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Probing the interaction between asphaltene-wax and its effects on the crystallization behavior of waxes in heavy oil via molecular dynamics simulation

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Petroleum Science 2024年第04期21卷 2839-2848页

作者： Yong Hu Xi Lu Hai-Bo Wang Ji-Chao fang Yi-Ning Wu jian fang sun SINOPEC Petroleum Exploration and Production Research Institute Shandong Key Laboratory of Oilfield Chemistry School of Petroleum Engineering China University of Petroleum (East China)

High content of asphaltenes and waxes leads to the high pour point and the poor flowability of heavy oil,which is adverse to its efficient development and its transportation in *** the interaction mechanism between asphaltene-wax is crucial to solve these problems,but it is still *** this paper,molecular dynamics simulation was used to investigate the interaction between asphaltenewax and its effects on the crystallization behavior of waxes in heavy *** show that molecules in pure wax are arranged in a paralleled *** wax molecules in heavy oil,which are close to the surface of asphaltene aggregates,are bent and arranged *** the mass fraction of asphaltenes in asphaltene-wax system(ωasp) is 0-25 wt%,the attraction among wax molecules decreases and the bend degree of wax molecules increases with the increase of ω*** ωaspincreases from 0 to 25 wt%,and the attraction between asphaltene-wax is stronger than that among *** causes that the wax precipitation point changes from 353 to 333 *** the ωaspincreases to 50 wt%,wax molecules are more dispersed owing to the steric hindrance of asphaltene aggregates,and the interaction among wax molecules transforms from attraction to *** causes that the ordered crystal structure of waxes can't be formed at normal ***,the asphaltene,with the higher molecular weight or the more hetero atoms,has more obvious inhibition to the formation of wax ***,resins also have an obvious inhibition on the wax crystal due to the formation of asphalteneresin aggregates with a larger *** results reveal the interaction mechanism between asphaltene-wax,and provide useful guidelines for the development of heavy oil.

关键词： Heavy oil Interaction mechanism Asphaltenes Waxes Molecular dynamics

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Influence of pore structure heterogeneity on channeling channels during hot water flooding in heavy oil reservoir based on CT scanning

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Petroleum Science 2024年第04期21卷 2407-2419页

作者： Qing-Jun Du Hao-Yu Zheng jian Hou Yong-Ge Liu jian-fang sun Dong Zhao State Key Laboratory of Deep Oil and Gas China University of Petroleum (East China) School of Petroleum Engineering China University of Petroleum (East China) Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and Technology Petroleum Exploration and Production Research Institute

Hot water flooding is an effective way to develop heavy oil reservoirs. However, local channeling channels may form, possibly leading to a low thermal utilization efficiency and high water cut in the reservoir. The pore structure heterogeneity is an important factor in forming these channels. This study proposes a method that mixes quartz sand with different particle sizes to prepare weakly heterogeneous and strongly heterogeneous models through which hot water flooding experiments are *** the experiments, computer tomography(CT) scanning identifies the pore structure and micro remaining oil saturation distribution to analyze the influence of the pore structure heterogeneity on the channeling channels. The oil saturation reduction and average pore size are divided into three levels to quantitatively describe the relationship between the channeling channel distribution and pore structure heterogeneity. The zone where oil saturation reduction exceeds 20% is defined as a channeling *** scanning area is divided into 180 equally sized zones based on the CT scanning images, and threedimensional(3D) distributions of the channeling channels are developed. Four micro remaining oil distribution patterns are proposed, and the morphology characteristics of micro remaining oil inside and outside the channeling channels are analyzed. The results show that hot water flooding is more balanced in the weakly heterogeneous model, and the oil saturation decreases by more than 20% in most zones without narrow channeling channels forming. In the strongly heterogeneous model, hot water flooding is unbalanced, and three narrow channeling channels of different lengths form. In the weakly heterogeneous model, the oil saturation reduction is greater in zones with larger pores. The distribution range of the average pore size is larger in the strongly heterogeneous model. The network remaining oil inside the channeling channels is less than outside the channeling channels,

关键词： Heavy oil Hot water flooding Pore structure Channeling channels CT scanning

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The Role of Endoplasmic Reticulum Stress in Melanoma

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International Journal of Dermatology and Venereology 2023年第3期6卷 150-156页

作者： Hao-Ze Shi jian-fang sun Hao Chen Department of Pathology Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Evidence has shown that endoplasmic reticulum(ER)stress plays a role in the regulation of skin physiological functions such as melanocyte transformation and keratinocyte-related epidermal *** pathological processes may also be ***,more evidence has suggested that ER stress participates in the pathogenesis of *** biological functions of melanoma can be affected by the disturbance of ER *** herein review the network of ER stress and its role in melanoma and discuss several chemicals or drugs that may act as tumor inhibitors by influencing ER stress.

