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海上稠油冷采井多元热流体吞吐堵塞机理及活性油解堵

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石油钻采工艺 2024年第1期46卷 89-96页

作者：刘义刚白健华孟祥海邹剑张伟韩晓冬张梦琪钟立国中海石油(中国)有限公司天津分公司天津300450 中国石油大学(北京) 北京102249

渤海南堡油田稠油冷采井采用温度低于150℃的多元热流体吞吐开采,吞吐开采后地层堵塞严重,甚至导致油井不出液。通过室内实验分析了地层堵塞原因,明确了注入水与地下稠油乳化后会使稠油黏度增大,乳滴(聚集体)通过孔喉的液阻效应增强导... 详细信息

渤海南堡油田稠油冷采井采用温度低于150℃的多元热流体吞吐开采,吞吐开采后地层堵塞严重,甚至导致油井不出液。通过室内实验分析了地层堵塞原因,明确了注入水与地下稠油乳化后会使稠油黏度增大,乳滴(聚集体)通过孔喉的液阻效应增强导致“启动压力”提高,当乳化区驱替压力低于启动压力时地层出现堵塞;开展了掺稀降黏和活性剂辅助降黏降阻实验,按3∶1∶1的摩尔比配制了由脂肪醇聚氧乙烯醚羟丙基磺酸钠、十二烷基三甲基铵盐和琥珀磺酸钠组成的活性油解堵体系,加入2%该体系后的稀油与含水50%稠油按照稀稠比2∶8混合后,其黏度相较含水50%稠油(7698 mPa·s)降低了98.5%,界面张力相较稠油-水(21.86 mN/m)降低了74.5%,同时乳化区启动压力降至1.86 MPa;通过数值模拟实验,优化了稀油注入量和活性剂质量分数,预测注入2000 m^(3)稀油并在1000 m^(3)前置稀油中加入2%活性剂可实现乳化区解堵,净增油量为4016.5 m^(3)。现场试验表明,解堵后油井日产油5.9 m^(3)/d,累计增油980.7 m^(3),解堵增产效果明显。该技术对海上稠油冷采井解堵和增产具有指导作用。

关键词：稠油乳化液阻效应启动压力梯度活性油解堵海上油田

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基于翻转课堂的混合式教学模式在骨科学本科教学中的应用效果分析

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上海医药 2024年第5期45卷 5-8页

作者：邹剑陈云丰杨庆诚陆耀红刘珅上海交通大学医学院附属第六人民医院骨科上海200233

目的:分析基于翻转课堂的混合式教学模式在骨科学本科教学中的应用效果。方法:选取参加骨科学学习的24名八年制学生和25名临床医学专业“4+4”(以下简称“4+4”)学生作为研究对象,其中八年制学生接受传统授课学习(对照组),“4+4”学生... 详细信息

目的:分析基于翻转课堂的混合式教学模式在骨科学本科教学中的应用效果。方法:选取参加骨科学学习的24名八年制学生和25名临床医学专业“4+4”(以下简称“4+4”)学生作为研究对象,其中八年制学生接受传统授课学习(对照组),“4+4”学生接受基于翻转课堂的混合式教学模式学习(观察组)。比较2组学生的总成绩、理论考试成绩、见习成绩和对教学的满意率。结果:观察组学生的总成绩高于对照组学生,但差异没有统计学意义。2组学生理论考试成绩和见习成绩的差异也均没有统计学意义。2组学生对教学的总满意率相当,但观察组学生对教学的非常满意率显著高于对照组学生(P=0.03)。结论:在骨科学本科教学中应用基于翻转课堂的混合式教学模式可提高学生的学习效果,培养学生的自主学习能力,得到学生及教师的认可。

