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World Journal of Clinical Cases 2024年第15期12卷 2636-2641页

作者： Zhi-Yun Weng Wen-Ye huang bin-Kan Shi jian-Jia Pan Department of Hematology The Affiliated Yueqing Hospital of Wenzhou Medical UniversityYueqing 325600Zhejiang ProvinceChina

BACKGROUND Brain metastases(BM)are very rare in gastric adenocarcinoma(GaC),and patients with BMs have a higher mortality rate due to stronger tumor aggressiveness.However,its pathogenesis remains unclear.Genetic testing revealed cellular-mesenchymal epithelial transition factor receptor(MET)amplification.Therefore,treatment with savolitinib,a small molecule inhibitor of c-Met,was selected.CASE SUMMARY A 66-year-old woman was diagnosed with advanced GaC 6 months prior to presentation due to back pain.Cerebellar and meningeal metastases were observed during candonilimab combined with oxaliplatin and capecitabine therapy.The patient experienced frequent generalized seizures and persistent drowsiness in the emergency department.Genetic testing of cerebrospinal fluid and peripheral blood revealed increased MET amplification.After discussing treatment options with the patient,savolitinib tablets were administered.After a month of treatment,the intracranial lesions shrank considerably.CONCLUSION BM is very rare in advanced GaC,especially in meningeal cancer,that is characterized by rapid disease deterioration.There are very few effective treatment options available;however,technological breakthroughs in genomics have provided a basis for personalized treatment.Furthermore,MET amplification may be a key driver of BM in gastric cancer;however,this conclusion requires further investigation.

关键词： Cellular-mesenchymal epithelial transition factor receptor Savolitinib Meningeal carcinomatosis Gastric adenocarcinoma Case report

Difference in microstructural characteristics of stamp-charged coke and gravity-charged coke with approximate macroscopic performance

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Journal of Iron and Steel Research(International) 2024年第5期31卷 1050-1062页

作者： Chong Zou Zheng-yan huang jian-yun Li bin Li Shi-wei Liu Yuan She School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710311ShaanxiChina Technical Center of Shandong Iron and Steel Co. Ltd.(Laiwu Branch)Jinan271104ShandongChina

The microstructural characteristics including optical texture,porosity and pore structure and chemical structure of stamp-charged coke(SCC)and gravity-charged coke(GCC)with similar conventional macro-indicators were investigated,and the properties including micro-strength,reactivity of coke matrix and that after alkali enrichment were comparatively studied by various characterization methods.The anisotropic structure of SCC is composed of high content of fine mosaic texture,while the content of medium mosaic texture,coarse texture and fibrous texture is low.The statistical average shows that the fine mosaic average of SCC(24.89%)is 3.78 times the GCC average(6.58%),and the coarse mosaic average(1.24%)is only about 1/3 of the GCC average(3.43%).The porosity of SCC is lower than that of GCC,but tamping process does not lead to the fact that the number of closed pores of SCC is significantly lower than that of GCC.Although the structure of SCC is compact,its pore number is large and the pore wall is thin.Pores of coke with diameter less than 150 nm seem unaffected by tamping process.The aromatic structure of SCC was less ordered than that of GCC,which was speculated to be related to the addition of more low metamorphic coal in coking.The microscopic strength and structural strength of SCC are lower than those of GCC.The reactivity of coke matrix is affected by the specific surface area,but it is not the determining factor of its macro-reactivity.The improvement in dissolution reactivity of coke after potassium enrichment is independent of coke type.

关键词： Stamp-charged coke Optical texture Porosity Microstructure Reactivity

Enhanced cycling stability and rate performance of Co-doped and La_(2)O_(3)-coated LiNi_(0.9)Mn_(0.1)O_(2) toward power battery

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Rare Metals 2024年第2期43卷 658-670页

作者： Jia-Qi Peng Yuan-Yuan Wei Dong-Ming Liu Yun Li bin Hu bin huang jian-Wen Yang Shun-Hua Xiao Ren-Heng Wang Guangxi Key Laboratory of Electrochemical and Magneto-Chemical Functional Materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin541004China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China

Ultra-high nickel layered oxide cathode material with high energy density is the most promising material to improve the electrochemical performance of lithium-ion batteries(LIBs).However,the poor structural stability and severe surface/interface side reactions of the material lead to poor rate performance and cyclic stability,which limits its application in practice.In this paper,the dual-modification strategy of Co doping and La_(2)O_(3) coating is used to meet the above challenges.Co doping can effectively widen layer spacing and reduce Li^(+)/Ni^(2+) mixing,and La_(2)O_(3) coating can effectively eliminate the residual alkali on the surface of active material,inhibit the thickening of cathode electrolyte interphase(CEI)film and reduce surface/interface side reactions.Therefore,the modified material(NM90-CL)with excellent electrochemical properties is achieved through the synergistic enhancement of Co doping and La_(2)O_(3) coating.Its capacity retention rate can reach 77.9%after 200 cycles at 1.0℃ and 75.7%after 200 cycles at 5.0℃.Its reversible capacity can up to 153.5 mAh·g^(–1) at 10.0℃.This dual-modification strategy will provide theoretical guidance and technical support for the synthesis of other high-performance electrode materials.

