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LOW DOSE PIRFENIDONE SUPPRESSES TRANSFORMING GROWTH FACTOR BETA-1 AND TISSUE INHIBITOR OF METALLOPROTEINASE-1, AND PROTECTS RATS FROM LUNG FIBROSIS INDUCED BY BLEOMYCIN

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Chinese Medical Sciences Journal 2006年第3期21卷 145-151页

作者： Xin-lun Tian Wei Yao Zi-jian guo Li gu Yuan-jue Zhu Department of Respiratory Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆Peking Union Medical College Beijing 100730

Objective To investigate the optimal dosage of pirfenidone for the treatment of pulmonary fibrosis induced by bleomycin in Wistar rats, and the alteration of expressions of transforming growth factor beta-1 （ TGF-β1 ）, tissue inhibitor of metalloproteinase-1 （ TIMP-1 ）, and matrix metalloproteinase-13 （ MMP-13 ） in lung tissue. Methods Male Wistar rats were endotracheally instilled with bleomycin or normal saline. Pirfenidone （25-800 mg · kg^-l · d^-1 ）, dexamethasone （3 mg/kg）, or 1% carboxymethylcellulose sodium were given daily by feed 2 days before instillation of bleomycin. Groups T7 and T14 were fed pirfenidone 50 mg · kg^-1 · d^-1 at 7 days or 14 daYs after bleomycin instillation. Lungs were harvested at 28 days after bleomycin instillation. Patholological changes in luffg tissues were evaluated with HE staining. Lung collagen was stained by sirius red and measured by content of hydroxypro- line. Expression of proteins of TGF-β1 TIMP-1, and MMP-13 were detected by Western blotting. Results At doses of 25, 50, and 100 mg· kg^- 1 · d ^- 1, pirfenidone had significant anti-fibrotic effects for bleomy- cin-induced rat pulmonary fibrosis, and these effects were most significantly attenuated at the dosage of 50 mg · kg^-1 ·d^ -1（ HE： P 〈 0. 01, P 〈 0.01, and P = 0.064; sirius red： P 〈0.05, P 〈 0.01, and P 〈 0.05 ; hydroxyproline： P = 0.595, P 〈 0.01, and P = 0.976）. Pirfenidone at a dosage of 50 mg · kg^- l · d^-1 inhibited protein expression of TGF-131 and TIMP-1 in lung tissue in the early phase （0.79 and 0.75 times of control group）, but had no effect on ex- nr^eelnn nf MMP-13. Conclusion Low dose pirfenidone, especially at dosage of 50 mg · kg^-1 · d^-1, has significant anti-fibrotic effects on bleomycin-induced rat pulmonary fibrosis. Pirfenidone partially inhibits the enhancement of the expression of TGF-131 and TIMP-β1 in lung tissue.

关键词： pulmonary fibrosis bleomycin pirfenidone transforming growth factor beta-1 tissue inhibitor of metalloproteinase-1

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Self-assembly of Gold Nanoparticle Chains between Nanoelectrodes

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Chinese Chemical Letters 2006年第6期17卷 845-847页

作者： Ning gu jian Hui LIAO Lan HUANG Zhi Rui guO Wei YU Li Na XU Jing WANG Key Laboratory of Molecular and Biomolecular Electronics Department of Biological Science and Medical Engineering Southeast University Nanjing 210096

A novel strategy has been developed for construction of nanoparticle chains between nanoelectrodes with bifunctional molecules by taking advantage of linear aggregation of colloidal particles in organis solvents. As confirmed by scanning electron microscopy （SEM）,an individual nanoparticle chain bridged the electrode pair. The present approach makes this technique to be cheap and may be applicable in microelectronic industry.

关键词： Self-assembly nanoparticle chain nanoelectrode.

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Pride of National Industry——Shanghai Household Cosmetics Allied Corporation

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中国对外贸易 1995年第7期 41-42页

作者： jian gu

The Shanghai Household CosmeticsAllied Corporation was establishedin 1898. It is the earliest national cosmeticsenterprise in China. From the guangSheng Hang(an old firm)in Qing dynastyto a group corporation with modern scaleoperation today, almost a century haselapsed from beginning to end. Thedevelopment of the Shanghai HouseholdCosmetics Corporation bears witness tothe national cosmetics industry’s growthfrom small to large, and from weak tostrong. After entering the 1980s, theShanghai Household CosmeticsCorporation has made considerableprogress, especially in recent years, underthe guidance of the operating strategy

关键词： Shanghai Household Cosmetics Allied Corporation Pride of National Industry

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Pride of National Industry——Shanghai Household Cosmetics Allied Corporation

