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加载速率和加载位置对炸药缝隙扩展过程影响的数值模拟

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含能材料 2022年第12期30卷 1259-1265页

作者：楼建锋张树道北京应用物理与计算数学研究所北京100094

为研究弱载荷作用下炸药起裂、裂缝扩展过程,分析加载条件对缝隙扩展的影响规律,研究基于钝感炸药的三点弯曲试验,采用考虑了材料的拉压异性、应变率效应,以及损伤失效的本构模型,开展了炸药起裂和裂缝演化过程的数值模拟研究,拟合了主... 详细信息

为研究弱载荷作用下炸药起裂、裂缝扩展过程,分析加载条件对缝隙扩展的影响规律,研究基于钝感炸药的三点弯曲试验,采用考虑了材料的拉压异性、应变率效应,以及损伤失效的本构模型,开展了炸药起裂和裂缝演化过程的数值模拟研究,拟合了主要的计算参数,计算结果与试验数据符合较好,校验了计算模型及其适用性;数值模拟获得了炸药样品中裂缝产生和扩展过程的典型特征图像,分析了加载速率和加载位置对炸药裂缝扩展演化规律的影响。研究表明,初始裂缝尺寸越大,起裂越早;随着加载速率增大,起裂荷载也增大,反映了炸药样品的应变率效应;加载位置偏离初始裂缝位置时,对于不同加载速率情况,样品中的裂缝扩展演化路径差异很大,存在4种破坏模式。

关键词：裂缝扩展初始裂缝加载速率炸药三点弯曲试验

Longitudinal Surveillance of Betacoronaviruses in Fruit Bats in Yunnan Province,China During 2009–2016

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Virologica Sinica 2018年第1期33卷 87-95页

作者： Yun Luo Bei Li Ren-Di jiang Bing-Jie Hu Dong-Sheng Luo Guang-jian Zhu Ben Hu Hai-Zhou Liu Yun-Zhi zhang Xing-lou Yang Zheng-Li Shi CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China Eco Health Alliance New York NY 10001 USA Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention Yunnan Institute of Endemic Diseases Control and Prevention Dali 671000 China School of Public Health Dali University Dali 671000 China University of Chinese Academy of Sciences Beijing 100049 China

Previous studies indicated that fruit bats carry two betacoronaviruses,BatCoV HKU9 and BatCoV *** investigate the epidemiology and genetic diversity of these coronaviruses,we conducted a longitudinal surveillance in fruit bats in Yunnan province,China during 2009–2016.A total of 59(10.63%)bat samples were positive for the two betacorona-viruses,46(8.29%)for HKU9 and 13(2.34%)for GCCDC1,or closely related *** identified a novel HKU9 strain,tentatively designated as BatCoV HKU9-2202,by sequencing the full-length *** BatCoV HKU9-2202 shared 83%nucleotide identity with other BatCoV HKU9 stains based on whole genome *** most divergent region is in the spike protein,which only shares 68%amino acid identity with BatCoV *** PCR revealed that the intestine was the primary infection organ of BatCoV HKU9 and GCCDC1,but some HKU9 was also detected in the heart,kidney,and lung tissues of *** study highlights the importance of virus surveillance in natural reservoirs and emphasizes the need for preparedness against the potential spill-over of these viruses to local residents living near bat caves.

关键词： Betacoronavirus Surveillance Genetic diversity

Structural basis for mechanochemical role of Arabidopsis thaliana dynamin-related protein in membrane fission

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Journal of Molecular Cell Biology 2011年第6期3卷 378-381页

作者： Liming Yan Yuanyuan Ma Yuna Sun jian Gao Xiaoyue Chen Jiewei Liu Congwan Wang Zihe Rao Zhiyong lou Laboratory of Structural Biology and MOE Laboratory of Protein Science School of MedicineTsinghua UniversityBeijing 100084China College of Life Sciences and Tianjin State Laboratory of Protein Science Nankai UniversityTianjin 300071China National Laboratory of Macromolecules Institute of BiophysicsChinese Academy of ScienceBeijing 100101China Beijing 107 Middle School BeijingChina

Dear Editor,Dynamins and dynamin-related proteins(DRPs)constitute a large superfamily of GTPases throughout animal,plant,and bacteria and play essential roles in core cellular processes(Praefcke and McMahon,2004).Plant specific dynamin-related subfamilies share essential functions with those in mammalian cell,***mediated endocytosis and fission of mitochondria.

