检索结果-南通市图书馆

COVID-19-like sy.ptoms observed in Chinese tree shrews infected with SARS-CoV-2

在线全文

学校读者我要写书评

暂无评论

z.ological Research 2020年第5期41卷 517-526页

作者： Ling Xu Dan-Dan y. y.-Hua ma y.-Lin y.o Rong-Hua Luo Xiao-Li Feng Hou-Rong cai jian-Bao Han xue-Hui wang Ming-Hua Li Chang-Wen Ke y.ng-Tang z.eng y.ng-Gang y.o Key.Laboratory.of Animal Models and Human Disease Mechanisms of the Chinese Academy.of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming National High-level Biosafety.Research Center for Non-Human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academic of SciencesKunmingYunnan 650107China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Department of Respiratory.and Critical Care Medicine the Affiliated Drum Tower Hospital of Nanjing UniversityNanjingJiangsu 210008China Medical Key.Laboratory.for Repository.and Application of Pathogenic Microbiology Guangdong Provincial Center for Disease Control and PreventionGuangzhouGuangdong 510440China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 2Q0Q3AChina

Thecoronavirusdisease2019(COVID-19)pandemic continues to pose a global threat to the human population. Identify.ng animal species susceptible to infection with the SARS-CoV-2/HCoV-19 pathogen is essential for controlling the outbreak and for testing valid prophy.actics or therapeutics based on animal model studies. Here,different aged Chinese tree shrews(adult group, 1 y.ar old;old group, 5–6 y.ars old), which are close relatives to primates, were infected with SARS-CoV-2. X-ray. viral shedding, laboratory. and histological analy.es were performed on different day. postinoculation(dpi). Results showed that Chinese tree shrews could be infected by.SARS-CoV-2. Lung infiltrates were visible in X-ray.radiographs in most infected animals. Viral RNA was consistently.detected in lung tissues from infected animals at 3,5, and 7 dpi, along with alterations in related parameters from routine blood tests and serum biochemistry. including increased levels of aspartate aminotransferase(AST) and blood urea nitrogen(BUN). Histological analy.is of lung tissues from animals at 3 dpi(adult group) and 7 dpi(old group) showed thickened alveolar septa and interstitial hemorrhage. Several differences were found between the two different aged groups in regard to viral shedding peak. Our results indicate that Chinese tree shrews have the potential to be used as animal models for SARS-CoV-2 infection.

关键词： SARS-CoV-2/HCoV-19 Treeshrews Animal model Susceptibility COVID-19

Identification and characteriz.tion of a cathepsin-F-like protease in Trichinella spiralis

在线全文

学校读者我要写书评

暂无评论

Identification and characterization of a cathepsin-F-like pr...

STCF conceptual design report (Volume 1): Phy.ics & detector

中国畜牧兽医学会兽医寄生虫学分会第十三次学术研讨会

作者： z.-gang Qu xue-ting ma Wen-hui Li Nian-z.ang z.ang Long y.e jian-min Cui jian-ping cai wan-z.ong Jia Bao-quan Fu State Key.Laboratory.of Veterinary.Etiological Biology Key Laboratory of Veterinary Public Health of the Ministry of AgricultureKey Laboratory of Veterinary Parasitology of Gansu ProvinceLanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease

Trichinellosis is a an emerging and reemerging infectious disease,caused by.Trichinella *** F belongs to cy.teine protease that is a major virulence factor for parasitic helminths,and it may.be a potential anti-helminth drug target and vaccine *** this study.the cDNA encoding a putative cathepsin F-like peptidase in Trichinella spiralis,TsCF1,was obtained and its biochemical characteriz.tion and expression profile were *** demonstrated that the TsCF1 gene encodes a protein of 366 aa with the theoretical molecular weight of 41.9 ku and isoelectric point of *** signal peptide sequence of TsCF1 located between amino acids 1 and 19 and 3 putative N-gly.osy.ation sites were *** cy.teine protease conserved active site of Cy.173,His309 and Asn333 were identified and cathepsin F specific motif ERFNAQ like KLFNAQ sequence was revealed in the propeptide of *** analy.is revealed a higher than 40%identity.with other cathepsin F from parasitic helminth and phy.ogenetic analy.is indicated TsCF1 located in the different clans with trematode cathepsin ***-PCR revealed the gene was expressed in muscle larvae,newborn larvae and adult *** SDS-PAGE revealed the recombinant protein was expressed with the molecular weight of 45 *** analy.is showed that TsCF1 located on the inner lay.r of the cuticle and stichosome of the parasite,which probably.play.a vital role in nutrition *** purified recombinant TsCF1 was used to immuniz. rabbit and the immune serum could recogniz. a band of soluble protein of muscle larvae at about 46 *** renaturation the TsCF1 recombinat protein demonstrated substantial enz.0}e activity.to z.Phe-Arg-AMC substrate with the optimal pH 5.5 and this activity.could be inhibited by.cy.teine protease inhibitor *** analy.is revealed the kinetic parameters of the recombinant peptidase to be Km=0.5091 μM and Vmax= 6.12 RFU/sμM at pH 5.5,and the IC50 value of E64 was 1

