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Vascular complications following prophylactic balloon occlusion of the internal iliac arteries resolved by successful interventional thrombolysis in a patient with morbidly adherent placenta

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第3期18卷 272-276页

作者： Ning zhang Wei-hua lou Xue-bin zhang Jia-ning FU Yun-yan CHEN Zhi-guo ZHUANG jian-hua LIN Department of Obstetrics and Gynecology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200126 China Department of lnterventional Oncolog Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200126 China Columbia Center for Translational Immunology Columbia University Medical Center New York NY 10032 USA Department of Radiology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200126 China

The increasing incidence of morbidly adherent placenta （MAP） is placing women at a higher risk of life-threatening massive hemorrhage. The involvement of interventional radiology to manage this complex condition by performing prophylactic lilac artery balloon occlusion has been reported recently. However, the effectiveness and safety of this technique have not been fully determined. Here we report the case of a 25-year-old woman with placenta increta with preemptive bilateral internal lilac artery balloons who had external lilac artery thrombosis detected by computed tomography angiography （CTA） 72 h post cesarean section. A digital subtraction angiogram （DSA） and intra-arterial thrombolysis were instantly performed followed by supplementary conservative treatments, leading to a desirable resolution, of thrombus without sequela. This is the first report of vascular complications with successful interventional thrombolysis in this setting. Our experience suggests that prophylactic lilac artery balloon occlusion should be used cautiously in cases of MAP and consideration given to minimizing vascular complications given the hypercoagulable state of pregnancy.

关键词： Balloon catheter Internal iliac artery Placenta accrete Vascular complication Interventional thrombolysis

Prognostic Values of Serum Chloride and Sodium Levels in Patients with Three-vessel Disease

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Biomedical and Environmental Sciences 2019年第4期32卷 250-259页

作者： zhang Ce WANG Dong HOU Bing Jie jianG Lin XU Lian Jun TIAN jian ZHAO Yan Yan ZHAO Xue Yan FENG Xin Xing zhang Yin SUN Kai XU Bo ZHAO Wei HUI Ru Tai GAO Run Lin lou Hui Ling YUAN Jin Qing SONG Lei Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Department of Internal Medicine The People's Hospital of Tang County Medical Research & Biometrics Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Department of Endocrinology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Information Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Department of Geriatrics Guangzhou First People's HospitalSchool of MedicineSouth China University of Technology

Objective Identification of new risk factors is needed to improve prediction of adverse outcomes in patients with three-vessel disease(TVD). The present study aimed to evaluate the prognostic values of serum chloride and sodium levels in patients with TVD. Methods We used data from a prospective cohort of consecutive patients with angiographically confirmed TVD. The primary endpoint was all-cause death. Cox proportional hazard regression was used to analyze the relationship of serum chloride and sodium levels with long-term outcomes of TVD patients. Results A total of 8,318 participants with available serum chloride and sodium data were included in this analysis. At baseline, patients in the low tertiles group of serum chloride level(≤ 102.0 mmol/L) or serum sodium level(≤ 139.0 mmol/L) had more severe disease conditions. During a median follow-up of 7.5-year, both low serum chloride level and low serum sodium level were found to be associated with an increased risk for mortality in univariate analysis. However, when both parameters were incorporated into a multivariate model, only low serum sodium level remained to be an independent predictor of all-cause death(hazard ratio: 1.16, 95% confidence interval: 1.01-1.34, P = 0.041). Modest but significant improvement of discrimination was observed after incorporating serum sodium level into the Synergy between percutaneous coronary intervention(PCI) with Taxus and Cardiac Surgery score. Conclusion Serum sodium level is more strongly associated with long-term outcomes of TVD patients compared with serum chloride level. Low serum sodium level is an independent risk factor for mortality, but only provides modest prognostic information beyond an established risk model.

关键词： Coronary disease Prognosis Biomarkers

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一种强干扰条件下阵列天线波达方向估计方法

西安电子科技大学学报 2018年第1期45卷 168-172页

作者：宫健楼顺天张伟涛西安电子科技大学电子工程学院陕西西安710071 空军工程大学防空反导学院陕西西安710051

为解决强干扰条件下阵列天线的波达方向估计问题,定义了保向正交性和特征波束的概念,证明了信源同时满足功率差和角度差较大条件时,所对应的特征矢量具有保向正交性,提出了一种基于干扰特征矢量剔除的波达方向估计算法.最后,通过计算机... 详细信息

为解决强干扰条件下阵列天线的波达方向估计问题,定义了保向正交性和特征波束的概念,证明了信源同时满足功率差和角度差较大条件时,所对应的特征矢量具有保向正交性,提出了一种基于干扰特征矢量剔除的波达方向估计算法.最后,通过计算机仿真,验证了所提算法在强干扰条件下比干扰阻塞算法有更高的估计性能.

