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孔径对第三代镍基单晶高温合金DD33板式试样室温拉伸性能的影响

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材料研究学报 2016年第5期30卷 343-347页

作者：周忠娇刘涛张功王莉楼琅洪中国科学院金属研究所沈阳110016

本文研究了孔径(φ=0.5、0.7及0.9 mm)对第三代镍基单晶高温合金DD33板式试样室温拉伸性能的影响。采用ARAMIS-光学动态应变测量系统原位观测了拉伸过程中不同孔径孔周围的应变分布,并利用扫描电镜观察了拉伸试样的断口形貌。结果表明:... 详细信息

本文研究了孔径(φ=0.5、0.7及0.9 mm)对第三代镍基单晶高温合金DD33板式试样室温拉伸性能的影响。采用ARAMIS-光学动态应变测量系统原位观测了拉伸过程中不同孔径孔周围的应变分布,并利用扫描电镜观察了拉伸试样的断口形貌。结果表明:随着孔径的增大,试样的屈服强度和抗拉强度均降低。拉伸过程中孔周围产生应变集中,而且只在孔边很小的范围。弹性变形阶段,孔边应变增长缓慢;一旦发生塑性变形,应变快速增长。孔径越大,孔周围的应变集中越严重,应变梯度越大。上述研究结果对理解含冷却孔单晶叶片的变形行为,优化叶片结构,从而提高叶片寿命具有重要意义。

关键词：金属材料材料的组织结构缺陷与性能室温拉伸 ARAMIS系统镍基单晶高温合金孔径应变

Magneto-Impedance in Amorphous FeCuNbSiB Films

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Chinese Physics Letters 1998年第10期15卷 748-749页

作者： XIAO Shu-qin LIU Yi-hua zhang Lin HU Ji-fan lou jian-xin HUANG Bao-xin DAI You-yong Department of Physics Shandong UniversityJinan 250100

Longitudinal and transverse magneto-impedance effects have been observed in amorphous FeCuNbSiB films made by radio frequency *** magneto-impedance values have been obtained at lower *** field dependence and frequency... 详细信息

关键词： impedance amorphous transverse

Histone deacetylase 6 mediated NALP3 inflammasome activation contributes to dopaminergic injury in experimental models of Parkinson disease

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中国药理学与毒理学杂志 2018年第9期32卷 686-687页

作者： YAN Shao-qi WEI Xin-bing jian Wen-cheng QIN Yue jianG Fan lou Hai-yan zhang Bin Department of Pharmacology School of Basic Medical SciencesShandong University Jinan 250012China Department of Radiology Qilu HospitalShandong University Jinan 250012China Department of Pathophysiology School of Basic Medical SciencesShandong University Jinan 250012China

OBJECTIVE To investigate the mechanisms of histone deacetylase 6(HDAC6)deacetylation activity on NALP3 inflammasome activation and explore the protective effect s of pharmacological inhibition of HDAC6 on dopaminergic *** In vitro and in vivo6-OHDA induced Parkinson disease(PD) model was *** distinguish the effect of deacetylase catalytic domains of HDAC6,we used a specific HDAC6 inhibitor tubastatin A(TBA),siRNAHDAC6,and pcDNA-HDAC6-FLAG ***,the role of pharmacological inhibition or siRNA or overexpression of HDAC6 on NALP3 inflammasome and cell death was explored by using Western blotting,TUNEL,and flow cytometric ***,the acetylation level of peroxiredoxin 2(Prx2) and the production of reactive oxygen species(ROS) in cells under different treatments was examined by using immunoprecipitation and DCFH-DA fluorescence *** effects of TBA on neuroinflammation and nigrostriatal dopaminergic system in vivo was further investigated by using Western blotting,immunohistochemistry and HPLC *** TBA remarkably inhibited 6-OHDA induced NALP3 inflammasome activation,reduced dopaminergic neurodegeneration and neuroinflammation as demonstrated by increased TH-positive neurons,striatal levels of DA and its metabolites,and decreased gliocyte *** recovered acetylation of Prx2,and reduced ROS production,which was associated with decreased NALP3 inflammasome *** HDAC6 may medicate deacetylation of Prx2 contributes to NALP3 inflammasome activation in PD pathology,suggesting that the development of specific pharmacological inhibitors of HDAC6 be required for this kind of disease.