关键词： Trichinella spiralis cy.teine protease Cathepsin F enz.0}e activity

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Frontiers of phy.ics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.z.Bai y.Bai O.Bakina A.Barny.kov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomy.gkov A.Bondar I.Boy.o z.H.Bu F.M.cai H.cai J.J.Cao Q.H.Cao X.Cao z.Cao Q.Chang K.T.Chao D.y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen y.Chen y.Q.Chen H.y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.z.Ding L.y.Dong W.H.Dong V.Druz.inin D.S.Du y.J.Du z.G.Du L.M.Duan D.Epifanov y.L.Fan S.S.Fang z.J.Fang G.Fedotovich C.Q.Feng X.Feng y.T.Feng J.L.Fu J.Gao y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo y.P.Guo z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He y.L.He z.B.He z.X.Heng B.L.Hou T.J.Hou y.R.Hou C.y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.y.Huang W.Q.Huang X.T.Huang X.J.Huang y.B.Huang y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia z.K.Jia H.B.jiang J.jiang S.z.jiang J.B.Jiao z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenz.e A.Khoukaz.I.Koop E.Kravchenko A.Kuz.in y.Lei E.Levichev C.H.Li C.Li D.y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li y.Li y.y.Li z.J.Li H.Liang J.H.Liang y.T.Liang G.R.Liao L.z.Liao y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu y.W.Liu y.Liu y.L.Liu z.Q.Liu z.y.Liu z.W.Liu I.Logashenko y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü y.Lu y.Lu z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo y.H.Luo H.J.Ly. X.R.Ly. J.P.ma P.ma y.ma y.M.ma F.maas S.malde D.matvienko z.X.Meng R.Mitchell A.Nefediev y.Nefedov S.L.Olsen Q.Ouy.ng P.Pakhlov G.Pakhlova X.Pan y.Pan E.Passemar y.P.Pei H.P.Peng L.Peng X.y.Peng X.J.Peng K.Peters S.Pivovarov E.Py.ta B.B.Qi y.Q.Qi W.B.Qian y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Phy.ics Novosibirsk 630090Russia CAS Key.Laboratory.of Theoretical Phy.ics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University.of Geosciences Wuhan 430074China China University.of Mining and Technology Xuzhou 221116China École Poly.echnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University.Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangz.ou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University.of Technology Hefei 230601China Helmholtz.Institute mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy.Phy.ics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy.11 Pokrovsky.Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University.of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University.of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy.Phy.ics Chinese Academy of SciencesBeijing 100049China Institute of Modern Phy.ics Chinese Academy of SciencesLanzhou 730000China Institute of Phy.ics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Phy.ics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility.STCF)is an electron–positron collider proposed by.the Chinese particle phy.ics *** is designed to operate in a center-of-mass energy.range from 2 to 7 GeV with a peak luminosity.of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory.the BEPCII,providing a unique platform for exploring the asy.metry.of matter-antimatter(charge-parity.violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and phy.ics bey.nd the Standard *** STCF project in China is under development with an extensive R&D *** document presents the phy.ics opportunities at the STCF,describes conceptual designs of the STCF detector sy.tem,and discusses future plans for detector R&D and phy.ics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

Line-of-shower trigger method to lower energy.threshold for GRB detection using LHAASO-WCDA

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Radiation Detection Technology.and Methods 2021年第4期5卷 531-541页