关键词：阵列天线电子干扰波达方向估计信号处理

熔炼次数对M17返回料合金成分、组织和性能的影响

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特殊钢 2008年第3期29卷 27-29页

作者：董加胜楼琅洪张匀孙晓峰中国科学院金属研究所沈阳110016

实验结果表明,M17铸造高温合金(%:0.16C、8.79Cr、5.79A1、4.93Ti、3.29Mo、15.20Co、0.78V、0.015B、0.073Zr、0.002S、0.001P、0.001 1O、0.001 0N)经25 kg真空感应炉返回重熔后,Si含量随重熔次数的增加而略有增加,合金中主要元素和其它杂质元素S、P、H的含量变化不大,而氧、氮略有增加;合金中初生碳化物由新合金中的草书体逐渐向返回合金块状转变,初生碳化物的遗传性堵塞合金凝固时的补缩通道,使返回料合金的疏松倾向增大,高温塑性下降较大。

关键词：铸造高温合金M17 重复熔炼返回合金成分组织性能

A Single Central Pattern Generator for the Control of a Locomotor Rolling Wave in Mollusc Aplysia

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Research 2023年第3期2023卷 711-726页

作者： Hui-Ying Wang Ke Yu Zhe Yang Guo zhang Shi-Qi Guo Tao Wang Dan-Dan Liu Ruo-Nan Jia Yu-Tong Zheng Yan-Nan Su Yi lou Klaudiusz RWeiss Hai-Bo Zhou Feng Liu Elizabeth C.Cropper Quan Yu jian Jing State Key Laboratory of Pharmaceutical Biotechnology Institute for Brain SciencesChinese Academy of Medical Sciences Research Unit of Extracellular RNAJiangsu Engineering Research Center for MicroRNA Biology and BiotechnologyAdvanced Institute for Life SciencesChemistry and Biomedicine Innovation CenterSchool of Life SciencesNanjing UniversityNanjingJiangsu 210023China National Laboratory of Solid State Microstructures Department of PhysicsInstitute for Brain Sciencesand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjingJiangsu 210093China Department of Neuroscience and Friedman Brain Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA School of Electronic Science and Engineering Nanjing UniversityNanjingJiangsu 210023China Peng Cheng Laboratory Shenzhen 518000China

Locomotion in mollusc Aplysia is implemented by a pedal rolling wave,a type of axial ***-studied examples of axial locomotion(pedal waves in Drosophila larvae and body waves in leech,lamprey,and fish)are generated in a segmented nervous system via activation of multiple coupled central pattern generators(CPGs).Pedal waves in molluscs,however,are generated by a single pedal ganglion,and it is unknown whether there are single or multiple CPGs that generate rhythmic activity and phase shifts between different body *** locomotion in intact Aplysia,bursting activity in the parapedal commissural nerve(PPCN)was found to occur during tail contraction.A cluster of 20 to 30 P1 root neurons(P1Ns)on the ventral surface of the pedal ganglion,active during the pedal wave,were *** cluster analysis revealed that there are 2 phases to the motor program:phase I(centered around 168°)and phase II(centered around 357°).PPCN activity occurs during phase *** majority of P1Ns are *** P1Ns tend to be electrically *** classes of pedal interneurons(PIs)were *** 1(PI1 and PI2)is active during phase *** axons make a loop within the pedal ganglion and contribute to locomotor pattern *** are electrically coupled to P1Ns that fire during phase *** 2(PI3)is active during phase II and innervates the contralateral pedal ***3 may contribute to bilateral ***,our findings support the idea that Aplysia pedal waves are generated by a single CPG.

关键词： phase cluster pattern

Severe hypoxemia after radiofrequency ablation for atrial fibrillation in palliatively repaired tetralogy of Fallot: A case report

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World Journal of Cardiology 2024年第3期16卷 161-167页

作者： Zhi-Hang Li Lian lou Yu-Xiao Chen Wen Shi Xuan zhang jian Yang Department of Cardiovascular Medicine The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Cardiology The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Patients with tetralogy of Fallot(TOF)often have arrhythmias,commonly being atrial fibrillation(AF).Radiofrequency ablation is an effective treatment for AF and does not usually cause severe postoperative hypoxemia,but the risk of complications may increase in patients with conditions such as *** SUMMARY We report a young male patient with a history of TOF repair who developed severe hypoxemia after radiofrequency ablation for AF and was ultimately confirmed to have a new right-to-left *** patient subsequently underwent atrial septal occlusion and eventually *** Radiofrequency ablation may cause iatrogenic atrial septal injury;thus possible complications should be predicted in order to ensure successful treatment and patient safety.