关键词： High nickel cathode material Co doping La_(2)O_(3) coating Electrochemical performance Electrochemical mechanism

Grain refinement of 5A06 aluminum alloy welds caused by tungsten inert gas welding arc characteristics under Ar-He alternating gas supply conditions:a coupled method of water-cooled copper plate test/numerical simulation

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Journal of Iron and Steel Research(International) 2024年第3期31卷 767-777页

作者： Hong-bin Dai jian Miao Jia-xin Lin School of Materials Science and Engineering Harbin University of Science and TechnologyHarbin 150040HeilongjiangChina

The welding arc,as a carrier for the conversion of electrical energy to thermal energy,has a direct impact on the quality of welding by its properties and states.In the tungsten inert gas(TIG)welding process under the condition of Ar-He alternating gas supply,the arc is alternately converted between Ar arc and He arc with an alternating gas supply cycle,which has obvious arc change characteristics.The FLUENT software was used to numerically simulate the characteristics of the TIG arc under the condition of alternating gas supply,and the arc temperature field,arc pressure,electric potential and current density distribution under the condition of alternating gas supply were obtained.Combined with the real-time data of arc pressure measured by the water-cooled copper plate with holes,it is proved that the TIG arc has obvious dynamic characteristics under the condition of Ar-He alternating gas supply.This unique dynamic TIG arc acts on the 5A06 aluminum alloy weld,causing the molten pool to stir,resulting in uniform microstructure and grain refinement at the weld,and thereby improving the mechanical properties of the welded joint.

关键词： Alternating gas supply Grain refinement Numerical simulation Tungsten argon arc morphology Microstructure Mechanical property

Electrolyte effect on electrochemical behaviors of manganese fluoride material for aqueous asymmetric and symmetric supercapacitors

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Rare Metals 2024年第3期43卷 1048-1061页

作者： Zheng-Hua He jian-Fei Gao Ling-bin Kong State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of TechnologyLanzhou730050China School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou730050China

Exploring wide voltage window materials is not only an available measure to enhance the energy density of hybrid supercapacitor(HSCs),but also avoids the dynamic mismatch caused by different energy storage mechanisms of two electrodes in assembled symmetrical HSC.However,there are few reports about the wide potential window materials except Bi_(2)O_(3)and VO_(2).Therefore,the MnF_(2)synthesized by solvothermal reaction was served as the electrode for HSC.The MnF_(2)exhibited electrochemical activity in alkaline solution in three-electrode system,especially with a wide potential window from-0.8 to+0.5 V in 2 mol·L^(-1)NaOH.Furthermore,the assembled MnF_(2)//MnF_(2)symmetrical HSC had a potential window of 1.5 V,and it exhibited outstanding long-cycle capability.Meanwhile,when MnF_(2)was taken as the negative and positive respectively,the potential windows of asymmetric devices CoMoO_(4)//MnF_(2)and MnF_(2)//Activated Carbon(AC)could reach 1.3 and 1.45 V,respectively,showing excellent cycle stability.This work shows that MnF_(2)material has great research value in HSC,and provides a new research direction for developing high-performance devices.

关键词： Manganese fluoride Potential window Hybrid supercapacitors Electrochemical performance

A micro-crosslinked amphoteric hydrophobic association copolymer as high temperature-and salt-resistance fluid loss reducer for water-based drilling fluids

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Petroleum Science 2024年第3期21卷 1980-1991页

作者： jian Li Yu-Xi Ji Xiao-Xiao Ni Kai-He Lv Xian-bin huang Jin-Sheng Sun School of Petroleum Engineering China University of Petroleum(East China) Key Laboratory of Unconventional Oil & Gas Development China University of Petroleum(East China) Inspection and Testing Center of Huabei Oil Field Company PetroChina Drilling Fluid Research Institute CNPC Engineering Technology R&D Company Limited