作者： F.Aharonian Q.An Axikegu L.X.Bai y.X.Bai y.W.Bao D.Bastieri X.J.Bi y.J.Bi H.cai J.T.cai z.Cao z.Cao J.Chang J.F.Chang X.C.Chan B.M.Chen J.Chen L.Chen L.Chen L.Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.z.Chen T.L.Chen X.L.Chen y.Chen N.Chen y.D.Chen S.W.Cui X.H.Cui y.D.Cui B.z.Dai H.L.Dai z.G.Dai Danz.ngluobu D.della Volpe B.D’Ettorre Piaz.oli X.J.Don J.H.Fan y.z.Fan z.X.Fan J.Fang K.Fan C.F.Feng L.Feng S.H.Fen y.L.Feng B.Gao C.D.Gao Q.Gao W.Gao M.M.Ge L.S.Gen G.H.Gong Q.B.Gou M.H.Gu J.G.Guo X.L.Guo y.Q.Guo y.y.Guo y.A.Han H.H.He H.N.He J.C.He S.L.He X.B.He y.He M.Heller y.K.Hor C.Hou X.Hou H.B.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huan W.H.Huang X.T.Huang z.C.Huang F.Ji X.L.Ji H.y.Jia K.jiang z.J.jiang C.Jin D.Kuleshov K.Levochkin B.B.Li C.Li C.Li F.Li H.B.Li H.C.Li H.y.Li J.Li K.Li W.L.Li X.Li X.Li X.R.Li y.Li y.z.Li z.Li z.Li E.W.Liang y.F.Liang S.J.Lin B.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.y.Liu M.y.Liu R.y.Liu S.M.Liu W.Liu y.N.Liu z.X.Liu W.J.Long R.Lu H.K.Lv B.Q.ma L.L.ma X.H.ma J.R.mao A.masood W.Mitthumsiri T.Montaruli y.C.Nan B.y.Pang P.Pattarakijwanich z.y.Pei M.y.Qi D.Ruffolo V.Rulev A.Sáiz.L.Shao O.Shchegolev X.D.Shen J.R.Shi H.C.Song y..V.Stenkin V.Stepanov Q.N.Sun X.N.Sun z.B.Sun P.H.T.Tam z.B.Tang W.W.Tian B.D.wan C.wang H.wang H.G.wang J.C.wang J.S.wang L.P.wang L.y.wan R.N.wang W.wang W.wang X.G.wang X.J.wan X.y.wang y.D.wan y.J.wan y.P.wang z.wang z.wang z.H.wang z.X.wang D.M.Wei J.J.Wei y.J.Wei T.Wen C.y.Wu H.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang G.Xiao H.B.Xiao G.G.Xin y.L.Xin y.Xing D.L.Xu R.X.Xu L.xue D.H.y.n C.W.y.ng F.F.y.ng J.y.y.ng L.L.y.ng M.J.y.n R.z.y.ng S.B.y.ng y.H.y.o z.G.y.o y.M.y. L.Q.y.n N.y.n X.H.y.u z.y.y.u y.H.y. Q.y.an H.D.z.ng T.X.z.ng W.z.ng z.K.z.ng M.z.a X.X.z.ai B.B.z.ang H.M.z.ang H.y.z.ang J.L.z.ang J.W.z.ang L.z.ang L.z.ang L.X.z.ang P.F.z.ang P.P.z.ang R.z.ang S.R.z.ang S.S.z.an X.z.ang X.P.z.an y.z.an y.z.ang y.F.z.ang y.L.z.an B.z.ao J.z.ao L.z.ao L.z.z.ao S.P.z.ao F.z.eng y.z.eng B.z.ou H.z.ou J.N.z.ou P.z.ou R.z.ou X.X.z.ou C.G. Key.Laboratory.of Particle Astrophy.ics&Experimental Phy.ics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University.of Chinese Academy.of Sciences Beijing 100049China TIANFU Cosmic Ray.Research Center ChengduSichuanChina State Key.Laboratory.of Particle Detection and Electronics BeijingChina University.of Science and Technology.of China Hefei 230026AnhuiChina Department of Engineering Phy.ics Tsinghua UniversityBeijing 100084China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Phy.ics Peking UniversityBeijing 100871China Center for Astrophy.ics Guangzhou UniversityGuangzhou 510006GuangdongChina School of Phy.ics and Astronomy.School of Phy.ics(Guangz.ou) Sun Yat-sen UniversityZhuhai 519000GuangdongChina School of Phy.ical Science and Technology Guangxi UniversityNanning 530004GuangxiChina Hebei Normal University Shijiazhuang 050024HebeiChina School of Phy.ics and Microelectronics Zhengzhou UniversityZhengzhou 450001HenanChina School of Astronomy.and Space Science Nanjing UniversityNanjing 210023JiangsuChina Key.Laboratory.of Dark matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Institute of Frontier and Interdisciplinary.Science Shandong UniversityQingdao 266237ShandongChina Key.Laboratory.for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Tsung-Dao Lee Institute&School of Phy.ics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China School of Phy.ical Science and Technology.School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina College of Phy.ics Sichuan UniversityChengdu 610065SichuanChina Key.Laboratory.of Cosmic Ray.(Tibet University. Ministry of EducationLhasa 850000TibetChina School of Phy.ic

Purpose Observation of high energy.and very.high emission from Gamma Ray.Bursts(GRBs)is crucial to study.the gigantic explosion and the underline *** a large field-of-view and almost full duty.cy.le,the Water Cherenkov Detector Array.WCDA),a sub-array.of the Large High Altitude Air Shower Observatory.LHAASO),is appropriate to monitor the very.high energy.emission from unpredictable transients such as *** Nevertheless,the main issue for an extensive air shower array.is the high energy.threshold which limits the horiz.n of the *** address this issue a new trigger method is developed in this article to lower the energy.threshold of WCDA for GRB *** The proposed method significantly.improves the detection efficiency.of WCDA for gamma-ray. around the GRB direction at 10-300 *** sensitivity.of the WCDA for GRB detection with the new trigger method is *** achieved sensitivity.of the quarter WCDA array.above 10 GeV is comparable with that of *** data analy.is process and corresponding fluence upper limit for GRB 190719C is presented as an example.

