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Chinese Chemical Letters 2024年第5期35卷 151-154页

作者： Ze-Yuan Ma Mei Xiao Cheng-Kun Li Adedamola Shoberu jian-Ping zou Key Laboratory of Organic Synthesis of jiangsu Province College of Chemistry and Chemical EngineeringSoochow UniversitySuzhou 215123China

An efficient synthesis of the electrophilic reagent,S-(1,3-dioxoisoindolin-2-yl)O,O-diethyl phosphorothioate(SDDP)is described.Moreover,the synthetic applications of SDDP wherein the transfer of the SP(O)(OEt)_(2) moiety occurs were investigated.In this manner,SDDP underwent facile SP(O)(OEt)_(2) transfer with electron-rich substrates such as ketones,indoles,and thiols to formα-phosphorothiolated ketones,3-phosphorothiolated indoles and S-phosphorothiolated thioethers,respectively.

关键词： Electrophilic reagent Phosphorothiolation Electrophilic substitution

Ginsenoside Rk2, a dehydroprotopanaxadiol saponin, alleviates alcoholic liver disease via regulating NLRP3 and NLRP6 inflammasome signaling pathways in mice

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Journal of Pharmaceutical Analysis 2023年第9期13卷 999-1012页

作者： jian zou Rujie Yang Ruibing Feng Jiayue Liu jian-Bo Wan State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina

Heavy alcohol consumption results in alcoholic liver disease(ALD)with inadequate therapeutic options.Here,we first report the potential beneficial effects of ginsenoside Rk2(Rk2),a rare dehydroprotopanaxadiol saponin isolated from streamed ginseng,against alcoholic liver injury in mice.Chronic-plus-single-binge ethanol feeding caused severe liver injury,as manifested by significantly elevated serum aminotransferase levels,hepatic histological changes,increased lipid accumulation,oxidative stress,and inflammation in the liver.These deleterious effects were alleviated by the treatment with Rk2(5 and 30 mg/kg).Acting as an nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3(NLRP3)inhibitor,Rk2 ameliorates alcohol-induced liver inflammation by inhibiting NLRP3 inflammasome signaling in the liver.Meanwhile,the treatment with Rk2 alleviated the alcohol-induced intestinal barrier dysfunction via enhancing NLRP6 inflammasome in the intestine.Our findings indicate that Rk2 is a promising agent for the prevention and treatment of ALD and other NLPR3-driven diseases.

关键词： Alcoholic liver disease Ginsenoside Rk2 NLRP3 inflammasome NLRP6 inflammasome Intestinal barrier dysfunction

Click chemistry-based enrichment strategy for tracing cellular fatty acid metabolism by LC-MS/MS

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Journal of Pharmaceutical Analysis 2023年第10期13卷 1221-1231页

作者： Ru-Jie Yang jian zou Jia-Yue Liu jiang-Kun Dai jian-Bo Wan State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR999078China

Fatty acids(FAs),which were initially recognized as energy sources and essential building blocks of biomembranes,serve as the precursors of important signaling molecules.Tracing FA metabolism is essential to understanding the biochemical activity and role of FAs in physiological and pathological events.Inspired by the advances in click chemistry for protein enrichment,we herein established a click chemistry-based enrichment(CCBE)strategy for tracing the cellular metabolism of eicosapentaenoic acid(EPA,20:5 n-3)in neural cells.Terminal alkyne-labeled EPA(EPAA)used as a surrogate was incubated with N2a,mouse neuroblastoma cells,and alkyne-labeled metabolites(ALMs)were selectively captured by an azide-modified resin via a Cu(I)-catalyzed azide-alkyne cycloaddition reaction for enrichment.After removing unlabeled metabolites,ALMs containing a triazole moiety were cleaved from solid-phase resins and subjected to liquid chromatography mass spectrometry(LC-MS)analysis.The proposed CCBE strategy is highly selective for capturing and enriching alkyne-labeled metabolites from the complicated matrices.In addition,this method can overcome current detection limits by enhancing MS sensitivity of targets,improving the chromatographic separation of sn-position glycerophospholipid regioisomers,facilitating structural characterization of ALMs by a specific MS/MS fragmentation signature,and providing versatile fluorescence detection of ALMs for cellular distribution.This CCBE strategy might be expanded to trace the metabolism of other FAs,small molecules,or drugs.

