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工业机器人在机械制造自动化产线上的应用

内燃机与配件 2024年第3期 90-92页

作者：岳建设段好运商丘技师学院河南商丘476000

工业机器人是典型的机电一体化装置,是先进制造业中不可替代的重要装备,在多个领域有着广泛应用。本文介绍了工业机器人的基本概况,阐述了工业机器人的工作原理,分析了工业机器人在机械制造自动化产线上的应用案例,为研究工业机器人在... 详细信息

工业机器人是典型的机电一体化装置,是先进制造业中不可替代的重要装备,在多个领域有着广泛应用。本文介绍了工业机器人的基本概况,阐述了工业机器人的工作原理,分析了工业机器人在机械制造自动化产线上的应用案例,为研究工业机器人在其它场景的应用和推广提供参考。

关键词：工业机器人机械制造自动化产线印章加工

Suadimins D—J,Monoterpenoid Indole-Quinoline and Bisindole Alkaloids from Melodinus suaveolens

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Chinese Journal of Chemistry 2023年第18期41卷 2296-2304页

作者： Xin-Hua Gao Pei-Qian Wu Yao-yue Fan Bin Zhou jian-Min yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences555 Zuchongzhi RoadShanghai201203China shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantaiShandong 264117China Research Units of Discovery of New Drug Lead Molecules Chinese Academy of Medical SciencesShanghai 201203China

Comprehensive Summary,Compounds 1—12,including seven complex monoterpenoid indole-quinoline and bisindole alkaloids,suadimins D—J(1—7)with previously unreported carbon-carbon linkages,were isolated and identified from the twigs and leaves of Melodinus suaveolens.Their structures were elucidated by a combination of diverse methods,especially the extensive spectroscopic data analysis and electric circular dichroism(ECD)calculations.The cytotoxicity of these compounds against three cancer cell lines was evaluated,some of which showed moderate activities with IC50 values ranging from 2.4 to 8.0μM.

关键词： Melodinus suaveolens Alkaloids Dimerization Structure elucidation ECD calculations Cytotoxic activity

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花青素类化合物影响淀粉理化性质研究进展

食品工业科技 2024年第1期45卷 343-351页

作者：李斌王琳岳健苏娟杨曙方杨一鋆牛文博边媛媛沈阳农业大学食品学院辽宁沈阳110866 云南山里红生物科技有限公司云南昆明650299 浙江蓝美技术股份有限公司浙江诸暨311800 锦州海关综合技术服务中心辽宁锦州121001

花青素类化合物包括原花青素、花青素、花色苷等。其中,原花青素是一种聚多酚类化合物,花青素和花色苷均属黄酮类化合物。当在酸性介质中加热时,原花青素可产生花青素,花青素可通过糖苷键与糖相结合可产生花色苷。在深色谷物、浆果及蔬... 详细信息

花青素类化合物包括原花青素、花青素、花色苷等。其中,原花青素是一种聚多酚类化合物,花青素和花色苷均属黄酮类化合物。当在酸性介质中加热时,原花青素可产生花青素,花青素可通过糖苷键与糖相结合可产生花色苷。在深色谷物、浆果及蔬菜中,原花青素、花青素、花色苷广泛分布,均具有多种功效。淀粉价格低廉、来源丰富,具有多种功能特性,淀粉基食品的感官品质及营养价值主要由淀粉糊化性质、热力学性质、流变学性质、老化性质及消化性质等变化所决定。对于淀粉与其他化合物共存能够改善淀粉原本性质已有很多研究,但关于花青素类化合物对淀粉性质影响的概述较少。因此,本文综述了花青素类化合物提高淀粉的糊化温度,降低淀粉的糊化焓值,进而影响淀粉的热力学性质,同时降低淀粉的老化焓以及老化率,降低淀粉的消化速率等对淀粉糊化特性、热力学特性、流变学特性、老化特性和消化性质影响的最新研究进展,为利用花青素类化合物等改善淀粉基食品的加工性能、感官和营养品质提供指导。

