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Fluorescence in situ hybridization-based confirmation of acute graftvs-host disease diagnosis following liver transplantation:A case report

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World Journal of Gastrointestinal Surgery 2021年第9期13卷 1102-1109页

作者： Jing-Jing Xiao Jin-Yu Ma Jun Liao Di Wu Chao Lv Hai-Yang Li Shi Zuo Hai-Tao Zhu Hua-jian gu School of Clinical Medicine Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Hepatobiliary Surgery The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Pediatric Surgery The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

BACKGROUND Although acute graft-vs-host disease(aGvHD)is a rare complication of liver transplantation,it is poorly understood and has an extremely high mortality *** standardized diagnostic criteria or treatment regimens currently *** SUMMARY The present study investigated the etiology,diagnosis,and treatment of aGvHD following liver ***,diagnosis,disease course,histology,and treatment of an aGvHD case are reported,and associated literature is reviewed.A 64-year-old female required LTx due to primary biliary *** donor was a 12-year-old *** weeks following liver transplantation,the recipient developed pyrexia,diarrhea,rashes,and antibiotic-unresponsive *** symptoms together with laboratory investigations suggested a diagnosis of aGvHD,which was confirmed via peripheral blood fluorescent in situ *** XY chromosome fluorescent in situ hybridization indicating early chimerism achieved 93%sensitivity in the detection of *** immunosuppressants were discontinued,and high-dose intravenous methylprednisolone was initiated along with *** diarrhea resolved,the patient’s general condition continued to deteriorate until demise due to multi-system organ failure at 37 d post-liver *** case illustrates the life-threatening nature of *** Herein,we have summarized a post-LTx aGvHD case and reviewed associated literature in order to increase awareness and provide potentially risk-mitigating recommendations.

关键词： Liver transplantation Graft-vs-host disease Fluorescence in situ hybridization cytogenetics Chimerism Diagnosis Case report

Analysis of the urinary peptidome associated with Helicobacter pylori infection

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World Journal of Gastroenterology 2011年第5期17卷 618-624页

作者： Di Xiao Fan-Liang Meng Li-Hua He Yi-Xin gu jian-Zhong Zhang National Institute for Communicable Disease Controland Prevention Chinese Center for Disease Control and Pre-vention Beijing 102206 China

AIM： To investigate the relationship between urinary peptide changes and Helicobacter pylori （H. pylorl） infection using urinary peptidome profiling. METHODS： The study was performed in volunteers （n = 137） who gave informed consent. Urinary peptides were enriched by magnetic beads based weak cation exchange chromatography＇and spectrums acquired by matrix-assisted laser desorption/ionization time-of-flight （MALDI-TOF） mass spectrometry （MS）. ClinProTools bioinformatics software was used for statistical analysis and the recognition of peptide patterns. The marker peptides were identified by LTQ Obitrap XL tandem MS. RESULTS： Approximately 50 proteins or peptides which loaded onto the magnetic beads were detected by MAL-DI-TOF MS. By optimizing the parameters of the model, the Genetic Algorithm model had good recognition capability （97%） and positive predictive value （94%）. Based on the model, 2 markers with molecular masses of 6788 and 1912 Da were found that differentiated between H. pylori positive and negative volunteers. The m/z 1912 sequence was parsed as SKQFTSSTSYN- RGDSTF. The peptide was identified as isoform 1 of the fibrinogen a chain precursor, whose concentration in urine was markedly higher in H. pylori infected volunteers than in H. pylori non-infected ones. CONCLUSION： The appearance of urinary fibrinogen degradation products is caused by an active H. pyloriinduced process.

关键词： Urinary peptidome profiling MB-matrix-assisted laser desorption/ionization time-of-flight massspectrometry Helicobacter pylori Fibrinogen degrada-tion products

Branching Ratios ofαDecay for Heavy Nuclei Near Deformed Shell Closures

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Branching Ratios ofαDecay for Heavy Nuclei Near Deformed Sh...