关键词：教学模式翻转课堂骨科学

地层流体对覆膜陶粒人工岩心性能影响室内研究

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辽宁化工 2024年第3期53卷 351-353页

作者：高尚兰夕堂邹剑张丽平符扬洋曹丹张云飞中海石油(中国)有限公司天津分公司天津300452 中海油能源发展股份有限公司工程技术分公司天津300452 不详

为考察覆膜陶粒进入地层后地层流体对其固结强度的影响,室内开展了不同流体耐受性评价。结果表明:经压裂液破胶液、地层油水在60℃条件下浸泡一定时间后,覆膜陶粒形成的人工岩心抗压强度变化不大,抗压强度最大下降率不超过1.5%。

关键词：覆膜砂地层流体压裂液破胶液抗压强度

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THREE-DIMENSIONAL FLOW AROUND TWO TANDEM CIRCULAR CYLINDERS WITH VARIOUS SPACING AT Re=220

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Journal of Hydrodynamics 2006年第1期18卷 48-54页

作者： DENG jian REN An-lu zou jian-feng Department of Mechanics Zhejiang University Hangzhou 310027 China

The flow around two tandem circular cylinders was studied by a three-dimensional numerical simulation of the Navier-Stokes equations at Re=220 . The improved virtual boundary method was applied to model the no-slip boundary condition of the cylinders. The results show that as the spac ing ratio L/D≥4 , the three dimensionality occurs in the wake. When L/D≤3.5 the wake keeps a two-dimensional state at the Reynolds number Re=220 . The critical spacing for the appearance of three-dimensional instability obtained is at the range 3.5〈 L/D 〈 4, similar to the critical spacing found in two-dimensional case. Two sources of instability from upstream and downstream cylinder generate a complicat ed vortex structures in the wake, investigated by streamlines topology analysis in the streamwise plane. Many other interesting problems were also addressed in this paper.

关键词： three-dimensional Navier-Stokes equations,virtual boundary method flow around two tandem circular cylinders three-dimensional vortex structure

Syntheses of new di-nuclear and tetra-nuclear lanthanide 9-anthracenecarboxylates:Magnetocaloric effect,slow magnetic relaxation and luminescent properties

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Journal of Rare Earths 2024年第6期42卷 1101-1109,I0004页

作者： Xing Liu Ruonan Yang Lu Zhang jian Zhou Chunmei Huang Huahong zou Zunhong Xiao Chongqing Key Laboratory of Inorganic Functional Materials College of ChemistryChongqing Normal UniversityChongqing401331China Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China) School of Chemistry and Chemical Engineering of Guangxi Normal UniversityGuilin541004China School of Chemistry and Materials Guizhou Normal UniversityGuiyang550025China

Lanthanide complex-based materials with magnetic and luminescent properties have received a great deal of attention,owing to their importantly potential applications in diverse fields.In this work,the 9-anthracenecarboxylic acid(9-Haca)as bridging ligand was applied in combination with optically activeπ-conjugated 2,4,6-tri(2-pyridyl)-1,3,5-triazine(tptz)to construct a series of new di-nuclear and tetranuclear lanthanide 9-anthracenecarboxylates[La_(2)(9-aca)_(6)(tptz)_(2)(μ-H_(2)O)]·0.25H_(2)O(1),[Ln_(2)(9-aca)_(6)(tptz)_(2)(H_(2)O)_(2)]·0.5AQ·CH_(3)COOH_(2)H_(2)O[Ln=Sm(2a),Eu(2b),Gd(2c),Tb(2d),Dy(2e),Tm(2f);AQ=9,10-anthracenedione]and[Ln_(4)(9-aca)_(10)(tptz)_(2)(CH3COO)2]·H_(2)O[Ln=Eu(3a),Gd(3b),Dy(3c)].1 displays a di-nuclear centrosymmetric moiety[La_(2)(9-aca)_(6)(tptz)_(2)(μ-H_(2)O)]built up from two complex[La(9-aca)_(2)(tptz)]groups bridged by one H_(2)O molecule and two syn-syn-μ2-η1:η1-9-aca-bridging ligands,while 2a-2f are isostructural and co mprise another di-nuclear centrosymmetric moieties[Ln_(2)(9-aca)_(6)(tptz)_(2)(H_(2)O)_(2)]based on two complex[Ln(9-aca)_(2)(tptz)(H_(2)O)]groups connected by two syn-syn-μ2-η1:η1-9-aca-bridging ligands,3a-3c are isostructural and show tetra-nuclear centro symmetric moieties[Ln4(9-aca)10(tptz)2(CH3COO)2]containing three types of coordination modes of 9-aca-ligands.The present compounds offer the only examples of lanthanide 9-anthracenecarboxylates decorated by optically active tptz.Magnetic investigations of 2a,2c-2f,and 3b-3c indicate that 3c is typical of slow relaxation of the magnetization,while 2c and 3b show significant magnetocaloric effect(MCE)with the value of-ΔSm of 5.26 J/(kg·K)at 4 K and 15.65 J/(kg·K)at 2 K(ΔH=7 T),respectively.The luminescent properties were also studied and reveal that the characteristic luminescent properties of the 7r-conjugated aromatic ligands are introduced into magnetic lanthanide 9-anthracenecarboxylates,simultaneously exhibiting slow magnetic relaxation(or MCE)and luminescent properties.

