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Study on the blood-borne virus co-infection and T lymphocyte subset among intravenous drug users

World Journal of Gastroenterology 2007年第16期13卷 2357-2362页

作者： jian-Rong Li Rui-Yu gong Kun-Lun Tian Jing Wang Yi-Xin Wang Han-Ju Huang Department of Pathogenic Biology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China Basic Medical Department Dali College Dali 671000 Yunnan Province China

AIM： To investigate the features of various blood- borne virus infections and co-infection in intravenous drug users （IDUs）, and to examine the correlation of T lymphocyte subsets with virus co-infection. METHODS： Four hundred and six IDUs without any clinical manifestation of hepatitis and 102 healthy persons were enrolled in this study. HBV-DNA and HCV-RNA were detected by fluorescence quantitative PCR. HBsAg, HBeAg, anti-HBc, anti-HCV, HDV-Ag, anti-HGV, anti-HIV, and HCMV-IgM were assayed by enzyme-linked immunosorbent assay （ELISA） and immunochromatographic tests. The levels of Th1 and Th2 cytokines were measured by ELISA and radioactive immune assay （RIA）. The T lymphocyte subpopulation was detected by using fluorescence immunoassay. The similar indices taken from the healthy persons served as controls. RESULTS： The viral infection rate among IDUs was 36.45% for HBV, 69.7% for HCV, 47.3% for HIV, 2.22% for HDV, 1.97% for HGV, and 3.45% for HCMV. The co- infection rate of blood-borne virus was detected in 255 of 406 （62.81%） IDUs. More than 80% （161/192） of subjects infected with HIV were co-infected with the other viruses, such as HBV, HCV. In contrast, among the controls, the infection rate was 17.65% for HBV and 0% for the other viruses. Our investigation showed that there was a profound decrease in the proportion of CD4/CD8 and the percentage of CD3 and CD4, but not in the percentage of CD8. The levels of PHA-induced cytokines （IFN-γ and IL-4） and serum IL-2 were obviously decreased in IDUs. On the other hand, the level of serum IL-4 was increased. The level of IFN-γ and the percentage of CD4 were continuously decreased when the IDUs were infected with HIV or HIV co-infection. IDUs with HIV and HBV co-infection was 15.1% （29/192）. Of those 29 IDU with HIV and HBV co-infection, 51.72% （15/29） and 37.93% （11/29） were HBV-DNA-positive and HBeAg-positive, respectively. But, among IDUs without HIV infection, only 1.68% （2/119） of cases were HBV- ***

关键词： Intravenous drug users T lymphocyte subpopulation Blood-borne virus Co-infection Cytokine

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EFFECTS OF SYLLABLE STRUCTURES ON THE PERCEPTION OF L2 ENGLISH LEXICAL STRESS AMONG TEENAGE MANDARIN LISTENERS

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中国语音学报 2021年第1期 121-128页

作者： ZHOU Weijing ZHAN Lamei NOLAN Francis gong jian XUE Xiaojiao WANG Zhiyan Chuzhou High School Huai'anJiangsu University of Cambridge UK School of Foreign Languages Jiangsu University of Science and Technology School of International Studies Yangzhou 不详

This study explores the effects of syllable structures on the perception of L2 English lexical stress among Chinese junior ELF ***,it focuses on to what extent syllable numbers and syllable patterns differentiate the subjects’perception of target English lexical *** subjects were 93 junior middle-school students from two natural classes in Grade *** target lexical stress was the primarily stress placed on the 1;and 2;syllables respectively,which were embedded in two kinds of carrier words(nonsense&real English words)with three types of syllabic patterns(CVC.V,***&***).The subjects first listened to the stimuli read by a British RP phonetician in falling tone and then did the perception tests in the pen-and-paper *** correct perception ratios(CPRs)of the target English lexical stress were calculated and compared according to syllable numbers and syllable *** results reveal that the CPRs of L2 English lexical stress in disyllabic words significantly outperformed those in trisyllabic words,and that among the disyllabic words,the CPRs ranked top,second,and bottom with the disyllabic patterns of CVC.V,***,and ***,*** findings provide considerable evidence for the impact of syllabic structures on teenage Mandarin listeners’perception of L2 English lexical stress.

关键词： Perception of L2 English lexical stress Syllable structures Teenage Mandarin listeners

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Induction of Apoptosis in Hormone-resistant Human Prostate Cancer PC3 Cells by Inactivated Sendai Virus

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Biomedical and Environmental Sciences 2014年第7期27卷 506-514页

作者： GAO Hui gong Xiao cheng CHEN Ze Dong XU Xiao Shuang ZHANG Quan XU Xiang Ming College of Clinical Medicine of Yangzhou University jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou University Suzhou Polytechnic Institute of Agriculture