During ultradeep oil and gas drilling, fluid loss reducers are highly important for water-based drilling fluids, while preparing high temperature-and salt-resistance fluid loss reducers with excellent rheology and filtration performance remains a challenge. Herein, a micro-crosslinked amphoteric hydrophobic association copolymer(i.e., DADC) was synthesized using N,N-dimethyl acrylamide, diallyl dimethyl ammonium chloride, 2-acrylamido-2-methylpropane sulfonic acid, hydrophobic monomer, and pentaerythritol triallyl ether crosslinker. Due to the synergistic effects of hydrogen bonds, electrostatic interaction, hydrophobic association, and micro-crosslinking, the DADC copolymer exhibited outstanding temperature-and salt-resistance. The rheological experiments have shown that the DADC copolymer had excellent shear dilution performance and a certain degree of salt-responsive viscosity-increasing performance. The DADC copolymer could effectively adsorb on the surface of bentonite particles through electrostatic interaction and hydrogen bonds, which bring more negative charge to the bentonite, thus improving the hydration and dispersion of bentonite particles as well as the colloidal stability of the drilling fluids. Moreover, the drilling fluids constructed based on the DADC copolymer exhibited satisfactory rheological and filtration properties(FLHTHP= 12 m L) after aging at high temperatures(up to200°C) and high salinity(saturated salt) environments. Therefore, this work provided new insights into designing and fabricating high-performance drilling fluid treatment agents, demonstrating good potential applications in deep and ultradeep drilling engineering.

关键词： Fluid loss reducer Temperature- and salt-resistance Hydrophobic association Amphoteric Micro-crosslinking

Patterns and drivers of avian taxonomic and phylogenetic beta diversity in China vary across geographical backgrounds and dispersal abilities

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Zoological Research 2024年第1期45卷 125-135页

作者： jian-Chao Liang Zhi-Feng Ding Chun-Lin Li Yi-Ming Hu Zhi-Xin Zhou Gan-Wen Lie Xiao-Nan Niu Wen-bin huang Hui-jian Hu Xing-Feng Si Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhouGuangdong 510260China School of Resources and Environmental Engineering Anhui UniversityHefeiAnhui 230601China Guangdong Eco-Engineering Polytechnic GuangzhouGuangdong 510520China Huizhou Institute of Forestry(Huizhou Botanical Garden Management Service Center) HuizhouGuangdong 516001China Administration of National Nature Reserve for Marine Ecology of Guangdong Nanpeng Islands ShantouGuangdong 515900China Zhejiang Zhoushan Archipelago Observation and Research Station Institute of Eco-ChongmingZhejiang Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China

Geographical background and dispersal ability may strongly influence assemblage dissimilarity;however,these aspects have generally been overlooked in previous large-scale beta diversity studies.Here,we examined whether the patterns and drivers of taxonomic beta diversity(TBD)and phylogenetic beta diversity(PBD)of breeding birds in China vary across(1)regions on both sides of the Hu Line,which demarcates China’s topographical,climatic,economic,and social patterns,and(2)species with different dispersal ability.TBD and PBD were calculated and partitioned into turnover and nestedness components using a moving window approach.Variables representing climate,habitat heterogeneity,and habitat quality were employed to evaluate the effects of environmental filtering.Spatial distance was considered to assess the impact of dispersal limitation.Variance partitioning analysis was applied to assess the relative roles of these variables.In general,the values of TBD and PBD were high in mountainous areas and were largely determined by environmental filtering.However,different dominant environmental filters on either side of the Hu Line led to divergent beta diversity patterns.Specifically,climate-driven species turnover and habitat heterogeneity-related species nestedness dominated the regions east and west of the line,respectively.Additionally,bird species with stronger dispersal ability were more susceptible to environmental filtering,resulting in more homogeneous assemblages.Our results indicated that regions with distinctive geographical backgrounds may present different ecological factors that lead to divergent assemblage dissimilarity patterns,and dispersal ability determines the response of assemblages to these ecological factors.Identifying a single universal explanation for the observed pattern without considering these aspects may lead to simplistic or incomplete conclusions.Consequently,a comprehensive understanding of large-scale beta diversity patterns and effective planning of conservation strategies necessitate the

关键词： Beta diversity Environmental filtering Dispersal limitation Hu Line Species dispersal ability Breeding birds

The early life immune dynamics and cellular drivers at single-cell resolution in lamb forestomachs and abomasum

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Journal of Animal Science and Biotechnology 2024年第1期15卷 218-235页

作者： Kailang huang bin Yang Zebang Xu Hongwei Chen Jiakun Wang Institute of Dairy Science College of Animal SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Molecular Animal Nutrition Ministry of EducationZhejiang UniversityHangzhou 310058China

