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Natural Products and Bioprospecting 2021年第3期11卷 325-332页

作者： Yi-Jie Zhai jian-Nan Li Yu-Qi Gao Lin-Lin Gao Da-cheng Wang Wen-Bo Han Jin-Ming Gao Shaanxi Key Laboratory of Natural Products and Chemical Biology College of Chemistry and PharmacyNorthwest A&F UniversityYanglingShaanxi 712100People’s Republic of China

Two new sterpurane sesquiterpenoids named sterpurol D(1)and sterpurol E(2),and one skeletally new sesquiterpene,cryptomaraone(3),bearing a 5,6-fused bicyclic ring system,along with five known ones,sterpurol A(4),sterpurol B(5),paneolilludinic Acid(6),murolane-2α,9β-diol-3-ene(7)and(-)-10,11-dihydroxyfarnesol(8)were isolated from an endolichenic fungus Cryptomarasmius *** structures of the new compounds were elucidated by analysis of NMR spectroscopic spectra and HRESIMS *** absolute configurations of 1 and 2 were established by spectroscopic data analysis and comparison of specific optical rotation,as well as the biosynthetic ***,compounds 1,2,4-6,and 8 showed significant nitric oxide(NO)production inhibition in Lipopolysaccharide(LPS)-induced BV-2 microglial cells with the IC50 values ranging from 9.06 to 14.81μM.

关键词： Endolichenic fungus Cryptomarasmius aucubae Sesquiterpenes Anti-neuroinflammatory activity

The first year follow-up after colorectal adenoma polypectomyis important: A multiple-center study in symptomatichospital-based individuals in China

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Frontiers of Medicine 2010年第4期4卷 436-442页

作者： Qin-Yan GAO Hui-Min CHEN jian-Qiu SHENG Ping ZHENG cheng-gong YU Bo jianG Jing-Yuan FANG Department of Gastroenterology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai Institute of Digestive DiseaseShanghai 200001China Department of Gastroenterology PLA.The Military General Hospital of BeijingBeijing 100700China Shanghai 1st Hospital Shanghai Jiao Tong UniversityShanghai 200001China Department of Gastroenterology The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Gastroenterology Nanfang HospitalNanfang UniversityGuangzhou 510515China

The recurrence of colorectal adenoma(CRA)is *** there are guidelines for colonoscopy surveillance after polypectomy in other countries,little is known about its recurrence rate and recurrence peak,especially in *** aim of the present research is to investigate how long after polypectomy follow-up should take and to analyze risk factors of recurrence.1208 patients who received polypectomies fromﬁve clinical research centers in four regions of China(Shanghai,Guangzhou,Nanjing and Beijing)were *** were divided into 4 groups:group A(follow-up≤1 year after poly-pectomy),group B(follow-up 2–3 years after polypect-omy),group C(follow-up 4–5 years after polypectomy),and group D(follow-up>5 years after polypectomy).The sex,age,adenoma location,size,number,and pathological characteristics were *** the whole,the recur-rence rate was 59.46%in group A,61.09%in group B,78.07%in group C,and 87.12%in group D,which indicated an increased tendency with a prolonged follow-up *** was a signiﬁcant difference between group A and C or D,and between group B and C or D(P<0.01),but there was no statistical difference between group A and ***,the recurrent patients in theﬁrst year had a recurrence rate of 97.33%in theﬁrst three years(59.46/61.09),which means that the peak of recurrence was almost entirely concentrated in theﬁrst *** recurrence rate was higher in males and the *** risk factors included multiple numbers,villous feature,high-grade dysplasia of medium or smaller size and location in the distal *** conclusion,the peak of recurrence was almost totally concentrated in theﬁrst year;meanwhile,theﬁrst year follow-up is of critical importance in *** may not be necessary to do the follow-up examination during the second and third years,but after three years,another colonoscopy should be undertaken.

关键词： colorectal adenoma polypectomy follow-up recurrence risk factor

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系统生物医学与中医现代化

医学与哲学（A） 2006年第12期27卷 13-15,29页

作者：蒋功成淮阴师范学院生物系江苏淮安223300

中医的阴阳平衡理论与辨证施治的临床实践与系统生物学追求的整体论和系统论不谋而合,两者相结合而产生的生物系统医学体现了我国学者在医学研究中的创新之路,其中代谢组学的研究为中医药的现代化和国际化开辟了新的方向。第一届系统生... 详细信息

中医的阴阳平衡理论与辨证施治的临床实践与系统生物学追求的整体论和系统论不谋而合,两者相结合而产生的生物系统医学体现了我国学者在医学研究中的创新之路,其中代谢组学的研究为中医药的现代化和国际化开辟了新的方向。第一届系统生物医学上海论坛——代谢组学与中医药国际化研讨会的召开标志着我国传统医学走上了新的发展道路。