Objective Inactivated Sendai virus particle [hemagglutinating virus of Japan envelope （HVJ-E）] has a potential oncolytic effect due to its ability to induce apoptosis in tumor cells. However, the molecular mechanism of apoptosis induction in cancer cells mediated by HVJ-E has not been fully elucidated. This paper aims to investigate the underlying mechanism of apoptosis induction by HVJ-E in prostate cancer cells （PC3）. Methods PC3 cells were treated with HVJ-E at various MOI, and then interferon-β（IFN-β） production, and the cell viability and apoptosis were detected by ELISA, MTl--based assay and flow cytometry, respectively. Next, the roles of Jak-Stat, MAPK and Akt pathways played in HVJ-E-induced apoptosis in PC3 cells were analyzed by immunoblot assay. To further evaluate the cytotoxic effect of HVJ-E on PC3 cells, HVJ-E was intratumorally injected into prostate cancers on BALB/c-nude mice, and the tumor volume was monitored for 36 days. Results HVJ-E induced iFN-β production and activated Jak-Stat signaling pathway, which resulted in the activation of caspase-8, caspase-3, and PARP in PC3 prostate cancer cells post HVJ-E treatment. Furthermore, we observed for the first time that p38 and Jnk MAPKs in PC3 cells contributed to HVJ-E-induced apoptosis. In addition, intratumoral HVJ-E treatment displayed a direct inhibitory effect in an in vivo BALB/c nude mouse prostate cancer model. Conclusion Our findings have provided novel insights into the underlying mechanisms by which HVJ-E induces apoptosis in tumor cells.

关键词： Inactivated Sendai virus (HVJ-E) Apoptosis Caspase Mitogen-activated protein kinase(MAPK)

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Massive bleeding from a gastric artery pseudoaneurysm in hepatocellular carcinoma treated with atezolizumab plus bevacizumab: A case report

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1232-1239页

作者： Fu-Wen Pang Bin Chen De-Ti Peng jian He Wei-cheng Zhao Tuan-Tuan Chen Zong-Gui Xie Hai-Hui Deng Department of Interventional Radiology Shenzhen Traditional Chinese Medicine HospitalShenzhen 518033Guangdong ProvinceChina Department of Hepatology Shenzhen Traditional Chinese Medicine HospitalShenzhen 518033Guangdong ProvinceChina

BACKGROUND The combination of atezolizumab(ATZ)and bevacizumab(BVZ)was approved as first-line systemic therapy for advanced hepatocellular carcinoma(HCC)owing to its superior rates of response and patient ***,ATZ+BVZ is associated with increased risk of upper gastrointestinal(GI)bleeding,including arterial bleeding,which is rare and potentially *** present a case of massive upper GI bleeding from a gastric pseudoaneurysm in a patient with advanced HCC who had been treated with ATZ+*** SUMMARY A 67-year-old man presented with severe upper GI bleeding after atezolizumab(ATZ)+bevacizumab(BVZ)therapy for *** failed to detect the bleeding *** subtraction angiography revealed a gastric artery pseudoaneurysm and contrast extravasation from the inferior splenic artery and a branch of the left gastric *** hemostasis was achieved with *** HCC patients who have been treated with ATZ+BVZ should be followed for 3 to 6 mo to monitor for development of massive GI *** may require *** is an effective treatment.

关键词： Atezolizumab Bevacizumab Hepatocellular carcinoma Gastric artery pseudoaneurysm Gastrointestinal bleeding Case report

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中频淬火设备的维修

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金属热处理 2006年第7期31卷 95-96页

作者：宫玉成山东拖拉机厂山东兖州272011

在工业生产中可控硅中频装置的效率高、体积小、操作方便、响应快、维护方便，已广泛应用于金属熔炼、烧结、零部件或毛坯透热，表面淬火、焊接等方面。

关键词：中频淬火设备维修中频装置工业生产操作方便金属熔炼表面淬火可控硅体积小零部件

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应用于实时系统中存储器故障测试的一种新方法

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中国空间科学技术 2005年第6期25卷 26-29页

作者：杨孟飞孙增圻龚健清华大学北京100084 北京控制工程研究所北京100080

针对实时存储器系统的常见故障类型提出了一种新的存储器测试方法,其最大特点是在测试过程中不使用缓冲区,从而节省了系统资源,增加了测试覆盖率;同时证明了该存储器测试方法的正确性。

关键词：存储器故障检测方法

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Effect of Strontium Ion on the Growth and Second-Harmonic Generation Properties of GdCa_(4)O(BO_(3))_(3) Crystal

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Chinese Physics Letters 2001年第1期18卷 63-64页

作者： ZHANG Shu-Jun cheng Zhen-Xiang LIU Jun-Hai HAN jian-Ru WANG Ji-Yang SHAO Zong-Shu CHEN Huan-Chu State Key Laboratory of Crystal Materials Shandong UniversityJi'nan 250100

Large sized and optical quality GdCa_(4)O(BO_(3))_(3)(GdCOB)crystal with calcium partially substituted by strontium(Sr)ions was grown for the first *** x-ray powder diffraction shows that the Sr ion has an effect on the cell parameters of the GdCOB crystal Second-harmonic generation(SHG)experiments were performed on the Sr:GdCOB and GdCOB crystals along the spatial phase-matching *** results show that the cw green laser output power is 1.04 W when the laser diode pump power is 10 W in the Nd:YVO_(4)/Sr:GdCOB intracavity *** the slope efficiency of Nd:YVO_(4) and the fundamental laser in cavity,the intracavity SHG conversion efficiency of the GdCOB crystal is 21%while it is 24%for the Sr:GdCOB crystal,the SHG conversion efficiency is improved by 14%.The effect of the Sr ions on the nonlinearity of the GdCOB crystal is also discussed by using the anion group theory.

