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Exosome-mediated renal protection:Halting the progression of fibrosis

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Genes & Diseases 2024年第6期11卷 135-154页

作者： Chuanqi Liu Qingfeng Li jian-xing Ma Baisong Lu Tracy Criswell Yuanyuan Zhang Department of Plastic and Reconstructive Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Biochemistry Wake Forest School of MedicineWinston-SalemNC 27101United States Institute for Regenerative Medicine Wake Forest School of MedicineWinston-SalemNC 27157United States

Renal fibrosis is a complex and multifactorial process that involves inflammation,cell proliferation,collagen,and fibronectin deposition in the kidney,ultimately leading to chronic kidney disease and even end-stage renal *** main goal of treatment is to slow down or halt the progression of fibrosis and to improve or preserve kidney *** significant progress made in understanding the underlying mechanisms of renal fibrosis,cur-rent therapies have limited renal protection as the disease *** derived from stem cells are a newer area of research for the treatment of renal *** as nano-sized extracellular vesicles carry proteins,lipids,and nucleic acids,which can be taken up by local or distant cells,serving as mediators of intercellular communication and as drug delivery *** deliver molecules that reduce inflammation,renal fibrosis and extracel-lular matrix protein production,and promote tissue regeneration in animal models of kidney ***,they have several advantages over stem cells,such as being non-immu-nogenic,having low risk of tumor formation,and being easier to produce and *** re-view describes the use of natural and engineered exosomes containing therapeutic agents capable of mediating anti-inflammatory and anti-fibrotic processes during both acute kidney injury and chronic kidney ***-based therapies will be compared with stem cell-based treatments for tissue regeneration,with a focus on renal ***,future directions and strategies for improving the therapeutic efficacy of exosomes are discussed.

关键词： Chronic kidney disease Exosomes Growth factors Renal fibrosis Stem cells

Carbon dioxide sorption and diffusion in coals:Experimental investigation and modeling

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Science China Earth Sciences 2012年第4期55卷 633-643页

作者： xing jian Ping Guan Wei Zhang Peking Univ MOE Key Lab Orogen Belts & Crustal Evolut Sch Earth & Space Sci Beijing 100871 Peoples R China

CO2 sorption and diffusion in coal are closely related to the occurrence of coal and gas outburst,geological sequestration of CO2 in coalbeds,and enhancing coalbed methane recovery by injecting ***,it is significant to investigate the sorption properties and diffusion models of CO2 in *** we used a newly designed experimental apparatus at Peking University to investigate the sorption and diffusion properties of CO2 in natural coal samples from Dashucun Mine and Wutongzhuang Mine in Handan city,Hebei province,and Jinhuagong Mine in Datong city,Shanxi province,and obtained CO2 sorption isotherms and diffusivity *** results indicate that,in a certain pressure range,CO2 sorption isotherms for the coal samples are consistent with the Langmuir model,which assumes that monolayer sorption occurs at the interface between coal matrix and CO2 molecules,and the sorption isotherms feature nonstandard hyperbolas in *** the same pressure and temperature,as the vitrinite content increases,coal adsorbs more CO2 *** relation between the sorption capacity and the coal rank may be described as a "U-type" trend,and medium rank coal has the least sorption *** bulk diffusivity of CO2 in coal is not constant;in the range of CO2 mass fraction greater than 1%,it increases roughly linearly with increasing mass fraction of CO2 adsorbed(or CO2 partial pressure) in ***2 diffusivity in coal is approximately 10-4 to 10-2 mm2/s in magnitudes,and the diffusivity ranges in coal samples are 3×10-4 to 8×10-3 mm2/s from Dashucun Mine,2×10-4 to 4×10-3 mm2/s from Wutongzhuang Mine,and 2×10-4 to 4×10-3 mm2/s from Jinhuagong *** results of the CO2 sorption and diffusion study can be applied to help predict and prevent coal and gas outburst as well as to evaluate the feasibility in geological sequestration of CO2 and to enhance coalbed methane recovery.