关键词： LHAASO WCDA GRB

Reconstruction of Cherenkov image by.ultiple telescopes of LHAASO-WFCTA

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Radiation Detection Technology.and Methods 2022年第4期6卷 544-557页

作者： F.Aharonian Q.An Axikegu L.X.Bai y.X.Bai y.W.Bao D.Bastieri X.J.Bi y.J.Bi J.T.cai z.e Cao z.en Cao J.Chang J.F.Chang E.S.Chen Liang Chen Liang Chen Long Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.z.Chen T.L.Chen y.Chen H.L.Cheng N.Cheng y.D.Cheng S.W.Cui X.H.Cui y.D.Cui B.D’Ettorre Piaz.oli B.z.Dai H.L.Dai z.G.Dai Danz.ngluobu Ddella Volpe K.K.Duan J.H.Fan y.z.Fan z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng X.T.Feng y.L.Feng B.Gao C.D.Gao L.Q.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.S.Geng G.H.Gong Q.B.Gou M.H.Gu F.L.Guo J.G.Guo X.L.Guo y.Q.Guo y.y.Guo y.A.Han H.H.He H.N.He S.L.He X.B.He y.He M.Heller y.K.Hor C.Hou X.Hou H.B.Hu Q.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang W.H.Huang X.T.Huang X.y.Huang y.Huang z.C.Huang X.L.Ji H.y.Jia K.Jia K.jiang z.J.jiang M.Jin M.M.Kang T.Ke D.Kuleshov K.Levochkin B.B.Li Cheng Li Cong Li F.Li H.B.Li H.C.Li H.y.Li J.Li jian Li Jie Li K.Li WLLi XRLi Xin Li Xin Li y.Li z.e Li z.uo Li E.W.Liang y.F.Liang S.J.Lin B.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.y.Liu M.y.Liu R.y.Liu S.M.Liu W.Liu y.Liu y.N.Liu W.J.Long R.Lu Q.Luo H.K.Lv B.Q.ma L.L.ma X.H.ma J.R.mao A.masood z.Min W.Mitthumsiri y.C.Nan z.W.Ou B.y.Pang P.Pattarakijwanich z.y.Pei M.y.Qi y.Q.Qi B.Q.Qiao J.J.Qin D.Ruffolo A.Sáiz.C.y.Shao L.Shao O.Shchegolev X.D.Sheng J.y.Shi H.C.Song y..V.Stenkin V.Stepanov y.Su Q.N.Sun X.N.Sun z.B.Sun P.H.T.Tam z.B.Tang W.W.Tian B.D.wang C.wang H.wang H.G.wang J.C.wang J.S.wang L.P.wang L.y.wang R.wang R.N.wang W.wang X.G.wang X.y.wang y.wang y.D.wang y.J.wang y.P.wang z.H.wang z.X.wang z.en wang z.eng wang D.M.Wei J.J.Wei y.J.Wei T.Wen C.y.Wu H.R.Wu S.Wu X.F.Wu y.S.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang D.X.Xiao G.Xiao G.G.Xin y.L.Xin y.Xing z.Xiong D.L.Xu R.X.Xu L.xue D.H.y.n J.z.y.n C.W.y.ng F.F.y.ng H.W.y.ng J.y.y.ng L.L.y.ng M.J.y.ng R.z.y.ng S.B.y.ng y.H.y.o z.G.y.o y.M.y. L.Q.y.n N.y.n X.H.y.u z.y.y.u y.H.y. Q.y.an H.y.e H.D.z.ng T.X.z.ng W.z.ng z.K.z.ng M.z.a X.X.z.ai B.B.z.ang F.z.ang H.M.z.ang H.y.z.ang J.L.z.ang L.X.z.ang Li z.ang Lu z.ang P.F.z.ang P.P.z.ang R.z.ang S.B.z.ang S.R.z.ang S. Key.Laboratory.of Particle Astrophy.cs&Experimental Phy.ics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University.of Chinese Academy.of Sciences Beijing 100049China TIANFU Cosmic Ray.Research Center ChengduSichuanChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2DublinIreland max-Planck-Institut for Nuclear Phy.ics P.O.Box 10398069029 HeidelbergGermany State Key.Laboratory.of Particle Detection and Electronics BeijingChina University.of Science and Technology.of China Hefei 230026AnhuiChina School of Phy.ical Science and Technology.School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina College of Phy.ics Sichuan UniversityChengdu 610065SichuanChina School of Astronomy.and Space Science Nanjing UniversityNanjing 210023JiangsuChina Center for Astrophy.ics Guangzhou UniversityGuangzhou 510006GuangdongChina Key.Laboratory.of Dark matter and Space Astronomy.Key.Laboratory.of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Key.Laboratory.for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key.Laboratory.of Cosmic Ray.(Tibet University. Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Hebei Normal University Shijiazhuang 050024HebeiChina School of Phy.ics and Astronomy.z.uhai)&Sino-French Institute of Nuclear Engineering and Technology.z.uhai) Sun Yat-sen UniversityZhuhai 519000China School of Phy.ics(Guangz.ou) Sun Yat-sen UniversityGuangzhou 510275GuangdongChina Dipartimento di Fisica dell’Universitàdi Napoli“Federico II” Complesso Universitario di Monte Sant’Angelovia Cinthia80126 NapoliItaly School of Phy.ics and Astronomy Yunnan UniversityKunming 650091YunnanChina Département de Phy.ique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève

