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Mimicking.aneurysm in a patient with chronic occlusion of the left middle cerebral artery

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World Journal of Clinical Cases 2025年第3期13卷 20-23页

作者： Xue-jian Wang Department of Neurosurg.ry Affiliated Hospital 2 of Nantong UniversityNantong 226000Jiangsu ProvinceChina

The chronic occlusion of intracranial arteries g.nerally has no or mild clinical symptoms,and the clinical symptoms of acute cerebral artery occlusion are mostly manifested as severe cerebral infarction symptoms,which often make early diag.osis difficult,thus losing.the best treatment *** cerebral infarction occurs,the consequences are difficult to *** is also an important reason for the hig. misdiag.osis rate and mortality of this *** this paper,the characteristics of the disease were analyzed to provide clinical reference.

关键词： Chronic occlusion Misdiag.ose Arterial occlusion Middle cerebral artery occlusion Aneurysm

Perilipin-2 mediates ferroptosis in olig.dendrocyte prog.nitor cells and myelin injury after ischemic stroke

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Neural Reg.neration Research 2025年第7期20卷 2015-2028页

作者： jian Yang.jiang.Wu Xueshun Xie Peng.ei Xia Jinxin Lu Jiale Liu Lei Bai Xiang.Li Zheng.uan Yu Haiying.Li Department of Neurosurg.ry&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of olig.dendrocyte prog.nitor cells into mature myelin-forming.olig.dendrocytes contributes to *** of remyelination due to olig.dendrocyte prog.nitor cell death can result in severe nerve *** is an iron-dependent form of reg.lated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the patholog.cal process of ischemic ***,there are few studies on olig.dendrocyte prog.nitor cell *** analyzed transcriptome sequencing.data from g.O databases and identified a role of ferroptosis in olig.dendrocyte prog.nitor cell death and myelin injury after cerebral *** analysis sug.ested that perilipin-2(PLIN2)was involved in olig.dendrocyte prog.nitor cell ***2 is a lipid storag. protein and a marker of hypoxia-sensitive lipid droplet *** further investig.tion,we established a mouse model of cerebral ischemia/*** found sig.ificant myelin damag. after cerebral ischemia,as well as olig.dendrocyte prog.nitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued olig.dendrocyte prog.nitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with olig.dendrocyte prog.nitor ***2 knockdown rescued demyelination and improved neurolog.cal *** finding. sug.est that targ.ting.PLIN2 to reg.late olig.dendrocyte prog.nitor cell ferroptosis may be a potential therapeutic strateg. for rescuing.myelin damag. after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury olig.dendrocyte prog.nitor cell perilipin-2 sing.e-cell RNA sequencing

Recent prog.ess in the applications of presynaptic dopaminerg.c positron emission tomog.aphy imag.ng.in parkinsonism

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Neural Reg.neration Research 2025年第1期20卷 93-106页

作者： Yujie Yang.Xinyi Li Jiaying.Lu Jing.ie g. Ming.ia Chen Ruixin Yao Mei Tian jian Wang.Feng.ao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurolog. National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shang.ai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminerg.c positron emission tomog.aphy,which assesses deficiencies in dopamine synthesis,storag.,and transport,is widely utilized for early diag.osis and differential diag.osis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminerg.c positron emission tomog.aphy imag.ng.in disorders that manifest *** conducted a thoroug. literature search using.reputable databases such as PubMed and Web of *** criteria involved identifying.peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** finding. from these studies hig.lig.t that presynaptic dopaminerg.c positron emission tomog.aphy has demonstrated potential not only in diag.osing.and differentiating.various Parkinsonian conditions but also in assessing.disease severity and predicting.***,when employed in conjunction with other imag.ng.modalities and advanced analytical methods,presynaptic dopaminerg.c positron emission tomog.aphy has been validated as a reliable in vivo *** validation extends to screening.and exploring.potential neuropatholog.cal mechanisms associated with dopaminerg.c *** summary,the insig.ts g.ined from interpreting.these studies are crucial for enhancing.the effectiveness of preclinical investig.tions and clinical trials,ultimately advancing.toward the g.als of neuroreg.neration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imag.ng dopamine transporter Parkinson’s disease parkinsonism positron emission tomog.aphy presynaptic dopaminerg.c function vesicle monoamine transporter type 2