关键词： chemical families constitute

第二取向对镍基单晶高温合金DD33热疲劳性能的影响

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材料研究学报 2014年第9期28卷 663-667页

作者：王莉周忠娇姜卫国王迪申健楼琅洪中国科学院金属研究所

选用不同第二取向的第三代镍基单晶高温合金DD33板式试样进行热疲劳实验,研究了第二取向对单晶高温合金热疲劳性能的影响和不同第二取向样品的热疲劳裂纹扩展动力学。结果表明:第二取向严重影响合金的热疲劳性能。两种第二取向样品,其... 详细信息

选用不同第二取向的第三代镍基单晶高温合金DD33板式试样进行热疲劳实验,研究了第二取向对单晶高温合金热疲劳性能的影响和不同第二取向样品的热疲劳裂纹扩展动力学。结果表明:第二取向严重影响合金的热疲劳性能。两种第二取向样品,其热疲劳裂纹萌生位置和扩展方向明显不同。在第二取向[100]的样品中,热疲劳裂纹在与定向凝固方向呈45°的孔壁处萌生并沿与定向凝固方向呈45°方向扩展;而在第二取向为[110]的样品中,热疲劳裂纹优先在与定向凝固方向垂直的孔壁处萌生并沿定向凝固方向扩展且裂纹萌生及扩展速度都明显快于第二取向[100]的样品。

关键词：金属材料镍基单晶高温合金热疲劳第二取向

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铼对镍基单晶高温合金恒温氧化行为的影响

材料研究学报 2017年第9期31卷 695-702页

作者：常剑秀王栋董加胜王迪吴汉昌张功楼琅洪西安石油大学材料科学与工程学院西安710065 中国科学院金属研究所沈阳110016 中国航发贵阳中航动力精密铸造有限公司贵阳550014

采用不连续增重法研究了Re对一种镍基单晶高温合金1000℃恒温氧化行为的影响,采用扫描电镜(SEM)和X射线衍射分析仪(XRD)对样品的组织进行了观察。结果表明,两种合金生成的氧化膜成分相似,都生成了以含Cr、Ti氧化物为主的外氧化层、Al_2... 详细信息

采用不连续增重法研究了Re对一种镍基单晶高温合金1000℃恒温氧化行为的影响,采用扫描电镜(SEM)和X射线衍射分析仪(XRD)对样品的组织进行了观察。结果表明,两种合金生成的氧化膜成分相似,都生成了以含Cr、Ti氧化物为主的外氧化层、Al_2O_3内氧化层以及含有TiN的内氮化层。但二者氧化速率及氧化层结构存在较大差异,含Re合金的氧化速率较慢,Al_2O_3层较完整且TiN数量较少。Re的作用机理在于它提高了合金中Cr的活度,增大氧化膜中Cr_2O_3的含量,加快Al的选择性氧化,促进合金氧化膜内部连续Al_2O_3层的形成,抑制合金内部氮化物的生成,提高长期氧化下氧化膜的稳定性。

关键词：金属材料镍基单晶高温合金高温氧化 Re 活度选择性氧化

A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors

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Signal Transduction and Targeted Therapy 2023年第6期8卷 3070-3086页