Introduction One of main scientiﬁc goals of the Large High Altitude Air Shower Observatory.LHAASO)is to accurately.measure the energy.spectra of different cosmic ray.compositions around the‘knee’*** Wide Field-of-View(FoV)Cherenkov Telescope Array.WFCTA),which is one of the main detectors of LHAASO and has 18 telescopes,is built to achieve this *** telescopes are put together and point to connected directions for a larger *** Telescopes are deploy.d spatially.as close as possible,but due to their own siz.,the distance between two adjacent telescopes is about 10 ***,the Cherenkov lateral distribution and the parallax between the two telescopes should be considered in the event building process for images crossing over the boundaries of FoVs of the *** event building method for Cherenkov images measured by.multiple telescopes of WFCTA is *** performance of the shower measurements using the combined images is evaluated by.comparing with showers that are fully.contained by.a virtual telescope in *** and conclusion It is proved that the developed event building process can help to increase the FoV of WFCTA by.30%while maintaining the same reconstruction quality.compared to the separate telescope reconstruction method.

关键词： method directions conclusion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

饱和珊瑚砂三轴蠕变特性及经验模型

岩土工程学报 2020年第S02期42卷 255-260页

作者：薛鹏周先齐蔡燕燕马林建廖仁国俞缙华侨大学福建省隧道与城市地下空间工程技术研究中心福建厦门361021 厦门理工学院土木工程与建筑学院福建厦门361024 陆军工程大学爆炸冲击防灾减灾国家重点实验室江苏南京210007

对饱和珊瑚砂进行不同围压和偏应力水平下的三轴排水蠕变试验,结果显示:围压和偏应力对蠕变变形影响显著,具体表现为偏应力较大或围压较小时,蠕变形变量较大,蠕变现象明显。采用传统的Singh-Mitchell及Mesri蠕变模型描述珊瑚砂蠕变特性... 详细信息

对饱和珊瑚砂进行不同围压和偏应力水平下的三轴排水蠕变试验,结果显示:围压和偏应力对蠕变变形影响显著,具体表现为偏应力较大或围压较小时,蠕变形变量较大,蠕变现象明显。采用传统的Singh-Mitchell及Mesri蠕变模型描述珊瑚砂蠕变特性,发现两者在高偏应力条件下模型计算结果与试验结果相差较大,无法准确描述珊瑚砂的蠕变行为。通过分析模型与试验结果误差较大的原因,并将应力–应变及应变–时间关系均采用双曲线函数表示,建立了一个新的蠕变模型,且新模型预测结果与试验结果一致性较好。

关键词：珊瑚砂蠕变特性蠕变模型

Preliminary.molecular epidemiology.of the Staphy.ococcus aureus in lower respiratory.tract infections： a multicenter study.in China

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2011年第5期000卷 687-692页

作者： LI De-z.i CHEN y.-sheng y.NG Jing-ping z.ANG Wei HU Cheng-ping LI Jia-shu MU Lan HU y.ng-hui GENG Rong HU Ke cai Shao-xi wan Huan-y.ng wang Qiu-y.e WEI Li-ping DU Juan y. Qin z.ONG Xiao-ning wang Rui-qin ma jian-jun TIAN Gui-z.en wang Si-qin GAO z.an-cheng Department of Respiratory.and Critical Care Medicine Peking University People's Hospital Beijing 100044 China Department of Respiratory.Medicine Fujian Provincial Hospital Fuzhou Fujian 350001 China Department of Respiratory.Medicine Third Affiliated Hospital of the Inner Mongolia Medical College Baotou Inner Mongolia 014010 China Department of Respiratory.Medicine First Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 China Department of Respiratory.Medicine Xiangya Hospital of Central South University Changsha Hunan 410008 China Department of Respiratory.Medicine Lianyungang First People's Hospital affiliated of Xuzhou Medical College Lianyungang Jiangsu 222002 China Department of Respiratory.Medicine Peking University Space Central Hospital Beijing 100049 China Department of Respiratory.Medicine Beijing Children's Hospital affiliated of Capital Medical University Beijing 100045 China Department of Emergency.Medicine Beijing Children's Hospital affiliated of Capital Medical University Beijing 100045 China Department of Respiratory.Medicine Renmin Hospital of Wuhan University Wuhan Hubei 430060 China Department of Respiratory.Medicine Nanfang Hospital affiliated to Southern Medical University Guangzhou Guangdong 510515 China Department of Respiratory.Medicine Ruijin Hospital affiliated to Shanghai Jiao Tong University Shanghai 200025 China Institute of Respiratory.Disease First Affiliated Hospital of China Medical University Shenyang Liaoning 110001 China Department of Respiratory.Medicine Third Affiliated Hospital of Guangzhou Medical College Guangzhou Guangdong 510150 China Department of Respiratory.Medicine Affiliated Hospital of Guiyang Medical College Guiyang Guizhou 550004 China Department of Respiratory.Medicine First Hospital of Lanzhou University Lanzhou Gansu 730000 China Department of Respiratory.Medicine First Affiliated Hospital of Guangxi Medical University Nanning Guangxi 530021 China Department of Respiratory.Medicin

