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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui yu Yan Xie jian yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang yu-Ying Tan Li Zhang Wen-Tao jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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神经营养因子3经受体切换促进大鼠脊髓损伤后神经功能的恢复

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中国组织工程研究 2025年第11期29卷 2268-2276页

作者：丛岩于健孙志德康大伟承德医学院附属医院急诊科河北省承德市067000

背景:神经营养因子是治疗脊髓损伤的新方法,调控自噬是其发挥作用的机制之一,但具体的信号通路尚不明确。目的:探讨神经营养因子3如何通过P75NTR/Trk C受体切换来调节少突胶质细胞的自噬以及促进脊髓损伤后神经功能恢复的作用,进一步明... 详细信息

背景:神经营养因子是治疗脊髓损伤的新方法,调控自噬是其发挥作用的机制之一,但具体的信号通路尚不明确。目的:探讨神经营养因子3如何通过P75NTR/Trk C受体切换来调节少突胶质细胞的自噬以及促进脊髓损伤后神经功能恢复的作用,进一步明确具体的分子机制。方法:将24只SD大鼠随机分为3组:假手术组、脊髓损伤组和神经营养因子3组,通过大鼠后肢神经功能评分来评估神经营养因子3对脊髓损伤大鼠的治疗效果,采用Western blot检测各组大鼠脊髓组织中神经营养因子3、Olig1、MBP蛋白以及自噬标记蛋白LC3B的表达水平。在细胞实验中,将少突胶质细胞接种在培养皿中,分为糖氧剥夺组、糖氧剥夺+神经营养因子3组、糖氧剥夺+神经营养因子3+P75NTR质粒组、糖氧剥夺+神经营养因子3+Trk C质粒组、糖氧剥夺+3-甲基腺嘌呤(自噬抑制剂)组及糖氧剥夺+雷帕霉素(自噬激活剂)组。光学显微镜观察少突胶质细胞形态变化,TUNEL染色观察细胞凋亡现象,Western blot检测Trk C受体、P75NTR、LC3B表达及PI3K/AKT/m TOR和AMPK/m TOR信号途径的磷酸化状态。结果与结论:(1)动物实验显示,与假手术组相比,脊髓损伤后神经营养因子3的表达显著增加(P<0.05);与脊髓损伤组相比,外源性神经营养因子3治疗能够加快大鼠神经功能的恢复(P<0.05),并增加Olig1和MBP蛋白的表达(P<0.05);(2)细胞实验发现,3 h是损伤早期与中后期的分界点,与糖氧剥夺组相比,糖氧剥夺+神经营养因子3组少突胶质细胞能够更长时间地维持其形态,Trk C受体在早期表达水平较低而中后期显著上调(P<0.05),P75NTR则在早期上调而中后期下调(P<0.05),自噬水平呈现出先升高后降低的趋势(P<0.05);(3)通过对比糖氧剥夺+神经营养因子3组、糖氧剥夺+雷帕霉素组和糖氧剥夺+3-甲基腺嘌呤组的细胞形态和TUNEL染色结果,发现单独促进或抑制自噬对少突胶质细胞的存活均有不利影响,而类似神经营养因子3这样调节自噬的方法则能最大限度地维持细胞存活;(4)神经营养因子3在早期通过P75NTR/AMPK/m TOR信号通路促进自噬,而在后期通过Trk C/PI3K/AKT/m TOR信号通路抑制自噬。根据上述结果,得到如下结论,即神经营养因子3可以通过P75NTR/Trk C受体的切换能够双向调控少突胶质细胞的自噬,从而维持细胞存活,有助于脊髓损伤后大鼠的神经功能恢复。

关键词：神经营养因子3 自噬少突胶质细胞受体切换凋亡脊髓损伤

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SOLVABILITY OF VECTOR KY FAN INEQUALITIES WITH APPLICATIONS

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Journal of Systems Science & Complexity 2013年第6期26卷 978-990页

作者： yu jian PENG Dingtao College of Science Guizhou University School of Science Beijing Jiaotong University

This paper aims to study the solvability of vector Ky Fan inequalities and the compactness of its solution *** vector-valued functions with the cone semicontinuity and the cone quasiconvexity in infinite dimensional spaces,the authors prove some existence results of the solutions and the compactness of the solution ***,some results for the vector Ky Fan inequalities on noncompact sets are built and the compactness of its solution sets are also *** applications,some existence theorems of the solutions of vector variational inequalities are obtained.