关键词： coal C02 sorption isotherm C02 desorption diffusion diffusivity

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Centrifugal Casting of High Speed Steel/Nodular Cast Iron Compound Roll Collar

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Journal of Iron and Steel Research International 2002年第1期9卷 32-35页

作者： FU Han-guang ZHAO Ai-min xing jian-dong FU Ding-mei Xi'an Jiaotong University University of Science and Technology Beijing

The centrifugal casting of compound HSS/nodular cast iron roll collar was studied,and the factors affecting transition zone quality were *** pouring temperature and interval in pouring are the main factors affecting transition zone *** controlling process parameter and flux adding during casting,high quality roll collar was *** cause,why in the casting of HSS part,segregation appears easily,was analyzed and the countermeasure eliminating segregation was put forward,the measure eliminating heat treatment crackling was also put forward.

关键词： high-speed steel nodular cast iron centrifugal compound casting combining layer roll collar

Probabilistic Teleportation of an Arbitrary Two-Particle State and Its Quantum Circuits

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Communications in Theoretical Physics 2006年第6期45卷 1013-1017页

作者： GUO Zhan-Ying FANG jian-xing ZHU Shi-Qun QIAN Xue-Min School of Physical Science and Technology Suzhou University Suzhou 215006 China Department of Physics Jiaozuo Normal College Jiaozuo 454001 China

Two simple schemes for probabilistic teleportation of an arbitrary unknown two-particle state using a non-maximally entangled EPR pair and a non-maximally entangled GHZ state as quantum channels are proposed. After receiving Alice＇s Bell state measurement results, Bob performs a collective unitary transformation on his inherent particles without introducing the auxiliary qubit. The original state can be probabilistically teleported. Meanwhile, quantum circuits for realization of successful teleportation are also presented.

关键词： probabilistic teleportation arbitrary two-particle state unitary transformation quantum circuit

The effect of adjuvant transarterial chemoembolization for hepatocellular carcinoma after liver resection based on risk stratification

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Hepatobiliary & Pancreatic Diseases International 2023年第5期22卷 482-489页

作者： Jin-Shu Zeng jian-xing Zeng Yao Huang Jing-Feng Liu Jin-Hua Zeng Department of Ultrasonic Medical The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005China The Liver Center of Fujian Province Fujian Medical UniversityFuzhou 350025China Department of Hepatobiliary Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005China Department of Hepatobiliary Surgery Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou 350005China

Background:There is currently no standard adjuvant treatment proven to prevent hepatocellular carcinoma(HCC)*** studies suggest that postoperative adjuvant transarterial chemoembolization(PA-TACE)is beneficial for patients at high risk of tumor ***,it is difficult to select the *** present study aimed to develop an easy-to-use score to identify these ***:A total of 4530 patients undergoing liver resection were *** risk factors were identified by Cox regression model in the training cohort and the Primary liver cancer big data transarterial chemoembolization(PDTE)scoring system was ***:The scoring system was composed of ten risk factors including alpha-fetoprotein(AFP),albuminbilirubin(ALBI)grade,operative bleeding loss,resection margin,tumor capsular,satellite nodules,tumor size and number,and microvascular and macrovascular *** 5 points as risk stratification,the patients with PA-TACE had higher recurrence-free survival(RFS)compared with non-TACE in>5 points group(P5 points may benefit from PA-TACE.

关键词： Hepatocellular carcinoma Liver resection Adjuvant transarterial chemoembolization Scoring system Risk stratification

Quench Dynamics of Bose–Einstein Condensates in Boxlike Traps

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Chinese Physics Letters 2022年第7期39卷 18-23页

作者： Rong Du jian-Chong xing Bo Xiong Jun-Hui Zheng Tao Yang Shaanxi Key Laboratory for Theoretical Physics Frontiers Institute of Modern PhysicsNorthwest UniversityXi'an 710127China School of Science Wuhan University of TechnologyWuhan 430070China NSFC-SPTP Peng Huanwu Center for Fundamental Theory Xi'an 710127China

By quenching the interatomic interactions, we investigate the nonequilibrium dynamics of two-dimensional Bose–Einstein condensates in boxlike traps with power-law potential boundaries. We show that ring dark solitons can be excited during the quench dynamics for both concave and convex potentials. The quench's modulation strength and the steepness of the boundary are two major factors influencing the system's evolution. In terms of the number of ring dark solitons excited in the condensate, five dynamic regimes have been identified. The condensate undergoes damped radius oscillation in the absence of ring dark soliton excitations. When it comes to the appearance of ring dark solitons, their decay produces interesting structures. The excitation patterns for the concave potential show a nested structure of vortex-antivortex pairs. The dynamic excitation patterns for the convex potential, on the other hand, show richer structures with multiple transport behaviors.