作者： Chao zhang Qiang Guo Lifeng Chen Zheming Wu Xiao-jian Yan Chengyang Zou Qiuxue zhang Jiahong Tan Tian Fang Qunxian Rao Yang Li Shizhen Shen Min Deng Liewei Wang Huanyao Gao Jia Yu Hu Li Cheng zhang Somaira Nowsheen Jake Kloeber Fei Zhao Ping Yin Chunbo Teng Zhongqiu Lin Kun Song Shuzhong Yao Liangqing Yao Lingying Wu Yong zhang Xiaodong Cheng Qinglei Gao jian Yuan Zhenkun lou Jin-San zhang Beijing Institute of Basic Medical Sciences 100850BeijingChina Department of Oncology Mayo ClinicRochesterMN55905USA School of Pharmaceutical Sciences Wenzhou Medical University325035WenzhouZhejiangChina Key Laboratory of Endocrine Gland Diseases of Zhejiang Province Zhejiang Provincial People’s Hospital310014HangzhouZhejiangChina Department of Gynecology Zhejiang Provincial People’s Hospital310014HangzhouZhejiangChina Department of Gynecology the First Affiliated Hospital of Wenzhou Medical University325000WenzhouZhejiangChina Wuhan Kingwise Biotechnology Co. Ltd.430206WuhanHubeiChina Cancer Biology Research Center(Key Laboratory of the Ministry of Education) Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology430030WuhanHubeiChina Department of Gynecological Oncology Sun Yat-sen Memorial HospitalSun Yat-sen University510120GuangzhouGuangdongChina Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine for Reproductive Health Research 310006HangzhouZhejiangChina Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases 310006HangzhouZhejiangChina Department of Molecular Pharmacology and Experimental Therapeutics Mayo ClinicRochesterMN55905USA Department of Dermatology University of California San DiegoSan DiegoCA92122USA Key Laboratory of Saline-alkali Vegetation Ecology Restoration Ministry of EducationCollege of Life ScienceNortheast Forestry University150040HarbinChina Division of Gynecology Oncology Department of Obstetrics and GynecologyQilu HospitalShandong University250012JinanShandongChina Department of Obstetrics and Gynecology the First Affiliated HospitalSun Yat-Sen University510080GuangzhouGuangdongChina Department of Gynecologic Oncology Obstetrics and Gynecology Hospital of Fudan University200090ShanghaiChina Department of Gynecologic Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of

Poly(ADP-ribose)polymerase(PARP)inhibitors are one of the most exciting classes of targeted therapy agents for cancers with homologous recombination(HR)***,many patients without apparent HR defects also respond well to PARP inhibitors/*** biomarker responsible for this mechanism remains ***,we identified a set of ribosomal genes that predict response to PARP inhibitors/cisplatin in HR-proficient *** inhibitor/cisplatin selectively eliminates cells with high expression of the eight genes in the identified panel via DNA damage(ATM)signaling-induced pro-apoptotic ribosomal stress,which along with ATM signaling-induced pro-survival HR repair constitutes a new model to balance the cell fate in response to DNA ***,the combined examination of the gene panel along with HR status would allow for more precise predictions of clinical response to PARP inhibitor/*** gene panel as an independent biomarker was validated by multiple published clinical datasets,as well as by an ovarian cancer organoids library we *** importantly,its predictive value was further verified in a cohort of PARP inhibitor-treated ovarian cancer patients with both RNA-seq and WGS ***,we identified several marketed drugs capable of upregulating the expression of the genes in the panel without causing HR deficiency in PARP inhibitor/cisplatin-resistant cell *** drugs enhance PARP inhibitor/cisplatin sensitivity in both intrinsically resistant organoids and cell lines with acquired ***,our study identifies a marker gene panel for HR-proficient patients and reveals a broader application of PARP inhibitor/cisplatin in cancer therapy.

关键词： drugs BRCA panel

Immunoregulatory Effects of Ethyl-acetate Fraction of Extracts from Tetrastigma Hemsleyanum Diels et. Gilg on Immune Functions of ICR Mice

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Biomedical and Environmental Sciences 2008年第4期21卷 325-331页

作者： CAI-JU XU GANG-QIANG DING jian-YUN FU JIA MENG RONG-HUA zhang XIAO-MING lou Department of Toxicology Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310009 Zhejiang China

Objective To evaluate the effects of ethyl-acetate fraction （EAF） of extracts from Tetrastigma hemsleyanum Diels et. Gilg （TDG） on immune functions of ICR mice. Methods ICR mice were exposed to different doses of EAF for 15 or 30 days and then their immune functions were analyzed, including ConA-induced splenic lymphocyte transformation, SRBC- induced delayed type hypersensitivity response, serum hemolysin analysis, antibody-producing cells, peritoneal macrophage phagocytized chicken red blood cells, natural killer cell activity, and serum level of cytoldnes. Results EAF of extracts from TDG at different doses had various effects on immune functions of ICR mice. As compared with the controls, it increased the mouse spleen lymphocyte transformation induced by ConA, the left-hind voix pedis thickness and the number of plague forming cells （PFCs） at the dose of 1.82 mg/mL, 5.48 mg/mL, and 9.12 mg/mL, respectively; increased the ink clearance ability at the dose of 0.91 mg/mL, 1.82 mg/mL, 5.48 mg/mL, and 9.12 mg/mL, respectively; increased the phagocytosis index of mononuclear-macrophages and production of serum interferon-gamma （IFN-？） at the dose of 5.48 mg/mL; and could promote the production of serum tumor necrosis factor-alpha （TNF-α） at the dose of 9.12 mg/mL. Conclusion EAF of extracts from TDG can regulate mouse immune functions in vivo.

