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Clinical observation of physiological and psychological reactions to electric stimulation of the amygdaloid nucleus and the nucleus accumbens in heroin addicts after detoxification

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Chinese Medical Journal 2012年第1期125卷 63-66页

作者： FANG Jun gu jian-wen YANG Wen-tao QIN Xue-ying HU Yong-hua Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100191 China Department of Neurosurgery General Hospital of the Chinese People＇s Liberation Army Chengdu Military District Chengdu 610083 Sichuan China

Background Stereotactic surgery has been used to treat heroin abstinence in China since 2000 by ablating the amygdaloid nucleus （AMY） and the nucleus accumbens （NAc）,which also provides opportunity to identify the relationship between these nuclei and *** study aimed to explore the physiological and psychological effects of electrically stimulating the AMY and the NAc in herein addicts after detoxification by observing changes of heart rate,arterial pressure and occurrence of euphoria similar to heroin induced *** A total of 70 heroin addicts after detoxification were recruited,and 61 of them were eligible to be given stereotactic surgery for heroin *** operation was carried out after determining the coordinates of all target nucleuses,and stimulation was performed at the AMY and the NAc solely or *** rate,arterial pressure and occurrence of euphoria similar to heroin induced euphoria were recorded and *** The average heat rate was （66±10） beats/min before electric stimulation,and significantly increased to （84±14） beats/min during stimulation,and changed to （73±12） beats/min 10 minutes after *** was a significant elevation of the average arterial pressure from 83 mmHg before stimulation to 98 mmHg during the stimulation,and it then decreased to 90 mmHg after ***-three of the 61 patients showed intense euphoria similar to heroin induced *** largest number （118/186） of euphoric responses occurred when the AMY and the NAc were stimulated at the same *** ratio was 5.4 （95% CI： 2.4-11.9,P 〈0.0001） to quantify the *** from a Logistic regression model showed a positive correlation between unilateral stimulation of either the AMY or NAC and induction of euphoria （OR 〉1 ）,especially when the left AMY or left NAc was stimulated （P 〈0.05）.Conclusions Our data are consistent with existing results that the AMY and the NAc are related to *** roles i

关键词： the amygdaloid nucleus the nucleus accumbens heroin dependence electric stimulation

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激发态丰质子核的双质子发射

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物理学报 2022年第6期71卷 94-101页

作者：邢凤竹崔建坡王艳召顾建中石家庄铁道大学数理系石家庄050043 石家庄铁道大学应用物理研究所石家庄050043 中国原子能科学研究院北京102413

将有效液滴模型和推广的液滴模型推广至激发态丰质子核的双质子发射半衰期研究,发现这两个模型都能较好地再现双质子发射半衰期的实验数据.基于这两个模型预言了一些核的激发态的双质子发射的半衰期,为将来的实验提供参考,并将上述半衰... 详细信息

将有效液滴模型和推广的液滴模型推广至激发态丰质子核的双质子发射半衰期研究,发现这两个模型都能较好地再现双质子发射半衰期的实验数据.基于这两个模型预言了一些核的激发态的双质子发射的半衰期,为将来的实验提供参考,并将上述半衰期与统一裂变模型给出的半衰期进行了比较和分析.此外,以^(94)Ag的21^(+)激发态的双质子发射为例,讨论了衰变能和衰变过程中带走的轨道角动量对其半衰期的影响,发现半衰期对它们的依赖很敏感,半衰期对衰变能的强烈依赖表明了精确测量核质量和激发能的重要性和必要性.

关键词：双质子发射激发态半衰期有效液滴模型推广的液滴模型

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Controlled synthesis of Ce(OH)CO_3 flowers by a hydrothermal method and their thermal conversion to CeO_2 flowers

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Particuology 2012年第6期10卷 771-776页

作者： Dongen Zhang Feng Li jian gu Qing Xie Shanzhong Li Xiaobo Zhang guiquan Han Ailing Ying Zhiwei Tong Department of Chemical Engineering Huaihai Institute of Technology SORST Japan Science and Technology Agency(JST)Japan College of Chemistry China University of Mining and Technology

Highly uniform Ce（OH）CO3 flowers were successfully prepared in large quantities using a facile hydrothermal approach from the reaction of Ce（NH4）（NO3）4 with CO（NH2）2 at 160℃ in a water-N2H4 complex. The influences of the N2H4 content and temperature on flower formation were discussed. CeO2 flowers were prepared by thermal conversion of Ce（OH）CO3 flowers at 500 ℃ in air. Both Ce（OH）CO3 and CeO2 flowers were characterized by X-ray powder diffraction （XRD）, and scanning electron microscopy （SEM）. The UV-vis adsorption spectrum of the CeO2 flowers showed that the band gap energy （Eg） is 2.66 eV, which is lower than that of bulk ceria.