关键词： Compactness noncompact set solvability vector Ky Fan inequalities vector variationalinequality.

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Characterization of Essential Stability in Lower Pseudocontinuous Optimization Problems

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Journal of Systems Science & Complexity 2015年第3期28卷 638-644页

作者： ZHOU Yonghui yu jian School of Mathematics and Computer Sciences Guizhou Normal University Department of Mathematics Guizhou University

Characterization of essential stability of minimum solutions for a class of optimization problems with boundedness and lower pseudocontinuity on a compact metric space is given. It shows that any optimization problem considered here has one essential component(resp. one essential minimum solution) if and only if its minimum solution set is connected(resp. singleton) and that those optimization problems which have a unique minimum solution form a residual set(however, which need not to be dense).

关键词： Essential component essential minimum solution pseudocontinuity unique solution.

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Larix olgensis growth-climate response between lower and upper elevation limits:an intensive study along the eastern slope of the Changbai Mountains,northeastern China

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Journal of Forestry Research 2020年第1期31卷 231-244页

作者： jian yu Qijing Liu Forestry College Beijing Forestry University

Larix olgensis is a dominant tree species in the forest ecosystems of the Changbai Mountains of northeast *** assess the growth response of this species to global climate change,we developed three tree-ring width and biomass chronologies across a range of elevations in the subalpine forests on the eastern slope of the Changbai *** used dendroclimatic analyses to study key factors limiting radial growth in *** and its variation with *** statistical characteristics of chronologies suggested that elevation is a determinant of tree growth patterns in the study *** function analysis of chronologies with climate factors indicated that climate–growth relationships changed with increasing elevation:tree growth at high elevation was strongly limited by June temperatures of the previous year,and as elevation decreases,the importance of temperature decreased;tree radial growth at mid-elevation was mainly controlled by precipitation towards the end of the growing season of the current *** chronologies reflected a stronger climatic signal than tree-ring width *** correlation with gridded climate data revealed that our chronologies contained a strong regional temperature signal for northeast *** growing below timberline appeared to be more sensitive to climate,thus optimal sites for examining growth trends as a function of climate variation are considered to be just below *** study objective was to provide information for more accurate prediction of the growth response of *** to future climate change on the eastern slope of the Changbai Mountains,and to provide information for future climate reconstructions using this tree species in humid and semi humid regions.

关键词： Tree-ring width Dendrochronology Changbai Mountains Elevation gradient Timberline Larix olgensis

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Direct numerical simulation of shock wave/boundary layer interaction controlled by steady microjet in a compression ramp

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Chinese Journal of Aeronautics 2024年第10期37卷 83-102页

作者： Ruoye XIAO Dong SUN jian yu School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China State Key Laboratory of Aerodynamics Mianyang 621000China

Shock wave/boundary layer interaction in a 24°turning angle of the compression ramp at Mach number 2.9 controlled by steady microjet is investigated using direct numerical *** different jet spacings which are termed as sparse,moderate and dense are considered,and the induced vortex system and shock structures are compared.A moderate jet spacing configuration is found to generate counter-rotating vortex pairs that transport high-momentum fluid towards the vicinity of wall and strengthen the boundary layer to resist separation,reducing the separation *** dense jet spacing configuration creates a larger momentum deficit region,reducing the friction downstream of the *** of pressure and pressure gradient reveals that dense jet spacing configuration reduces the intensity of separation *** impact of varying jet spacings on the turbulent kinetic energy transport mechanism is also investigated by decomposing the budget terms in the transport ***,the spectral characteristics of the separation region are studied using power spectral density and dynamic mode decomposition methods,revealing that moderate jet spacing configuration suppresses low-frequency fluctuations in the separation region.