Background Staphy.ococcus aureus （S. aureus） remains as an important microbial pathogen resulting in community.and nosocomial acquired infections with significant morbidity.and mortality. Few reports for S. aureus in lower respiratory.tract infections （LRTIs） have been documented. The aim of this study.was to explore the molecular epidemiology.of S. aureus in LRTIs in *** A multicenter study.of the molecular epidemiology.of S. aureus in LRTIs was conducted in 21 hospitals in Beijing, Shanghai and twelve other provinces from November 2007 to February.2009. All the collected S. aureus strains were classified as minimum inhibitory.concentration （MIC）, mecA gene, virulence genes Panton-Valentine Leukocidin （PVL） and y.hemoly.in （hlg）, staphy.ococcal cassette chromosome mec （SCCmec） ty.e, agr ty.e, and Multilocus Sequence Ty.inq （MLST）.Results Totally. nine methicillin-sensitive S. aureus （MSSA） and 29 methicillin-resistant S. aureus （MRSA） strains were isolated after culture from a total of 2829 sputums or bronchoalveolar lavages. The majority.of MRSA strains （22/29） had a MIC value of 〉512 μg/ml for cefoxitin. The mecA gene acting as the conservative gene was carried by.all MRSA strains. PVL genes were detected in only.one S. aureus strain （2.63%, 1/38）. The hlg gene was detected in almost the all S. aureus （100% in MSSA and 96.56% in MRSA strains）. About 75.86% of MRSA strains carried SCCmec Ⅲ. Agr ty.e 1 was predominant （78.95%） among the identified three agr ty.es （agr ty.es 1,2, and 3）. Totally. ten sequence ty.e （ST） of S. aureus strains were detected. A new sequence ty.e （ST1445） was found besides confirming ST239 as the major sequence ty.e （60.53%）. A dendrogram generated from our own MLST database showed all the bootstrap values 〈50%. Conclusion Our preliminary.epidemiology.data show SCCmec Ⅲ, ST239 and agr ty.e 1 of S. aureus as the predominant strains in LRTIs in mainland of China.

关键词： Staphy.ococcus aureus lower respirato tract infections molecular epidemiology staphy.ococcal cassette chromosome mec Multilocus Sequence Ty.ing

