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一种引入成对代价的子类判别分析

软件学报 2013年第11期24卷 2597-2609页

作者：万建武杨明南京师范大学计算机科学与技术学院江苏南京210023 常州大学信息科学与工程学院江苏常州213164

传统的降维方法追求较低的识别错误率,假设不同错分的代价相同,这个假设在一些实际应用中往往不成立.例如,在基于人脸识别的门禁系统中,存在入侵者类和合法者类,将入侵者错分成合法者的损失往往高于将合法者错分成入侵者的损失,而将合... 详细信息

传统的降维方法追求较低的识别错误率,假设不同错分的代价相同,这个假设在一些实际应用中往往不成立.例如,在基于人脸识别的门禁系统中,存在入侵者类和合法者类,将入侵者错分成合法者的损失往往高于将合法者错分成入侵者的损失,而将合法者错分成入侵者的损失又大于将合法者错分成其他合法者的损失.为此,首先通过对人脸识别门禁系统进行分析,将其归为一个代价敏感的子类学习问题,然后将错分代价以及子类信息同时注入判别分析的框架中,提出一种近似于成对贝叶斯风险准则的降维算法.在人脸数据集Extended Yale B以及ORL上的实验结果表明了该算法的有效性.

关键词：代价敏感降维人脸识别子类学习

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代价敏感学习方法综述

软件学报 2020年第1期31卷 113-136页

作者：万建武杨明常州大学信息科学与工程学院江苏常州213164 南京师范大学计算机科学与技术学院江苏南京210023

分类是机器学习的重要任务之一.传统的分类学习算法追求最低的分类错误率,假设不同类型的错误分类具有相等的损失.然而,在诸如人脸识别门禁系统、软件缺陷预测、多标记学习等应用领域中,不同类型的错误分类所导致的损失差异较大.这要求... 详细信息

分类是机器学习的重要任务之一.传统的分类学习算法追求最低的分类错误率,假设不同类型的错误分类具有相等的损失.然而,在诸如人脸识别门禁系统、软件缺陷预测、多标记学习等应用领域中,不同类型的错误分类所导致的损失差异较大.这要求学习算法对可能导致高错分损失的样本加以重点关注,使得学习模型的整体错分损失最小.为解决该问题,代价敏感学习方法引起了研究者的极大关注.以代价敏感学习方法的理论基础作为切入点,系统阐述了代价敏感学习的主要模型方法以及代表性的应用领域.最后,讨论并展望了未来可能的研究趋势.

关键词：代价敏感损失分类人脸识别软件缺陷预测多标记学习

ON THE DISCOVERY OF EIFELIAN FAUNA FROM WESTERN TSINLING

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古生物学报 1964年第3期 480-481页

作者： jian wan-CHOU AND KUO YONG-LING (Department of Geology,Northwestern University)

In soumeastern Kansu,there is a vast area of metamorphosed sed(?)mentary rockscomposed of quartzites,crystallized limestones and slates with some intercalations ofhematites exposed in the valley of Lengputze to the north of Wen Xian,and in the valleyof Sunchiayuan to the west of Kang *** 1944,Yeh and Kwan named the abovementioned strata at Lengputze Lupanchiao Quartzite and referred it to Lower ***(1959),by the discovery of Tabulata(Favosites sp.),*** re-garded it as the upper part of the so-called Pikou Group of Lower Palaeozoic in *** carrying on a field exploration in 1960,one of the writers,Kuo,collected a fewfossils from the same section and the corresponding strata in Kang *** arelisted helow:

关键词：切面甘肃康县产地甘肃文县 ON THE DISCOVERY OF EIFELIAN FAUNA FROM WESTERN TSINLING 秦岭西段图版

Bayesian optimization based on a unified figure of merit for accelerated materials screening:A case study of halide perovskites

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Science China Materials 2020年第6期63卷 1024-1035页

作者： Xiwen Chen Chen wang Zhenzhu Li Zhufeng Hou wan-jian Yin College of Energy Soochow Institute for Energy and Materials Innovations(SIEMIS)and Jiangsu Provincial Key Laboratory for Advanced Carbon Materials and Wearable Energy TechnologiesSoochow UniversitySuzhou 215006China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Key Lab of Advanced Optical Manufacturing Technologies of jiangsu Province&Key Lab of Modern Optical Technologies of Education Ministry of China Soochow UniversitySuzhou 215006China

The figure of merit is of crucial importance in materials design to search for candidates with optimal *** the field of photovoltaics,the bandgap(E_g)is a well-recognized figure of merit for screening solar cell absorbers subject to the Shockley-Queisser *** this paper,the bandgap as the figure of merit is challenged since an ideal solar cell absorber requires multiple criteria such as stability,optical absorption,and carrier *** criteria make the quantitative description of material candidates difficult and computationally *** halide perovskites as an example,we combine thermodynamic stability(ΔHd)and Eginto a unified figure of merit and use Bayesian optimization(BO)to accelerate materials *** have found that,in comparison to an exhaustive search via multiple parameters,BO based on the unified figure of merit can screen optimal candidates(E_g,PBEbetween 0.6–1.2 eV,ΔHd>-29 meV per atom)more ***,the proposed method opens a viable route for the search of optimal solar cell absorbers from a large amount of material candidates with less computational cost.