关键词： BEC RDS Einstein Condensates in Boxlike Traps Quench Dynamics of Bose

Hydrocarbon detections using multi-attributes based quantum neural networks in a tight sandstone gas reservoir in the Sichuan Basin, China

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Artificial Intelligence in Geosciences 2021年第1期2卷 107-114页

作者： Ya-juan Xue xing-jian Wang Jun-xing Cao Xiao-Fang Liao School of Communication Engineering Chengdu University of Information TechnologyChengdu610225China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu610059China College of Geophysics Chengdu University of TechnologyChengdu610059China

A direct hydrocarbon detection is performed by using multi-attributes based quantum neural networks with gas *** proposed multi-attributes based quantum neural networks for hydrocarbon detection use data clustering and local wave decomposition based seismic attenuation characteristics,relative wave impedance features of prestack seismic data as the selected multiple attributes for one tight sandstone gas reservoir and further employ principal component analysis combined with quantum neural networks for giving the distinguishing results of the weak responses of the gas reservoir,which is hard to detect by using the conventional *** the seismic data from a tight sandstone gas reservoir in the Sichuan basin,China,we found that multiattributes based quantum neural networks can effectively capture the weak seismic responses features associated with gas saturation in the gas *** study is hoped to be useful as an aid for hydrocarbon detections for the gas reservoir with the characteristics of the weak seismic responses by the complement of the multiattributes based quantum neural networks.

关键词： Hydrocarbon detection Multi-attributes Quantum neural networks Tight sandstone gas reservoir Weak seismic responses

A NEW WAKE OSCILLATOR MODEL FOR PREDICTING VORTEX INDUCED VIBRATION OF A CIRCULAR CYLINDER

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Journal of Hydrodynamics 2010年第3期22卷 381-386页

作者： XU Wan-hai WU Ying-xiang, ZENG Xiao-hui ZHONG xing-fu YU jian-xing Key Laboratory of Port and Ocean Engineering Tianjin University Tianjin 300072 China Key Laboratory for Hydrodynamics and Ocean Engineering Institute of Mechanics Chinese Academy ofSciences Beijing 100190 China Key Laboratory of Port and Ocean Engineering Tianjin University Tianjin 300072 China

This article proposes a new wake oscillator model for vortex induced vibrations of an elastically supported rigid circular cylinder in a uniform current. The near wake dynamics related with the fluctuating nature of vortex shedding is modeled based on the classical van der Pol equation, combined with the equation for the oscillatory motion of the body. An appropriate approach is developed to estimate the empirical parameters in the wake oscillator model. The present predicted results are compared to the experimental data and previous wake oscillator model results. Good agreement with experimental results is found.

关键词： vortex induced vibration wake oscillator model circular cylinder van der Pol equation

Quantum reflection of a Bose-Einstein condensate with a dark soliton from a step potential

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Chinese Physics B 2021年第12期30卷 214-221页

作者： Dong-Mei Wang jian-Chong xing Rong Du Bo Xiong Tao Yang Shaanxi Key Laboratory for Theoretical Physics Frontiers Institute of Modern PhysicsNorthwest UniversityXi’an 710127China School of Science Wuhan University of TechnologyWuhan 430070China School of Physics Northwest UniversityXi’an 710127China Peng Huanwu Center for Fundamental Theory Xi’an 710127China

We study dynamical behaviors of a Bose-Einstein condensate(BEC)containing a dark soliton reflected from potential wells and potential barriers,*** orientation angle of the dark soliton and the width of the potential change play key roles on the reflection probability *** of the reflection probability with respect to the orientation angleθof the dark soliton can be well described by a cosine function Rs~cos[λ(θ-π/2)],whereλis a parameter determined by the width of the potential *** are two characteristic lengths which determine the reflection *** dependence of the reflection probability on the width of the potential change shows distinct characters for potential wells and potential *** length of the dark soliton determines the sensitive width of potential wells,whereas for potential barriers,the decay length of the matter wave in the region of the barrier qualifies the sensitive width of the *** time evolution of the density profiles of the system during the reflection process is studied to disclose the different behaviors of matter waves in the region of the potential variation.

关键词： Bose-Einstein condensate dark soliton quantum reflection