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Decoding γδ T cell anticancer therapies: integrating CRISPR screens with tumor organoids

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5572-5574页

作者： jian zhou Min Wu Gen Yang Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325000 ZhejiangChina School of Physics Peking University100871 BeijingChina

In a recent publication in Nature,1 Mamedov and colleagues identified pathways that modulateγδT cell killing and BTN3A cellular expression through integrating genome-wide CRISPR screens and tumor organoid culture,deepening our comprehension ofγδT cell stress surveillance and proposing novel pathways to boostγδT cell’s anticancer functions(Fig.1).

关键词： integrating deepening culture

Tripyrrylmethane based 2D porous structure for hydrogen storage

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Frontiers of physics 2011年第2期6卷 220-223页

作者： Xiao zhou jian zhou Kun LV Qiang SUN Department of Advanced Materials and Nanoteehnology Peking University Beijing 100871 China Center for Applied Physics and Technology Peking University Beijing 1008V1 China

The key to hydrogen storage is to design new materials with light mass, large surface and rich adsorption sites. Based on the recent experimental success in synthesizing tripyrrylmethane, we have explored Ti-tripyrrylmethane based 2D porous structure for hydrogen storage using density functional theory. We have found that the structure is stable, and the exposed Ti sites can bind three hydrogen molecules with an average binding energy of 0.175 eV/H2, which lies in the energy window for storage and release of hydrogen in room temperature and at the ambient, pressure.

关键词： tripyrrylmethane hydrogen storage

Revealing the effect of anion-tuning in bimetallic chalcogenides on electrocatalytic overall water splitting

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Nano Research 2021年第12期14卷 4548-4555页

作者： jian zhou Yibo Dou Tao He Awu zhou Xiang-Jing Kong Xue-Qian Wu Tongxin Liu jian-Rong Li Beijing Key Laboratory for Green Catalysis and Separation Faculty of Environment and LifeBeijing University of TechnologyBeijing100124China

Enhancing electrocatalytic water splitting performance by modulating the intrinsic electronic structure is of great importance. Here, porous bimetallic oxide and chalcogenide nanosheets grown on carbon paper denoted as NiCo2X4/CP (X = O, S, and Se) are prepared to demonstrate how the anion components affect the electronic structures and thereby disclose the correlation between their intermediates interaction and catalytic activities. The experimental characterization and theoretical calculation demonstrate that Se and S substitution can promote the ratio of Co^(3+)/Co^(2+) and thereby modulate the electronic structure accompanied with the upshift of d band centers, which not only enhance the inner conductivity but also regulate the interaction between the catalyst surface and intermediates, especially for the adsorption of absorbed H and hydroperoxy intermediates towards respective hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). As a result, a full alkaline electrolyzer using NiCo2Se4/CP and NiCo2S4/CP as cathode and anode delivers a low voltage of 1.51 V at 10 mA·cm^(−2), which is comparable even superior to most transition metal-based electrolyzers.

关键词： electrocatalytic overall water splitting electronic structure bimetallic chalcogenide high valence Co3+ intermediates interaction

From molecule to cell:the expanding frontiers of plant immunity

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Journal of Genetics and Genomics 2024年第7期51卷 680-690页

作者： Lei Li Jing Liu jian-Min zhou Key Laboratory of Seed Innovation Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Hainan Yazhou Bay Seed Laboratory SanyaHainan 572025China

In recent years,the field of plant immunity has witnessed remarkable *** the co-evolution between plants and pathogens,plants have developed a wealth of intricate defense mechanisms to safeguard their *** identified immune receptors have added unexpected complexity to the surface and intracellular sensor networks,enriching our understanding of the ongoing plant–pathogen *** the molecular mechanisms of resistosome shapes our understanding of these mysterious molecules in plant ***,technological innovations are expanding the horizon of the plant–pathogen battlefield into spatial and temporal *** the development provides new opportunities for untangling the complex realm of plant immunity,challenges remain in uncovering plant immunity across spatiotemporal dimensions from both molecular and cellular levels.

关键词： Plant immunity Calcium Spatiotemporal Biomolecular condensate Immune receptor Resistosome

Influence of coating and dew point on hearth roll pickup

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Journal of Iron and Steel Research International 2019年第6期26卷 647-652页

作者： Xiao-fei Zheng Yong-lin Kang jian zhou School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Shougang Jingtang Iron and Steel United Co. Ltd. Tangshan 063200 Hebei China

Thermal spray coatings have been widely used on hearth rolls in a continuous annealing line to improve steel sheet quality and prolong the roll service life. One of the common defects formed on a working hearth roll is the oxide pickup. The most common cause of the pickup formation is that the active Mn oxide reacts with coating. The potentials of two different coatings, CoCrAlYTa-Al2O3 (No. 1) and CoCrYNi-Y2O3 (No. 2), to duplicate pickups by reacting with Fe and Mn oxides were studied. There are three stages during pickup producing and growing. No. 2 coating effectively reduced the corrosion of Mn oxide. The characterization and modification of the surface oxide formed can be changed with different dew points. The results indicate that the dew point from — 53 to — 10 ℃ can change the depth of Mn oxide, such that an alteration can prevent the first stage and second stage and is good for preventing the pickup growing.