关键词： descriptor machine learning Bayesian optimization DFT calculations

Comparative transcriptomic analysis reveals the molecular changes of acute pancreatitis in experimental models

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World Journal of Gastroenterology 2024年第14期30卷 2038-2058页

作者： Pan Zheng Xue-Yang Li Xiao-Yu Yang Huan wang Ling Ding Cong He jian-Hua wan Hua-Jing Ke Nong-Hua Lu Nian-Shuang Li Yin Zhu Department of Gastroenterology Digestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Acute pancreatitis(AP)encompasses a spectrum of pancreatic inflammatory conditions,ranging from mild inflammation to severe pancreatic necrosis and multisystem organ *** the challenges associated with obtaining human pancreatic samples,research on AP predominantly relies on animal *** this study,we aimed to elucidate the fundamental molecular mechanisms underlying AP using various AP *** To investigate the shared molecular changes underlying the development of AP across varying severity *** AP was induced in animal models through treatment with caerulein alone or in combination with lipopolysaccharide(LPS).Additionally,using Ptf1αto drive the specific expression of the hM3 promoter in pancreatic acinar cells transgenic C57BL/6J-hM3/Ptf1α(cre)mice were administered Clozapine N-oxide to induce ***,we conducted RNA sequencing of pancreatic tissues and validated the expression of significantly different genes using the Gene Expression Omnibus(GEO)*** Caerulein-induced AP showed severe inflammation and edema,which were exacerbated when combined with LPS and accompanied by partial pancreatic tissue *** with the control group,RNA sequencing analysis revealed 880 significantly differentially expressed genes in the caerulein model and 885 in the caerulein combined with the LPS *** Encyclopedia of Genes and Genomes enrichment analysis and Gene Set Enrichment Analysis indicated substantial enrichment of the TLR and NOD-like receptor signaling pathway,TLR signaling pathway,and NF-κB signaling pathway,alongside elevated levels of apoptosis-related pathways,such as apoptosis,P53 pathway,and phagosome *** significantly elevated genes in the TLR and NOD-like receptor signaling pathways,as well as in the apoptosis pathway,were validated through quantitative real-time PCR experiments in animal *** from the GEO database revealed that only MYD88 concurred in both mouse panc

关键词： Acute pancreatitis RNA-sequencing Experimental acute pancreatitis models Inflammatory Apoptosis TLR and NOD-like signaling pathways

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硫代乙酰胺光化学反应机理的理论研究

高等学校化学学报 2008年第12期29卷 2462-2468页

作者：彭亮丁万见于建国刘若庄北京师范大学化学学院北京100875

用B3LYP,MP2和CASSCF方法,采用cc-pVDZ和6-31++G**基组,研究了硫代乙酰胺在基态和最低三态上消除硫化氢以及其它光解离反应,并考虑了单个溶剂分子参与反应对质子迁移反应的影响,得到了消除硫化氢反应的反应机理,计算结果可以很好地解释... 详细信息

用B3LYP,MP2和CASSCF方法,采用cc-pVDZ和6-31++G**基组,研究了硫代乙酰胺在基态和最低三态上消除硫化氢以及其它光解离反应,并考虑了单个溶剂分子参与反应对质子迁移反应的影响,得到了消除硫化氢反应的反应机理,计算结果可以很好地解释实验结果.进而用CASSCF方法计算了第一激发单态上的各驻点,以及各交叉点.计算结果表明,在S1和T1态上发生除分子内转动以外的化学反应的可能性比较小,当分子被激发到S2态上时,将通过S2/S1交叉点到S1态,在S1态上的分子有两条途径去活化,通过S1/S0交叉点到热基态,通过S1/T1交叉点系间窜越到T1态.因而得出CH3CSNH2发生光解离反应的可能性不大.基于此,可将硫代酰胺结构引入蛋白或多肽中,有望在不破坏分子整体结构的情况下对其进行光化学研究.