关键词：花青素类化合物原花青素花青素花色苷淀粉

Anlotinib has good efficacy and low toxicity: a phase Ⅱ study of anlotinib in pre-treated HER-2 negative metastatic breast cancer

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Cancer Biology & Medicine 2021年第3期18卷 849-859页

作者： Nanlin Hu Yiran Si jian yue Tingting Sun Xue Wang Zhuqing Jia Songlin Gao Qiao Li Yang Shao Jiayu Wang Yang Luo Fei Ma Binghe Xu Peng Yuan Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of VIP Medical Services National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Nanjing Geneseeq Technology Inc. Nanjing 210032China Cancer Hospital of Huanxing Chaoyang District Beijing Beijing 100021China

Objective:Anlotinib is a novel tyrosine kinase inhibitor blocking angiogenesis.This study was performed to assess the efficacy and safety of anlotinib in patients with metastatic breast cancer.Methods:Patients with HER2-negative breast cancer,who were pre-treated with anthracycline or taxanes in a neoadjuvant,adjuvant,or metastatic setting,and had treatment failure after at least one prior chemotherapy regimen in the metastatic setting were enrolled.Anlotinib was administered at 12 mg daily for 14 days in a 21-day cycle until disease progression or unacceptable toxicity occurred.Simultaneously,5–10 m L of venous blood was collected to perform circulating tumor DNA(ct DNA)testing every 2 treatment cycles.The primary endpoint was the objective response rate(ORR).Secondary endpoints included the disease control rate(DCR),progression-free survival(PFS),overall survival,safety,and biomarkers.Results:Twenty-six eligible patients were enrolled,with a median age of 56(30–75)years.The median follow-up time was 10.5 months.The ORR was 15.4%,the DCR was 80.8%,and the median PFS was 5.22 months(95%confidence interval 2.86–6.24).Fourteen(53.8%)patients survived for more than 10 months.The changes in the detectable ct DNA variant allele frequency were consistent with the tumor response.The most common treatment-related adverse events were hypertension(57.7%),thyroidstimulating hormone elevation(34.6%),and hand-foot syndrome(23.1%).Conclusion:Anlotinib showed objective efficacy with tolerable toxicity in heavily pre-treated,metastatic HER2-negative breast cancer.The dynamic changes in the ct DNA variant allele fraction may be predictive of the tumor response.

关键词： Anlotinib angiogenesis HER2-negative breast cancer ct DNA

耳穴压丸与腕踝针干预青少年运动员赛前焦虑及睡眠质量的比较研究

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兰州文理学院学报（自然科学版） 2024年第1期38卷 100-104,128页

作者：王建月郑丽芳安徽体育运动职业技术学院体育教育管理系安徽合肥230051

将30例有赛前焦虑及睡眠问题的青少年运动员随机分为A组、B组和C组,分别进行耳穴压丸、腕踝针及安慰干预.结果显示:干预后3组青少年运动员的心率、血压均有所升高,A组、B组的认知、躯体状态焦虑量表评分及PSQI总分均下降,状态自信心升高... 详细信息

将30例有赛前焦虑及睡眠问题的青少年运动员随机分为A组、B组和C组,分别进行耳穴压丸、腕踝针及安慰干预.结果显示:干预后3组青少年运动员的心率、血压均有所升高,A组、B组的认知、躯体状态焦虑量表评分及PSQI总分均下降,状态自信心升高,对照组(C组)则相反;与对照组相比,A组、B组的心率、认知、躯体状态焦虑量表评分、PSQI总分均下降,A组的收缩压也有所下降,且差异显著(P<0.05或<0.01);A组与B组相比,所有指标均无差异.结果表明,两种干预方法均可缓解青少年运动员的赛前焦虑及睡眠障碍,也可稳定心率、血压水平,干预效应相似.