关键词： intracavity pump Crystal

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高速网络中入侵检测的抽样方法

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通信学报 2009年第11期30卷 27-36,47页

作者：宁卓龚俭顾文杰东南大学计算机科学与工程学院江苏南京210096 江苏省计算机网络技术重点实验室江苏南京210096 教育部计算机网络与信息集成重点实验室江苏南京210096

提出了一个面向主干网入侵检测,以内存瓶颈消耗量为测度的动态自适应抽样方法IDSampling。通过分析攻击流量的流长和熵聚类信息特征指导抽样,过滤掉攻击可疑性低的报文,采取"节流"方法解决万兆网络入侵检测存在的性能和精度不平衡问题... 详细信息

提出了一个面向主干网入侵检测,以内存瓶颈消耗量为测度的动态自适应抽样方法IDSampling。通过分析攻击流量的流长和熵聚类信息特征指导抽样,过滤掉攻击可疑性低的报文,采取"节流"方法解决万兆网络入侵检测存在的性能和精度不平衡问题。在大规模异常发生时采用基于单报文属性熵的单一抽样策略,其他情况下采用带反馈指导的混合抽样策略,试图用尽可能小的检测代价来取得同样的检测效果。实验结果表明①IDSampling可以大幅减低IDS处理输入,同时保证对主干网大规模攻击趋势性信息的检测精度;②相较于随机报文抽样和随机流抽样方法,IDSampling凭借流长、熵聚类信息和后期检测结果等启发式信息的指导,其抽取攻击报文的准确性高于前2种方法,尤其是在大规模、高强度攻击情况下IDSampling抽中攻击报文的数目甚至高于其他2种方法一个数量级。

关键词：入侵检测单报文属性熵抽样样本熵

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胶州湾潮滩湿地CHBr_3通量特征及影响因素研究

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中国环境科学 2018年第7期38卷 2699-2705页

作者：宫健谢文霞柴娜青岛大学环境科学与工程学院山东青岛266071

在2016年7月~2017年5月期间,运用静态箱法对胶州湾潮滩湿地系统的CHBr_3排放通量进行了观测,并对影响CHBr_3通量的主要影响因子进行了探究.结果表明,胶州湾潮滩湿地是CHBr_3的排放源,互花米草湿地和光滩释放CHBr_3的通量均值分别为10.92... 详细信息

在2016年7月~2017年5月期间,运用静态箱法对胶州湾潮滩湿地系统的CHBr_3排放通量进行了观测,并对影响CHBr_3通量的主要影响因子进行了探究.结果表明,胶州湾潮滩湿地是CHBr_3的排放源,互花米草湿地和光滩释放CHBr_3的通量均值分别为10.92nmol/(m^2?d)和8.96nmol/(m^2?d),说明互花米草湿地在一定程度上能够促进CHBr_3的排放.不同潮滩湿地之间CHBr_3的排放通量有明显区别.互花米草湿地在夏秋季节较高的CHBr_3通量可能主要是受温度和植被生物量的影响,光滩在冬春季节较高的CHBr_3通量可能与冻融循环过程有关.胶州湾潮滩湿地环境因素变化比较复杂,CHBr_3的排放通量受多种因素的影响.温度对CHBr_3排放通量的影响显著,而植被生长状况、水盐条件和营养元素等对CHBr_3排放通量的影响也不容忽视.

关键词：胶州湾互花米草湿地 CHBr3 通量特征影响因素

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带时效性约束的配送中心多源选址问题研究

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数学的实践与认识 2007年第11期37卷 27-31页

作者：龚延成汽车管理学院装备技术系安徽蚌埠233011

应用启发式算法求解带时效性约束的多源选址问题.分析物流配送的时效性问题,建立带时效性约束的配送中心多源选址模型.构造两步启发式算法:1)借助传统迭代算法,求解物流服务分配矩阵,把多源选址问题转化为单源选址问题;2)基于M ATLAB函... 详细信息

应用启发式算法求解带时效性约束的多源选址问题.分析物流配送的时效性问题,建立带时效性约束的配送中心多源选址模型.构造两步启发式算法:1)借助传统迭代算法,求解物流服务分配矩阵,把多源选址问题转化为单源选址问题;2)基于M ATLAB函数,设计优化程序,计算带时效性约束的单源选址模型.并给出算例,验证模型和算法的可行性.研究表明两步启发式算法是求解带时效性约束的物流配送中心多源连续选址问题的有效算法.

关键词：物流配送选址模型时效约束启发式算法

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