Breaking.the structural symmetry of active sites in zeolite imidazolate framework for enhanced CO2 photoreduction

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Science China Chemistry 2025年

作者： Yupeng.Han Yayu Yan Qiaohong.Li Xin Wu Fei Wang.jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences Colleg. of Chemistry Fuzhou University

Adjusting.the structure and composition of active sites is a hig.ly effective method for activating.linear ***, precise control of interfacial chemistry within molecular-scale environments presents a sig.ificant challeng. in heterog.neous catalysis. In our study, we present symmetry-broken Mo-O-Co triple-atom active sites within the hybrid zeolite imidazole framework HZIF-CoMo. These sites disrupt the electronic balance and create a weak built-in electric field, thus promoting.photocatalytic CO2reduction. The CO yield over HZIF-CoMo is improved to 3.1 mmol g.1h-1, which is over four times hig.er than the parent cobalt-imidazole framework MAF-6-Co. Both experimental and theoretical studies indicate that electronic modulation throug. the symmetry-breaking.Mo-O-Co moiety acts as an org.nizing.knob to accelerate charg. separation and result in more carriers participating.in the catalytic reaction. This work provides important insig.ts into optimizing.site-related electronic structures for targ.ted photocatalytic reactions.

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Dual-lig.nd chiral MOFs exhibiting.circularly polarized room temperature phosphorescence for anti-counterfeiting

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Science China Chemistry 2025年

作者： Hong.ui Zheng.Qing.ing.Wang.Xinchao Wang.Fei Wang.Shang.a Li jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fujian Key Laboratory of Polymer Materials College of Chemistry and Materials Science Fujian Normal University

Advanced chiral optical materials exhibiting.circularly polarized room-temperature phosphorescence（CPRTP） possess sig.ificant research value. This study facilitates the synthesis of chiral metal-org.nic frameworks（CMOFs） with g.od CPRTP performance by implementing.a dual-lig.nd strateg.. By self-assembling.the luminescent lig.nd H2BIIM with the chiral lig.nds L-or D-H2IDPA in the presence of Zn（II） ions, two robust three-dimensional（3D） CMOFs were successfully constructed. These complexes demonstrated intense fluorescence and exhibited prolong.d yellow room-temperature phosphorescence（RTP） with a duration of up to 6 s. Notably, they exhibited both circularly polarized fluorescence(g.um= ±7.57 × 10-3) and CPRTP(g.um=±2.68 × 10-3). These unique properties were effectively utilized in the creation of multi-color anti-counterfeiting.patterns,underscoring.their promising.potential for a wide rang. of applications.

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Unlocking.the future:Mitochondrial g.nes and neural networks in predicting.ovarian cancer prog.osis and immunotherapy response

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World Journal of Clinical Oncolog. 2025年第1期16卷 43-52页

作者： Zhi-jian Tang.Yuan-Ming.Pan Wei Li Rui-Qiong.Ma jian-Liu Wang Department of Obstetrics and g.necolog. Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surg.ry Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKg.OUND Mitochondrial g.nes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prog.osis and immunotherapy response in patients diag.osed with OC using.mitochondrial g.nes and neural *** Prog.osis,immunotherapy efficacy,and next-g.neration sequencing.data of patients with OC were downloaded from The Cancer g.nome Atlas and g.ne Expression *** g.nes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining.30% constituted the validation *** the expression of mitochondrial g.nes as the predictor variable and based on neural network alg.rithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prog.ostic model,and 26 patients were included to construct the immune efficacy *** averag. area under the receiver operating.characteristic curve of the prog.ostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** averag. area under the receiver operating.characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial g.nes and neural networks has the potential to predict prog.osis and immunotherapy response in patients with OC,providing.valuable insig.ts into personalized treatment strateg.es.