关键词： EAF of extracts from TDG Immuno-regulation Cellular immunity Humoral immunity Macrophage phagocytosis NK cytoactivity Serum cytokines

Increased Oxidative Stress and Damage in Patients With Chronic Bacterial Prostatitis

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Biomedical and Environmental Sciences 2006年第6期19卷 481-486页

作者： jian-GUO lou JIE DONG Yt-CHUN ZHENG SHU-MEI zhang WEJ-QIANG XIAO AND JUN-FU ZHOU Laboratory for Free Radical Medicine Medical College Second Hospital Zhejiang University Hangzhou 310009 Zhejiang China Department of Traditional Chinese Medicine Medical College Second Hospital Zhejiang University Hangzhou 310009 Zhejiang China Department of Urology Medical College Second Hospital Zhejiang University Hangzhou 310009 Zhejiang China

Objective To investigate whether chronic bacterial prostatitis （CBP） increases oxidative stress and damage in patients with CBP, and to explore its possible mechanism. Methods Eighty patients with CBP and 80 healthy adults as controls were enrolled in a case-control study, in which levels of nitric oxide （NO）, vitamin C （VC）, and vitamin E （VE） in plasma, as well as malondialdehyde （MDA）, activities of superoxide dismutase （SOD）, and eatalase （CAT） in erythrocytes were determined by spectrophotometry. Results Compared with the average values of NO, VC, VE, MDA, SOD, and CAT in the healthy control group, those of plasma N O and erythrocyte MDA in the CBP group were significantly increased （P〈0.00 1）, and those of plasma VC and VE as well as erythrocyte SOD and CAT in the CBP group were significantly decreased （P〈0.001）. Findings from partial correlation analysis for course of the disease and NO, VC, VE, MDA, SOD, and CAT in 80 patients with CBP, adjusted for age, suggested that with prolonged course of the disease, values of NO and MDA were gradually increased （P〈0.001）, and those of VC, VE, SOD, and CAT were gradually decreased （P〈0.05-0.001）. The findings from stepwise regression analysis for course of the disease and NO, VC, VE, MDA, SOD, and CAT in CBP group suggested that the model of stepwise regression was Y = -19.1160 ＋0.3112MDA ＋ 0.0337NO, F = 22.1734, P〈0.001, r = 0.6045, P〈0.001. The findings from the reliability analysis for VC, VE, SOD, CAT, NO, and MDA in the CBP group showed that the reliability coefficients＇ alpha （6 items） was 0.7195, P〈0.0001, and the standardized item alpha was 0.9307, P〈0.0001. Conclusion There exist increased oxidative stress and damage induced by chronic bacterial prostatitis in patients, and such a phenomenon is closely related to the course of disease.

关键词： Chronic bacterial prostatitis Oxidative stress Oxidative damage Free radicals Oxidation Lipid peroxidation Antioxidant Antioxidative enzyme Nitric oxide Malondialdehyde

Adiabatic Enhanced Compression of Ultrashort Pulses in Fibres with Slowly Decreasing Dispersion

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Chinese Physics Letters 2001年第10期18卷 1360-1362页

作者： XU Wen-cheng zhang Shu-Min LUO Ai-ping CHEN Wei-Cheng LIAO Chang-Jun LIU Song-Hao WU jian lou Cai-Yun GAO Yi-zhi Institute of Quantum Electronics South China Normal UniversityGuangzhou 510631 Department of Electronical Engineering Tsinghua UniversityBeijing 100084

We investigate the adiabatic enhanced compression of ultrashort pulses from a distributed feedback laser operated at 1550 nm in fibres with slowly decreasing dispersion (FSDD). High-quality pulse compressions from 4.4 ps down to 1.1ps in a l00m FSDD and from 4.4ps down to 830fs in a 500m FSDD are obtained. The Raman self frequency shift of femtosecond pulses in the compression is observed. Theoretical analyses are in good agreement with experimental results.

关键词： ultrashort Dispersion slowly