关键词： histone deacetylase 6 NALP3 peroxiredoxin 2 reactive oxygen species

Scedosporium apiospermum infection of the lumbar vertebrae:A case report

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World Journal of Clinical Cases 2022年第10期10卷 3251-3260页

作者： Xue-Wen Shi Sheng-Tang Li Jin-Peng lou Bo Xu jian Wang Xin Wang Hua Liu Song-Kai Li Ping Zhen Tao zhang Orthopaedic Centers The 940^(th) Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Orthopaedic Centers The Clinical Medical College of Ningxia Medical UniversityYinchuan 750000Ningxia Hui Autonomous RegionChina Orthopaedic Centers The Second Clinical Medical College of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Orthopaedic Centers The Clinical Medical College of Gansu University of Traditional Chinese MedicineLanzhou 730000Gansu ProvinceChina

BACKGROUND Scedosporium apiospermum(***)is a clinically rare and aggressive fungus mainly found in contaminated water,wetlands,decaying plants,stagnant water,and potted plants in *** lung,bone,joint,eye,brain,skin,and other sites are easily infected,and there is a marked risk of *** have been few case reports of infection by *** of the lumbar vertebrae;most reports have focused on infection of the *** SUMMARY An otherwise healthy 60-year-old man presented with a 4-mo history of lumbosacral pain,stooping,and limited *** symptoms were significantly aggravated 10 d prior to hospitalization,and radiating pain in the back of his left lower leg developed,which was so severe that he could not *** of the lumbar spine was significantly limited,anterior flexion was about 30°;backward extension,right and left lateral curvature,and rotational mobility were about 10°;tenderness of the spinous processes of the lumbar 3-5 vertebrae was evident,and the muscle strength of both lower limbs was gradeⅣ.Imaging suggested bony destruction of the lumbar 3,4,and 5 vertebrae and sacral 1 vertebra;in addition,the corresponding intervertebral spaces were narrowed and the lumbar 5 vertebra was posteriorly displaced and *** vertebral infection was also noted,and the possibility of lumbar tuberculosis was *** first performed surgical intervention on the lesioned lumbar vertebrae,cleared the infected lesion,and performed stable fixation of the lesioned vertebral body using a lumbar internal fixation device,which restored the stability of the lumbar *** and pathological examination of the lesioned tissue removed during surgery confirmed *** infection of the lumbar vertebrae;on this basis,the patient was administered *** the 6-mo followup,efficacy was significant,no drug-related side effects were observed,and imaging examination showed no evidence of ***

关键词： Scedosporium apiospermum Lumbar vertebrae Fungal infection Treatment Voriconazole Case report

基于CIM/SVG和面向对象的配电单线图自动生成

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电力系统自动化 2008年第22期32卷 61-65页

作者：章坚民楼坚杭州电子科技大学系统集成研究所浙江省杭州市310037

研究了基于公共信息模型(CIM)数据和可伸缩矢量图形(SVG)格式的配电单线图的自动构图。首先提出了符合常规配电单线图布置原则的分级支线配电数据模型和基于CIM的馈电线路分支化方法;提出了具备自动构图要素的干线图元对象和支线图元对... 详细信息

研究了基于公共信息模型(CIM)数据和可伸缩矢量图形(SVG)格式的配电单线图的自动构图。首先提出了符合常规配电单线图布置原则的分级支线配电数据模型和基于CIM的馈电线路分支化方法;提出了具备自动构图要素的干线图元对象和支线图元对象,构成递推的图形描述模型,通过最低级支线逐级向上进行图形参数识别,并生成其SVG子图形(叶子),并逐级组装最后生成整条馈线的SVG;逐级形成的图形独占空间,在原理上根本避免了交叉和重叠。根据数据模型自动生成电网单线图,并对图元自动增加其控制属性,提高了电网自动化的自动工程配置能力。所提出的算法已通过浙江省某县市的验证。