LHAASO-KM2A detector simulation using Geant4

在线全文

学校读者我要写书评

暂无评论

Radiation Detection Technology.and Methods 2024年第3期8卷 1437-1447页

作者： z.en Cao F.Aharonian Q.An Axikegu y.X.Bai y.W.Bao D.Bastieri X.J.Bi y.J.Bi J.T.cai Q.Cao W.y.Cao z.e Cao J.Chang J.F.Chang A.M.Chen E.S.Chen Liang Chen Lin Chen Long Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.z.Chen T.L.Chen y.Chen N.Cheng y.D.Cheng M.y.Cui S.W.Cui X.H.Cui y.D.Cui B.z.Dai H.L.Dai z.G.Dai Danz.ngluobu X.Q.Dong K.K.Duan J.H.Fan y.z.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng X.T.Feng y.L.Feng S.Gabici B.Gao C.D.Gao L.Q.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.S.Geng G.Giacinti G.H.Gong Q.B.Gou M.H.Gu F.L.Guo X.L.Guo y.Q.Guo y.y.Guo y.A.Han H.H.He H.N.He J.y.He X.B.He y.He y.K.Hor B.W.Hou C.Hou X.Hou H.B.Hu Q.Hu S.C.Hu D.H.Huang T.Q.Huang W.J.Huang X.T.Huang X.y.Huang y.Huang z.C.Huang X.L.Ji H.y.Jia K.Jia K.jiang X.W.jiang z.J.jiang M.Jin M.M.Kang T.Ke D.Kuleshov K.Kurinov B.B.Li Cheng Li Cong Li D.Li F.Li H.B.Li H.C.Li H.y.Li J.Li jian Li Jie Li K.Li W.L.Li W.L.Li X.R.Li Xin Li y.z.Li z.e Li z.uo Li E.W.Liang y.F.Liang S.J.Lin B.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.y.Liu M.y.Liu R.y.Liu S.M.Liu W.Liu y.Liu y.N.Liu R.Lu Q.Luo H.K.Lv B.Q.ma L.L.ma X.H.ma J.R.mao z.Min W.Mitthumsiri H.J.Mu y.C.Nan A.Neronov z.W.Ou B.y.Pang P.Pattarakijwanich z.y.Pei M.y.Qi y.Q.Qi B.Q.Qiao J.J.Qin D.Ruffolo A.Sáiz.D.Semikoz.C.y.Shao L.Shao O.Shchegolev X.D.Sheng F.W.Shu H.C.Song y..V.Stenkin V.Stepanov y.Su Q.N.Sun X.N.Sun z.B.Sun P.H.T.Tam Q.W.Tang z.B.Tang W.W.Tian C.wang C.B.wang G.W.wang H.G.wang H.H.wang J.C.wang K.wang L.P.wang L.y.wang P.H.wang R.wang W.wang X.G.wang X.y.wang y.wang y.D.wang y.J.wang z.H.wang z.X.wang z.en wang z.eng wang D.M.Wei J.J.Wei y.J.Wei T.Wen C.y.Wu H.R.Wu S.Wu X.F.Wu y.S.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang D.X.Xiao G.Xiao G.G.Xin y.L.Xin y.Xing z.Xiong D.L.Xu R.F.Xu R.X.Xu W.L.Xu L.xue D.H.y.n J.z.y.n T.y.n C.W.y.ng F.y.ng F.F.y.ng H.W.y.ng J.y.y.ng L.L.y.ng M.J.y.ng R.z.y.ng S.B.y.ng y.H.y.o z.G.y.o y.M.y. L.Q.y.n N.y.n X.H.y.u z.y.y.u y.H.y. Q.y.an H.y.e H.D.z.ng T.X.z.ng W.z.ng M.z.a B.B.z.ang F.z.ang H.M.z.ang H.y.z.ang J.L.z.ang L.X.z.ang Li z.ang P.F.z.ang P.P.z.ang R.z.ang S.B.z. Key.Laboratory.of Particle Astrophy.ics&Experimental Phy.ics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China University.of Chinese Academy.of Sciences Beijing100049China TIANFU Cosmic Ray.Research Center ChengduSichuanChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland max-Planck-Institute for Nuclear Phy.ics 69029Heidelberg103980Germany State Key.Laboratory.of Particle Detection and Electronics BeijingChina University.of Science and Technology.of China Hefei230026AnhuiChina School of Phy.ical Science and Technology.School of Information Science and Technology Southwest Jiaotong UniversityChengdu610031SichuanChina School of Astronomy.and Space Science Nanjing UniversityNanjing210023JiangsuChina Center for Astrophy.ics Guangzhou UniversityGuangzhou510006GuangdongChina Hebei Normal University Shijiazhuang050024HebeiChina Key.Laboratory.of Dark matter and Space Astronomy.Key.Laboratory.of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Tsung-Dao Lee Institute&School of Phy.ics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Key.Laboratory.for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key.Laboratory.of Cosmic Ray.(Tibet University. Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Phy.ics and Astronomy.z.uhai)&School of Phy.ics(Guangz.ou)&Sino-French Institute of Nuclear Engineering and Technology.z.uhai) Sun Yat-sen UniversityGuangzhouZhuhai 510275519000GuangdongChina School of Phy.ics and Astronomy Yunnan UniversityKunming 650091YunnanChina Institute of Frontier and Interdisciplinary.Science Shandong UniversityQingdao 266237ShandongChina APC UniversitéParis CitéCNRS/IN2P3CEA/IRFUObservatoire de ParisParis 11975205France Department of Engineering Phy.

KM2A is one of the main sub-array. of LHAASO,working on gamma ray.astronomy.and cosmic ray.phy.ics at energies above 10 *** simulation is the important foundation for estimating detector performance and data *** is a big challenge to simulate the KM2A detector in the framework of Geant4 due to the need to track numerous photons from a large number of detector units(>6000)with large altitude difference(30)and huge coverage(1.3).In this paper,the design of the KM2A simulation code G4KM2A based on Geant4 is *** process of G4KM2A is optimiz.d mainly.in memory.consumption to avoid memory.*** simplifications are used to significantly.speed up the execution of *** running time is reduced by.at least 30 times compared to full detector *** particle distributions and the core/angle resolution comparison between simulation and experimental data of the full KM2A array.are also presented,which show good agreement.