关键词： Lanthanide complexes Luminescence Magnetic properties Magnetocaloric effect Slow magnetic relaxation Rare earths

Evaluation of the traditional Chinese medicine Shensongyangxin capsule on treating premature ventricular contractions： a randomized, double-blind, controlled multicenter trial

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Chinese Medical Journal 2011年第1期124卷 76-83页

作者： zou jian-gang ZHANG jian JIA Zhen-hua CAO Ke-jiang Department of Cardiology First Hospital Affiliated to Nanjing Medical University Nanjing Jiangsu 210029 China Integration of Traditional and Western Medical Research Academy of Hebei Province/Key Research Centre of Collateral Disease of State Administration of Traditional Chinese Medicine Shijiazhuang Hebei 050035 China

Background Premature ventricular contraction （PVC） is one of the most common kinds of arrhythmias for which the treatment falls into dilemma. Previous clinical application showed that the traditional Chinese Medicine Shensongyangxin （SSYX） capsule is efficacious for the treatment of PVCs. This randomized clinical trial aimed to further evaluate the efficacy and safety of SSYX capsule on treating PVC. Methods The subjects who had frequent PVCs with or without organic heart disease and normal cardiac function were enrolled in the study. The primary endpoint was the change of PVC numbers after eight-week medication with SSYX capsule. The secondary endpoints included change of clinical symptoms related to PVCs and the safety evaluation of SSYX capsule. Totally 188 PVC patients were randomly enrolled in the non-organic heart disease PVCs trial and orally took either $SYX capsules or analogues （three times per day, 4 capsules one time）. A total of 671 PVCs patients were randomly enrolled in the organic heart disease PVCs trial, and orally took either SSYX capsules （three times per day, 4 capsules one time） or mexiletine tablet （three times per day, 150 mg one time）. The PVCs were monitored and calculated with 24-hour Holter electrocardiogram. Routine blood, liver and kidney function were tested before and after medication with SSYX capsule. Results SSYX capsules significantly decreased the PVCs numbers and alleviated the related symptoms in patients with or without organic heart disease. In non-organic heart disease group, SSYX capsules and the placebos decreased the PVCs from 12561.34±9777.93 to 4806.87±6507.17, and 12 605.69±8736.34 to 10364.94±9903.41, respectively. The total effective rate was 74.2% and 28.9% in SSYX and placebo groups （P〈0.001）. In organic heart disease group, SSYX capsule and mexiletine decreased the PVCs from 8641.01±8923.57 to 3853.68±7096.42, 8621.61±8367.74 to 5648.29±8667.38, respectively, The total effective rate was 65.8% and 50.7% in SSYX and mexiletine groups （P〈0.001）. In addition, SSYX

关键词： premature ventricular contraction Shensongyangxin capsule randomized controlled trial

Dual roles of Crbumbs polarity complex during epithelial apical lumen formation in zebrafish

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Dual roles of Crbumbs polarity complex during epithelial api...