关键词：配电单线图自动生成 CIM SVG 面向对象设计

缺口取向及温度对第三代单晶高温合金DD33热疲劳行为的影响

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材料研究学报 2024年第2期38卷 111-120页

作者：郑明瑞李亚微刘静王莉郑伟董加胜张健楼琅洪中国科学院金属研究所沈阳110016 中国科学技术大学材料科学与工程学院沈阳110016

使用OM、SEM和EDS等手段,研究了第三代镍基单晶高温合金DD33不同V型缺口取向([100]、[210]和[110])片状试样从室温到不同上限温度(1000℃、1100℃和1200℃)的热疲劳过程中裂纹的萌生和扩展行为。结果表明,在三种上限温度,DD33合金的热... 详细信息

使用OM、SEM和EDS等手段,研究了第三代镍基单晶高温合金DD33不同V型缺口取向([100]、[210]和[110])片状试样从室温到不同上限温度(1000℃、1100℃和1200℃)的热疲劳过程中裂纹的萌生和扩展行为。结果表明,在三种上限温度,DD33合金的热疲劳性能均出现明显的各向异性。在三个上限温度[100]取向试样均表现出最好的热疲劳性能;上限温度为1000℃和1200℃[110]取向试样的热疲劳性能最差,上限温度为1100℃[210]取向试样的热疲劳性能最差。不同取向试样的热疲劳裂纹的萌生和扩展行为,均呈现出一定的晶体学取向规律。热应力、氧化以及滑移系的开动,导致不同取向试样裂纹的扩展速率不同。

关键词：金属材料单晶高温合金缺口取向热疲劳各向异性氧化

Mapping of fruit apex shape related QTLs across multi-genetic backgrounds in cucumber(Cucumis sativus L.)

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Horticultural Plant Journal 2022年第3期8卷 328-340页

作者： Pinyu Zhu Yongjiao Meng Kaijing zhang Xueyan Wang Kun Liang Tuantuan Wang jian Xu Xiaodong Qin Zhe Wu Chunyan Cheng Xiaqing Yu Chuntao Qian Qunfeng lou Jinfeng Chen Ji Li State Key Laboratory of Crop Genetics and Germplasm Enhancement College of HorticultureNanjing Agricultural UniversityNanjing 210095China College of Engineering/jiangsu Province Engineering Lab for Modern Facility Agriculture Technology&Equipment Nanjing Agricultural UniversityNanjing 210031China College of Agriculture Anhui Science and Technology UniversityFengyang 233100China

The shape of fruit apex is critical to appearance quality in cucumber(Cucumis sativus L.),of which the genetic basis was poorly understood,and the use of marker-assisted breeding for fruit apex improvement is not available *** this study,the variation of fruit apex in different cucumber ecotypes was evaluated by fruit apex angle(variation coefficient from 7.1%to 15.7%)and fruit apex index(variation coefficient from 8.8%to 22.6%).Fruit apex associated QTLs were mapped by using 145 F_(2:3) families and 155 F_(2:6) population that were derived from the cross of different ecotype *** of the mapping populations were conducted in four experiments in 2 *** majoreffect QTLs,Bfal4.1,Bfai4.1,Bfad6.1 and Bfai6.1 were consistently and reliably detected across two environments which could explain 11.6%-33.6%phenotypic variations(R^(2))in the F_(2:3) *** major-effect QTLs,Ofai4.1(R^(2)=13.4%-15.5%),Ofal4.1(R^(2)=10.7%-12.8%),and Ofad6.1(R^(2)=11.6%-12.4%)were stably detected in the F_(2:6) population in two ***4.1,Bfal4.1,Ofai4.1 and Ofal4.1 were integrated to be consensus QTL fa4.1,within which 11 candidate genes were ***6.1 and Bfad6.1 were integrated to be consensus QTL *** interaction analysis showed that Bfai6.1 has epistatic effect with *** study revealed two reliable major-effect fruit apex related QTLs across multi-genetic backgrounds and environments in *** possible candidate genes regulating the shape of fruit apex,and the relationship between cell division and fruit apex morphogenesis were discussed.