关键词： Click chemistry-based enrichment EPA metabolism Terminal alkyne-labeled EPA Azide-modified resin LC-MS/MS

Genetic and epigenetic regulators of retinal Müller glial cell reprogramming

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Advances in Ophthalmology Practice and Research 2023年第3期3卷 126-133页

作者： Xueqi Xiao Zhiyong Liao jian zou Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection College of Life and Environmental ScienceWenzhou UniversityWenzhouChina Department of Ophthalmology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina The Institute of Translational Medicine Zhejiang UniversityHangzhouChina

Background:Retinal diseases characterized with irreversible loss of retinal nerve cells,such as optic atrophy and retinal degeneration,are the main causes of blindness.Current treatments for these diseases are very limited.An emerging treatment strategy is to induce the reprogramming of Müller glial cells to generate new retinal nerve cells,which could potentially restore vision.Main text:Müller glial cells are the predominant glial cells in retinae and play multiple roles to maintain retinal homeostasis.In lower vertebrates,such as in zebrafish,Müller glial cells can undergo cell reprogramming to regenerate new retinal neurons in response to various damage factors,while in mammals,this ability is limited.Interestingly,with proper treatments,Müller glial cells can display the potential for regeneration of retinal neurons in mammalian retinae.Recent studies have revealed that dozens of genetic and epigenetic regulators play a vital role in inducing the reprogramming of Müller glial cells in vivo.This review summarizes these critical regulators for Müller glial cell reprogramming and highlights their differences between zebrafish and mammals.Conclusions:A number of factors have been identified as the important regulators in Müller glial cell reprogramming.The early response of Müller glial cells upon acute retinal injury,such as the regulation in the exit from quiescent state,the initiation of reactive gliosis,and the re-entry of cell cycle of Müller glial cells,displays significant difference between mouse and zebrafish,which may be mediated by the diverse regulation of Notch and TGFβ(transforming growth factor-β)isoforms and different chromatin accessibility.

关键词： Müller glial cell reprogramming Genetic regulation Epigenetic modification retinal neuron regeneration

Copper diffusion related phase change and voltage decay in CuS cathode

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Nano Research 2023年第6期16卷 8497-8503页

作者： jian zou Zhenrui Wu Ruilin Tang Zhenzhen Ren Xiaobin Niu Liping Wang School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China School of Engineering Faculty of Applied ScienceThe University of British ColumbiaKelowna V1V 1V7Canada

Copper sulfide(CuS)is a promising cathode for lithium-ion batteries(LIBs)due to its impeccable theoretical energy density(~1015 Wh·kg^(−1) and 4743 Wh·L^(−1)).However,it suffers from voltage decay leaded energy density loss and low energy efficiency,which hinders its application.In this work,with combined ex-situ/in-situ X-ray diffraction(XRD)and electrochemical analysis,we explore detailed degradation mechanisms.For the voltage decay,it is attributed to a spontaneous reaction between CuS cathode and copper current collector(Cu CC).This reaction leads to energy density loss and active materials degradation(CuS→Cu_(1.81)S).As for energy efficiency,CuS undergoes a series of phase transformations.The main phase transition processes are CuS→α-LiCuS→Li_(2−x)Cu_(x)S+Cu→Li_(2)S+Cu for discharge;Li_(2)S+Cu→Li_(2−x)Cu_(x)S→β-LiCuS→CuS for charge.Here,α-LiCuS,β-LiCuS,and Li_(2−x)CuxS are newly identified phases.These phase changes are driven by topotactic-reaction-related copper diffusion and rearrangement.This work demonstrates the significance of transition-metal diffusion in the intermediates formation and phase change in conversion-type materials.

关键词： copper sulfides conversion-type materials copper diffusion Li-free cathode lithium metal battery

Bottom-up lithium growth guided by Ag concentration gradient in 3D PVDF framework towards stable lithium metal anode

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Journal of Energy Chemistry 2022年第2期31卷 666-673页

作者： Yulin Zhao Liping Wang jian zou Qiwen Ran Li Li Pengyu Chen Hailong Yu jian Gao Xiaobin Niu School of Materials and Energy University of Electronic Science and Technology of Chin1Chengdu 610054SichuanChina New Energy Materials Laboratory Sichuan Changhong Electric Co.Ltd.Chengdu 610041SichuanChina Key Laboratory for Renewable Energy Chinese Academy of SciencesBeijing Key Laboratory for New Energy Materials and DevicesBeijing 100190China