关键词：系统生物学系统生物医学代谢组学中医

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在役核压力管道模糊失效概率的计算方法

核动力工程 2006年第3期27卷 47-52页

作者：周剑秋程凌南京工业大学机械与动力工程学院 210009

含缺陷核压力管道的失效概率实质上是一个模糊随机概率。本文应用模糊随机概率理论,同时考虑压力管道评定参数的随机性和失效模式判定的模糊性影响,提出了计算含缺陷核压力管道模糊失效概率的方法。与传统的压力管道可靠性分析方法相比... 详细信息

含缺陷核压力管道的失效概率实质上是一个模糊随机概率。本文应用模糊随机概率理论,同时考虑压力管道评定参数的随机性和失效模式判定的模糊性影响,提出了计算含缺陷核压力管道模糊失效概率的方法。与传统的压力管道可靠性分析方法相比,本方法考虑了模糊失效区域,评定的结果更为精确。

关键词：缺陷核管道随机性模糊性模糊随机概率

CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumorassociated macrophage polarization via FBXW7-N0TCHCCL2/ CSF1 axis

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Signal Transduction and Targeted Therapy 2021年第2期6卷 482-495页

作者： Yao-Hui Huang Kun Cai Peng-Peng Xu Li Wang Chuan-Xin Huang Ying Fang Shu cheng Xiao jian Sun Feng Liu Jin-Yan Huang Meng-Meng Ji Wei-Li Zhao Shanghai Istitute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRulin Hospital Afliated to Shanghai Jiao Tong University School of MedicineShanghaiChina School of Life Sciences and Biotechnology.Shanghai Jiao Tong Universiy ShanghalChina Department of Immunobiology and Microbiology Shanghai Istitute of ImmunologyShanghai Jiao Tong University School of MedicineShanghaiChina Pole de Recherches Sino Francais en Science du Vivant et Genomique Laboratory of Molecular PathologyShanghalChina

Epigenetic alterations play an important role in tumor progression of diffuse large B-cell lymphoma(DL BCL).However,the biological relevance of epigenetic gene mutations on tumor microenvironment remains to be *** core set of genes relating to histone methylation(KMT2D,KMT2C,EZH2),histone acetylation(CREBBP,EP300),DNA methylation(TET2),and chromatin remodeling(ARID1A)were detected in the training cohort of 316 patients by whole-genome/exome sequencing(WGS/WES)and in the validation cohort of 303 patients with newly diagnosed DL BCL by targeted *** correlation with peripheral blood immune cells and clinical outcomes were *** mechanisms on tumor microenvironment were investigated both in vitro and in *** all 619 DLBCL patients,somatic mutations in KMT2D(19.5%)were most frequently observed,followed by mutations in ARID1A(8.7%),CREBBP(8.4%),KMT2C(8.2%),TET2(7.8%),EP300(6.8%),and EZH2(2.9%).Among them,CREBBP/EP300 mutations were signifcantly associated with decreased peripheral blood absolute lymphocyte-to-monocyte ratios,as well as inferior progression-free and overall *** B-lymphoma cells,the mutation or knockdown of CREBBP or EP300 inhibited H3K27 acetylation,downregulated FBXW7 expression,activated the NOTCH pathway,and downstream CCL2/CSF1 expression,resulting in tumor-associated macrophage polarization to M2 phenotype and tumor cell *** B-lymphoma murine models,xenografted tumors bearing CREBBP/EP300 mutation presented lower H3K27 acetylation,higher M2 macrophage recruitment,and more rapid tumor growth than those with CREBBP/EP300 wild-type control via FBXW7-NOTCH-CCL2/CSF1 *** work thus contributed to the understanding of aberrant histone acetylation regulation on tumor microenvironment as an alternative mechanism of tumor progression in DLBCL.

关键词： FBXW7 P300 macrophage

基于双频Bode图设计磁悬浮弹性转子陷波器

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光学精密工程 2008年第5期16卷 789-796页

作者：魏彤房建成北京航空航天大学仪器科学与光电工程学院北京100083

提出一种基于双频Bode图的陷波器(NF)参数设计方法,采用双频Bode图分析转子弹性模态稳定性,得出不同转子转速下对NF相位校正角的要求,然后在保证转子章动稳定性的前提下优化设计NF参数。采用该方法设计的NF有效地抑制了转子的弹性自激振... 详细信息

提出一种基于双频Bode图的陷波器(NF)参数设计方法,采用双频Bode图分析转子弹性模态稳定性,得出不同转子转速下对NF相位校正角的要求,然后在保证转子章动稳定性的前提下优化设计NF参数。采用该方法设计的NF有效地抑制了转子的弹性自激振荡,使所研制的磁悬浮控制力矩陀螺稳定升速到20 000 r/min,从而验证了该方法的实用性和有效性。

关键词：控制力矩陀螺磁悬浮弹性转子弹性模态自激振荡陷波器双频Bode图

Enhanced head-to-head photodimers in the photocyclodimerization of anthracenecarboxylic acid with a cationic pillar[6]arene

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Chinese Chemical Letters 2016年第7期27卷 1017-1021页