关键词： Cucumber Fruit apex Variation QTL Candidate gene

A Preliminary Study of the Therapeutic Role of Human Early Fetal Aorta-derived Endothelial Progenitor Cells in Inhibiting Carotid Artery Neointimal Hyperplasia

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Chinese Medical Journal 2015年第24期128卷 3357-3362页

作者： Rong-Wei Xu Wen-jian zhang jian-Bin zhang jian-Yan Wen Meng Wang Hong-Lin Liu Lin Pan Chang-An Yu Jin-Ning lou Peng Liu Department of Cardiovascular Surgery China-Japan Friendship Hospital Beijing 100029 China Graduate School of Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100073 China Institute of Clinical Medical Sciences China-Japan Friendship Hospital Beijing 100029 China

Background： Endothelial cell damage is an important pathophysiological step of restenosis after angioplasty and stenting. Cell transplantation has great therapeutic potential for endothelial recovery. We investigated the effect of transplanting endothelial progenitor cells （EPCs） derived from human early fetal aortas in rat injured arteries. Methods： The carotid arterial endothelium of Sprague-Dawley rats was damaged by dilatation with a 1.5 F balloon catheter, and then EPCs derived from human early fetal aortas （〈14 weeks） were injected into the lumen of the injured artery in transplanted rats, with an equal volume of normal saline injected into control rats. Rats were sacrificed at 2 and 4 weeks after treatment and transplanted cells were identified by immunohistochemical staining with anti-human CD31 and anti-human mitochondria antibodies. Arterial cross-sections were analyzed by pathology, immunohistochemistry, and morphometry. Results： Green fluorescence-labeled EPCs could be seen in the endovascular surface of balloon-injured vessels after transplantation. The intimal area and intimal/medial area ratio were significantly smaller in the transplanted group than in the control （P 〈 0.05） and the residual lumen area was larger （P 〈 0.05）. After EPC transplantation, a complete vascular endothelial layer was formed, which was positive for human yon Willebrand factor after immunohistochemical staining, and immunohistochemical staining revealed many CD31- and mitochondria-positive cells in the re-endothelialized endothelium with EPC transplantation but not control treatment. Conclusion： EPCs derived from human early fetal aorta were successfully transplanted into injured vessels and might inhibit neointimal hyperplasia after vascular injury.

关键词： Carotid Artery Injury Cell Transplantation Endothelial Progenitor Cell Human Fetal Aorta Neointima

炸药装药爆炸反应演化过程和约束影响的数值模拟

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含能材料 2021年第12期29卷 1186-1191页

作者：楼建锋张树道北京应用物理与计算数学研究所北京100094

为分析弱刺激条件下炸药装药反应演化问题和约束条件对炸药爆炸反应的影响,构建了炸药爆炸反应速率增长的唯像模型,采用多介质任意拉式欧拉和流固耦合算法,实现了约束装药局部点火后缓慢燃烧反应到剧烈爆炸反应增长及其与壳体相互作用... 详细信息

为分析弱刺激条件下炸药装药反应演化问题和约束条件对炸药爆炸反应的影响,构建了炸药爆炸反应速率增长的唯像模型,采用多介质任意拉式欧拉和流固耦合算法,实现了约束装药局部点火后缓慢燃烧反应到剧烈爆炸反应增长及其与壳体相互作用的数值模拟。基于强约束球形装药中心点火实验,数值模拟分析了约束条件对压装PBX⁃2炸药爆炸反应压力增长过程的影响,结果表明壳体强度或厚度增加,装药内反应压力的峰值也增大;随着钢壳厚度从5 mm增加到20 mm,压力峰值从163 MPa增大到1357 MPa,而且压力增长过程存在很大的差异,但随着壳体破裂解体,抑制了爆炸向爆轰反应的转变。

关键词：燃烧反应剧烈爆炸约束强弱唯像模型数值模拟