关键词： Crystal growth Flowers Self-assembly

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太钢5号高炉炉况波动的原因及应对措施

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炼铁 2022年第1期41卷 39-43页

作者：谷健郑伟山西太钢不锈钢股份有限公司

对太钢5号高炉炉况波动的原因及应对措施进行了总结分析。认为5号高炉炉况波动的原因主要是原燃料的波动、上部装料制度不适宜、下部调剂不及时,以及两铁口对角出铁,炉缸活跃性差等。为此,通过采取建立原燃料预警机制、中心加焦技术、... 详细信息

对太钢5号高炉炉况波动的原因及应对措施进行了总结分析。认为5号高炉炉况波动的原因主要是原燃料的波动、上部装料制度不适宜、下部调剂不及时,以及两铁口对角出铁,炉缸活跃性差等。为此,通过采取建立原燃料预警机制、中心加焦技术、优化操作管理、炉前实行均匀出铁等一系列措施,使得炉缸活跃性增强,炉内煤气流分布向好,炉况逐渐恢复正常,高炉顺行、增产的目标得以实现,并取得了较好的技术经济指标。

关键词：大型高炉炉况波动原燃料中心加焦稳定顺行

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Comparison of total splenic artery embolization and partial splenic embolization for hypersplenism

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World Journal of Gastroenterology 2012年第24期18卷 3138-3144页

作者： Xin-Hong He jian-jian gu Wen-Tao Li Wei-Jun Peng guo-Dong Li Sheng-Ping Wang Li-Chao Xu Jun Ji Department of Radiology Cancer Hospital/Cancer Institute Shanghai Medical CollegeFudan University Shanghai 200032 China Department of Oncology People's Hos-pital of Tongzhou District Nantong 226300 Jiangsu ProvinceChina

AIM:To evaluate whether total splenic artery embolization(TSAE) for patients with hypersplenism delivers better long-term outcomes than partial splenic embolization(PSE).METHODS:Sixty-one patients with hypersplenism eligible for TSAE(n = 27,group A) or PSE(n = 34,group B) were enrolled into the trial,which included clinical and computed tomography *** on technical success,length of hospital stay,white blood cell(WBC) and platelet(PLT) counts,splenic volume and complications were collected at 2 wk,6 mo,and 1,2,3,4 years ***:Both TSAE and PSE were technically successful in all *** were significantly fewer(P = 0.001),and hospital stay significantly shorter(P = 0.007),in group A than in group *** WBC and PLT counts in group A were significantly higher than those in group B from 6 mo to 4 years(P = 0.001),and post-procedure residual splenic volume in group A was significantly less than that observed in group B at 1,2,3 and 4 years post-procedure(P = 0.001).No significant differences were observed in red blood cell counts and liver function parameters between the two groups following the ***:Our results indicate that TSAE for patients with hypersplenism not only delivers a better longterm outcome,but is also associated with lower complication rates and a shorter hospital stay than PSE.

关键词：脾动脉栓塞血小板计数计算机断层扫描红细胞计数 PSE 并发症数据收集

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ENZYME REACTION IN AQUEguB-ORGANIC BYSTEM —KINETIC RESOLUTION OP RACEMIC OXIRANECARBOXYLIC ESTERS WITH LIPASE

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Chinese Chemical Letters 1992年第3期3卷 173-174页

作者： jian Xing gu Zu Yi LI Shanghai Institute of Organic Chemistry Academia Sinica345 Lingling LuShanghai 200032

The chiral oxiranecarboxylic acids or esters 2a-e were obtained with lipase (CCL) in aqueous-organic *** ee and the absolute configurations of the products were determined.

关键词： Miller Co OP KINETIC RESOLUTION OP RACEMIC OXIRANECARBOXYLIC ESTERS WITH LIPASE ENZYME REACTION IN AQUEguB-ORGANIC BYSTEM

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Transurethral assistant transumbilical laparoendoscopic single-site radical prostatectomy

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Asian Journal of Andrology 2017年第4期19卷 473-476页

作者： Chen Zhu jian Su Lin Yuan Yang Zhang Zi-Jie Lu Yun Su Ning-Hong Wang Xiao-jian gu Qing-Yi Zhu Department of Urology Affiliated Hospital of Nanjing University of Traditional Chinese Medicine Nanjing China.

The laparoendoscopic single-site （LESS） technique is the latest technical innovation in laparoscopic surgery to undergo exponential development in urology. This study undertaken to illustrate our initial experience LESS radical prostatectomy （RP） and analyze early outcomes. Nineteen patients diagnosed with prostate cancer underwent LESS-RP in our institute. The patients were divided into two groups： conventional LESS and transurethral assistant LESS. Preoperative, perioperative, postoperative, pathologic, and functional outcomes data were assessed. With the help of a transurethral assistant, the mean operation and anastomosis time were decreased markedly. No focal positive margins were encountered. No prostate-specific antigen recurrence was detected 1 month postoperatively. Complete continence recovery （no pad） was observed in 32% of the patients at 1 month after the operation. No intraoperative and postoperative complications were reported, LESS-RP is a feasible and effective surgical procedure for treatment of prostate cancer. Moreover, transurethral assistant LESS could reduce the difficulty of LESS-RP and shorten the operation time.