关键词： Pickup Coating Dew point Surface oxide Hearth roll

Aeroelastic effect on aerothermoacoustic response of metallic panels in supersonic flow

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Chinese Journal of Aeronautics 2016年第6期29卷 1635-1648页

作者： Wang Xiaochen Yang Zhichun zhou jian Hu Wei School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Xi’an Aerospace Propulsion Institute Xi’an 710100China

A finite element formulation is presented for the analysis of the aeroelastic effect on the aerothermoacoustic response of metallic panels in supersonic flow. The first-order shear deformation theory(FSDT) and the von Karman nonlinear strain-displacement relationships are employed to consider the geometric nonlinearity induced by large deflections. The piston theory and the Gaussian white noise are used to simulate the mean flow aerodynamics and the turbulence from the boundary layer. The thermal loading is assumed to be steady and uniformly distributed, and the material properties are assumed to be temperature independent. The governing equations of motion are firstly formulated in structural node degrees of freedom by using the principle of virtual work,and then transformed and reduced to a set of coupled nonlinear Duffing oscillators in modal coordinates. The dynamic response of a panel is obtained by the Runge-Kutta integration method. The results indicate that the increasing aeroelastic effect can lead the panel vibration from a random motion to a highly ordered motion in the fashion of diffused limit cycle oscillations(LCOs), and remarkably alter the stochastic bifurcation and the spectrum of the aerothermoacoustic *** the other hand there exists a counterbalance mechanism between the external random loading and the aeroelastic effect, which mainly functions through the nonlinear frequency-amplitude response. It is surmised that the aeroelastic effect must be considered in sonic fatigue analysis for panel structures in supersonic flow.

关键词： Aeroelastic effect Aerothermoacoustic response Metallic panels Nonlinear frequencyamplitude response Sonic fatigue

3-D CFD simulation of transients in multiple pump system with some pumps being stopped

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Journal of Hydrodynamics 2021年第3期33卷 583-592页

作者： Yue-fei Liu jian-xu zhou Qiang Guo Ai-li Shen jian Zhang College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210024China

The computational fluid dynamics(CFD)approach can be used to obtain both internal and external characteristics of centrifugal pumps,and the variations of the hydrodynamic force,the pressure and the torque on the blades acquired by the CFD are highly associated with the safety of the pumping *** on the CFD simulations,this paper investigates the stopping characteristics of multiple pumps with some pumps being *** 3-D geometric model is built,including all 6 pumps,the valves,the pipes,the tanks and other components,and using the Realizable k-ε turbulence *** CFD results for the operating points agree well with the results from the theoretical *** some pumps being stopped,the key parameters of the operating pumps would not be stable,with a larger fluctuation;the direction of the hydrodynamic force might be opposite with more than 3 stopped *** the stopped pumps,the maximum reverse values of the discharge and the rotational speed would be larger when fewer pumps are stopped,and could be more than 120%of the rated values,which is dangerous for the pumping *** CFD results could help understanding the stopping process of multiple pump systems with some pumps being stopped.

关键词： Centrifugal pumps some pumps stop computational fluid dynamics(CFD) operating points maximum reverse value

Environmental effects induced by excavation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第1期9卷 50-57页

作者： Yu-qi LI jian zhou Kang-he XIE Department of Civil Engineering Shanghai University Shanghai 200072 China Department of Geotechnical Engineering Tongji University Shanghai 200092 China Institute of Geotechnical Engineering Zhejiang University Hangzhou 310027 China

Based on 3D Biot’s consolidation theory and nonlinear Duncan-Chang’s model, a 3D FEM (finite element method) program is developed considering the coupling of groundwater seepage and soil skeleton deformation during excavation. The comparison between the analysis result considering the variation of water head difference and that without considering it shows that the porewater pressure distribution of the former is distinctly different from that of the latter and that the foundation pit de- formations of the former are larger than those of the latter, so that the result without considering the variation of water head dif- ference is unreliable. The distribution rules of soil horizontal and vertical displacements around the pit and excess porewater pressure are analyzed in detail in time and space, which is very significant for guiding underground engineering construction and ensuring environment safety around the pit.

关键词： Environmental effect Excavation Deformation Excess porewater pressure

Effects of elevated CO_2 concentration on growth and water usage of tomato seedlings under different ammonium/nitrate ratios

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Journal of Environmental Sciences 2007年第9期19卷 1100-1107页

作者： LI Juan zhou jian-min DUAN Zeng-qiang State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 China. Nanjing Institute of Geography and Limnology Chinese Academy of Sciences Nanjing 210008 China.

Increasing atmospheric CO2 concentration is generally expected to enhance photosynthesis and growth of agricultural C3 vegetable crops, and therefore results in an increase in crop yield. However, little is known about the combined effect of elevated CO2 and N species on plant growth and development. Two growth-chamber experiments were conducted to determine the effects of NH4^＋/NO3^- ratio and elevated CO2 concentration on the physiological development and water use of tomato seedlings. Tomato was grown for 45 d in containers with nutrient solutions varying in NH4^＋/NO3^- ratios and CO2 concentrations in growth chambers. Results showed that plant height, stem thickness, total dry weight, dry weight of the leaves, stems and roots, G value （total plant dry weight/seedling days）, chlorophyll content, photosynthetic rate, leaf-level and whole plant-level water use efficiency and cumulative water consumption of tomato seedlings were increased with increasing proportion of NO3- in nutrient solutions in the elevated CO2 treatment. Plant biomass, plant height, stem thickness and photosynthetic rate were 67%, 22%, 24% and 55% higher at elevated CO2 concentration than at ambient CO2 concentration, depending on the values of NH4^＋/NO3^- ratio. These results indicated that elevating CO2 concentration did not mitigate the adverse effects of 100% NH4^＋-N （in nutrient solution） on the tomato seedlings. At both CO2 levels, NH4^＋/NO3^- ratios of nutrient solutions strongly influenced almost every measure of plant performance, and nitrate-fed plants attained a greater biomass production, as compared to ammonium-fed plants. These phenomena seem to be related to the coordinated regulation of photosynthetic rate and cumulative water consumption of tomato seedlings.

关键词： CO2 enrichment NH4^+/NO3^- ratio physiological and biochemical indices growth water use tomato seedling