关键词：青少年运动员耳穴压丸腕踝针赛前焦虑睡眠质量

通过添加微量Mn元素激活非基面滑移提高镁合金塑性

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Transactions of Nonferrous Metals Society of China 2024年第2期34卷 504-518页

作者：周世博刘婷婷汤爱涛时慧敬学锐彭鹏章建跃潘复生重庆大学材料科学与工程学院重庆400044 Institute of Metallic Biomaterials Helmholtz-Zentrum HereonMax-Planck-Straße 1D-21502GeesthachtGermany 西南大学材料与能源学院重庆400715 重庆大学镁合金国家工程研究中心重庆400044 重庆科技学院冶金和材料工程学院重庆401331 Department of Materials Science and Engineering The Ohio State UniversityColumbusOH 43210USA

分析微量锰添加对镁合金显微组织和力学性能的影响。采用电子背散射技术、迹线分析、透射电镜和粘塑性自洽模拟等方法研究变形过程中的塑性变形机理。结果表明:Mn的加入使Mg−Mn合金的平均晶粒尺寸由28.30μm减小到5.10μm;同时,随着Mn... 详细信息

分析微量锰添加对镁合金显微组织和力学性能的影响。采用电子背散射技术、迹线分析、透射电镜和粘塑性自洽模拟等方法研究变形过程中的塑性变形机理。结果表明:Mn的加入使Mg−Mn合金的平均晶粒尺寸由28.30μm减小到5.10μm;同时,随着Mn含量的增加,样品的断裂伸长率由14.33%提高到20.33%,屈服强度则由84 MPa提高到180 MPa。这种同时提高塑性和强度的原因是基面滑移和非基面滑移之间的临界剪切应力差从173 MPa减小到115 MPa,导致非基面滑移活动明显增加。通过微合金元素调整滑移系统差异为开发具有高强度和延展性的镁合金提供了一种途径。

关键词：镁合金显微组织演变力学性能塑性变形机理

西藏地区青稞酒曲微生物群落结构及多样性分析

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中国食品学报 2024年第5期24卷 381-392页

作者：张二豪奉综涛何萍刘盼盼简阅徐雨婷禄亚洲罗章西藏农牧学院食品科学学院西藏林芝860000

为分析西藏地区青稞酒曲中微生物群落结构组成差异,基于高通量测序技术对西藏7个地区青稞酒曲中的微生物群落结构组成及多样性进行分析。结果表明,青稞酒曲中富含丰富的微生物类群,且细菌多于真菌;那曲(NQ)样品细菌多样性最高,昌都(CD)... 详细信息

为分析西藏地区青稞酒曲中微生物群落结构组成差异,基于高通量测序技术对西藏7个地区青稞酒曲中的微生物群落结构组成及多样性进行分析。结果表明,青稞酒曲中富含丰富的微生物类群,且细菌多于真菌;那曲(NQ)样品细菌多样性最高,昌都(CD)样品真菌多样性最高;青稞酒曲中的优势细菌菌群为乳酸杆菌属、明串珠菌属和魏斯氏菌属,优势真菌菌群为根霉菌属和曲霉菌属,不同地区青稞酒曲中优势微生物类群存在一定的共性和差异性。主成分分析表明,NQ、阿里(AL)、日喀则(RKZ)和山南(SN)样品间细菌群落结构相似,CD、林芝(LZ)和拉萨(LS)样品间细菌群落结构相似;AL、NQ、LS、LZ和SN样品中的真菌群落聚为一类,而CD和RKZ各聚为一类。LEfSe差异判别分析表明,不同地区青稞酒曲中均有各自的标志性细菌类群,真菌菌群除SN样品外,其它地区均有标志性真菌类群。结论:西藏不同地区青稞酒曲中的微生物群落结构组成存在明显差异。本研究为进一步开发利用益生微生物类群和复合型酒曲的制备提供了理论依据。