关键词： laparoendoscopic single-site surgery prostate cancer transurethral assistant

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Inhibition of the proliferation of human gastric cancer cells SGC-7901 in vitro and in vivo using Bcl-2 siRNA

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Chinese Medical Journal 2007年第23期120卷 2105-2111页

作者： HAO jian-hong gu Qin-long LIU Bing-ya LI jian-fang CHEN Xue-hua JI Yu-bao ZHU Zheng-gang LIN Yan-zhen Department of Surgery Shanghai Institute of Digestive Surgery Affiliated Ruijin Hospital School of Medicine Shanghai Jiaotong University Shanghai 200025 China

Background Bcl-2, the anti-apoptotic protein is overexpressed in the majority of gastric cancers and associated with its pathogenesis. To better understanding of the role of Bcl-2, RNA interference （RNAi） was used to inhibit Bcl-2 expression in the human gastric cancer cells in vitro and in vivo. Methods Bcl-2 small interfering RNA （siRNA） was transfected into human gastric cancer cells $GC-7901, and Bcl-2 expression was monitored by real-time polymerase chain reaction （PCR） and Western blot. Cell proliferation, apoptosis, and telomerase activity were examined by MTT, flow cytometry, and TRAP assay, respectively. Gastric cancer cells treated with 100 nmol/L Bcl-2 siRNA were subcutaneously transplanted into nude mice and tumor growth was assessed. Results Bcl-2 siRNA significantly inhibited the expression of Bcl-2 in human gastric cancer cells at both mRNA and protein levels in a time- and dose-dependent manner. Bcl-2 siRNA also decreased telomerase activity （by 78.76%） and increased the rate of apoptosis （by 37.47%）. SGC-7901 cell growth was also significantly suppressed in vivo and in vitro. Conclusions Bcl-2 expression knockdown suppressed the growth of gastric cancer cells. Thus, Bcl-2 may play a very important role in carcinogenesis of gastric cancer and its knockdown may offer a new potential gene therapy approach for human gastric cancer in future.

关键词： gastric cancer RNA interference Bcl-2 gene therapy telomerase

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Chip-Level MMSE Equalization for CDMA Downlink

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The Journal of China Universities of Posts and Telecommunications 2005年第2期12卷 82-86页

作者： ZHANG Yi gu jian YANG Da-cheng Beijing University of Posts and Telecommunications Beijing 100876 P.R. China

This work is focused on the structure design of MMSE linear equalizers in the downlink of CDMA-based multi-user communication systems. Previous work was mostly focused on the performance comparison between ZF and MMSE linear equalizers and the conclusion is that the performance based on MMSE criterion is much better than that based on ZF one. In this paper, we only discuss MMSE equalizer and a new block structure of MMSE linear equalizer is derived from the traditional structure of this kind of equalizer. Furthermore, a block MMSE linear equalizer is improved through using the overlap-save technique. Simulation results shaw that the average performance of improved block MMSE linear equalizers is better than those of the block MMSE equalizers and traditional MMSE equalizers. At the same time, the computation complexity of all these MMSE equalizers is given. It is shown that the comple：rity of proposed block MMSE equalizers is lower than that of the traditional equalizers with optimal delay, D, when the length of the filter in traditional MMSE equalizers equals the block size of block MMSE equalizers.

关键词： MMSE ZF equalization chip-level overlap

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中药多酚类成分抗肿瘤表观遗传机制的研究进展

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中草药 2023年第14期54卷 4722-4731页

作者：王琴杨斌顾健龚普阳西南民族大学药学院四川成都610041

表观遗传调控紊乱导致的基因表达异常是肿瘤的发生的重要特征之一。近年来,中药活性成分调控肿瘤表观遗传机制研究成为热点。多酚是多种抗肿瘤中药的主要物质基础。姜黄素、表没食子儿茶素没食子酸酯、白藜芦醇、槲皮素和原花青素等可... 详细信息

表观遗传调控紊乱导致的基因表达异常是肿瘤的发生的重要特征之一。近年来,中药活性成分调控肿瘤表观遗传机制研究成为热点。多酚是多种抗肿瘤中药的主要物质基础。姜黄素、表没食子儿茶素没食子酸酯、白藜芦醇、槲皮素和原花青素等可通过多种表观遗传机制调控肿瘤抑制基因或癌基因的表达,发挥抗肿瘤作用。通过对代表性中药多酚类成分调节DNA甲基化、组蛋白修饰和非编码RNA等表观遗传方面发挥抗肿瘤的作用进行综述,为中药对肿瘤的干预治疗提供理论依据和研究策略。

关键词：表观遗传多酚肿瘤 DNA甲基化组蛋白修饰姜黄素表没食子儿茶素没食子酸酯白藜芦醇槲皮素原花青素

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