Three-dimensional(3 D)frameworks have received much attention as an effective modification strategy for next-generation high-energy-density lithium metal batteries.However,the top-growth mode of lithium(Li)on the 3 D framework remains a tough challenge.To achieve a uniform bottom-up Li growth,a scheme involving Ag concentration gradient in 3 D PVDF framework(C-Ag/PVDF)is proposed.Ag nanoparticles with a concentration gradient induce an interface activity gradient in the 3 D framework,and this gradient feature is still maintained during the cycle.As a result,the C-Ag/PVDF framework delivers a long lifespan over 1800 h at a current density of 1 mA cm^(-2) with a capacity of 1 mAh cm^(-2),and shows an ultra-long life(>1300 h)even at a high current density of 4 mA cm^(-2) with a capacity of 4 mAh cm^(-2).The advantage of concentration gradient provides further insights into the optimal design of the 3 D framework for stable Li metal anode.

关键词： Lithium metal anode 3D framework Bottom-up growth Concentration gradient Ag nanoparticles

Biodiversity and distribution of benthic dinoflagellates in tropical Zhongsha Islands,South China Sea

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Journal of Oceanology and Limnology 2022年第6期40卷 2120-2145页

作者： Hang XIE jian zou Chengzhi ZHENG Yuchen QU Kaixuan HUANG Songhui LÜ Research Center of Harmful Algae and Marine Biology College of Life Science and TechnologyJinan UniversityGuangzhou 510362China Southern Marine Science and Engineering Guangdong Laboratory Zhuhai 519000China Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes Jinan UniversityGuangzhou 510632China

Benthic dinoflagellates have attracted increasing attention in recent years because of their toxicity and ability to form extensive harmful algal blooms.Ostreopsis producing palytoxin and its analogs,Gambierdiscus producing ciguatera toxins,and Prorocentrum producing okadaic acid and dinophysis toxins,have been concerned as serious human poisonings.We explored the benthic dinoflagellate biodiversity and distribution characteristics of a series of tropical reefs in 20-40-m water depth in wet season in the Zhongsha Islands in South China Sea using morphological,phylogenetic,and cell counting methods.Results show that benthic dinoflagellates in the islands are rich in biodiversity and 15 species from genera Amphidinium,Coolia,Ostreopsis,and Prorocentrum were identifi ed:Amphidinium carterae,A.magnum,A.massartii,A.operculatum,Coolia canariensis,C.malayensis,C.palmyrensis,C.tropicalis,Ostreopsis cf.ovata,Prorocentrum concavum,P.cf.sculptile,P.emarginatum,P.hof fmannianum,P.lima,and P.rhathymum.Among them,A.magnum is reported for the first time in Chinese waters.The abundance of benthic dinoflagellates was relatively low at 88-4345 cells/100 cm^(2) on sediment and 10-91 cells/g on macroalgae.Prorocentrum and Amphidinium were the dominant and subdominant genera,respectively.It is speculated that the low abundance of benthic dinoflagellates is closely related to the scarcity of macroalgae and stronger water motion at the depth>15 m in Zhongsha Islands.This study expanded the study in biodiversity of benthic dinoflagellates in Chinese waters,and revealed the distribution characteristics of harmful benthic microalgae in reef habitats.

关键词： benthic dinoflagellates Zhongsha Islands South China Sea biodiversity distribution

恶劣海况中大外飘型舰船的总载荷颤振响应分析

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中国舰船研究 2024年第2期19卷 140-147页

作者：曲雪郑凯邹璐遥邹健中国船舶及海洋工程设计研究院上海200011

[目的]舰船遭遇恶劣海况时艏部砰击会激起船体梁颤振响应,威胁到总纵强度的安全。砰击颤振弯矩与船体刚度和外飘构型相关,但不同船型结构布置和型线差异大,有必要针对大外飘型舰船开展颤振响应分析。[方法]首先,采用COMPASS-WALCS-NE势... 详细信息

[目的]舰船遭遇恶劣海况时艏部砰击会激起船体梁颤振响应,威胁到总纵强度的安全。砰击颤振弯矩与船体刚度和外飘构型相关,但不同船型结构布置和型线差异大,有必要针对大外飘型舰船开展颤振响应分析。[方法]首先,采用COMPASS-WALCS-NE势流时域水弹性方法预报设计海况下的船体梁总载荷,并与分段自航模试验对比验证;然后,再提取艏部砰击合力、典型时刻的船体运动状态和船体梁总载荷响应的时历曲线,通过分析波浪载荷高低频分量的相位差异,研究船舯砰击弯矩与艏部砰击合力的关联性;最后,围绕船体主要设计参数进行敏感度分析。[结果]在设计海况艏部入水时,其砰击合力出现了2次峰值,分别对应于底板和外飘区域的大面积触水过程;颤振弯矩主要由艏部外飘砰击引起,受力面积大,合力距离船舯远,导致砰击弯矩达到了波浪弯矩的同等幅值;大外飘型舰船的砰击弯矩对波高变化最为敏感。[结论]对于大外飘型舰船的总纵强度评估应考虑砰击颤振的影响,对于中垂砰击弯矩需要直接与静水成分、低频的波浪成分叠加,而中拱砰击弯矩应考虑阻尼耗散,可先折减再叠加。