关键词： biological process endoplasmic reticulum stress(ER stress) melanoma

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Concurrence of Merkel Cell Carcinoma and Squamous Cell Carcinoma in A Patient with Generalized Actinic Keratosis: A Case Report

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International Journal of Dermatology and Venereology 2022年第1期5卷 53-55页

作者： Zhang-Hui Yue Yan Wang fang fang jian-fang sun Department of Pathology Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Department of Dermatologic Surgery Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Introduction:Merkel cell carcinoma(MCC)is a rare,aggressive cutaneous malignancy,and its pathogenesis might relate to ultraviolet light and Merkel cell polyomavirus *** in the Chinese population is ***,we present a case of MCC that occurred based on widespread actinic keratosis(AK)in a Chinese *** report:An 82-year-old woman presented with two rapidly enlarging and rupture lesions on the face for 1 *** was suggestive of squamous cell carcinoma(SCC)on the forehead and MCC on the left *** patient had a history of generalized AK for 3 *** lesion on the left cheek was also revealed as an AK by histopathological examination 1 year *** surgical resection was performed to remove the two ***:The co-occurrence of AK,SCC,and MCC in a Chinese woman is *** examination is vital for correct *** three tumors,in this case,may originate from two different precursor cells and are affected by the same ***,they may come from the same pluripotent epidermal stem cells,and chronic exposure to ultraviolet light and Merkel cell polyomavirus lead to the formation of different types of *** coexist of MCC with other cutaneous tumors provided a train of thought for exploring the origin of ***:We reported a rare co-existence phenomenon of MCC associated with AK and ***,long-term follow-up and early treatment are imperative for patients with premalignant lesions,such as widespread AK.

关键词： Merkel cell carcinoma squamous cell carcinoma actinic keratosis concurrence case report

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Cutaneous Manifestations and Treatment Advances of Adult T-Cell Leukemia/Lymphoma

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International Journal of Dermatology and Venereology 2022年第1期5卷 40-44页

作者： Ying Zhang Hao Chen jian-fang sun Department of Pathology Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Adult T-cell leukemia/lymphoma(ATLL)is an aggressive peripheral T-cell lymphoma caused by the human T lymphotropic virus *** skin is affected in approximately half of ATLL patients,and skin lesions may be the first manifestation of the *** skin lesions of ATLL are polymorphous,and depend on the type of skin eruption,which makes it possible for doctors to predict the prognosis of the disease based on the characteristics of skin *** this review article,we describe the clinical manifestations and histopathological patterns of skin lesions in ATLL,focus on its diagnostic and prognostic significance,and also summarize the advances in the treatment of ATLL.

关键词： adult T cell leukemia/lymphoma(ALL) cutaneous treatment advances

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Enhanced cold mercury atom production with two-dimensional magneto-optical trap

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Chinese Physics B 2022年第7期31卷 262-267页

作者： Ye Zhang Qi-Xin Liu jian-fang sun Zhen Xu Yu-Zhu Wang Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800China Key Laboratory of Quantum Optics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

A cold atom source is important for quantum metrology and precision *** reduce the quantum projection noise limit in optical lattice clock,one can increase the number of cold atoms and reduce the dead time by enhancing the loading *** this work,we realize an enhanced cold mercury atom source based on a two-dimensional(2D)magnetooptical trap(MOT).The vacuum system is composed of two titanium chambers connected with a differential pumping *** stable cooling laser systems are adopted for the 2D-MOT and the three-dimensional(3D)-MOT,*** an optimized 2D-MOT and push beam,about 1.3×10^(6)atoms,which are almost an order of magnitude higher than using a pure 3D-MOT,are loaded into the 3D-MOT for202Hg *** enhanced cold mercury atom source is helpful in increasing the frequency stability of a neutral mercury lattice clock.

关键词： magneto-optical trap atomic beam neutral mercury atom laser cooling and trapping

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Dermoscopy Features of Trichofolliculoma: A Case Report

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International Journal of Dermatology and Venereology 2020年第3期3卷 179-181页

作者： Lu Gan Hao Chen Wei Zhang jian-fang sun Department of Pathology Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Introduction:Trichofolliculoma characterized clinically by the presence of acentral dilated pore with tufted hairs and corresponds histologically to a central primary follicle and many secondary vellus hair follicles originating from *** far,dermoscopy dascription of trichofolliculoma has been ***,we describe a typical case of trichofolliculoma,particularly the special manifestation under the *** presentation:A 29-year-old man complained a five-year history of a nodule containing a central whitish hair plug on his left *** examination revealed a well-defined,yellow macule with a central whitish hair plug surrounded by dilated capillaries,and histopathological analysis was consistent with ***:The findings of dermoscopy were also vary,which may be affected by the origin of the disease,various phases of the hair cycle,depth of the lesion,and even external ***:Diagnosis of trichofolliculoma is sometimes difficult because the presence of the central crater and visible hairs is low,and dermoscopy examination may be a potentially useful diagnostic tool.