关键词： Shock wave/boundary layer interaction Compression ramp Steady microjet Different jet spacings Direct numerical simulation

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Integrated Modeling of Process–Microstructure–Property Relations in Friction Stir Additive Manufacturing

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Acta Metallurgica Sinica(English Letters) 2020年第1期33卷 75-87页

作者： Zhao Zhang Zhi-Jun Tan jian-yu Li yu-Fei Zu jian-Jun Sha State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsFaculty of Vehicle Engineering and MechanicsDalian University of TechnologyDalian 116024China School of Aeronautics and Astronautics Dalian University of TechnologyDalian 116024China

Friction stir additive manufacturing is a newly developed solid-state additive manufacturing *** material in the stirring zone can be re-stirred and reheated,and mechanical properties can be changed along the building *** integrated model is developed to investigate the internal relations of process,microstructure and mechanical *** heat source model is used to simulate the friction stir additive manufacturing process to obtain the temperature histories,which are used in the following microstructural *** Carlo method is used for simulation of recrystallization and grain *** evolution model is used for calculation of precipitate size *** property is then *** are used for validation of the predicted grains and *** indicate that the average grain sizes on diff erent layers depend on the temperature in stirring and re-stirring *** the increase in building height,average grain size is decreased and hardness is *** increase in layer thickness can lead to temperature decrease in reheating and re-stirring processes and then lead to the decrease in average grain size and increase of hardness in stir zone.

关键词： Additive manufacturing Friction stir welding Integrated model Precipitate Re-stirring Reheating

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Mendelian Randomization Analysis to Analyze the Effect of Emergency Caesarean Section on Different Allergic Diseases and Related Blood Markers

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Biomedical and Environmental Sciences 2023年第11期36卷 1084-1089页

作者： LI yu jian KAN Xuan Department of Pediatrics General Hospital of Tianjin Medical UniversityTianjin 300052China

Caesarean section is a well-established surgical procedure that allows for maximum fetal rescue under special circumstances,such as intrauterine distress and intrauterine hypoxia,and minimizes injuries to pregnant women who cannot tolerate vaginal *** caesarean section is a special type of caesarean section that plays an important role in protecting the lives of pregnant mothers and fetuses[1].

关键词： Blood injuries Emergency

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Revisit of dilation-based shock capturing for discontinuous Galerkin methods

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Applied Mathematics and Mechanics(English Edition) 2018年第3期39卷 379-394页

作者： jian yu Chao YAN Zhenhua jianG School of Aeronautic Science and Engineering Beihang University

The idea of using velocity dilation for shock capturing is revisited in this paper, combined with the discontinuous Galerkin method. The value of artificial viscosity is determined using direct dilation instead of its higher order derivatives to reduce cost and degree of difficulty in computing derivatives. Alternative methods for estimating the element size of large aspect ratio and smooth artificial viscosity are proposed to further improve robustness and accuracy of the model. Several benchmark tests are conducted, ranging from subsonic to hypersonic flows involving strong shocks. Instead of adjusting empirical parameters to achieve optimum results for each case, all tests use a constant parameter for the model with reasonable success, indicating excellent robustness of the method. The model is only limited to third-order accuracy for smooth flows. This limitation may be relaxed by using a switch or a wall function. Overall, the model is a good candidate for compressible flows with potentials of further improvement.

关键词： discontinuous Galerkin method axtificial viscosity compressible flow

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High-order implicit discontinuous Galerkin schemes for unsteady compressible Navier–Stokes equations

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Chinese Journal of Aeronautics 2014年第6期27卷 1384-1389页

作者： jiang Zhenhua Yan Chao yu jian School of Aeronautic Science and Engineering Beihang University

Efficient solution techniques for high-order temporal and spatial discontinuous Galerkin（DG） discretizations of the unsteady Navier–Stokes equations are developed. A fourth-order implicit Runge–Kutta（IRK） scheme is applied for the time integration and a multigrid preconditioned GMRES solver is extended to solve the nonlinear system arising from each IRK stage. Several modifications to the implicit solver have been considered to achieve the efficiency enhancement and meantime to reduce the memory requirement. A variety of time-accurate viscous flow simulations are performed to assess the resulting high-order implicit DG methods. The designed order of accuracy for temporal discretization scheme is validate and the present implicit solver shows the superior performance by allowing quite large time step to be used in solving time-implicit systems. Numerical results are in good agreement with the published data and demonstrate the potential advantages of the high-order scheme in gaining both the high accuracy and the high efficiency.

关键词： Discontinuous Galerkin scheme GMRES solver High order Implicit Runge–Kutta method Unsteady flows

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