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China's Foreign Trade 1995年第7期 42-43页

作者： jian gu

关键词： In Shanghai Household Cosmetics Allied Corporation Pride of National Industry

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Metal–Organic Framework‑Based Photodetectors

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Nano-Micro Letters 2024年第11期16卷 675-703页

作者： Jin‑Biao Zhang Yi‑Bo Tian Zhi‑Gang gu jian Zhang State Key Laboratory of Structural Chemistry Structure of MatterFujian Institute of ResearchChinese Academy of SciencesFuzhouFujian 350002People’s Republic of China College of Chemistry and Materials Science Fujian Nornal UniversityFuzhou 350007FujianPeople’s Republic of China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108FujianPeople’s Republic of China University of Chinese Academy of Science Beijing 100049People’s Republic of China

The unique and interesting physical and chemical properties of metal–organic framework(MOF)materials have recently attracted extensive attention in a new generation of photoelectric *** this review,we summarized and discussed the research progress on MOF-based *** methods of preparing MOF-based photodetectors and various types of MOF single crystals and thin film as well as MOF composites are introduced in ***,the photodetectors applications for X-ray,ultraviolet and infrared light,biological detectors,and circularly polarized light photodetectors are ***,summaries and challenges are provided for this important research field.

关键词： Metal-organic frameworks Semiconductor Photodetectors

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Is laparoscopic hepatectomy superior to open hepatectomy for hepatocellular carcinoma?

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World Journal of Hepatology 2017年第4期9卷 167-170页

作者： jian-Hong Zhong Ning-Fu Peng jian-Hong gu Ming-Hua Zheng Le-Qun Li Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Yangzhou University and jiangsu Co-Innovation Center Department of Hepatology Liver Research Center the First Affiliated Hospital of Wenzhou Medical University

The low perioperative morbidity and shorter hospital stay associated with laparoscopic hepatectomy have made it an often-used option at many liver centers, despite the fact that many patients with hepatocellular carcinoma have cirrhosis, which makes the procedure more difficult and dangerous. Type of surgical procedure proves not to be a primary risk factor for poor outcomes after hepatic resection for hepatocellular carcinoma, the available evidence clearly shows that laparoscopic hepatectomy is an effective alternative to the open procedure for patients with early-stage hepatocellular carcinoma, even in the presence of cirrhosis. Whether the same is true for patients with intermediate or advanced disease is less clear, since laparoscopic major hepatectomy remains a technically demanding procedure.

关键词： Hepatocellular carcinoma Laparoscopic hepatectomy Open hepatectomy

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Classical Dynamics of a Nucleon in Heavy Nuclei

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Chinese Physics Letters 1998年第5期15卷 318-320页

作者： gu jian-zhong ZHAO En-guang ZHUO Yi-zhong WU Xi-zhen ZONG Hong-shi Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100080 China Institute of Atomic Energy Beijing 102413

Within the framework of the two-center shell model,the classically dynamical behaviour of a nucleon in heavy nuclei is investigated when nuclear shape parameters are changed *** is found that there is a good quantum-classical correspondence of nucleonic regular(chaotic)motion so that Bohigas,Giannoni and Schmit conjecture is confirmed once again.

关键词： behaviour chaotic correspondence

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Simulation of long-term nutrient removal in a full-scale closed-loop bioreactor for sewage treatment： an example of Bayesian inference

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Frontiers of Environmental Science & Engineering 2015年第3期9卷 534-544页

作者： Zheng LI Rong QI Wei AN Takashi MINO Tadashi SHOJI Willy VERSTRAETE jian gu Shengtao LI Shiwei XU Min YANG State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100086 China Socio-Cultural Environmental Studies the University of Tokyo Kashiwa City 277-8563 Japan Environmental Science Research Laboratory Central Research Institute of Electric Power Industry Chiba 270-1194 Japan Laboratory of Microbial Ecology and Technology (LabMET) Ghent University Gent 9000 Belgium Beijing Drainage Group Co. Ltd Beijing 100044 China

In this study, the performance of nitrogen and phosphorus removal in a full-scale closed-loop bioreactor （oxidation ditch） system was simulated using the ASM2d model. Routine data describing the process for two years were compiled for calibration and validation. To overcome the identifiability problem, the classic Bayesian inference approach was utilized for parameter estimation. The calibrated model could describe the long-term trend of nutrient removal and short-term variations of the process performance, showing that the Bayesian method was a reliable and useful tool for the parameter estimation of the activated sludge models. The anoxic phosphate uptake by polyphosphate accumulating organisms （PAO） contributed 71.2% of the total Poly-P storage, which reveals the dominance of denitrifying phosphorus removal process under the oxygen limiting conditions. It was found that 58.7% of the anoxic Poly-P storage and denitrification by PAO in the reactor was achieved in the aerated compartment, implying that the PAO＇s anoxic activity was significantly stimulated by the low dissolved oxygen （DO） level in this compartment due to the oxygen gradient caused by brush aerator.