柔性路面结构设计的动力安定下限理论与分析方法

作者： WANG Yan-zhao PENG Bang-bao DONG jian-min gu jian-zhong Institute of Modern Physics Chinese Academy of Sciences

Nowadays,the study on the deformation of heavy nuclei and super-heavy nuclei(SHN) is a hot subject in nuclear physics.A number of heavy nuclei and SHN around Hs have already been observed *** theoretical study of deformed SHN suggests that Hs is a doubly magic deformed ***,there is no experimental evidence for the deformed shapes of the above-mentioned *** such evidence would be of great *** would confirm the unexpected structure of these *** 2001,Sobiczewski et *** to observe the refined structure of the decay to a rotational spectrum of the daughter nucleus to extract information on heavy nuclei and SHN deformation.

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交通运输工程学报 2023年第4期23卷 45-59页

作者：钱建固戴浴晨同济大学土木工程学院上海200092 同济大学岩土及地下工程教育部重点实验室上海200092

为研究长期交通荷载作用下柔性路面路基的力学响应与服役性能,回顾了安定理论在柔性路面路基设计过程中的研究现状、存在问题及前沿进展,阐释了经典上限、下限动力安定理论的基本原理及其在交通岩土工程领域的应用与发展现状,阐述了下... 详细信息

为研究长期交通荷载作用下柔性路面路基的力学响应与服役性能,回顾了安定理论在柔性路面路基设计过程中的研究现状、存在问题及前沿进展,阐释了经典上限、下限动力安定理论的基本原理及其在交通岩土工程领域的应用与发展现状,阐述了下限安定的判别准则与数值分析方法;结合人工边界-动力有限元案例揭示了交通移动荷载作用下路面-路基系统的动力响应,讨论了材料横观各向同性、轮-路摩擦等因素对道路结构动力安定性的影响规律。分析结果表明:交通荷载作用下道路结构的动力效应对安定极限有重要影响,下限安定极限水平随车辆移动速度的增大而降低,当移动速度增至结构体系的Rayleigh波速时,道路结构体系的安定极限降至最低;路基材料力学属性与各向异性程度、轮-路摩擦因数等因素对柔性道路结构的下限动力安定极限也有重要影响;道路结构体系的下限动力安定极限随结构上层与下层弹性模量比的增加先增大后减小;对应最大安定极限的最优模量比表明安定极限临界位置从下层路基向上层路面的转变;考虑水平向摩擦时,轮-路摩擦因数的增大会明显降低结构的动力安定极限,同时减弱荷载移动速度对道路结构动力效应的影响。

关键词：路面工程动力安定下限有限元模拟荷载移动速度横观各向同性摩擦因数

Properties ofαDecay to Rotational Bands of Heavy Nuclei

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Properties ofαDecay to Rotational Bands of Heavy Nuclei

Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products

作者： WANG Yan-zhao PENG Bang-bao DONG jian-min gu jian-zhong Institute of Modern Physics Chinese Academy of Sciences

The a radioactivity has been explained successfully by Gamow and by Condon and gurney as a quantum tunneling *** the basis of Gamow’s theory,the experimentalα-decay half-lives of nuclei can be explained by both phenomenological and microscopic *** a long time,theoretical investigation on a-decay has mainly concentrated on the favored cases,e.g.,the ground state a transitions of even-even *** addition to the favored a transitions,the ground states of the parent nucleus can also decay to the excited states of the daughter *** a transitions belong to the unfavored cases,which are strongly hindered compared to the favored *** is important to study such transitions experimentally to build the level schemes of daughter ***,the hinderedαtransition is an effective tool to study the

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1113-1115页

作者： Chang-Long He Lu-Yi Huang Kai Wang Chen-jian gu Jie Hu gui-Ji Zhang Wei Xu You-Hua Xie Ni Tang Ai-Long Huang Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education) Institute for Viral HepatitisDepartment of Infectious DiseasesThe Second Affiliated HospitalChongqing Medical UniversityChongqingChina Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) Department of Medical Microbiology and ParasitologySchool of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghaiChina Children's Hospital Fudan UniversityShanghaiChina

Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a major public health *** spike(S)protein mutation D614G became dominant in SARS-CoV-2 during a global pandemic,which displayed increased infectivity.1 Entry of a virus into host cells is one of the most critical steps in the viral life *** blockade of the entry process is a promising therapeutic option for COVID-19,research attention has been focused on the discovery of viral entry *** SARS-CoV-2 entry inhibitor development is very attractive,no candidates have progressed into clinical trials yet.