关键词： trichofolliculoma dermoscopy case report

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A highly sensitive LITES sensor based on a multi-pass cell with dense spot pattern and a novel quartz tuning fork with low frequency

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Opto-Electronic Advances 2024年第3期7卷 26-34页

作者： Yahui Liu Shunda Qiao Chao fang Ying He Haiyue sun jian Liu Yufei Ma National Key Laboratory of Science and Technology on Tunable Laser Harbin Institute of TechnologyHarbin 150000China Zhengzhou Research Institute Harbin Institute of TechnologyZhengzhou 450000China Advanced Microscopy and Instrumentation Research Center School of Instrumentation Science and EngineeringHarbin Institute of TechnologyHarbin 150080China.

A highly sensitive light-induced thermoelectric spectroscopy(LITES)sensor based on a multi-pass cell(MPC)with dense spot pattern and a novel quartz tuning fork(QTF)with low resonance frequency is reported in this *** erbi-um-doped fiber amplifier(EDFA)was employed to amplify the output optical power so that the signal level was further *** optical path length(OPL)and the ratio of optical path length to volume(RLV)of the MPC is 37.7 m and 13.8 cm^(-2),respectively.A commercial QTF and a self-designed trapezoidal-tip QTF with low frequency of 9461.83 Hz were used as the detectors of the sensor,*** target gas selected to test the performance of the system was acetylene(C2H2).When the optical power was constant at 1000 mW,the minimum detection limit(MDL)of the C2H2-LITES sensor can be achieved 48.3 ppb when using the commercial QTF and 24.6 ppb when using the trapezoid-al-tip *** improvement of the detection performance by a factor of 1.96 was achieved after replacing the commer-cial QTF with the trapezoidal-tip QTF.

关键词： light-induced thermoelectric spectroscopy quartz tuning fork multi-pass cell gas sensing

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MiR-107-3p/Atp6v0e1 contributes to protective effects of two selenium-containing peptides,TSeMMM and SeMDPGQQ on lead-induced neurotoxicity

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Food Science and Human Wellness 2024年第4期13卷 2060-2067页

作者： Yong fang Tianhang Huang jian Wu Xieqi Luo Fengjiao Fan Peng Li jian Ding Xinyang sun College of Food Science and Engineering Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and SafetyNanjing 210023China Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi School of MedicineJiangnan UniversityWuxi 214122China

Two selenium(Se)-containing peptides from Se-enriched rice,TSeMMM and SeMDPGQQ,possess neuroprotective potency against lead(Pb2+)-induced ***,the crosstalk between mRNA and microRNAs(miRNA)involved in the neuroprotection mechanism remains to be *** this study,RNA-sequencing and miRNA-sequencing were used to independently identify differentially expressed mRNAs and small RNAs profiles in Pb^(2+)-treated primary fetal rat cortical neurons and then the correlated miRNA-mRNA target pairs were *** was found that 34 mRNAs related to oxidative phosphorylation could be reversed by pretreatment of TSeMMM and *** protective effect of TSeMMM and SeMDPGQQ was mediated by upregulation of miR-107-3p,which downregulates the ATPase H+transporting V0 subunit e1(Atp6v0e1)mRNA level.A zebrafish model was applied to verify the relevance between the targeted mRNA and miRNA by real-time quantitative *** results indicated that miR-107-3p was a potential therapeutic target to achieve neuroprotection of Se-containing peptides via stimulation of Atp6v0e1.

关键词： Lead Se-containing peptides Neuroprotection miRNA

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A New Method for Solving Nonlinear Partial Differential Equations Based on Liquid Time-Constant Networks

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Journal of Systems Science & Complexity 2024年第2期37卷 480-493页

作者： sun Jiuyun DONG Huanhe fang Yong College of Mathematics and Systems Science Shandong University of Science and TechnologyQingdao 266590China

In this paper,physics-informed liquid networks(PILNs)are proposed based on liquid time-constant networks(LTC)for solving nonlinear partial differential equations(PDEs).In this approach,the network state is controlled via ordinary differential equations(ODEs).The significant advantage is that neurons controlled by ODEs are more expressive compared to simple activation *** addition,the PILNs use difference schemes instead of automatic differentiation to construct the residuals of PDEs,which avoid information loss in the neighborhood of sampling *** this method draws on both the traveling wave method and physics-informed neural networks(PINNs),it has a better physical ***,the KdV equation and the nonlinear Schr¨odinger equation are solved to test the generalization ability of the *** the best of the authors’knowledge,this is the first deep learning method that uses ODEs to simulate the numerical solutions of PDEs.

关键词： Nonlinear partial differential equations numerical solutions physics-informed liquid networks physics-informed neural networks

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