关键词：硫代乙酰胺密度泛函理论光化学反应机理溶剂效应

Control of Leaf Senescence by an MeOH- Jasmonates Cascade that Is Epigenetically Regulated by OsSRT1 in Rice

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Molecular Plant 2016年第10期9卷 1366-1378页

作者： ChuanYing Fang Hua Zhang jian wan YangYang Wu Kang Li Cheng Jin Wei Chen ShouChuang wang WenSheng wang HaiWei Zhang Pan Zhang Fei Zhang LiangHuan Qu Xianqing Liu Dao-Xiu Zhou Jie Luo National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan) Huazhong Agricultural University Wuhan 430070China Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai200031 China College of Life Science and Technology Huazhong Agricultural University Wuhan 430070 China Institute of Plant Sciences Paris-Saclay Universite Paris-sud 11 Orsay 91405 France

Although considerable progress has been made in identifying the genes regulating accumulation of hormones that are involved in leaf senescence, only a few studies have focused on natural variations in jasmonates content and much less on the underlying genetic basis. Moreover, the epigenetic regulation of jasmonate-mediated leaf senescence remains largely unknown, in this study, we carried out metabolic profiling of a worldwide collection of rice accessions and demonstrated that there are substantial variations in jasmonate levels among these accessions. A subsequent metabolite-based genornewide association study identified candidates for two major quantitative genes （QTGs）, OsPME1 and OsTSD2, affecting the content of jasmonates. Further investigations using a series of relevant mutants and transgenic lines revealed the MeOH-jasmonata cascade plays an important role in regulating leaf senescence. Moreover, we showed that OsSRT1, one of the two Sir2 （silent information regugator 2） homologs in rice, negatively regulates leaf senescence by repressing expression of the biosynthetic genes of this metabolic cascade and at least particiaUy through histone H3K9 deacetylation of OsPME1. Taken together, our results indicate that the MeOH-jasmonates cascade and its epigenetic regulation are crucial for controlling leaf senescence process in rice.

关键词： MeOH-jasmonate cascade leaf senescence natural variation epigenetic regulation

王安石《诗经·卷耳》义中的“后妃求贤审官”探析

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孔子研究 2021年第6期 55-63,155页

作者：万剑江西抚州王安石国际研究中心江西抚州344000

宋代是儒学的争鸣时代。在宋代的《诗经》学中,王安石的《卷耳》义继承汉唐传统注疏,尊信小序,肯定后妃可以承担一定的政治职责,"辅佐君子,求贤审官"。欧阳修、苏辙、朱熹则从"妇人无外事"理念出发,质疑小序,否定后妃参政的正当性,与宋... 详细信息

宋代是儒学的争鸣时代。在宋代的《诗经》学中,王安石的《卷耳》义继承汉唐传统注疏,尊信小序,肯定后妃可以承担一定的政治职责,"辅佐君子,求贤审官"。欧阳修、苏辙、朱熹则从"妇人无外事"理念出发,质疑小序,否定后妃参政的正当性,与宋代宫廷政治实际不符。王安石与欧阳修、苏辙、朱熹在《卷耳》注解上的分歧,反映了他们对女性政治作用的不同认识。宋代《诗经》学主流由尊信小序到质疑小序变化的背后,是《诗经》学政治劝诫和批判作用的弱化。

关键词：王安石宋代《诗经》学诗序卷耳求贤审官

让中国哲学说自己的话:做负责任的比较研究——访安乐哲教授

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哲学动态 2024年第4期 119-126页

作者：万建中国社会科学院大学哲学院

安乐哲(Roger ***),中西比较哲学家、汉学家。伦敦大学亚非学院博士,曾任夏威夷大学哲学系教授、美国东西方中心亚洲发展项目主任、《东西方哲学》《国际中国书评》主编,现任北京大学人文讲席教授、世界儒学文化研究联合会会长、国际儒... 详细信息

安乐哲(Roger ***),中西比较哲学家、汉学家。伦敦大学亚非学院博士,曾任夏威夷大学哲学系教授、美国东西方中心亚洲发展项目主任、《东西方哲学》《国际中国书评》主编,现任北京大学人文讲席教授、世界儒学文化研究联合会会长、国际儒学联合会副会长、山东省特聘“儒学大家”、博古睿研究院中国中心学术委员会主席。曾获“孔子文化奖”“儒学经典翻译特殊贡献奖”“杜威学术学会2019终身成就奖”“中国政府友谊奖”等。翻译了《论语》《道德经》《中庸》《孙子兵法》《孙兵法》《孝经》《淮南子》等多部中国传统典籍。出版的独著有《主术:中国古代政治艺术之研究》(1995年)、《汉哲学思维的文化探源》(1999年)、《儒家角色伦理学——一套特色伦理学词汇》(2017年)、《孔子与杜威:跨时空的镜鉴》(2020年)、《“生生”的中国哲学》(2021年)、《经典儒学核心概念》(2021年)等;合著有《先贤的民主:杜威、孔子与中国民主之希望》(2004年)、《通过孔子而思》(2005年)、《期望中国:对中西文化的哲学思考》(2005年)、《切中伦常:的新诠与新译》(2011年)、《儒家角色伦理——21世纪道德视角》(2020年)、《哲读论语》(2022年)等。

关键词：夏威夷大学友谊奖终身成就奖国际儒学联合会《淮南子》孔子文化儒学经典特殊贡献奖