关键词：大外飘型舰船结构强度砰击颤振响应总载荷

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Management of Lisfranc injury with anterolateral calcaneal compression fracture

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Chinese Medical Journal 2022年第6期135卷 727-729页

作者： Wenqi Gu Rui Zhang Wanjun Liu Zhongmin Shi Guohua Mei jianfeng Xue jian zou Xiaokang Wang jiantao jiang Department of Orthopedics Shanghai Jiaotong University Affiliated Sixth People's HospitalShanghai 200233China Department of Orthopedics The People's Hospital of Ludian CountyLudianYunnan 657100China

To the Editor:The mechanism of Lisfranc injury is complex and may cause different patterns of fractures or dislocation of the midfoot complex.Abduction force injury is a special injury pattern,which may cause the fracture or(and)dislocation of the lateral column of the Lisfranc joint,especially the cuboid.[1,2,3]However,the anterolateral calcaneus is less commonly involved.Since the fragment of the calcaneocuboid(CC)joint facet is too uncon-spicuous to manifest on a plain X-ray,and surgeons always pay more attention to the Lisfranc joint,anterolateral calcaneal compression fracture and even Chopart joint injuries are often overlooked,which may lead to a delayed surgical management,chronic foot deformities,and functional disability.

关键词： fracture dislocation injuries

Taxonomy and toxin profi le of harmful benthic Prorocentrum(Dinophyceae)species from the Xisha Islands,South China Sea

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Journal of Oceanology and Limnology 2022年第3期40卷 1171-1190页

作者： jian zou Qun LI Hui LIU Ying LIU Lifen HUANG Haiyan WU jiangbing QIU Hua ZHANG Songhui LÜ Research Center of Harmful Algae and Marine Biology College of Life Science and TechnologyJinan UniversityGuangzhou 510362China State Environmental Protection Key Laboratory of Drinking Water Source Management and Technology Shenzhen Academy of Environmental ScienceShenzhen 510008China Yellow Sea Fisheries Research Institute Qingdao 266071China College of Environmental Science and Engineering Ocean University of ChinaQingdao 266100China Shenzhen Academy of Environmental Science Shenzhen 510008China Southern Marine Science and Engineering Guangdong Laboratory Zhuhai 519000China

Some benthic Prorocentrum can produce okadaic acid(OA)and dinophysistoxins(DTXs)that cause diarrheic shellfish poisoning(DSP)in humans.The diversity and toxin profi les(OA and DTXs)of benthic Prorocentrum were investigated in the Xisha Islands,South China Sea.The benthic Prorocentrum was identified by both morphological features and molecular phylogenies.Morphologies were examined by light,fluorescence,and scanning electron microscopy,and phylogenetic analyses were based on partial large subunit(LSU)rDNA and ITS1-5.8S-ITS2(ITS)region.Seven Prorocentrum species including P.borbonicum,P.caipirignum,P.concavum,P.elegans,P.cf.emarginatum,P.lima complex,and P.rhathymum were identified in Xisha Islands.Among them,P.borbonicum and P.elegans were recorded in Chinese waters for the first time.OA and DTXs contents of seven benthic Prorocentrum species were evaluated based on liquid chromatography-tandem mass spectrometry(LC-MS/MS).All Xisha Islands strains of P.lima complex produced OA at contents ranging from 1663 to 3816 fg/cell.P.caipirignum also generated OA at 407 fg/cell,but other five species had no detectable toxins.Besides,interestingly,two strains of P.lima complex produced DTX-1 only(74 and 183 fg/cell)and another two strains generated an isomer of OA and DTX-2.Our findings provided insight into the biodiversity of benthic Prorocentrum in the Xisha Islands and pointed out the potential risk of DSP in this area.

关键词： Prorocentrum diversity dinofl agellate okadaic acid dinophysistoxins Xisha Islands