关键词： activated sludge model Bayesian inference biological nutrient removal closed-loop bioreactor oxidation ditch denitrifying polyphosphate accumulating organisms

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各年龄段人群血清神经元特异性烯醇化酶与外周动脉硬化的相关性分析

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川北医学院学报 2024年第2期39卷 198-203页

作者：张小琴辜建伟杨云凤李芸刘菊华川北医学院附属医院老年科四川南充637000 川北医学院附属医院健康管理中心四川南充637000

目的:研究各年龄段人群血清神经元特异性烯醇化酶(NSE)与外周动脉硬化的相关性。方法:以体检人群为研究对象,收集一般临床资料,采用免疫化学发光法测定血清NSE浓度,通过肱-踝脉搏波传导速度(baPWV)评估外周动脉硬化;根据年龄将研究人群... 详细信息

目的:研究各年龄段人群血清神经元特异性烯醇化酶(NSE)与外周动脉硬化的相关性。方法:以体检人群为研究对象,收集一般临床资料,采用免疫化学发光法测定血清NSE浓度,通过肱-踝脉搏波传导速度(baPWV)评估外周动脉硬化;根据年龄将研究人群分为3组:青年组(≤44岁)、中年组(45~59岁)和老年组(≥60岁),评估不同年龄组血清NSE水平与baPWV及外周动脉硬化的相关性。结果:共纳入7338名研究对象,青年组2847例,中年组3614例,老年组877例;各年龄组中,血清NSE浓度、收缩压、超敏C反应蛋白均为baPWV的独立影响因素(P<0.05),年龄越大,血清NSE浓度与baPWV相关性越高;各年龄组中,血清NSE浓度、心率、吸烟史、高血压、糖尿病、空腹血糖、收缩压、舒张压、甘油三酯、肌酐、白细胞均为外周动脉硬化(baPWV≥1400 cm/s)的危险因素(P<0.05);青年组及中年组中,高密度脂蛋白是外周动脉硬化的保护因素(P<0.05)。按NSE浓度四分位数进一步将各组研究人群分为4组,校正分析影响外周动脉硬化的因素。结果提示,与Q1组相比,除青年组外,中年组及老年组发生外周动脉硬化的OR值均随NSE浓度梯度递增而逐步递增(P<0.05)。结论:各年龄组人群中,baPWV数值随血清NSE浓度增加而增加,NSE是外周动脉硬化的独立危险因素,随着NSE浓度梯度递增,中年及老年人群发生外周动脉硬化的风险也逐步递增。

关键词：外周动脉硬化神经元特异性烯醇化酶肱-踝脉搏波传导速度

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Prediction of gastric cancer metastasis through urinary metabolomic investigation using GC/MS

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World Journal of Gastroenterology 2011年第6期17卷 727-734页

作者： Jun-Duo Hu Hui-Qing Tang jian-Z-hong gu Qiang Zhang Jing Fan Jing Hong Jin-Lian Chen Medical College Soochow University Suzhou 215213 Jiangsu Province China Shanghai Laboratory Animal Center Chinese Academy of Sciences Shanghai 201615 China Department of Gastroenterology Shanghai Sixth People's Hospital Shanghai Jiao Tong University Shanghai 200233 China

AIM:To gain new insights into tumor metabolism and to identify possible biomarkers with potential diagnostic values to predict tumor ***:Human gastric cancer SGC-7901 cells were implanted into 24 severe combined immune deficiency (SCID) mice,which were randomly divided into metastasis group (n=8),non-metastasis group (n=8),and normal group (n=8).Urinary metabolomic information was obtained by gas chromatography/mass spectrometry (GC/MS).RESULTS:There were significant metabolic differences among the three groups (t test,P < 0.05).Ten selected metabolites were different between normal and cancer groups (non-metastasis and metastasis groups),and seven metabolites were also different between non-metastasis and metastasis *** diagnostic models for gastric cancer and metastasis were constructed respectively by the principal component analysis (PCA).These PCA models were confirmed by corresponding receiver operating characteristic analysis (area under the curve=1.00).CONCLUSION:The urinary metabolomic profile is different,and the selected metabolites might be instructive to clinical diagnosis or screening metastasis for gastric cancer.

关键词： Metabolomic profile Gastric cancer Metastasis Biomarker Gas chromatography/mass spectrometry

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