作者： jian-Chang Gui Zhi-Qiang Yan Yuan Peng Ji-Gao Yi Da-Yang Zhou Dan Su Zhi-Hui Zhong Guo-Wei Gao Wan-Hua Wu cheng Yang Key Laboratory of Green Chemistry & Technology College of Chemistry State Key Laboratory of Biotherapy West China Medical Center and State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610064 China chengdu Environmental Monitoring Center Chengdu 610042 China Comprehensive Analysis Center ISIR Osaka University 8-I Mihogaoka lbaraki Osaka 5670047 Japan

The complexation behaviors of anthracenecarboxylic acid and water-soluble cationic pillararenes have been investigated by 1H NMR,UV-vis and ITC *** cationic pillar[6]arene was found to stepwise form 1：1 and 1：2 complexes,having a large K1 and a relatively small K2 *** of AC within the pillar[6]arene improved the yield of the head-to-head *** to 4.97 HH/HT ratio has been reached by optimizing the reaction conditions.

关键词： Pillararene Photocyclodimerization Anthracenecarboxylic acid Supramolecular complexation

高速大惯量磁悬浮转子系统章动交叉控制的保相角裕度设计

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光学精密工程 2007年第6期15卷 858-865页

作者：魏彤房建成北京航空航天大学仪器科学与光电工程学院北京100083

研究了章动交叉反馈校正的参数设计方法。针对大惯量高速磁悬浮转子支承系统,采用双频Bode图进行章动稳定性分析。在此基础上,提出一种基于双频Nyquist曲线的交叉参数保相角裕度设计方法。在给定相位超前角的情况下,通过矢量合成确定章... 详细信息

研究了章动交叉反馈校正的参数设计方法。针对大惯量高速磁悬浮转子支承系统,采用双频Bode图进行章动稳定性分析。在此基础上,提出一种基于双频Nyquist曲线的交叉参数保相角裕度设计方法。在给定相位超前角的情况下,通过矢量合成确定章动交叉的比例系数和高通滤波器截止频率,实现了章动交叉反馈的鲁棒稳定设计。设计的交叉控制器使研制的磁悬浮控制力矩陀螺转子临界稳定转速由10 500 r/min提高到20 400 r/min。试验结果表明,保相角裕度方法为交叉反馈校正提供了有效的参数设计手段。

关键词：磁轴承陀螺效应章动稳定性交叉控制双频Nyquist曲线

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基于波叠加方法的半自由场声辐射灵敏度分析

农业机械学报 2008年第7期39卷 173-177页

作者：高煜程昊陈剑合肥工业大学噪声振动工程研究所安徽省汽车NVH工程技术研究中心安徽省汽车NVH与可靠性重点实验室

利用半自由和自由场波叠加方法,在存在反射声的半自由空间中,对声辐射灵敏度进行分析,仿真结果表明在半自由场空间中用自由场波叠加方法计算声辐射灵敏度,其幅值大小与理论值大不一样,两者的变化趋势也相差较大。而应用半自由场波叠加方... 详细信息

利用半自由和自由场波叠加方法,在存在反射声的半自由空间中,对声辐射灵敏度进行分析,仿真结果表明在半自由场空间中用自由场波叠加方法计算声辐射灵敏度,其幅值大小与理论值大不一样,两者的变化趋势也相差较大。而应用半自由场波叠加方法,不论是灵敏度幅值还是其变化趋势都与理论值相吻合,脉动球声源误差为3.85%,振动球声源误差为3.78%。

关键词：半自由声场声辐射波叠加灵敏度分析

磁悬浮控制力矩陀螺动框架效应的FXLMS自适应精确补偿控制方法仿真研究

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宇航学报 2006年第6期27卷 1205-1210页

作者：魏彤房建成北京航空航天大学第五研究室北京100083

在磁悬浮控制力矩陀螺(CMG)中,框架运动对磁悬浮转子支承系统的扰动可以采用角速率前馈加以补偿,但前馈系数固定时的补偿精度受磁轴承系统模型误差影响而显著下降。为了提高补偿精度,本文针对MIMO磁悬浮转子系统,提出一种基于FXLMS(filt... 详细信息

在磁悬浮控制力矩陀螺(CMG)中,框架运动对磁悬浮转子支承系统的扰动可以采用角速率前馈加以补偿,但前馈系数固定时的补偿精度受磁轴承系统模型误差影响而显著下降。为了提高补偿精度,本文针对MIMO磁悬浮转子系统,提出一种基于FXLMS(filtered-X least mean square)算法的自适应前馈方法,采用梯度估计和最速下降策略推导前馈权值更新算法,并根据算法收敛性和收敛速度设计收敛因子和权初值。仿真结果表明,该方法收敛速度快,抗噪声能力强,相同模型误差情况下使转子的动框架位移降低到固定特性前馈时的20%,大幅度提高了动框架前馈补偿精度,有利于进一步提高磁悬浮CMG的力矩输出精度。

关键词：控制力矩陀螺磁轴承动框架效应自适应前馈 FXLMS