基础医学杂志 2019年第3期25卷 390-391,416页

作者：方惠玉简小兵广州中医药大学附属广州中医院广州510000 广州市中医医院广州510130

五更泻是以晨起即泻、泻下急迫、泻后则舒,伴或不伴腹痛的泄泻。许多书籍认为五更泻即肾泄,实则不然,肾泄仅为五更泻的一种,尚有其他证型如肝经郁热型有待进一步认识。五更为黎明之际,阴消阳长,人与天地相参,一身阳气处于升发之时。肝... 详细信息

五更泻是以晨起即泻、泻下急迫、泻后则舒,伴或不伴腹痛的泄泻。许多书籍认为五更泻即肾泄,实则不然,肾泄仅为五更泻的一种,尚有其他证型如肝经郁热型有待进一步认识。五更为黎明之际,阴消阳长,人与天地相参,一身阳气处于升发之时。肝主左升,肺主右降,一身之气的升降全耐肝肺。情志不畅、感受外邪等因素引起肝失疏泄,致肝气上升不及,流注于肺的经气减少,肺经失于充盛,肝气旺盛化热。肝旺侮肺,肺气不降,水道通调失职,水液运行不循常道,不入膀胱偏走大肠,与糟粕同下则发为泄泻。其病机为肝旺侮肺、热移大肠,治疗给予疏肝清热、因势利导之法可收良效。

关键词：五更泄肝旺侮肺热移大肠疏肝清热因势利导

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Motivational interviewing in postoperative rehabilitation and chronic disease management: Current findings and future research directions

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World Journal of Psychiatry 2025年第1期15卷 26-31页

作者： bing-Ren Zhang xiao Yang Affiliated Hospital(School of Clinical Medicine) Hangzhou Normal UniversityHangzhou 311121Zhejiang ProvinceChina Mental Health Education and Counseling Center Hangzhou Normal UniversityHangzhou 311121Zhejiang ProvinceChina

This editorial highlights a recently published study examining the effectiveness of music therapy combined with motivational interviewing(MI)in addressing an-xiety and depression among young and middle-aged patients following percuta-neous coronary *** further explores existing evidence and potential future research directions for MI in postoperative rehabilitation and chronic disease *** aims to facilitate behavioral change and promote healthier lifestyles by fostering a trusting relationship with patients and enhan-cing intrinsic *** has demonstrated its effectiveness in posto-perative recovery for oncological surgery,stroke,organ transplants,and gastroin-testinal procedures,as well as in managing chronic conditions such as diabetes,obesity,and periodontal *** approach is patient-centered,adaptable,cost-effective,and easily replicable,though its limitations include reliance on the therapist’s expertise,variability in individual responses,and insufficient long-term follow-up *** research could focus on developing individualized and precise intervention models,exploring applications in digital health management,and confirming long-term outcomes to provide more compre-hensive support for patient rehabilitation.

关键词： Chronic disease management Motivational interviewing Patient-centered Postoperative rehabilitation Treatment adherence

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论产业联动对可持续发展的作用——以江苏为例

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生态经济(学术版) 2007年第2期 158-161页

作者：施同兵简晓彬徐州师范大学淮海发展研究院徐州师范大学淮海发展研究院江苏徐州221009

区域产业联动通过促进区域经济的协调发展,以及产业、人口、资源环境三大要素在空间上的均衡分布,能够增强经济社会的可持续发展能力。本文以江苏为例,分析区域产业联动对可持续发展的作用机理,着重论述区域产业联动对区域经济共同发展... 详细信息

区域产业联动通过促进区域经济的协调发展,以及产业、人口、资源环境三大要素在空间上的均衡分布,能够增强经济社会的可持续发展能力。本文以江苏为例,分析区域产业联动对可持续发展的作用机理,着重论述区域产业联动对区域经济共同发展和资源生态环境保护的作用。

关键词：产业联动江苏区域经济资源环境可持续发展

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重组腺伴随病毒载体介导的hEPO转移及表达

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生物化学与生物物理学报 2002年第2期34卷 176-180页

作者：伍志坚吴小兵王宏卢斌董小岩侯云德中国预防医学科学院病毒学研究所病毒基因工程国家重点实验室中国预防医学科学院病毒学研?

为实现人促红细胞生成素 (humanerythropoietin ,hEPO)基因在体内的持续表达 ,构建了携带hEPO的重组腺伴随病毒 (recombinantadeno associatedvirus,rAAV)载体质粒 ,建立了稳定携带hEPO表达盒的rAAV载体细胞株 ,采用“一种辅助病毒感染... 详细信息

为实现人促红细胞生成素 (humanerythropoietin ,hEPO)基因在体内的持续表达 ,构建了携带hEPO的重组腺伴随病毒 (recombinantadeno associatedvirus,rAAV)载体质粒 ,建立了稳定携带hEPO表达盒的rAAV载体细胞株 ,采用“一种辅助病毒感染一个载体细胞株”的rAAV生产策略 ,制备并纯化了携带hEPO的rAAV(rAAV hEPO)。结果表明 ,rAAV介导的hEPO转移能够使hEPO在培养的BHK 2 1细胞中得到有效表达 ;用rAAV hEPO对Balb/c小鼠进行一次肌肉注射 ,可使hEPO在小鼠体内持续表达 10周以上 ,并可明显升高小鼠的红细胞比容

关键词：重组腺伴随病毒 hEPO 基因转移基因治疗载体

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Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao Chen Xie Liu Changqing Xu Da-jian Wu Ying Cheng xiao-Jun Liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure

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Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： xiaoqin Li jian Xiang Lu Qiu xiaohan Chen Yinkun Zhao Yujue Wang Qu Yue Taotao Gao Wenlong Liu Dan xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

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