关键词： acute respiratory attractive

Kriging与改进一次二阶矩融合的可靠性分析方法

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国防科技大学学报 2020年第6期42卷 150-156页

作者：袁修开孔冲冲顾健厦门大学航空航天学院福建厦门361005

针对结构可靠性分析问题,提出了Kriging与改进一次二阶矩方法相融合的分析方法。传统的改进一次二阶矩需要计算结构功能函数的梯度信息,在处理包含有限元模型的隐式极限状态问题时会比较困难。该方法将Kriging代理模型与改进一次二阶矩... 详细信息

针对结构可靠性分析问题,提出了Kriging与改进一次二阶矩方法相融合的分析方法。传统的改进一次二阶矩需要计算结构功能函数的梯度信息,在处理包含有限元模型的隐式极限状态问题时会比较困难。该方法将Kriging代理模型与改进一次二阶矩迭代有效而充分地结合,借助Kriging方法提供功能函数的梯度信息,以解决隐式极限状态函数的求导难题,提高分析效率。通过数值与工程算例验证了所提方法的可行性和高效性。

关键词：可靠性 Kriging方法改进一次二阶矩梯度计算失效概率

Plastic surgery after solid organ transplantations

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Chinese Medical Journal 2009年第10期122卷 1184-1187页

作者： QI Fa-zhi ZHANG Yong YANG Zhen FENG Zi-hao gu jian-ying Department of Plastic and Reconstructive Surgery Zhongshan Hospital Fudan University Shanghai 200032 China

Background More patients receive organ transplantation surgeries due to the advancement in immunosuppressive agents and surgical techniques. Some of those patients may need to undergo plastic or reconstructive surgery. Long-term use of immunosuppressive agents raises some serious problems. Therefore, this study aimed to introduce our experience about the safety and effectiveness of plastic surgeries after solid organ allograft transplantation. Methods A retrospective review of 17 transplant recipients who underwent different reconstructive or cosmetic operations was carried out. The subjects included 1 heart transplant, 1 liver transplant and 15 kidney transplant recipients. Results All patients tolerated the plastic surgery procedures well. Flaps and skin grafts were the main constructive methods. There were no postoperative infections and wound dehiscence. Transferred flaps survived completely. Skin grafts took well. Three of the cosmetic surgery patients were satisfied with the results. Conclusions Immunosuppressed organ transplant recipients can successfully undergo major reconstructive and cosmetic surgery when given special attention.

关键词： allograft organ transplantation plastic surgery

纯主应力轴旋转下饱和软黏土的循环弱化及非共轴性

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岩土工程学报 2016年第8期38卷 1381-1390页

作者：钱建固杜子博同济大学地下建筑与工程系上海200092 同济大学岩土及地下工程教育部重点实验室上海200092

采用空心圆柱扭剪仪对原状饱和软黏土进行了纯主应力轴旋转应力路径的循环不排水试验,加载过程中维持平均应力、广义剪应力和中主应力系数不变。观测了孔隙水压和各应变分量在循环加载过程中的变化特性,着重探讨了中主应力系数及广义剪... 详细信息

采用空心圆柱扭剪仪对原状饱和软黏土进行了纯主应力轴旋转应力路径的循环不排水试验,加载过程中维持平均应力、广义剪应力和中主应力系数不变。观测了孔隙水压和各应变分量在循环加载过程中的变化特性,着重探讨了中主应力系数及广义剪应力对变形刚度以及非共轴特性的影响规律。主应力偏转的循环剪切路径下,存在扭转剪切和轴向剪切两种不同的循环应力应变响应。试验结果表明:循环加载路径下饱和软黏土的孔压及应变产生累积效应,应力应变刚度呈现各向异性弱(强)化效应,而应变增量呈现显著的非共轴性;中主应力系数b影响特性表现为,b值越大则刚度弱化越显著。试验观察还发现,剪应力水平较低时循环变形刚度表现为强化,非共轴角趋于增大;反之,剪应力水平较高时,伴随着循环弱化,非共轴角趋于减小。

关键词：主应力轴旋转循环弱化非共轴各向异性饱和黏土