关键词： Atrial fibrillation Radiofrequency ablation Tetralogy of Fallot Right-to-left shunt Hypoxemia Medical decision Case report

基于多级回答域搜索算法的P2P搜索技术研究

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微计算机信息 2006年第5X期22卷 237-239页

作者：李洛张剑广东轻工职业技术学院华中科技大学

本文从基于P2P技术搜索方法的特点入手,阐述了P2P信息检索技术的原理、一般结构以及P2P模式的主要信息检索方式,分析了当前几种主流的P2P信息检索技术的研究方向和发展动态,提出一种基于分布式哈希表的协议搜索算法(Multi-RD,MRD),最后... 详细信息

本文从基于P2P技术搜索方法的特点入手,阐述了P2P信息检索技术的原理、一般结构以及P2P模式的主要信息检索方式,分析了当前几种主流的P2P信息检索技术的研究方向和发展动态,提出一种基于分布式哈希表的协议搜索算法(Multi-RD,MRD),最后用数理分析获得了网络资源查询的搜索效率概率。

关键词：信息检索 P2P MRD算法分布式

Antepartum hemorrhage from previous-cesarean-sectioned uterus as a potential sign of uterine artery pseudoaneurysm

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第5期18卷 441-444页

作者： Ning zhang Wei-hua lou Xue-bin zhang jian-hua LIN Wen DI Department of Obstetrics and Gynecology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200126China Department of lnterventional Oncology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200126China

目的:子宫动脉瘤多被认为与产程中创伤性操作相关,但近年陆续有报道显示子宫动脉瘤可发生于自然分娩过程中。本文将为自然分娩过程中子宫动脉瘤的发生和紧急处理等提供参考指导。创新点:产前出血可能是子宫动脉瘤发生的潜在危险信号。方... 详细信息

目的:子宫动脉瘤多被认为与产程中创伤性操作相关,但近年陆续有报道显示子宫动脉瘤可发生于自然分娩过程中。本文将为自然分娩过程中子宫动脉瘤的发生和紧急处理等提供参考指导。创新点:产前出血可能是子宫动脉瘤发生的潜在危险信号。方法:病例报道和文献汇纳分析。患者女,37岁,疤痕子宫,临产入院,产前出血,经阴顺产后12 h,突发阴道大量出血,常规对症处理(按摩子宫、阴道填塞、缩宫素静滴和欣母佩宫颈注射等)未能有效缓解,40 min内出血达1800 ml。床边B超未提示动脉瘤特征,数字减影血管造影(DSA)显示左侧子宫动脉瘤,即刻予动脉栓塞成功止血。患者产后4 d无并发症出院,随访无后遗症。结论:临床医师需要加强对子宫动脉瘤发生的警惕认识和急救处理水平。子宫动脉瘤和产程中的有创性操作无必然相关性,疤痕子宫的产前出血可能是子宫动脉瘤发生的潜在危险信号,产后随访应提高对晚期出血发生的警惕性。鉴于B超在诊断动脉瘤方面的有限性,高度怀疑动脉瘤时应尽快行血管造影明确诊断,及时栓塞处理。

关键词：子宫动脉瘤经阴分娩早期产后出血动脉栓塞

Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders

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National Science Review 2019年第6期6卷 1201-1222页

作者： Lian Deng Chao zhang Kai Yuan Yang Gao Yuwen Pan Xueling Ge Yaoxi He Yuan Yuan Yan Lu Xiaoxi zhang Hao Chen Haiyi lou Xiaoji Wang Dongsheng Lu Jiaojiao Liu Lei Tian Qidi Feng Asifullah Khan Yajun Yang Zi-Bing Jin jian Yang Fan Lu Jia Qu Longli Kang Bing Su Shuhua Xu Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational BiologyShanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of Sciences School of Life Science and Technology Shanghai Tech University State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences State Key Laboratory of Genetic Engineering and Ministry of Education (MOE) Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University The Eye Hospital School of Ophthalmology &Optometry Wenzhou Medical University China National Center for International Research in Regenerative Medicine and Neurogenetics Institute for Molecular Bioscience Queensland Brain Institute The University of Queensland Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region School of Medicine Xizang Minzu University Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Collaborative Innovation Center of Genetics and Development Human Phenome Institute Fudan University

Human genetic adaptation to high altitudes(>2500 m) has been extensively studied over the last few years,but few functional adaptive genetic variants have been identified, largely owing to the lack of deep-genome sequencing data available to previous studies. Here, we build a list of putative adaptive variants, including 63 missense, 7 loss-of-function, 1,298 evolutionarily conserved variants and 509 expression quantitative traits loci. Notably, the top signal of selection is located in TMEM247, a transmembrane protein-coding *** Tibetan version of TMEM247 harbors one high-frequency(76.3%) missense variant, rs116983452(c.248 C > T; ***83 Val), with the T allele derived from archaic ancestry and carried by >94% of Tibetans but absent or in low frequencies(<3%) in non-Tibetan populations. The rs116983452-T is strongly and positively correlated with altitude and significantly associated with reduced hemoglobin concentration(p = 5.78 × 10), red blood cell count(p = 5.72 × 10) and hematocrit(p = 2.57 × 10). In particular, TMEM247-rs116983452 shows greater effect size and better predicts the phenotypic outcome than any EPAS1 variants in association with adaptive traits in Tibetans. Modeling the interaction between TMEM247-rs116983452 and EPAS1 variants indicates weak but statistically significant epistatic *** results support that multiple variants may jointly deliver the fitness of the Tibetans on the plateau,where a complex model is needed to elucidate the adaptive evolution mechanism.

关键词： Tibetan adaptive genetic variant high-altitude adaptation next-generation sequencing(NGS) archaic ancestry expression quantitative traits loci(eQTL) tissue-specific expression hemoglobin concentration hypoxia