Background Four-chambered stomach including the forestomachs(rumen,reticulum,and omasum)and abomasum allows ruminants convert plant fiber into high-quality animal products.The early development of this four-chambered stomach is crucial for the health and well-being of young ruminants,especially the immune development.However,the dynamics of immune development are poorly understood.Results We investigated the early gene expression patterns across the four-chambered stomach in Hu sheep,at 5,10,15,and 25 days of age.We found that forestomachs share similar gene expression patterns,all four stomachs underwent widespread activation of both innate and adaptive immune responses from d 5 to 25,whereas the metabolic function were significantly downregulated with age.We constructed a cell landscape of the four-chambered stomach using single-cell sequencing.Integrating transcriptomic and single-cell transcriptomic analyses revealed that the immune-associated module hub genes were highly expressed in T cells,monocytes and macrophages,as well as the defense-associated module hub genes were highly expressed in endothelial cells in the four-stomach tissues.Moreover,the non-immune cells such as epithelial cells play key roles in immune maturation.Cell communication analysis predicted that in addition to immune cells,non-immune cells recruit immune cells through macrophage migration inhibitory factor signaling in the forestomachs.Conclusions Our results demonstrate that the immune and defense responses of four stomachs are quickly developing with age in lamb's early life.We also identified the gene expression patterns and functional cells associated with immune development.Additionally,we identified some key receptors and signaling involved in immune regulation.These results help to understand the early life immune development at single-cell resolution,which has implications to develop nutritional manipulation and health management strategies based on specific targets including key receptors and signaling pathways.

关键词： Early life Forestomachs Four-chambered stomach Immune cells Immune system maturation MIF signaling Rumen Ruminant development Single-cell transcriptomic sequencing

High-efficiency Multiplexed Buck-type PFC Converter

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1053-1063页

作者： Lunquan Li Qianhong Chen Jichao huang bin Liu School of Automation Nanjing University of Aeronautics and AstronauticsNanjing 211106China Gaoyi Zhineng Electric Ltd. Shenzhen 518101China School of Information Engineering Nanchang Hang Kong UniversityNanchang 330063China IEEE CSEE

This paper proposes a high-efficiency PFC rectifier based on multiplexing the switches.Compared with a traditional six-switch PFC rectifier,the proposed rectifier extends the switches’active angle by making use of three bridge rectifiers.As a result,lower conduction resistance can be realized for switches.Consequently,system efficiency can be improved.Compared with a traditional six-switch PFC rectifier with doubled switches,the proposed rectifier can achieve almost the same efficiency improvement while no additional switches are needed.Since continuous inductor current is chopped and resulting current pulses cannot be injected into the grid directly,input filter design and resonance damping are discussed for the proposed rectifier.The controller design of the rectifier is analyzed.The inductor current reference is shaped considering the input voltage envelope and forward duties.Finally,the effectiveness of the proposed rectifier is verified through simulations and experiments.

关键词： Buck-type rectifier commutation state controller design efficiency multiplex

Enhanced and asymmetric signatures of hybridization at climatic margins: Evidence from closely related dioecious fig species

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Plant Diversity 2024年第2期46卷 181-193页

作者： jian-Feng huang Clive T.Darwell Yan-Qiong Peng CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303China National Center for Genetic Engineering and Biotechnology(BIOTEC) 113 Thailand Science ParkPhahonyothin RoadKhlong NuengKhlong LuangPathum Thani 12120Thailand

Hybridization plays a significant role in biological evolution. However, it is not clear whether ecological contingency differentially influences likelihood of hybridization, particularly at ecological margins where parental species may exhibit reduced fitnesses. Moreover, it is unknown whether future ecosystem change will increase the prevalence of hybridization. Ficus heterostyla and F. squamosa are closely related species co-distributed from southern Thailand to southwest China where hybridization, yielding viable seeds, has been documented. As a robust test of ecological factors driving hybridization, we investigated spatial hybridization signatures based on nuclear microsatellites from extensive population sampling across a widespread contact range. Both species showed high population differentiation and strong patterns of isolation by distance. Admixture estimates exposed asymmetric interspecific gene flow.Signatures of hybridization increase significantly towards higher latitude zones, peaking at the northern climatic margins. Geographic variation in reproductive phenology combined with ecologically challenging marginal habitats may promote this phenomenon. Our work is a first systematic evaluation of such patterns in a comprehensive, latitudinally-based clinal context, and indicates that tendency to hybridize appears strongly influenced by environmental conditions. Moreover, that future climate change scenarios will likely alter and possibly augment cases of hybridization at ecosystem scales.

关键词： Hybridization Heterospecific visitation Fig Pollinator wasp Asymmetric gene flow