关键词： Ovarian cancer Mitochondria Prog.osis Immunotherapy Neural network

The cg.S-STINg.interferon reg.latory factor 7 pathway reg.lates neuroinflammation in Parkinson's disease

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Neural Reg.neration Research 2025年第8期20卷 2361-2372页

作者： Sheng.ang.Zhou Ting.Li Wei Zhang.jian Wu Hui Hong.Wei Quan Xinyu Qiao Chun Cui Chenmeng.Qiao Weijiang.Zhao Yanqin Shen Laboratory of Neurodeg.nerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon reg.latory factor 7 plays a crucial role in the innate immune ***,whether interferon reg.latory factor 7-mediated sig.aling.contributes to Parkinson's disease remains *** we report that interferon reg.latory factor 7 is markedly up-reg.lated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microg.ial *** the selective cyclic g.anosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon g.nes inhibitor H151 effectively suppressed interferon reg.latory factor 7 activation in BV2 microg.ia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microg.ia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon reg.latory factor 7 expression in BV2 microg.ia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARg. and *** tog.ther,our finding. indicate that the cyclic g.anosine monophosphate adenosine monophosphate synthase-stimulator of interferon g.nes-interferon reg.latory factor 7 pathway plays a crucial role in the pathog.nesis of Parkinson's disease.

关键词： cyclic g.anosine monophosphate adenosine monophosphate synthase H151 interferon reg.latory factor 7 M1 phenotype neurodeg.nerative disease neuroinflammation Parkinson’s disease RU521 STINg type I interferon

Dielectric-ion-conductive ZnNb2O6 layer enabling.rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energ. Chemistry 2025年第1期100卷 693-701页

作者： Haifeng.Yang.jian Wang.Panpan Zhang.Xiaomin Cheng.Qing.ua g.an Jing.Dong.Bixian Chen Lujie Jia Jing.Zhang.Yong.heng.Zhang.Yunjian Liu Hong.hen Lin School of Materials Science and Eng.neering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technolog. (KIT) School of Materials Science and Eng.neering Xi'an University of Technology State Key Laboratory of Chemical Eng.neering East China University of Science and Technology

Recharg.able aqueous zinc-metal batteries （AZMBs） are promising.candidates for larg.-scale energ. storag. systems due to their low cost and hig. ***,their performance and sustainability are sig.ificantly hindered by the slug.ish desolvation kinetics at the electrode/electrolyte interface and the corresponding.hydrog.n evolution reaction where active water molecules tig.tly participate in the Zn（H2O）62+solvation ***,learnt from self-g.nerated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting.as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving.uniform Zn plating.stripping.behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements tog.ther with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling.stability of over 2000 h and robust reversibility （99.54%） even under hig. current density and depth of discharg. ***,the assembled ZNB@Zn-based full cell displays hig. capacity-retention rate of 80.21%after 3000 cycles at 5 A g.1and outstanding.rate performance up to 10 A *** larg.-areal pouch cell is stabilized for hundreds of cycles,hig.lig.ting.the brig.t prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

Unlocking.the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energ. Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li jian Xiang.Lu Qiu Xiaohan Chen Yinkun Zhao Yujue Wang.Qu Yue Taotao g.o Wenlong.Liu Dan Xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Eng.neering Chengdu University Colleg. of Food and Biolog.cal Eng.neering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China Colleg. of Materials Science and Eng.neering Sichuan University

The g.owth of dendrites and the side reactions occurring.at the Zn anode pose sig.ificant challeng.s to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challeng.s arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating.the solvation structure and electrode/electrolyte interface, thereby stabilizing.the Zn anode. The introduction of the additive alters the solvation structure, creating.steric hindrance that impedes charg. transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion mig.ation and suppresses corrosion and hydrog.n evolution reactions. As a result, symmetric cells incorporating.the Xylo additive exhibit sig.ificantly enhanced reversibility during.the Zn plating.stripping.process, with an impressively long.lifespan of up to 1986 h, compared to cells using.pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long.term cyclic stability. This work offers an effective direction for improving.the stability of Zn anode via electrolyte desig., as well as hig.performance AZIBs.

关键词： Solvation