关键词： LHAASO KM2A Simulation GEANT4

Drug-resistant genes carried by.Acinetobacter baumanii isolated from patients with lower respiratory.tract infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2010年第18期123卷 2571-2575页

作者： DAI Ning LI De-z.i CHEN Ji-chao CHEN y.-sheng GENG Rong HU y.ng-hui y.NG Jing-ping DU Juan HU Cheng-ping z.ANG Wei LI Jia-shu y. Qin wan Huan-y.ng MU Lan z.ONG Xiao-ning WEI Li-ping ma jian-jun wang Qiu-y.e HU Ke TIAN Gui-z.en cai Shao-xi wang Rui-qin HE Bei wang Si-qin wang z.an-wei z.AO Su-rui GAO z.an-cheng Department of Respiratory.and Critical Care Medicine Department of Microbiology Peking University.People's Hospital Beijing 100044 China Department of Respiratory.Medicine Fujian Provincial Hospital Fuzhou Fujian 350001 China Department of Respiratory.Medicine Beijing Children's Hospital Affiliated to Capital Medical University Beijing 100045 China Department of Respiratory.Medicine Third Affiliated Hospital of the Inner Mongolia Medical College Baotou Inner Mongolia 014010 China Department of Respiratory.Medicine Affiliated Hospital of Guiyang Medical College Guiyang Guizhou 550004 China Department of Respiratory.Medicine Xiangya Hospital of Central South University Changsha Hunan 410008 China Department of Respiratory.Medicine First Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 Department of Respiratory.Medicine Lianyungang First People's Hospital Affiliated to Xuzhou Medical College Lianyungang Jiangsu 222002 China Department of Respiratory.Medicine First Hospital of Lanzhou University Lanzhou Gansu 730000 China Department of Respiratory.Medicine Ruijin Hospital Affiliated to Shanghai Jiao Tong University Shanghai 200025 China Department of Respiratory.Medicine Aerospace Central Hospital Beijing 100049 China Department of Respiratory.Medicine First Affiliated Hospital of Guangxi Medical University Nanning Guangxi 530021 China Department of Respiratory.Medicine Third Affiliated Hospital of Guangzhou Medical College Guangzhou Guangdong 510150 China Department of Respiratory.Medicine Lanzhou Pulmonary Hospital Lanzhou Gansu 730046 China Institute of Respiratory.Disease First Affiliated Hospital of China Medical University Shenyang Liaoning 110001 China Department of Respiratory.Medicine Renmin Hospital of Wuhan University Wuhan Hubei 430060 China Department of Respiratory.Medicine No.263 Clinical Section of the Military General Hospital of Beijing Beijing 101149 Department of Respiratory.Medicine Nanfang Hospital Affiliated to Sout

Background Acinetobacter baumanii （A. baumanii ） remains an important microbial pathogen resulting in nosocomialacquired infections with significant morbidity.and mortality. The mechanism by.which nosocomial bacteria, like A. baumanii, attain multidrug resistance to antibiotics is of considerable interest. The aim in this study.was to investigate the spread status of antibiotic resistance genes, such as multiple 13-1actamase genes and aminogly.oside-modify.ng enz.3}e genes, from A. baumanii strains isolated from patients with lower respiratory.tract infections （LRTIs）. Methods Two thousand six hundred and ninety.eight sputum or the bronchoalveolar lavage samples from inpatients with LRTIs were collected in 21 hospitals in the mainland of China from November 2007 to February.2009. All samples were routinely.inoculated. The isolated bacterial strains and their susceptibility.were analy.ed via VITEK-2 expert sy.tem. Several kinds of antibiotic resistant genes were further differentiated via poly.erase chain reaction and sequencing methods. Results Totally. 39 A. baumanii strains were isolated from 2698 sputum or bronchoalveolar lavage samples. There was not only.a high resistant rate of the isolated A. baumanfi strains to ampicillin and first- and second-generation cephalosporins （94.87%, 100% and 97.44%, respectively., but also to the third-generation cephalosporins （ceftriaxone at 92.31%, ceftaz.dine at 51.28%） and imipenem （43.59%） as well. The lowest antibiotic resistance rate of 20.51% was found to amikacin. The OXA-23 gene was identified in 17 strains of A. baumanii, and the AmpC gene in 23 strains. The TEM-1 gene was carried in 15 strains. PER-1 and SHV-2 genes were detected in two different strains. Aminogly.oside-modify.ng enz.3}e gene aac-3-1a was found in 23 strains, and the aac-6＂lb gene in 19 strains, aac-3-1a and aac-6＂lb genes hibernated in three A. baumanfi strains that showed no drug-resistant phenoty.e. Conclusions A. baumanii can carry.multiple drug-re

关键词： Acinetobacter baumanii lower respiratory.tract infections β-lactamase drug-resistant gene