关键词：青稞酒曲高通量测序细菌群落真菌群落多样性

Impact of coronavirus disease 2019 on the clinical diagnosis and treatment of breast cancer in China

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Chinese Medical Journal 2021年第5期134卷 590-592页

作者： Yi-Ran Si Feng Du Nan-Lin Hu Xue Wang jian yue Pei-Di jiang Bing-He Xu Peng Yuan the Breast Cancer Group,Chinese Association for Clinical Oncologist National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) The VIPII Gastrointestinal Cancer Division of Medical DepartmentPeking University Cancer Hospital and InstituteBeijing 100142China 不详

To the Editor:Since December 2019,the epidemic of coronavirus disease 2019(COVID-19)has become the focus of attention in China and worldwide.Despite the effective control of the outbreak in China,the global situation of COVID-19 was not optimistic which has gradually become a global threat of the year 2020.COVID-19 may cause high mortality in the elderly and patients with cardiovascular diseases,malignant tumors,and other underlying diseases.

关键词： diagnosis mortality cardiovascular

Polymorphisms of MTHFR and TYMS predict capecitabine-induced hand-foot syndrome in patients with metastatic breast cancer

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Cancer Communications 2019年第1期39卷 514-525页

作者： Shaoyan Lin jian yue Xiuwen Guan Peng Yuan Jiayu Wang Yang Luo Ying Fan Ruigang Cai Qiao Li Shanshan Chen Pin Zhang Qing Li Fei Ma Binghe Xu Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeNo.17Panjiayuan NanliChaoyang DistrictBeijing 100021P.R.China Department of VIP Medical Services National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021P.R.China

Background:Breast cancer is a global problem,and a large number of new cases are diagnosed every year.Capecit-abine is effective in patients with metastatic breast cancer(MBC).Hand-foot syndrome(HFS)is a common adverse effect of capecitabine.In this study,we investigated the association between single nucleotide polymorphisms(SNPs)in genes involved in capecitabine metabolism pathways and capecitabine-induced HFS in Chinese patients with MBC to identify some predictive genetic biomarkers.Methods:We selected 3 genes involved in capecitabine metabolism and screened genetic variants in these target genes.We genotyped a total of 22 SNPs in the thymidylate synthase gene(TYMS),the methylene tetrahydrofolate reductase gene(MTHFR),and the ribonucleotide reductase M1 gene(RRM1)in 342 MBC patients treated with capecit-abine-based chemotherapy.The genotype distributions of each SNP in patients with and without HFS were assessed using Pearson’sχ^(2)test,and the relationship between HFS and genotypes of SNPs was determined using logistic regression analysis.The association between SNPs and their corresponding gene expression was analyzed using the Blood expression quantitative trait loci(eQTL)browser online tools.Results:We found 4 positive sites for HFS in the TYMS and MTHFR genes:TYMS rs2606241(P=0.022),TYMS rs2853741(P=0.019),MTHFR rs3737964(P=0.029),and MTHFR rs4846048(P=0.030).Logistic regression analyses showed that the genotype AG of MTHFR rs3737964[odds ratio(OR)=0.54,95%confidence interval(CI)0.31-0.97,P=0.038]and MTHFR rs4846048(OR=0.54,95%CI 0.30-0.98,P=0.042)were protective factors of HFS,whereas the genotype CT of TYMS rs2853741(OR=2.25,95%CI 1.31-3.87,P=0.012)increased the risk of HFS.The association between the genotype GT of TYMS rs2606241(OR=1.27,95%CI 0.73-2.23,P=0.012)and HFS was uncertain.Further eQTL analyses confirmed that the alleles of rs3737964 and rs4846048 affected the gene expression levels of MTHFR in cis.Conclusions:We have identified four potentially useful pharmacogenetic markers,TYMS rs2606241,

关键词： Capecitabine Polymorphism Metastatic breast cancer Hand-foot syndrome TYMS MTHFR