第二届全国发育生物学大会

作者： jian zou Xiangyun Wei Institute of Translational Medicine Zhejiang University

Apical lumen is a common and key step in the organogenesis of many organs,such as neural tube and intestines.However,the cellular and molecular mechanisms remain to be fully understood.In this study,we show that early-onset Cadherins mediate"self-organization"of a bilateral symmetrical neural rod by adhering apical cell surfaces at the midline through two distinct types of apical adhesion:Parallel adhesion coheres neighbor cells of the same orientations;and opposing adhesion coheres cells of opposite orientations.Subsequently,Crumbs complexes are required to down-regulate the opposing adhesion but enhance the parallel adhesion via Pard3-Pard6-aPKC-Cdc42 complex.Finally,late-onset Na/KATPase which localization is controlled by Crbumbs complex inflates a lumen by ion-transporting activity.This rod-to-tube stepwise construction of a bilateral symmetrical cytoarchitecture also underlies the morphogenesis of the intestines and possibly other tubular tissues.

关键词： Polarity proteins Cell-cell adhesion Tubulogenesis Crbumbs complex Zebrafish

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转录组分析番茄矮化突变体dwt的相关基因

西华师范大学学报（自然科学版） 2024年第2期45卷 134-141页

作者：王倩杨军陈卫英文国琴杨鹏李正国邹建西华师范大学西南野生动植物资源保护教育部重点实验室四川南充637009 西华师范大学生命科学学院四川南充637009 重庆大学生命科学学院重庆40004 南充市农业科学院四川南充637000

为了挖掘番茄(Solanum lycopersicum)株高发育调控相关基因,本文以樱桃番茄Micro Tom及其矮化突变体dwt为材料,通过转录组测序和表达水平分析筛选鉴定到15个与株高发育调控相关的候选基因。其中,TCH4-like1、TCH4-like2、ABAR7、ABAR10... 详细信息

为了挖掘番茄(Solanum lycopersicum)株高发育调控相关基因,本文以樱桃番茄Micro Tom及其矮化突变体dwt为材料,通过转录组测序和表达水平分析筛选鉴定到15个与株高发育调控相关的候选基因。其中,TCH4-like1、TCH4-like2、ABAR7、ABAR10、PP2C7、PP2C13和PR1等基因的表达异常,从而影响BRs、ABA和SA信号途径,并抑制番茄的生长,进而导致dwt番茄矮化。同时,ABAR7、ABAR10、PP2C7、PP2C13、PR1等基因与WRKY33、MPK3基因共同影响MAPK信号途径,从而调控dwt突变体矮化性状的形成。另外,peroxidase-like1、peroxidase-like2和peroxidase-like3等基因的表达受到强烈抑制,从而影响dwt木质素合成,并促成dwt的矮化特征形成。结果可为番茄株高发育调控中关键调控基因的鉴定奠定良好基础,同时也为番茄矮化育种提供重要线索。

关键词：番茄矮化转录组测序激素

Quantum Information Processing in a Coupled Cavity Array

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Communications in Theoretical Physics 2008年第12期50卷 1312-1316页

作者： LI jian zou jian SHAO Bin Department of Physics Beijing Institute of Technology Beijing 100（}81 China

We consider a one-dimensional array of L identical coupled cavities,and each cavity is doped with atwo-level qubit.Experimentally,it has been developed in several varieties by the newest technology.We find that theone-qubit quantum state can be perfectly transferred through the cavity array,and the entanglement between the firsttwo qubits can also be transferred to the last two qubits.In addition,we successfully realized the entangling gate andswap gate in the coupled cavity array.

关键词：状态转移玻色-爱因斯坦凝聚体纠缠交换纠缠浓缩理论物理学